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https://read.qxmd.com/read/30767060/non-invasive-evaluation-of-the-relationship-between-electrical-and-structural-cardiac-abnormalities-in-patients-with-myotonic-dystrophy-type-1
#1
Lukas Chmielewski, Michael Bietenbeck, Alexandru Patrascu, Sabine Rösch, Udo Sechtem, Ali Yilmaz, Anca-Rezeda Florian
BACKGROUND: Cardiac involvement in myotonic dystrophy type 1 (MD1) includes conduction disease, arrhythmias, and left-ventricular (LV) systolic dysfunction leading to an increased sudden cardiac death risk. An understanding of the interplay between electrical and structural myocardial changes could improve the prediction of adverse cardiac events. We aimed to explore the relationship between signs of cardiomyopathy by conventional and advanced cardiovascular magnetic resonance (CMR), and electrical abnormalities in MD1...
February 14, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30719798/advanced-interatrial-block-is-a-surrogate-for-left-atrial-strain-reduction-which-predicts-atrial-fibrillation-and-stroke
#2
Juan Lacalzada-Almeida, María Manuela Izquierdo-Gómez, Javier García-Niebla, Roberto Elosua, Alejandro Jiménez-Sosa, Adrian Baranchuk, Antonio Bayes de Luna
BACKGROUND: The association between advanced interatrial block (aIAB) and atrial fibrillation (AF) is known as "Bayes' Syndrome." There is little information on the prognostic role that new speckle tracking echocardiographic (STE) imaging techniques could play in it. We have examined the relationship between left atrial (LA) STE and the prediction of new-onset AF and/or stroke in IAB patients. METHODS: This is an observational prospective and unicentric cohort study with 98 outpatients: 55 (56...
February 5, 2019: Annals of Noninvasive Electrocardiology
https://read.qxmd.com/read/30701837/role-of-electrocardiographic-and-echocardiographic-types-of-left-bundle-branch-block-in-prediction-of-response-to-cardiac-resynchronization-therapy
#3
S Yu Kashtanova, N A Mironova, V N Shitov, E M Gupalo, V G Kiktev, M A Saidova, S P Golitsyn
AIM: To assess the value of the complex analysis of electrocardiographic (ECG) variants and echocardiographic (echo) manifestation of left bundle branch block (LBBB) in predicting the success of cardiac resynchronization therapy (CRT). MATERIALS AND METHODS: The study included 39 patients (mean age 61.49±9.0 years) on sinus rhythm with LBBB, QRS duration ≥130 ms, left ventricular ejection fraction (LVEF) ≤35%, heart failure (HF) NYHA II-IV despite optimal pharmacological therapy during 3 month...
December 30, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30671988/cardiac-disease-in-mucopolysaccharidosis-type-iii
#4
Stephanie C M Nijmeijer, Rianne H A C M de Bruin-Bon, Frits A Wijburg, Irene M Kuipers
Mucopolysaccharidosis type III (MPS III; Sanfilippo disease) is primarily characterized by neurocognitive decline with limited somatic disease. Only few reports addressed cardiac disease (CD) in MPS III. We investigated the prevalence of CD in a relatively large cohort of patients. In this cross-sectional study, extensive echocardiographic studies were performed in 30 MPS III patients (16 patients <18 years), all without clinical symptoms of CD. Results were compared to data from matched controls. The mean global longitudinal strain on speckle-tracking echocardiography (STE) was impaired in both pediatric and adult patients vs controls (resp...
December 27, 2018: Journal of Inherited Metabolic Disease
https://read.qxmd.com/read/30665906/ecg-in-suspected-pulmonary-embolism
#5
Duncan Thomson, Georgios Kourounis, Rebecca Trenear, Claudia-Martina Messow, Petr Hrobar, Alistair Mackay, Chris Isles
OBJECTIVE: To establish the diagnostic value of prespecified ECG changes in suspected pulmonary embolism (PE). METHODS: Retrospective case-control study in a district general hospital setting. We identified 189 consecutive patients with suspected PE whose CT pulmonary angiogram (CTPA) was positive for a first PE and for whom an ECG taken at the time of presentation was available. We matched these for age±3 years with 189 controls with suspected PE whose CTPA was negative...
