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Janna L Koole, Martijn J L Bours, José J L Breedveld-Peters, Eline H van Roekel, Stéphanie O Breukink, Maryska L G Janssen-Heijnen, F Jeroen Vogelaar, Michel Aquarius, Eric Keulen, Jan Stoot, Matty P Weijenberg
BACKGROUND & AIMS: Supplement use among colorectal cancer (CRC) survivors is common, yet evidence supporting its beneficial health effects is mostly lacking and cancer-specific lifestyle guidelines advise against the use of supplements. We aimed to describe the use of supplements by CRC survivors from diagnosis to 2 years post-treatment and investigate how overall supplement use is longitudinally associated with fatigue. METHODS: In a prospective cohort study of stage I-III CRC survivors (n = 325), information on supplement use was collected during repeated home visits at diagnosis and at 6 weeks, 6, 12, and 24 months post-treatment...
January 29, 2019: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
N Latchana, L Davis, N G Coburn, A Mahar, Y Liu, A Hammad, D Kagedan, M Elmi, M Siddiqui, C C Earle, J Hallet
Background: Pancreatic cancer surgery is increasingly regionalized in high-volume centres. Provision of adjuvant chemotherapy in the same institution can place a burden on patients, whereas receiving adjuvant chemotherapy at a different institution closer to home may create disparities in care. This study compared long-term outcomes of patients with pancreatic adenocarcinoma receiving adjuvant chemotherapy at the institution where they had undergone surgery with outcomes for those receiving chemotherapy at a different institution...
February 2019: BJS open
Edward Tsai, Elie Mouhayar, Daniel Lenihan, Jaejoon Song, Jean-Bernard Durand, Anecita Fadol, Mona Massey, Carol Harrison, Karen Basen-Engquist
PURPOSE: Cancer treatment-related heart failure (HF) is an emerging health concern, as the number of survivors is increasing rapidly, and cardiac health issues are a leading cause of mortality in this population. While there is general evidence for the efficacy of exercise rehabilitation interventions, more research is needed on exercise rehabilitation interventions for patients specifically with treatment-induced HF and whether such interventions are safe and well-accepted. This study provides feasibility and health outcomes of a pilot exercise intervention for cancer survivors with chemotherapy-induced HF...
January 31, 2019: Journal of Cardiopulmonary Rehabilitation and Prevention
Eliana Stein, Meera Rayar, Upasana Krishnadev, Abha Gupta, Shannon Hyslop, Erin Plenert, Tal Schechter-Finkelstein, Lillian Sung
PURPOSE: Pediatric cancer patients experience symptoms that negatively impact quality of life; yoga may be an effective intervention. The primary objective was to determine the feasibility of a 10-week, weekly individualized yoga intervention for children and adolescents receiving outpatient cancer therapy primarily delivered remotely using Skype. Secondary objectives were to describe depression, anxiety, anger, fatigue, quality of life, and symptoms at 5 and 10 weeks after enrollment...
February 2, 2019: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Enikö Egyed, Markus M Heiss, Frank Wappler, Samir G Sakka
Mortality of patients treated on the intensive care unit suffering from cancer is high, especially when admitted with an unknown malignancy. Still, anti-tumor therapy in critically ill patients requiring mechanical ventilation is a clinical challenge. Over the last years, successful chemotherapy has been reported, even in critically ill patients with infections and organ failure. In this report, we present a 42-year old male patient who later was been diagnosed for a highly-malignant lymphoma (Burkitt) developed an abdominal compartment syndrome due to ileus, ascites and progressive intestinal tumor manifestation...
January 22, 2019: Journal of Critical Care
Matthew A Tyler, Abdallah S R Mohamed, Joshua B Smith, Jeremy M Aymard, Clifton D Fuller, Jack Phan, Steven J Frank, Renata Ferrarotto, Michael E Kupferman, Ehab Y Hanna, Gary B Gunn, Shirley Y Su
OBJECTIVE: To evaluate long-term global and site-specific health-related quality of life (HRQoL) in patients treated for sinonasal and nasopharyngeal malignancies. STUDY DESIGN: Cross-sectional. METHODS: One hundred fourteen patients with sinonasal and nasopharyngeal malignancies received surgery, radiation, systemic chemotherapy, or a combination thereof, with curative intent. Validated global ([EuroQol-5D] Visual Analogue Scale [EQ-5D VAS]) and disease-specific instruments (MD Anderson Symptom Inventory-Head and Neck [MDASI-HN], Anterior Skull Base Questionnaire [ASBQ]) were administered to patients who were both free of disease and had completed treatment at least 12 months previously...
February 1, 2019: Laryngoscope
Linnea Waldorff Lund, Gunn Ammitzbøll, Dorte Gilså Hansen, Elisabeth Anne Wreford Andersen, Susanne Oksbjerg Dalton
BACKGROUND: The purpose of the study was to examine adherence and identify patient- and treatment-related factors associated with adherence to a 20-week combined supervised and home-based progressive resistance training program in women treated for breast cancer. METHODOLOGY: The study population consisted of the intervention group in a randomized clinical trial examining the effect of resistance exercise on lymphoedema prevention (n = 82). The full program lasted 50 weeks, with an initial 20 weeks combined supervised and home-based exercise followed by 30 weeks self-administered exercise...
