Silvia Iori, Caterina D'Onofrio, Nihay Laham-Karam, Isidore Mushimiyimana, Lorena Lucatello, Ludovica Montanucci, Rosa Maria Lopparelli, Federico Bonsembiante, Francesca Capolongo, Marianna Pauletto, Mauro Dacasto, Mery Giantin
In human, the cytochrome P450 3A (CYP3A) subfamily of drug-metabolizing enzymes (DMEs) is responsible for a significant number of phase I reactions, with the CYP3A4 isoform superintending the hepatic and intestinal metabolism of diverse endobiotic and xenobiotic compounds. The CYP3A4-dependent bioactivation of chemicals may result in hepatotoxicity and trigger carcinogenesis. In cattle, four CYP3A genes (CYP3A74, CYP3A76, CYP3A28 and CYP3A24) have been identified. Despite cattle being daily exposed to xenobiotics (e...
April 20, 2024: Biochemical Pharmacology