January 21, 2019: Postgraduate Medical Journal
https://read.qxmd.com/read/30665806/transthoracic-echocardiography-guided-percutaneous-laser-ablation-of-the-interventricular-septum-a-successful-sheep-model-for-septal-thickness-reduction-and-one-year-follow-up
#6
Jianli Fu, Chao Sun, Fang Liu, Rui Hu, David H Hsi, Shengjun Tuo, Hong Shao, Hong Yin, Jianmin Zheng, Jianlei Zhang, Jian Yang, Jun Zhang, Xiangping Guan, Liwen Liu
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common genetic cardiovascular disease, causing breathlessness, chest pain, syncope and sudden death. One-year outcome of echo-guided transthoracic percutaneous laser ablation (TPLA) of the sheep interventricular septum was studied as a novel treatment to reduce the septal thickness. It may partially address the limitations of surgical myectomy and alcohol septal ablation in terms of trauma, safety, and efficacy. METHODS: Twelve healthy adult sheep were randomly categorized into two groups: with and without the laser application of TPLA of the interventricular septum (IVS) at the energy level of 5 W for 3 min...
January 4, 2019: International Journal of Cardiology
https://read.qxmd.com/read/30647209/echocardiographic-and-electrocardiographic-presentations-of-patients-with-endomyocardial-biopsy-proven-cardiac-amyloidosis
#7
A Roslan, S H Kamsani, T W Nay, K L Tan, N Hakim, A M Tan, W N Megat Samsudim, K L Tan, A T Jauhari, M Krishnan, D Leong, T Supramaniam, L K Tan, A A Nuruddin
OBJECTIVE: Cardiac amyloidosis is under diagnosed and its prevalence is unknown. This is a retrospective, nonrandomised, single centre study of patients with endomyocardial biopsy-proven cardiac amyloidosis focusing on their echocardiographic and electrocardiogram (ECG) presentations. This is the first case series in Malaysia on this subject. METHODS: We identified all of our endomyocardial biopsyproven cardiac amyloidosis patients from January 2010 to January 2018 and reviewed their medical records...
December 2018: Medical Journal of Malaysia
https://read.qxmd.com/read/30644941/an-ultra-stretchable-highly-sensitive-and-biocompatible-capacitive-strain-sensor-from-an-ionic-nanocomposite-for-on-skin-monitoring
#8
Haihua Xu, Ying Lv, Dexing Qiu, Yongjin Zhou, Haoxuan Zeng, Yican Chu
Flexible strain sensors that can be comfortably attached onto the skin for real-time and accurate detection of physiological signals are particularly important for the realization of healthcare, soft robotics and human-machine interfacing. It is still challenging to develop strain sensors that satisfy both high stretchability and high sensitivity. Here, we demonstrate an ultra-stretchable, highly sensitive and biocompatible capacitive-type strain sensor based on a nanocomposite containing ionic hydrogels and silver nanofibers (AgNFs)...
January 15, 2019: Nanoscale
https://read.qxmd.com/read/30608189/systems-genetics-approaches-in-rat-identify-novel-genes-and-gene-networks-associated-with-cardiac-conduction
#9
Michiel E Adriaens, Elisabeth M Lodder, Aida Moreno-Moral, Jan Šilhavý, Matthias Heinig, Charlotte Glinge, Charly Belterman, Rianne Wolswinkel, Enrico Petretto, Michal Pravenec, Carol Ann Remme, Connie R Bezzina
Background Electrocardiographic ( ECG ) parameters are regarded as intermediate phenotypes of cardiac arrhythmias. Insight into the genetic underpinnings of these parameters is expected to contribute to the understanding of cardiac arrhythmia mechanisms. Here we used HXB / BXH recombinant inbred rat strains to uncover genetic loci and candidate genes modulating ECG parameters. Methods and Results RR interval, PR interval, QRS duration, and QT c interval were measured from ECG s obtained in 6 male rats from each of the 29 available HXB / BXH recombinant inbred strains...
November 6, 2018: Journal of the American Heart Association
https://read.qxmd.com/read/30607624/stretchable-bio-potential-electrode-with-self-similar-serpentine-structure-for-continuous-long-term-stable-ecg-recordings
#10
Wentao Dong, Xiao Cheng, Tao Xiong, Xiaoming Wang
Current stretchable surface electrodes have attracted more and more attentions owing to their potential applications in the fields of biological signal monitoring, wearable human-machine interface (HMI) and Internet of Things (IoT). The paper presents that stretchable bio-potential electrode is designed with the second order self-similar serpentine structure to continuous, long-term, stable ECG signal recordings which is conformal contact with the soft skin surface. FEM and experiments have validated >30% deformability of the surface electrode with second order self-similar structure...