January 30, 2019: Acta Oncologica
Sara Fredslund Hajdú, Malene Bæk Christensen, Marlene Østermark Kristensen, Irene Wessel, Christoffer Johansen, Susanne Dalton
BACKGROUND: In recent years, preventive swallowing exercises have been investigated as a means to limit dysphagia in head and neck cancer patients. However, adherence to exercise regimes has been poorly documented limiting the conclusions drawn on the effects of the interventions. We investigated adherence to a preventive swallowing exercise program and identified possible associations between adherence and four selected baseline factors: HPV status, partner status, concomitant chemotherapy and tumor site and between adherence to swallowing exercises and attendance to supervised training sessions...
January 30, 2019: Acta Oncologica
Rowena Ivers, Brad Jackson, Trish Levett, Kyla Wallace, Scott Winch
OBJECTIVE: To evaluate the acceptability of a cancer care team based at an Australian Aboriginal medical service in supporting patients' cancer journeys and to assess improvements in access to cancer care. DESIGN: The cancer care team consisted of an Australian Aboriginal health worker, counsellor and enrolled nurse employed for 2 days a week, supported by a general practitioner. The cancer care team supported patients from prediagnosis while investigations were being undertaken, at diagnosis and through treatment, such as surgery, chemotherapy and radiotherapy, and follow-up, including to palliative care and grief support where these were required...
January 29, 2019: Australian Journal of Rural Health
Li Ling, Xiushan Feng, Tianqin Wei, Yan Wang, Yaping Wang, Ziling Wang, Dongyuan Tang, Yanjing Luo, Zhengai Xiong
BACKGROUND: Chemotherapy can induce premature ovarian insufficiency (POI) and reduce fertility in young female patients. Currently, there is no effective therapy for POI. Human amnion-derived mesenchymal stem cells (hAD-MSCs) may be a promising seed cell for regenerative medicine. This study investigated the effects and mechanisms of hAD-MSC transplantation on chemotherapy-induced POI in rats. METHODS: Chemotherapy-induced POI rat models were established by intraperitoneal injection of cyclophosphamide...
January 25, 2019: Stem Cell Research & Therapy
Qinghai Peng, Jordan Mechanic, Ahmed Shoieb, Ingrid D Pardo, Laura Schaevitz, Judith Fenyk-Melody, Allison Vitsky, Magalie Boucher, Chris Somps, Jon C Cook, Chang-Ning Liu
Chemotherapy-induced peripheral neuropathy (CiPN) is a serious adverse effect in the clinic, but nonclinical assessment methods in animal studies are limited to labor intensive behavioral tests or semi-quantitative microscopic evaluation. Hence, microRNA (miRNA) biomarkers and automated in-life behavioral tracking were assessed for their utility as non-invasive methods. To address the lack of diagnostic biomarkers, we explored miR-124, miR-183 and miR-338 in a CiPN model induced by paclitaxel, a well-known neurotoxic agent...
2019: PloS One
Parisa Shoaei, Hasan Shojaei, Farzin Khorvash, Sayed Mohsen Hosseini, Behrooz Ataei, Hossein Tavakoli, Mohammad Jalali, J Scott Weese
Background: Clostridium difficile infection (CDI) is known as one of the most important causes of nosocomial infections. The main objective of this study was to evaluate the presence of Clostridium difficile in the stool of hospitalized patients with diarrhea as well as in their environments. Methods: C. difficile isolates were characterized according to the presence of toxin genes and antibiotic resistance. Multilocus Sequence Typing Analysis (MLST) was applied for finding the genetic polymorphism and relationship among strain lineages...
2019: Antimicrobial Resistance and Infection Control
Pasquale Innominato, Sandra Komarzynski, Abdoulaye Karaboué, Ayhan Ulusakarya, Mohamed Bouchahda, Mazen Haydar, Rachel Bossevot-Desmaris, Magali Mocquery, Virginie Plessis, Francis Lévi
PURPOSE: To assess the impact of chronomodulated irinotecan fluorouracil-leucovorin and oxaliplatin (chronoIFLO4) delivered at home on the daily life of patients with cancer in real time using a home-based e-Health multifunction and multiuser platform. This involved multidimensional telemonitoring of circadian rest-activity rhythm (CircAct), sleep, patient-reported outcome measures, and body weight changes (BWCs). PATIENTS AND METHODS: Patients received chronoIFLO4 fortnightly at home...
