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JOURNAL ARTICLE
Andrew I Yang, Opeyemi O Alabi, Frederick L Hitti, Lenora Henry, Ryan Clanton, Gordon H Baltuch
No abstract text is available yet for this article.
June 30, 2021: Neurosurgery
#42
JOURNAL ARTICLE
Ingrid K Stake, Jon W Miles, Brenton W Douglass, Grant J Dornan, Thomas O Clanton
BACKGROUND: The percutaneous knotless repair technique for Achilles tendon ruptures utilizes a Percutaneous Achilles Repair System (PARS) device for suturing the proximal tendon and 2 suture anchors for fixing the sutures into the calcaneus. Determining the best position of the suture anchors may optimize the strength of this repair. METHODS: Twelve pairs of human ankle cadaveric specimens were randomly assigned to receive suture anchors placed at 45°, 90°, or 135° from the sagittal plane...
February 2022: Foot & Ankle Specialist
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JOURNAL ARTICLE
Christopher G Larkins, Alex W Brady, Zachary S Aman, Grant J Dornan, Craig T Haytmanek, Thomas O Clanton
BACKGROUND: Acute ankle sprains are common injuries. The anterior talofibular (ATFL) and calcaneofibular ligaments (CFL) are the most injured lateral structures. However, controversy exists on the optimal surgical treatment when the injury is both acute and severe or becomes chronic and unstable. Studies have evaluated the biomechanics of these ligaments, but no studies have robotically evaluated injury effects and surgical treatment of ATFL or ATFL and CFL injuries. PURPOSE: To quantitatively evaluate biomechanical effects of ATFL and CFL lesions, ATFL repair, ATFL and CFL repair, and augmentation of ATFL on ankle stability...
July 2021: American Journal of Sports Medicine
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JOURNAL ARTICLE
Guido G Urizar, Vivienne Nguyen, Jason Devera, Alexa J Saquillo, Lauren A Dunne, Cynthia Brayboy, Angela Dixon-Hamlett, Veronica Clanton-Higgins, Gwendolyn Manning
RATIONALE: African-American mothers in the U.S. experience high rates of stress, placing them at risk for depression, anxiety, and preterm births, and their children at risk for poor social-emotional development later in childhood. Yet, few studies have developed and tested family-based interventions that target optimal management of stress in this population. OBJECTIVE: The current mixed methods study examined whether a six-week family-based intervention (e.g., cognitive behavioral stress management intervention component for mothers and mindfulness-based kindness curriculum for their children) was effective in improving psychosocial outcomes among low-income African-American mothers and increasing prosocial behaviors in their children...
July 2021: Social Science & Medicine
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JOURNAL ARTICLE
Erik Nott, Lauren M Matheny, Thomas O Clanton, Carly Lockard, Brenton W Douglass, Kira K Tanghe, Nicholas Matta, Alex W Brady
BACKGROUND: The purposes of this study were to determine (1) if cartilage thicknesses on the talar dome and medial/lateral surfaces of the talus were similar, (2) whether there was sufficient donor cartilage surface area on the medial and lateral talar surfaces to repair talar dome cartilage injuries of the talus, and (3) whether the cartilage surface could be increased following anterior talofibular ligament (ATFL) and sectioning of the tibionavicular and tibiospring portion of the anterior deltoid...
