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Karen González-Madruga, Jack Rogers, Nicola Toschi, Roberta Riccelli, Areti Smaragdi, Ignazio Puzzo, Roberta Clanton, Jesper Andersson, Sarah Baumann, Gregor Kohls, Nora Raschle, Lynn Fehlbaum, Willeke Menks, Christina Stadler, Kerstin Konrad, Christine M Freitag, Stephane A De Brito, Edmund Sonuga-Barke, Graeme Fairchild
BACKGROUND: Previous studies of conduct disorder (CD) have reported structural and functional alterations in the limbic system. However, the white matter tracts that connect limbic regions have not been comprehensively studied. The uncinate fasciculus (UF), a tract connecting limbic to prefrontal regions, has been implicated in CD. However, CD-related alterations in other limbic tracts, such as the cingulum and the fornix, have not been investigated. Furthermore, few studies have examined the influence of sex and none have been adequately powered to test whether the relationship between CD and structural connectivity differs by sex...
January 30, 2019: Psychological Medicine
Paul Wehman, Lauren Avellone, Frederick Pecharka, Katti Sorboro, Joseph B Webster, Cynthia Young, Sharon Barton, William A Robbins, Samuel T Clanton
This article addresses employment as a critical part of community reintegration for polytrauma patients. Interdisciplinary polytrauma teams can work to effectively identify and eliminate known barriers to employment for veterans and offer continued support and guidance. This article discusses key themes pertinent to vocational reentry for service members/veterans, identifies evidenced-based employment models, highlights the essential role of everyday technology in meeting support needs, and describes 2 exemplar polytrauma models: the Louis Stokes Cleveland Veteran Affairs Medical Center in Cleveland, Ohio, and the Service member Transitional Advanced Rehabilitation (STAR) program at the Hunter Holmes McGuire Veterans Affairs Medical Center in Richmond, Virginia...
February 2019: Physical Medicine and Rehabilitation Clinics of North America
Orlando Laitano, Laila H Sheikh, Alex J Mattingly, Kevin O Murray, Leonardo F Ferreira, Thomas L Clanton
Hyperthermia and dehydration can occur during exercise in hot environments. Nevertheless, whether elevations in extracellular osmolality contributes to the increased skeletal muscle tension, sarcolemmal injury, and oxidative stress reported in warm climates remains unknown. We simulated osmotic and heat stress, in vitro , in mouse limb muscles with different fiber compositions. Extensor digitorum longus (EDL) and soleus (SOL) were dissected from 36 male C57BL6J and mounted at optimal length in tissue baths containing oxygenated buffer...
2018: Frontiers in Physiology
Thomas L Clanton
No abstract text is available yet for this article.
October 18, 2018: Journal of Applied Physiology
Charles P Hannon, Steve Bayer, Christopher D Murawski, Gian Luigi Canata, Thomas O Clanton, Daniel Haverkamp, Jin Woo Lee, Martin J O'Malley, Hua Yinghui, James W Stone
BACKGROUND: The evidence supporting best practice guidelines in the field of cartilage repair of the ankle are based on both low quality and low levels of evidence. Therefore, an international consensus group of experts was convened to collaboratively advance toward consensus opinions based on the best available evidence on key topics within cartilage repair of the ankle. The purpose of this article is to report the consensus statements on "Debridement, Curettage and Bone Marrow Stimulation" developed at the 2017 International Consensus Meeting on Cartilage Repair of the Ankle...
July 2018: Foot & Ankle International
Robert C Spang, Daniel B Haber, Brendin R Beaulieu-Jones, Kristen L Stupay, George Sanchez, Anthony Sanchez, Colin P Murphy, James M Whalen, Joseph J Van Allen, Mark D Price, Thomas O Clanton, Matthew T Provencher
Background: Jones fractures result in subsequent dysfunction and remain an issue for athletes. Purpose: To (1) describe the epidemiology, treatment, and impact of Jones fractures identified at the National Football League (NFL) Scouting Combine on players' early careers and (2) establish the value of computed tomography (CT) to determine bony healing after a fracture in prospective players. Study Design: Cohort study; Level of evidence, 3...
August 2018: Orthopaedic Journal of Sports Medicine
Kacy A Ramirez, Asim F Choudhri, Anami Patel, Noel T Lenny, Rebecca E Thompson, Leslie Berkelhammer Greenberg, Nancy Clanton Watson, Mehmet Kocak, John P DeVincenzo
BACKGROUND: Herpes Simplex Virus encephalitis (HSVE) is a devastating disease of all ages. Rigorous studies correlating viral load with neuroradiological and clinical severity have not been performed, particularly in neonates. Understanding these relationships may improve therapies. OBJECTIVES: To correlate molecularly quantified HSV in cerebrospinal fluid (CSF) and disease severity. STUDY DESIGN: HSV loads (VL) were evaluated by real-time PCR from the CSF of 33 patients (20 neonates, 5 children, 8 adults) with HSVE...
