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JOURNAL ARTICLE
Karen Stenner, Judith Edwards, Lesley Mills, Sam Sherrington, Freda Mold
In community nursing, the administration of insulin for people with type 2 diabetes can be delegated by registered nurses to healthcare support workers. Although a voluntary framework in England provides national guidance, little is known about its uptake. The project aim was to determine the roll-out, characteristics and support needs in relation to the delegation of insulin administration in community settings. An online survey was disseminated to community nursing services in England via social media and nursing networks...
May 2, 2024: British Journal of Community Nursing
#22
JOURNAL ARTICLE
Yen Hai Le, Kanoko Ikawa, Hoa Thi Thanh Hoang, Hatsue Isomura, Diep Thi Khong, Thang Nam Nguyen, Tram Anh Que, Dung Tien Pham, Kaori Tanaka, Yoshimasa Yamamoto
The degree of contamination of retail meat with colistin-resistant bacteria and its potential contribution to dissemination within communities remains to be determined. Thus, we aimed to elucidate the contamination status of colistin-resistance genes, indicative of colistin-resistant bacteria, in retail meats in Vietnam. In total, 46 chicken and 49 pork meats from stores in Vietnam and Japan were examined. Multiplex real-time polymerase chain reaction with TaqMan probes was performed for detecting mcr-1 , mcr-3 , and Escherichia coli 16S rRNA ...
May 3, 2024: Foodborne Pathogens and Disease
#23
REVIEW
Eizaburo Ohno, Teiji Kuzuya, Naoto Kawabe, Kazunori Nakaoka, Hiroyuki Tanaka, Takuji Nakano, Yohei Miyachi, Senju Hashimoto, Yoshiki Hirooka
Endoscopic ultrasonography (EUS) provides high spatial resolution and more detailed images than other diagnostic modalities. Furthermore, EUS-guided tissue acquisition (EUS-TA), such as EUS-guided fine needle aspiration or biopsy (EUS-FNA/FNB), is an indispensable tool in pancreaticobiliary disease diagnostics, supporting a conclusive pathological diagnosis. In this review, we evaluate the current status and the usefulness of EUS-TA for the diagnostics of the following biliary tract diseases: (A) biliary stricture diagnostics, (B) biliary tract cancer (BTC) itself, and (C) staging of advanced BTC...
May 3, 2024: Journal of Medical Ultrasonics
#24
JOURNAL ARTICLE
Niranjan Meher, Gary W Ashley, Kondapa Naidu Bobba, Anju Wadhwa, Anil P Bidkar, Chandrashekhar Dasari, Changhua Mu, Ramya Ambur Sankaranarayanan, Juan A Camara Serrano, Athira Raveendran, David P Bulkley, Rahul Aggarwal, Nancy Y Greenland, Adam Oskowitz, David M Wilson, Youngho Seo, Daniel V Santi, Henry F VanBrocklin, Robert R Flavell
BACKGROUND: The uptake of large (>10 nm) non-targeted nanocarriers by bulk tumors is thought to be dominated by passive extravasation through porous tumor vessels and limited lymphatic drainage, the enhanced permeability and retention (EPR) effect. Prior studies demonstrated radiolabeled tumor-targeted and non-targeted 4-arm 40 kDa star polyethylene glycol (StarPEG) polymers for cancer imaging. By adding small molecule ligands targeting prostate-specific membrane antigen (PSMA) to the StarPEG polymer, marked increase in tumor uptake, penetration and retention in the tumor core was observed...
May 3, 2024: Advanced Healthcare Materials
#25
JOURNAL ARTICLE
Brandon M Flatgard, Alexander D Williams, Mohammed Badrul Amin, Jon L Hobman, Dov J Stekel, Emily K Rousham, Mohammad Aminul Islam
UNLABELLED: Antimicrobial resistance (AMR) poses a significant threat to global health and sustainable development goals, especially in low- and middle-income countries (LMICs). This study aimed to understand the transmission of AMR between poultry, humans, and the environment in Bangladesh using a One Health approach. We analyzed the whole genome sequences (WGS) of 117 extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) isolates, with 46 being carbapenem resistant...
