Luregn J Schlapbach, Sainath Raman, David Buckley, Shane George, Megan King, Roberta Ridolfi, Amanda Harley, Michele Cree, Debbie Long, Simon Erickson, Puneet Singh, Marino Festa, Kristen Gibbons, Rinaldo Bellomo
OBJECTIVES: Adjunctive therapy with vitamin C, hydrocortisone, and thiamin has been evaluated in adults, but randomized controlled trial (RCT) data in children are lacking. We aimed to test the feasibility of vitamin C, hydrocortisone, and thiamin in PICU patients with septic shock; and to explore whether the intervention is associated with increased survival free of organ dysfunction. DESIGN: Open-label parallel, pilot RCT multicenter study. The primary endpoint was feasibility...
February 1, 2024: Pediatric Critical Care Medicine