August 18, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Mary K Mulcahey, Andrew S Bernhardson, Colin P Murphy, Angela Chang, Tyler Zajac, George Sanchez, Anthony Sanchez, James M Whalen, Mark D Price, Thomas O Clanton, Matthew T Provencher
Background: American football is a leading cause of sports-related injuries, with the knee, ankle, and shoulder most commonly involved. Purpose/Hypothesis: The purpose of this study was to describe the epidemiology, characteristics, and imaging findings of ankle injuries in football players at the National Football League (NFL) Combine and determine the relationship to player position. We hypothesized that there would be a high relative incidence of ankle injuries in these players compared with other sports and that there would be a direct correlation between the incidence of ankle injuries and player position...
July 2018: Orthopaedic Journal of Sports Medicine
Christian K Garcia, Alex J Mattingly, Gerard P Robinson, Orlando Laitano, Michelle A King, Shauna M Dineen, Lisa R Leon, Thomas L Clanton
With increasing participation of females in endurance athletics and active military service, it is important to determine if there are inherent sex-dependent susceptibilities to exertional heat injury or heat stroke. In this study we compared responses of male and female adult mice to exertional heat stroke (EHS). All mice were instrumented for telemetry core temperature measurements and were exercise-trained for 3 wk before EHS. During EHS, environmental temperature was 37.5°C (35% RH) while the mice ran on a forced running wheel, using incremental increases in speed...
September 1, 2018: Journal of Applied Physiology
Jesse Clanton, Stephen Oh, Stephen J Kaplan, Emily Johnson, Andrew Ross, Richard Kozarek, Adnan Alseidi, Thomas Biehl, Vincent J Picozzi, William S Helton, David Coy, Russell Dorer, Flavio G Rocha
BACKGROUND: Accurate prediction of mesenteric venous involvement in pancreatic ductal adenocarcinoma (PDAC) is necessary for adequate staging and treatment. METHODS: A retrospective cohort study was conducted in PDAC patients at a single institution. All patients with resected PDAC and staging CT and EUS between 2003 and 2014 were included and sub-divided into "upfront resected" and "neoadjuvant chemotherapy (NAC)" groups. Independent imaging re-review was correlated to venous resection and venous invasion...
October 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Gwen M Grimsby, Bruce J Schlomer, Vani S Menon, Lauren Ostrov, Melise Keays, Kunj R Sheth, Carlos Villanueva, Candace Granberg, Daniel Dajusta, Martinez Hill, Emma Sanchez, Clanton B Harrison, Micah A Jacobs, Berk Burgu, Halim Hennes, Linda A Baker
OBJECTIVE: To prospectively correlate pain duration, red scrotal skin, ultrasound appearance of testis, and intraoperative testis color to future testis atrophy after acute testicular torsion. METHODS: Patients 2 months-18 years old with unilateral acute scrotum were consecutively enrolled in a National Institutes of Health transcutaneous near-infrared spectroscopy study, with a subgroup analysis of the true torsion group. Presence or absence of red scrotal skin, pain duration, testicular heterogeneity on preoperative ultrasound, and intraoperative testis color based on a novel visual chart 5 minutes after detorsion were recorded...
June 2018: Urology
Daniel J Liechti, Gilbert Moatshe, Jonathon D Backus, Daniel Cole Marchetti, Thomas O Clanton
Achilles tendon ruptures are a common tendon injury, usually occurring in middle-aged men during recreational sporting activities. Both nonoperative and operative management are employed to treat these injuries. Several operative treatments are described in the literature, including percutaneous Achilles repair, mini-open repair, and open repair. Open Achilles repair is associated with higher rates of impaired wound healing and infection, whereas minimally invasive techniques have been reported to have an increased risk of iatrogenic sural nerve injury...
February 2018: Arthroscopy Techniques
Nora Maria Raschle, Willeke Martine Menks, Lynn Valérie Fehlbaum, Martin Steppan, Areti Smaragdi, Karen Gonzalez-Madruga, Jack Rogers, Roberta Clanton, Gregor Kohls, Anne Martinelli, Anka Bernhard, Kerstin Konrad, Beate Herpertz-Dahlmann, Christine M Freitag, Graeme Fairchild, Stephane A De Brito, Christina Stadler
Callous-unemotional traits are characterized by a lack of empathy, a disregard for others' feelings and shallow or deficient affect, such as a lack of remorse or guilt. Neuroanatomical correlates of callous-unemotional traits have been demonstrated in clinical samples (i.e., adolescents with disruptive behavior disorders). However, it is unknown whether callous-unemotional traits are associated with neuroanatomical correlates within normative populations without clinical levels of aggression or antisocial behavior...
2018: NeuroImage: Clinical
Patricia J Ward, Scott L Clanton, Arthur W English
Brief neuronal activation in injured peripheral nerves is both necessary and sufficient to enhance motor axon regeneration, and this effect is specific to the activated motoneurons. It is less clear whether sensory neurons respond in a similar manner to neuronal activation following peripheral axotomy. Further, it is unknown to what extent enhancement of axon regeneration with increased neuronal activity relies on a reflexive interaction within the spinal circuitry. We used mouse genetics and optical tools to evaluate the precision and selectivity of system-specific neuronal activation to enhance axon regeneration in a mixed nerve...