October 2021: Foot & Ankle International
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JOURNAL ARTICLE
Kerstin Konrad, Gregor Kohls, Sarah Baumann, Anka Bernhard, Anne Martinelli, Katharina Ackermann, Areti Smaragdi, Karen Gonzalez-Madruga, Amy Wells, Jack C Rogers, Ruth Pauli, Roberta Clanton, Rosalind Baker, Linda Kersten, Martin Prätzlich, Helena Oldenhof, Lucres Jansen, Anneke Kleeven, Aitana Bigorra, Amaia Hervas, Iñaki Kerexeta-Lizeaga, Eva Sesma-Pardo, Miguel Angel Gonzalez-Torres, Réka Siklósi, Roberta Dochnal, Zacharias Kalogerakis, Mara Pirlympou, Leonidas Papadakos, Harriet Cornwell, Wolfgang Scharke, Dimitris Dikeos, Aranzazu Fernández-Rivas, Arne Popma, Christina Stadler, Beate Herpertz-Dahlmann, Stephane A De Brito, Graeme Fairchild, Christine M Freitag
BACKGROUND: Conduct disorder (CD) rarely occurs alone but is typically accompanied by comorbid psychiatric disorders, which complicates the clinical presentation and treatment of affected youths. The aim of this study was to investigate sex differences in comorbidity pattern in CD and to systematically explore the 'gender paradox' and 'delayed-onset pathway' hypotheses of female CD. METHODS: As part of the FemNAT-CD multisite study, semistructured clinical interviews and rating scales were used to perform a comprehensive phenotypic characterization of 454 girls and 295 boys with CD (9-18 years), compared to 864 sex- and age-matched typically developing controls...
May 19, 2021: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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REVIEW
Robert T Mankowski, Orlando Laitano, Thomas L Clanton, Scott C Brakenridge
Sepsis survivors experience a persistent myopathy characterized by skeletal muscle weakness, atrophy, and an inability to repair/regenerate damaged or dysfunctional myofibers. The origins and mechanisms of this persistent sepsis-induced myopathy are likely complex and multifactorial. Nevertheless, the pathobiology is thought to be triggered by the interaction between circulating pathogens and impaired muscle metabolic status. In addition, while in the hospital, septic patients often experience prolonged periods of physical inactivity due to bed rest, which may exacerbate the myopathy...
April 26, 2021: Journal of Clinical Medicine
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JOURNAL ARTICLE
Pebbles Fagan, Thomas Eissenberg, Dina M Jones, Joanna E Cohen, Patricia Nez Henderson, Mark S Clanton
Introduction: Tobacco control policies have helped to reduce the health, social, and economic burden of commercial tobacco use worldwide. Little is known about the long-term impact of regulatory policies and functioning bodies that make recommendations to inform policies. The Tobacco Products Scientific Advisory Committee (TPSAC) of the U.S. Food and Drug Administration (FDA) was formed in 2009 to evaluate the safety, health, and dependence of tobacco products and provide related advice and recommendations to the FDA and the Secretary of Health and Human Services...
July 2020: Journal of Legal Medicine
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JOURNAL ARTICLE
Orlando Laitano, Gerard P Robinson, Kevin O Murray, Christian K Garcia, Alex J Mattingly, Deborah Morse, Michelle A King, John D Iwaniec, Jamal M Alzahrani, Thomas L Clanton
Skeletal muscles secrete a wide variety of immunologically active cytokines, but the functional significance of this response to in vivo innate immunity is not understood. We addressed this by knocking out the toll receptor adapter protein, Myd88, only in skeletal muscle fibers (skmMyd88KO), and followed male and female mice at 6 and 12 h after peritoneal injection of cecal slurry (CS), a model of polymicrobial sepsis. Because of a previously identified increase in mortality to CS injection, males received ~ 30% lower dose...
April 1, 2021: Scientific Reports
#50
Noam Ben-Eliezer, Marina Lysenko, Inbal E Biton, Ofra Golani, Jennifer L Bartels, Solana R Fernandez, Tolulope A Aweda, Nicholas A Clanton, Rebecca Beacham, Suzanne E Lapi, Joel R Garbow, Michal Neeman
No abstract text is available yet for this article.
March 15, 2021: Scientific Reports
#51
JOURNAL ARTICLE
Nicholas A Clanton, Taylor E Spiller, Eliezer Ortiz, Zhinong Gao, Juan Manuel Rodriguez-Poirier, Albert J DelMonte, Doug E Frantz
A simple metal-free method has been developed for the reductive N-alkylation of indoles employing aldehydes as the alkylating agent and inexpensive Et3 SiH as the reductant. A wide range of aromatic and aliphatic aldehydes are viable substrates along with a variety of substituted indoles. In addition, the method was applied to a one-pot sequential 1,3-alkylation of a substituted indole and successfully demonstrated on a 100 mmol scale.