December 2018: JCO Clinical Cancer Informatics
Misbahuddin Khaja, Toolsie Omesh, Masooma Niazi, Danial Shaikh, Sitarama Arvind Mudunuru, Olga Alexandra Reyes, Sandeep Malik
Background: Acute myeloid leukemia (AML) is the most common leukemia in adults. According to the French-American-British (FAB) system, monocytic leukemia is classified as M5. Myeloid sarcoma further occurs in 3-5% of AML. This is defined as an extramedullary tumor of myeloid cells in the lymph nodes, soft tissues, periosteum, bone, central nervous system (CNS), spinal cord, intestine, mediastinum, prostate, uterus, or ovaries. Case Presentation: Here, we describe the case of a 29-year-old female who presented with fever, swelling of gums, neck pain, and weakness, which had persisted for 1 week...
September 2018: Case Reports in Oncology
Michael J Chargualaf, Tieumy T Giao, Anna C Abrahamson, David Steeb, Miranda Law, Jill Bates, Teshome Nedi, Benyam Muluneh
PURPOSE: Ethiopia is home to a growing population of more than 100 million people. Healthcare in the region functions with a shortage of oncologists. Pharmacists as well as other healthcare providers can assist with expanding patient access to cancer care. A pilot project was proposed to provide education, determine areas to expand pharmacy services in oncology, and recommend interventions at Tikur Anbessa Specialized Hospital and Addis Ababa University. METHODS: A layered learning practice model comprising of a clinical pharmacist, a post-graduate year two oncology pharmacy resident, and two fourth-year student pharmacists was constructed for the experience...
January 7, 2019: Journal of Oncology Pharmacy Practice
Iknur Aydin Avci, Birsen Altay, Figen Cavusoglu, Ayse Cal, Nuran Mumcu, Dilek Celik Eren, Ozge Oz, Alaattin Altin, Ozden Karaoglanoglu, Ayse Buberci
This study was performed to evaluate effects of education, home visits, web, and phone counseling on chemotherapy symptoms and anxiety in patients with colorectal cancer receiving chemotherapy. This pretest-posttest, quasi-experimental study was conducted in a chemotherapy unit of a hospital between February 2014 and October 2015. Due to dropouts from the study, was completed on 51 participants in the control group and 31 participants in the experimental group. The experimental group was offered a program that includes home visit, nursing education, web counseling, and tele-counseling (HEWCOT), developed by the researchers, to control symptoms and to reduce anxiety...
January 3, 2019: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Ziliang Dong, Liangzhu Feng, Yu Chao, Yu Hao, Muchao Chen, Fei Gong, Xiao Han, Rui Zhang, Liang Cheng, Zhuang Liu
Amplification of intracellular oxidative stress has found to be an effective strategy to induce cancer cell death. To this end, we prepare a unique type of ultrasmall gallic acid-ferrous (GA-Fe(II)) nanocomplexes as the catalyst of Fenton reaction to enable persistent conversion of H2O2 to highly cytotoxic hydroxyl radicals (•OH). Then, both GA-Fe(II) and L-buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) synthesis, are co-encapsulated within a stealth liposomal nano-carrier. Interestingly, the obtained BSO/GA-Fe(II)@liposome is able to efficiently amplify intracellular oxidative stress via increasing •OH generation and reducing GSH biosynthesis...
December 28, 2018: Nano Letters
Scott M Rowley
CASE STUDY RS, a 36-year-old female, presented to the emergency department (ED) of a large academic medical center upon the advice of her primary care provider because of 3 weeks of progressive mental status changes, weakness, and decreased oral intake. According to her husband, RS was diagnosed with stage IIIA large cell lung cancer 8 months earlier and was treated with concurrent chemotherapy (carboplatin, pemetrexed, and bevacizumab) and radiation therapy that was completed 4 months prior to admission. No other specific information about her treatment or outside health records was available...
March 2018: Journal of the Advanced Practitioner in Oncology
Andrew K Mulville, Nancy N Widick, Neeharika Srivastava Makani
Hospice care is medical care provided to terminally ill patients with a life expectancy of 6 months or less. Hospice services include symptom control, pain management, palliative care, and other supportive services such as providing for home equipment or oxygen; however, it does not provide for life-prolonging therapies such as chemotherapy. Although oncologic benchmarks suggest patients should be enrolled in hospice 3 months prior to death, studies show that most hospice referrals are being made too late. These shorter stays in hospice result in increased cost of care especially at the end of life with most patients dying on aggressive treatments in the hospital...
December 26, 2018: American Journal of Hospice & Palliative Care
Shiyao Fu, Meng Liang, Yuli Wang, Lin Cui, Chunhong Gao, Xiaoyang Chu, Qianqian Liu, Ye Feng, Wei Gong, Meiyan Yang, Zhiping Li, Chunrong Yang, Xiang Yang Xie, Yang Yang, Chunsheng Gao
Glioma is a fatal disease with limited treatment options and very short survival. Although chemotherapy is one of the most important strategies in glioma treatment, it remains extremely clinically challenging largely due to the blood-brain barrier (BBB) and the blood-brain tumour barrier (BBTB). Therefore, the development of nanocarriers that possess both BBB and BBTB permeability, as well as glioma-targeting ability, is of great importance for glioma therapy. New frontiers in nanomedicine are advancing the research of novel biomaterials...
December 24, 2018: ACS Applied Materials & Interfaces
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