May 3, 2024: Microbiology Spectrum
#26
JOURNAL ARTICLE
Elsa De la Cadena, María Fernanda Mojica, Laura J Rojas, Betsy E Castro, Juan Carlos García-Betancur, Steven H Marshall, Natalia Restrepo, Nancy Patricia Castro-Caro, Magalis Fonseca-Carrillo, Christian Pallares, Robert A Bonomo, María Virginia Villegas
UNLABELLED: Resistance to ceftazidime-avibactam (CZA) due to Klebsiella pneumoniae carbapenemase (KPC) variants is increasing worldwide. We characterized two CZA-resistant clinical Klebsiella pneumoniae strains by antimicrobial susceptibility test, conjugation assays, and WGS. Isolates belonged to ST258 and ST45, and produced a KPC-31 and a novel variant KPC-197, respectively. The novel KPC variant presents a deletion of two amino acids on the Ω-loop (del_168-169_EL) and an insertion of two amino acids in position 274 (Ins_274_DS)...
May 3, 2024: Microbiology Spectrum
#27
JOURNAL ARTICLE
Subrahmanyam Karuturi
Coronavirus disease 2019's (COVID-19's) wide dissemination casts long-term health jeopardy for millions. Long COVID-19, a lingering multisystem malady, weaves a complex array of symptoms. Understanding its full impact requires extensive research over months or years. The pace of recovery remains uncertain, challenging healthcare systems. An evidence-based symphony of medical care and support is urgently needed for long haulers. Understanding long COVID's genesis and advocating for patients is vital. Our comprehension remains limited, prompting a systematic scoping study to explore the existing knowledge and pave the way for future research, illuminating the enigma of "long COVID" and guiding the path towards understanding this relentless condition...
September 2023: Journal of the Association of Physicians of India
#28
JOURNAL ARTICLE
Zachary A Colton, Sophia M Liles, Megan M Griffith, Charis J Stanek, Joseph Walden, Allison King, Toyetta Barnard-Kirk, Susan Creary, Leena Nahata
BACKGROUND: As survival rates for individuals with sickle cell disease (SCD) increase, calls have been made to improve their reproductive healthcare and outcomes. The research team created a web-based program entitled Fertility edUcaTion to Understand ReproductivE health in Sickle cell disease (FUTURES). The study aim was to use the Consolidated Framework for Implementation Research (CFIR) during pre-implementation to identify challenges and opportunities from the individual to systems level of implementation to ultimately optimize the integration of FUTURES into clinical practice...
May 2, 2024: Journal of Pediatric Psychology
#29
Ayemane Salif, Ferdinand Bigirimana, Sophie Willems, Gina Reichman, Johanna Noels, Sigi Van Den Wijngaert, Sophie Lecomte, Evelyne Maillart, Philippe Clevenbergh
INTRODUCTION: The Bacillus Calmette-Guérin (BCG) used as anti-tuberculous vaccine is also a well-known therapy for superficial urothelial cancer. Local or general side effects can occur, although it is generally well tolerated. CASE: We present the case of a 65 year-old caucasian man consulting for gross hematuria and lower urinary tract symptoms. Magnetic resonance imaging (MRI) demonstrated a non-invasive urothelial carcinoma (NMIBC) and Prostate Imaging-Reporting and Data System (PIRADS) IV lesions...
2024: IDCases
#30
Yuta Nakamura, Takahiro Namba, Yukiko Kawazu, Masato Yasui
After the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic emerged, the virus spread rapidly worldwide, and outbreaks continued to occur intermittently. Here, we present the case of a 5-year-old boy with acute disseminated encephalomyelitis (ADEM) and initial symptoms of dysphoria and pain in the right lower extremity. Around the time of this episode, the patient exhibited no fever or respiratory symptoms. Brain magnetic resonance imaging (MRI) revealed multiple T2-weighted image/fluid-attenuated inversion recovery high-signal areas bilaterally subcortical to the deep white matter, corpus callosum, and bilateral basal ganglia...