February 25, 2021: Organic Letters
#52
REVIEW
Sarah Gehlert, Mark Clanton, On Behalf Of The Shift Work And Breast Cancer Strategic Advisory Group
The rates of shift work outside of daylight hours have increased in recent years, and nighttime shift work is now considered a potential carcinogenic occupational exposure. Light at night exposure, lower melatonin production, and the production of stress-related mediators disrupt normal sleep-wake cycles. Women who work lower-wage jobs and part-time workers whose shifts are determined entirely by their supervisors (rotating shifts) may be subject to stress related to efforts to align childcare and other needs with the unpredictable nature of rotating shift work...
December 20, 2020: International Journal of Environmental Research and Public Health
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JOURNAL ARTICLE
Nicholas A Clanton, Shayne D Hastings, Griffin B Foultz, Julie A Contreras, Samantha S Yee, Hadi D Arman, April L Risinger, Doug E Frantz
Natural products have served as inspirational scaffolds for the design and synthesis of novel antineoplastic agents. Here we present our preliminary efforts on the synthesis and biological evaluation of a new class of electrophilic steroids inspired by the naturally occurring taccalonolides. We demonstrate that these simplified analogs exhibit highly persistent antiproliferative properties similar to the taccalonolides and retain activity against resistant cancer cell lines that warrants further preclinical development...
December 10, 2020: ACS Medicinal Chemistry Letters
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JOURNAL ARTICLE
Carly A Lockard, Ingrid K Stake, Alex W Brady, Madeleine G DeClercq, Kira K Tanghe, Brenton W Douglass, Erik Nott, Charles P Ho, Thomas O Clanton
OBJECTIVE: The purpose of this work was to compare measurements of talar cartilage thickness and cartilage and bone surface geometry from clinically feasible magnetic resonance imaging (MRI) against high-accuracy laser scan models. Measurement of talar bone and cartilage geometry from MRI would provide useful information for evaluating cartilage changes, selecting osteochondral graft sources or creating patient-specific joint models. DESIGN: Three-dimensional (3D) bone and cartilage models of 7 cadaver tali were created using (1) manual segmentation of high-resolution volumetric sequence 3T MR images and (2) laser scans...
December 3, 2020: Cartilage
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JOURNAL ARTICLE
Ben Eliezer Noam, Lysenko Marina, Biton E Inbal, Golani Ofra, Bartels L Jennifer, Fernandez R Solana, Aweda A Tolulope, Clanton A Nicholas, Beacham Rebecca, Lapi E Suzanne, Garbow R Joel, Neeman Michal
Vitamin H (biotin) is delivered to the fetus transplacentally by an active biotin-transport mechanism and is critical for fetal development. Our objective was to develop a comprehensive MRI technique for mapping biotin transporter activity in the murine placenta. Visualization of transporter activity can employ MRI's unique T2 *-dependent signal 'off-switch', which is triggered by transporter mediated aggregation of biotinylated contrast agent (b-BSA-Gd-DTPA). MRI data were collected from pregnant mice after administration of b-BSA-Gd-DTPA and analyzed using a new sub-voxel biophysical signal model...
November 27, 2020: Scientific Reports
#56
JOURNAL ARTICLE
Charles L Hofacre, Greg F Mathis, Brett S Lumpkins, Richard Sygall, Stefan Vaessen, Christa S Hofacre, John A Smith, Eric Clanton
Restrictions on the use of antibiotics in poultry production have increased interest in nonantibiotic alternatives to control necrotic enteritis (NE). Volatile fatty acids, and in particular butyric acid preparations, have shown potential as aids in controlling NE. Valeric acid compounds may be a new additional alternative. This series of three trials compared the effects of tributyrin, monovalerin, which is an organic acid mixture, and bacitracin in a NE challenge model consisting of challenge with coccidiosis followed by Clostridium perfringens...
