Yalin Cong, Rongrong Qiao, Xiaofeng Wang, Yinglu Ji, Jiacheng Yang, Didar Baimanov, Shengtao Yu, Rui Cai, Yuliang Zhao, Xiaochun Wu, Chunying Chen, Liming Wang
During biomedical applications, nanozymes, exhibiting enzyme-like characteristics, inevitably come into contact with biological fluids in living systems, leading to the formation of a protein corona on their surface. Although it is acknowledged that molecular adsorption can influence the catalytic activity of nanozymes, there is a dearth of understanding regarding the impact of the protein corona on nanozyme activity and its determinant factors. In order to address this gap, we employed the AuNR@Pt@PDDAC [PDDAC, poly(diallyldimethylammonium chloride)] nanorod (NR) as a model nanozyme with multiple activities, including peroxidase, oxidase, and catalase-mimetic activities, to investigate the inhibitory effects of the protein corona on the catalytic activity...
April 5, 2024: Journal of the American Chemical Society