January 3, 2019: Biomedical Microdevices
https://read.qxmd.com/read/30607387/right-atrial-deformation-mechanics-in-children-with-adenotonsillar-hypertrophy
#11
Soo Jung Kang, Yoo Won Kwon
BACKGROUND: Children with significant adenotonsillar hypertrophy (ATH) may show right ventricular (RV) dysfunction. We aimed to evaluate RV dysfunction in such children before adenotonsillectomy by evaluating peak longitudinal right atrial (RA) strain (PLRAS) in systole. PLRAS, electrocardiogram (ECG) and conventional echocardiographic parameters were compared to distinguish children with significant ATH with sleep-related breathing disorder (ATH-SRBD) from controls. METHODS: Fifty-six children (23 controls and 33 children with ATH-SRBD without symptoms of heart failure) were retrospectively studied...
December 2018: Journal of cardiovascular imaging
https://read.qxmd.com/read/30595328/determinants-of-in-hospital-clinical-outcome-in-patients-with-sub-massive-pulmonary-embolism
#12
Bishav Mohan, Rohit Tandon, Raahat Bansal, Maninder Singh, Bhupinder Singh, Abhishek Goyal, Shibba Takkar Chhabra, Naved Aslam, Gurpreet S Wander
INTRODUCTION: There is limited data regarding in hospital determinants of clinical deterioration and outcome in sub massive pulmonary embolism (PE). We aimed to evaluate these determinants by comparing biomarkers, CT pulmonary angiogram echocardiography, electrocardiography variables. METHODS: 57 patients of sub massive PE diagnosed on CT pulmonary angiogram were included. All patients received UFH on admission and were divided into two groups based on their clinical course...
December 2018: Indian Heart Journal
https://read.qxmd.com/read/30573540/pseudo-wellens-syndrome-in-pulmonary-embolism
#13
Yub Raj Sedhai, Soney Basnyat, Priyanka T Bhattacharya
Wellens' syndrome is described as characteristic biphasic or symmetrical T-wave inversion with normal precordial R-wave progression and the absence of Q waves in the right precordial leads. It is seen during chest pain-free interval in a subset of patients with unstable angina. Wellens' syndrome is associated with critical stenosis of proximal left anterior descending (LAD) coronary artery. Similar characteristic ECG changes associated with causes other than LAD stenosis have been described as pseudo-Wellens' syndrome...
December 19, 2018: BMJ Case Reports
https://read.qxmd.com/read/30568738/regional-mechanical-changes-assessed-by-2d-speckle-tracking-longitudinal-strain-do-not-parallel-electrical-post-pacing-cardiac-memory
#14
Suran Maria-Claudia-Berenice, Margulescu Andrei-Dumitru, Bruja Ramona, Siliste Calin, Vinereanu Dragos
Background: Cardiac memory (CM) refers to persistent T-wave changes that appear after cessation of a period of abnormal ventricular activation, such as ventricular pacing. Prior animal studies using tagged magnetic resonance imaging have suggested that CM is associated with prolonged action potential duration and increased strain of late-activated myocardial segments. Objective: The aim of the present study is to determine whether CM induced by ventricular pacing in human subjects is accompanied by regional mechanical changes in late-activated myocardial segments, assessed by left ventricular (LV) longitudinal strain (peak LS) and time-to-peak longitudinal strain (TTP-LS), using 2D-speckle tracking echocardiography (2DSE)...
September 2018: Mædica
https://read.qxmd.com/read/30560316/autonomic-neuromodulation-acutely-ameliorates-left-ventricular-strain-in-humans
#15
Nicole Tran, Zain Asad, Khaled Elkholey, Benjamin J Scherlag, Sunny S Po, Stavros Stavrakis
Low-level transcutaneous vagus nerve stimulation at the tragus (LLTS) is anti-adrenergic. We aimed to evaluate the acute effects of LLTS on left ventricular (LV) function and autonomic tone. Patients with diastolic dysfunction and preserved LV ejection fraction were enrolled in a prospective, randomized, double-blind, 2 × 2 cross-over study. Patients received two separate, 1-h sessions, at least 1 day apart, of active LLTS (20 Hz, 1 mA below the discomfort threshold) and sham stimulation. Echocardiography was performed after LLTS or sham stimulation to assess cardiac function...