2024: IDCases
#31
JOURNAL ARTICLE
Sheri Kingsdorf, Karel Pančocha, Jasmina Troshanska, Teuta Ramadani Rasimi
Effective practices for supporting families with autistic children ensure a match between their needs and the expectations and competencies of the clinician. Applied behavior analysis (ABA) services are a common provision for serving autistic individuals. However, in regions where ABA is in its infancy, like the Czech Republic and North Macedonia, culturally relevant resources, regulations for practice, and standardized coursework are missing. In their absence, it is necessary to investigate the degree to which practitioners in the regions are meeting the behavioral needs of families...
2024: International Journal of Developmental Disabilities
#32
JOURNAL ARTICLE
Seok-In Yoon, Hui-Yeong Park, Hyun Woo Lee, Chan Park, Sun-Yong Chung, Jong Woo Kim
BACKGROUND: Hwabyung is a Korean culture-bound syndrome characterized by anger-related physical and psychological symptoms. Depressive disorder is a common mental illness occurring worldwide, and has been reported to have a high comorbidity rate with Hwabyung. For patients with depressive disorders, differential diagnosis and combined treatment for Hwabyung should be considered. Mindfulness and Qigong may be effective alternatives for regulating emotions such as depression, anxiety, and anger...
2024: Frontiers in Psychiatry
#33
JOURNAL ARTICLE
Bobo Feng
Correction is an important tool to reduce the negative impact of health misinformation on social media. In the era of "I share, therefore I am" social media, users actively share corrective information to achieve the "anti-convincing" effect of health misinformation. Focusing on the local Chinese context, this study constructs a structural equation model using social capital as a mediating variable to explore whether usage of Chinese users' social media can promote corrective information sharing by influencing the structural, cognitive, and relational dimensions of social capital and the role of health literacy in corrective information sharing...
2024: Frontiers in Public Health
#34
JOURNAL ARTICLE
Rua Khogali, Armanda Bastos, Joel L Bargul, Dennis Getange, James Kabii, Daniel Masiga, Jandouwe Villinger
BACKGROUND: Tick-borne pathogen (TBP) surveillance studies often use whole-tick homogenates when inferring tick-pathogen associations. However, localized TBP infections within tick tissues (saliva, hemolymph, salivary glands, and midgut) can inform pathogen transmission mechanisms and are key to disentangling pathogen detection from vector competence. METHODS: We screened 278 camel blood samples and 504 tick tissue samples derived from 126 camel ticks sampled in two Kenyan counties (Laikipia and Marsabit) for Anaplasma, Ehrlichia, Coxiella, Rickettsia, Theileria , and Babesia by PCR-HRM analysis...
2024: Frontiers in Cellular and Infection Microbiology
#35
JOURNAL ARTICLE
Robin Kasper, Armando Rodriguez-Alfonso, Ludger Ständker, Sebastian Wiese, E Marion Schneider
INTRODUCTION: In septic patients the damage of the endothelial barrier is decisive leading to circulatory septic shock with disseminated vascular coagulation, edema and multiorgan failure. Hemadsorption therapy leads to rapid resolution of clinical symptoms. We propose that the isolation of proteins adsorbed to hemadsorption devices contributes to the identification of mediators responsible for endothelial barrier dysfunction. MATERIAL AND METHODS: Plasma materials enriched to hemadsorption filters (CytoSorb® ) after therapy of patients in septic shock were fractionated and functionally characterized for their effect on cell integrity, viability, proliferation and ROS formation by human endothelial cells...
2024: Frontiers in Immunology
#36
JOURNAL ARTICLE
Yihan Yang, Sanket More, Frederik De Smet, Steven De Vleeschouwer, Patrizia Agostinis
INTRODUCTION: Aberrant reactive oxygen species (ROS) production is one of the hallmarks of cancer. During their growth and dissemination, cancer cells control redox signaling to support protumorigenic pathways. As a consequence, cancer cells become reliant on major antioxidant systems to maintain a balanced redox tone, while avoiding excessive oxidative stress and cell death. This concept appears especially relevant in the context of glioblastoma multiforme (GBM), the most aggressive form of brain tumor characterized by significant heterogeneity, which contributes to treatment resistance and tumor recurrence...