September 1, 2020: Avian Diseases
#57
JOURNAL ARTICLE
Helena Oldenhof, Lucres Jansen, Katharina Ackermann, Rosalind Baker, Molly Batchelor, Sarah Baumann, Anka Bernhard, Roberta Clanton, Roberta Dochnal, Lynn Valérie Fehlbaum, Aranzazu Fernandez-Rivas, Sarah Goergen, Maider Gonzalez de Artaza-Lavesa, Karen Gonzalez-Madruga, Miguel Angel Gonzalez-Torres, Malou Gundlach, Mara Lotte van der Hoeven, Zacharias Kalogerakis, Krisztina Kapornai, Meinhard Kieser, Angeliki Konsta, Anne Martinelli, Ruth Pauli, Jack Rogers, Areti Smaragdi, Eva Sesma-Pardo, Réka Siklósi, Martin Steppan, Foteini Tsiakoulia, Robert Vermeiren, Noortje Vriends, Marleen Werner, Beate Herpertz-Dahlmann, Gregor Kohls, Stephane De Brito, Kerstin Konrad, Christina Stadler, Graeme Fairchild, Christine M Freitag, Arne Popma
Reduced responsiveness to emotions is hypothesized to contribute to the development of conduct disorder (CD) in children and adolescents. Accordingly, blunted psychophysiological responses to emotions have been observed in boys with CD, but this has never been tested in girls. Therefore, this study compared psychophysiological responses to sadness in girls and boys with and without CD, and different clinical phenotypes of CD: with versus without limited prosocial emotions (LPE), and with versus without comorbid internalizing disorders (INT)...
November 12, 2020: Journal of Abnormal Psychology
#58
JOURNAL ARTICLE
Kevin O Murray, Jason O Brant, John D Iwaniec, Laila H Sheikh, Lucas de Carvalho, Christian K Garcia, Gerard P Robinson, Jamal Alzahrani, Alberto Riva, Orlando Laitano, Michael P Kladde, Thomas L Clanton
KEY POINTS: Exposure to exertional heat stroke (EHS) has been linked to increased long-term decrements of health. Epigenetic reprogramming is involved in the response to heat acclimation, however, whether long-term effects of EHS are mediated by epigenetic reprogramming is unknown. In female mice, we observed DNA methylation reprogramming in bone marrow-derived (BMD) monocytes as early as 4 days of recovery from EHS and as late as 30 days compared to sham exercise controls (EXC). Whole blood, collected after 30 days of recovery from EHS, exhibited an immunosuppressive phenotype when challenged in vitro by lipopolysaccharide (LPS)...
October 9, 2020: Journal of Physiology
#59
JOURNAL ARTICLE
Jess Mullens, Ingrid K Stake, Lauren M Matheny, Blake Daney, Thomas O Clanton
BACKGROUND: Joint-preserving procedures of the ankle may postpone the need for ankle arthrodesis (AA) or total ankle replacement (TAR). The challenge for the surgeon is to determine which patients may benefit from these joint-preserving procedures. We hypothesized that patents with less than 2 mm of ankle joint space on preoperative radiographs would report inferior outcomes following joint-preserving surgery compared with those with 2 mm or greater joint space. METHODS: Patients 18 years of age or older treated with joint-preserving ankle surgery with a minimum of 2 years of follow-up were considered for study inclusion...
October 8, 2020: Foot & Ankle International
#60
JOURNAL ARTICLE
S Walter, O G Langford, T B Clanton, G A Jimenez-Maggiora, R Raman, M S Rafii, E J Shaffer, R A Sperling, J L Cummings, P S Aisen
BACKGROUND: The Trial-Ready Cohort for Preclinical and Prodromal Alzheimer's disease (TRC-PAD) aims to accelerate enrollment for Alzheimer's disease (AD) clinical trials by remotely identifying and tracking individuals who are at high risk for developing symptoms of AD, and referring these individuals to in-person cognitive and biomarker evaluation with the purpose of engaging them in clinical trials. A risk algorithm using statistical modeling to predict brain amyloidosis will be refined as TRC-PAD advances with a maturing data set...
2020: Journal of Prevention of Alzheimer's Disease
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