February 2018: European Journal of Neuroscience
Lu Su, Richen Li, Sarosh Khan, Ryan Clanton, Fuwu Zhang, Yen-Nan Lin, Yue Song, Hai Wang, Jingwei Fan, Soleil Hernandez, Andrew S Butters, Gamal Akabani, Ronan MacLoughlin, Justin Smolen, Karen L Wooley
Although nanomedicines have been pursued for nearly 20 years, fundamental chemical strategies that seek to optimize both the drug and drug carrier together in a concerted effort remain uncommon yet may be powerful. In this work, two block polymers and one dimeric prodrug molecule were designed to be coassembled into degradable, functional nanocarriers, where the chemistry of each component was defined to accomplish important tasks. The result is a poly(ethylene glycol) (PEG)-protected redox-responsive dimeric paclitaxel (diPTX)-loaded cationic poly(d-glucose carbonate) micelle (diPTX@CPGC)...
January 31, 2018: Journal of the American Chemical Society
Marta de Souza Albernaz, Sergio Hiroshi Toma, Jeff Clanton, Koiti Araki, Ralph Santos-Oliveira
PURPOSE: In this study we developed and tested an iron oxide nanoparticle conjugated with DTPA and Trastuzumab, which can efficiently be radiolabeled with 99m-Tc and Ga-68, generating a nanoradiopharmaceutical agent to be used for SPECT and PET imaging. METHODS: The production of iron oxide nanoparticle conjugated with DTPA and Trastuzumab was made using phosphorylethanolamine (PEA) surface modification. Both radiolabeling process was made by the direct radiolabeling of the nanoparticles...
January 5, 2018: Pharmaceutical Research
Alex J Mattingly, Orlando Laitano, Thomas L Clanton
Catecholamines stimulate interleukin-6 (IL-6) secretion in skeletal muscles. However, whether other cytokines are secreted is currently unknown. Skeletal muscle ex vivo preparations commonly used to study cytokine secretion have dealt with limitations including auto-oxidation of catecholamines. The use of metal chelators could be an alternative to avoid auto-oxidation and allow catecholamines to be used at physiological doses. We exposed isolated soleus muscles to 1 or 100 ng/mL epinephrine (EPI) and collected bath samples at 1 and 2 h for multiplex cytokine analysis...
December 2017: Physiological Reports
Pebbles Fagan, Pallav Pokhrel, Thaddeus A Herzog, Eric T Moolchan, Kevin D Cassel, Adrian A Franke, Xingnan Li, Ian Pagano, Dennis R Trinidad, Kari-Lyn K Sakuma, Kymberle Sterling, Dorothy Jorgensen, Tania Lynch, Crissy Kawamoto, Mignonne C Guy, Ian Lagua, Sarah Hanes, Linda A Alexander, Mark S Clanton, Camonia Graham-Tutt, Thomas Eissenberg
Introduction: Sugars are major constituents and additives in traditional tobacco products, but little is known about their content or related toxins (formaldehyde, acetaldehyde, and acrolein) in electronic cigarette (e-cigarette) liquids. This study quantified levels of sugars and aldehydes in e-cigarette liquids across brands, flavors, and nicotine concentrations (n = 66). Methods: Unheated e-cigarette liquids were analyzed using liquid chromatography mass spectrometry and enzymatic test kits...
July 9, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Joerg Mika, Olaf Brinkmann, Thomas O Clanton, Gabor Szalay, Raimund W Kinne
[This corrects the article on p. 5 in vol. 6, PMID: 27299113.].
July 2017: Journal of Orthopaedic Case Reports
Linda Kersten, Noortje Vriends, Martin Steppan, Nora M Raschle, Martin Praetzlich, Helena Oldenhof, Robert Vermeiren, Lucres Jansen, Katharina Ackermann, Anka Bernhard, Anne Martinelli, Karen Gonzalez-Madruga, Ignazio Puzzo, Amy Wells, Jack C Rogers, Roberta Clanton, Rosalind H Baker, Liam Grisley, Sarah Baumann, Malou Gundlach, Gregor Kohls, Miguel A Gonzalez-Torres, Eva Sesma-Pardo, Roberta Dochnal, Helen Lazaratou, Zacharias Kalogerakis, Aitana Bigorra Gualba, Areti Smaragdi, Réka Siklósi, Dimitris Dikeos, Amaia Hervás, Aranzazu Fernández-Rivas, Stephane A De Brito, Kerstin Konrad, Beate Herpertz-Dahlmann, Graeme Fairchild, Christine M Freitag, Arne Popma, Meinhard Kieser, Christina Stadler
Exposure to community violence through witnessing or being directly victimized has been associated with conduct problems in a range of studies. However, the relationship between community violence exposure (CVE) and conduct problems has never been studied separately in healthy individuals and individuals with conduct disorder (CD). Therefore, it is not clear whether the association between CVE and conduct problems is due to confounding factors, because those with high conduct problems also tend to live in more violent neighborhoods, i...
2017: Frontiers in Behavioral Neuroscience
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