December 17, 2018: Journal of Cardiovascular Translational Research
https://read.qxmd.com/read/30542082/cornell-product-in-an-electrocardiogram-is-related-to-reduced-lv-regional-wall-motion
#16
Joji Ishikawa, Yuko Yamanaka, Shintaro Watanabe, Ayumi Toba, Kazumasa Harada
Electrocardiographic left ventricular hypertrophy (LVH) diagnosed by Cornell product and the Sokolow-Lyon voltage are associated with anatomical LVH; therefore, we investigated whether Cornell product and the Sokolow-Lyon voltage were associated with echocardiographic regional wall motion (measured by 2D-strain imaging). We reviewed data on 288 consecutive hypertensive patients who underwent both echocardiography and electrocardiography. Electrocardiographic LVH was calculated as follows: Cornell voltage, S in lead V3 + R in lead aVL; Cornell product, Cornell voltage (+0...
December 12, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/30508549/electrocardiograms-of-mice-selectively-bred-for-high-levels-of-voluntary-exercise-effects-of-short-term-exercise-training-and-the-mini-muscle-phenotype
#17
Jarren C Kay, Gerald C Claghorn, Zoe Thompson, Thomas G Hampton, Theodore Garland
Changes in cardiac function that occur with exercise training have been studied in detail, but those accompanying evolved increases in the duration or intensity of physical activity are poorly understood. To address this gap, we studied electrocardiograms (ECGs) of mice from an artificial selection experiment in which four replicate lines are bred for high voluntary wheel running (HR) while four non-selected lines are maintained as controls (C). ECGs were recorded using an ECGenie (Mouse Specifics, Inc.) both before and after six days of wheel access (as used in the standard protocol to select breeders)...
November 30, 2018: Physiology & Behavior
https://read.qxmd.com/read/30497761/novel-electrocardiographic-features-in-carriers-of-hypertrophic-cardiomyopathy-causing-sarcomeric-mutations
#18
Mikko Jalanko, Tiina Heliö, Pirjo Mustonen, Jorma Kokkonen, Heini Huhtala, Mika Laine, Pertti Jääskeläinen, Mika Tarkiainen, Kirsi Lauerma, Petri Sipola, Markku Laakso, Johanna Kuusisto, Kjell Nikus
OBJECTIVES: The sensitivity and specificity of the conventional 12-lead ECG to identify carriers of hypertrophic cardiomyopathy (HCM) - causing mutations without left ventricular hypertrophy (LVH) has been limited. We assessed the ability of novel electrocardiographic parameters to improve the detection of HCM mutation carriers. METHODS: We studied 140 carriers (G+) of the TPM1-Asp175Asn or MYBPC3-Gln1061X pathogenic variants for HCM: The G+/LVH+ group (n = 98) consisted of mutation carriers with LVH and the G+/LVH- group (n = 42) without LVH...
November 2018: Journal of Electrocardiology
https://read.qxmd.com/read/30367318/left-ventricular-hypertrophy-in-athletes-differentiating-physiology-from-pathology
#19
REVIEW
Daniel X Augustine, Liz Howard
PURPOSE OF REVIEW: The changes that occur in athlete's heart are influenced by a number of factors including age, gender, ethnicity and the type of cardiovascular training. It is therefore important that the clinician is able to integrate all of these factors when assessing athletes to be able to guide investigations appropriately and to distinguish pathology from physiology. This review discusses the potential diagnostic conundrums when trying to differentiate physiological left ventricular hypertrophy from pathological hypertrophic cardiomyopathy in athletes...
October 26, 2018: Current Treatment Options in Cardiovascular Medicine
https://read.qxmd.com/read/30341669/left-atrial-longitudinal-strain-in-dilated-cardiomyopathy-patients-is-there-a-discrimination-threshold-for-atrial-fibrillation
#20
Jacek Kurzawski, Agnieszka Janion-Sadowska, Andrzej Gackowski, Marianna Janion, Łukasz Zandecki, Magdalena Chrapek, Marcin Sadowski
To determine the left atrial longitudinal strain discrimination threshold of atrial fibrillation (AF) in patients with dilated cardiomyopathy (DCM). A total of 100 DCM patients and LVEF < 25% were included. Of them, 50 had sinus rhythm (SR), and 50 had AF. Patients with significant valvular disease, cardiac pacemakers and prosthetic valves were excluded. Speckle tracking echocardiography was performed to visualize the inferior and lateral walls of the left atrium as well as the interatrial septum. The Q-Analysis software was used to assess left atrial contractile strain (εCT ) during the atrial systole and left atrial conduit strain (εCD ) during the atrial filling...
October 19, 2018: International Journal of Cardiovascular Imaging
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