2024: Frontiers in Immunology
#37
JOURNAL ARTICLE
Ahmad Farajzadeh Sheikh, Marjan Abdi, Zahra Farshadzadeh
BACKGROUND AND AIMS: The "hypervirulent" variant of Klebsiella pneumoniae (hvKp) is an emerging pathogen that cause life-threatening infection. The present study was conducted to identify the prevalence of hvKp and to investigate the presence class 1, 2, and 3 integrons in these isolates. METHODS: A cross-sectional study was conducted at three teaching hospitals, Ahvaz, South-west of Iran, from January 1, 2019 to December 31, 2020. Samples were collected from inpatients and included only the first samples collected from each patient...
May 2024: Health Science Reports
#38
JOURNAL ARTICLE
Jorge Berlanga-Acosta, Ernesto Arteaga-Hernandez, Ariana Garcia-Ojalvo, Dayanis Duvergel-Calderin, Marisol Rodriguez-Touseiro, Laura Lopez-Marin, Jose Suarez-Alba, Dasha Fuentes-Morales, Osmany Mendoza-Fuentes, Sheyla Fernández-Puentes, Yanier Nuñez-Figueredo, Gerardo Guillen-Nieto
Cancer remains a worldwide cause of morbidity and mortality. Investigational research efforts have included the administration of tumor-derived extracts to healthy animals. Having previously demonstrated that the administration of non-transmissible, human cancer-derived homogenates induced malignant tumors in mice, here, we examined the consequences of administering 50 or 100 µg of protein of crude homogenates from mammary carcinoma, pancreatic adenocarcinoma, and melanoma samples in 6 inoculations per week during 2 months...
2024: Frontiers in Molecular Biosciences
#39
JOURNAL ARTICLE
Allison Bond, Sandra Oreper, Priya Prasad, Emily Abdoler, Sarah Doernberg
BACKGROUND: Closing the gap between evidence-supported antibiotic use and real-world prescribing among clinicians is vital for curbing excessive antibiotic use, which fosters antimicrobial resistance and exposes patients to antimicrobial side effects. Providing prescribing information via scorecard improves clinician adherence to quality metrics. OBJECTIVE: We aimed to delineate actionable, relevant antimicrobial prescribing metrics extractable from the electronic health record in an automated way...
May 2, 2024: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
#40
JOURNAL ARTICLE
Yaseen M Arabi, Hasan M Al-Dorzi, Omar Aldibaasi, Musharaf Sadat, Jesna Jose, Dina Muharib, Haifa Algethamy, Abdulrahman A Al-Fares, Fahad Al-Hameed, Ahmed Mady, Ayman Kharaba, Ali Al Bshabshe, Khalid Maghrabi, Khalid AlGhamdi, Ghulam Rasool, Adnan AlGhamdi, Ghaleb A Almekhlafi, Jamal Chalabi, Haifaa Ibrahim AlHumedi, Maram Hasan Sakkijha, Norah Khalid Alamrey, Amjad Sami Alaskar, Rabeah Hamad Alhutail, Kaouthar Sifaoui, Rakan Alqahtani, Ahmad S Qureshi, Mohammed Moneer Hejazi, Hatim Arishi, Samah AlQahtani, Amro Mohamed Ghazi, Saleh T Baaziz, Abeer Othman Azhar, Sara Fahad Alabbas, Mohammed AlAqeely, Ohoud AlOrabi, Aliaa Al-Mutawa, Maha AlOtaibi, Madiha Fawazy Elghannam, Mohammed Almaani, Sarah Fadel Buabbas, Wadiah Alawi M Alfilfil, Mohammed S Alshahrani, Joel Starkopf, Jean-Charles Preiser, Anders Perner, Jumana Hani AlMubarak, Wafa Mansoor Hazem, Talal Albrahim, Abdulaziz Al-Dawood
BACKGROUND: The optimal amount and timing of protein intake in critically ill patients are unknown. REPLENISH (Replacing Protein via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients) trial evaluates whether supplemental enteral protein added to standard enteral nutrition to achieve a high amount of enteral protein given from ICU day five until ICU discharge or ICU day 90 as compared to no supplemental enteral protein to achieve a moderate amount of enteral protein would reduce all-cause 90-day mortality in adult critically ill mechanically ventilated patients...
May 2, 2024: Trials
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