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Light mood depression

Stine Daugaard, Jakob Markvart, Jens Peter Bonde, Jens Christoffersen, Anne Helene Garde, Åse Marie Hansen, Vivi Schlünssen, Jesper Medom Vestergaard, Helene Tilma Vistisen, Henrik Albert Kolstad
OBJECTIVE: To assess light exposure during days with indoor, outdoor, and night work and days off work. METHODS: Light intensity was continuously recorded for 7 days across the year among indoor (n = 170), outdoor (n = 151), and night workers (n = 188) in Denmark (55-56°N) equipped with a personal light recorder. White light intensity, duration above 80, 1000, and 2500 lux, and proportion of red, green, and blue light was depicted by time of the day and season for work days and days off work...
March 13, 2019: Annals of Work Exposures and Health
John H Krystal, Chadi G Abdallah, Gerard Sanacora, Dennis S Charney, Ronald S Duman
Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. Its discovery emerged from a reconceptualization of the biology of depression. Neurobiological insights into ketamine efficacy shed new light on the mechanisms underlying antidepressant efficacy.
March 6, 2019: Neuron
Annelies Brouwer, Daniel H van Raalte, Hoang-Ton Nguyen, Femke Rutters, Peter M van de Ven, Petra J M Elders, Annette C Moll, Eus J W Van Someren, Frank J Snoek, Aartjan T F Beekman, Marijke A Bremmer
OBJECTIVE: Depression is common in patients with type 2 diabetes, and adversely affects quality of life and diabetes outcomes. We assessed whether light therapy, an antidepressant, improves mood and insulin sensitivity in patients with depression and type 2 diabetes. RESEARCH DESIGN AND METHODS: This randomized, double-blind, placebo-controlled trial included 83 patients with depression and type 2 diabetes. The intervention comprised 4 weeks of light therapy (10,000 lux) or placebo light therapy daily at home...
February 22, 2019: Diabetes Care
Huijuan Li, Hong Chang, Xueqin Song, Weipeng Liu, Lingyi Li, Lu Wang, Yongfeng Yang, Luwen Zhang, Wenqiang Li, Yan Zhang, Dong-Sheng Zhou, Xingxing Li, Chen Zhang, Yiru Fang, Yan Sun, Jia-Pei Dai, Xiong-Jian Luo, Yong-Gang Yao, Xiao Xiao, Luxian Lv, Ming Li
Recent European genome-wide association studies (GWAS) have revealed strong statistical correlations between MDD and numerous zero-to-high linked variants in the genomic region containing major histocompatibility complex (MHC) genes (MHC region), but the underlying molecular mechanisms are still unclear. To better understand the roles of this genomic region in the neurobiology of MDD, we applied a convergent functional genomics approach to integrate GWAS data of MDD relevant biological phenotypes, gene-expression analyses results obtained from brain samples, and genetic analyses of independent Chinese MDD samples...
February 16, 2019: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Sonja Rutten, Chris Vriend, Jan H Smit, Henk W Berendse, Eus J W van Someren, Adriaan W Hoogendoorn, Jos W R Twisk, Ysbrand D van der Werf, Odile A van den Heuvel
OBJECTIVE: To assess the efficacy of bright light therapy (BLT) in reducing depressive symptoms in patients with Parkinson disease (PD) and major depressive disorder (MDD) compared to a control light. METHODS: In this double-blind controlled trial, we randomized patients with PD and MDD to treatment with BLT (±10,000 lux) or a control light (±200 lux). Participants were treated for 3 months, followed by a 6-month naturalistic follow-up. The primary outcome of the study was the Hamilton Depression Rating Scale (HDRS) score...
February 15, 2019: Neurology
Anastasiya Slyepchenko, Olivia R Allega, Xiamin Leng, Luciano Minuzzi, Maha M Eltayebani, Matthew Skelly, Roberto B Sassi, Claudio N Soares, Sidney H Kennedy, Benicio N Frey
OBJECTIVE: Disruptions in biological rhythms and sleep are a core aspect of mood disorders, with sleep and rhythm changes frequently occurring prior to and during mood episodes. Wrist-worn actigraphs are increasingly utilized to measure ambulatory activity rhythm and sleep patterns. METHODS: A comprehensive study using subjective and objective measures of sleep and biological rhythms was conducted in 111 participants (40 healthy volunteers [HC], 38 with major depressive disorder [MDD] and 33 with bipolar disorder [BD])...
February 13, 2019: Australian and New Zealand Journal of Psychiatry
Leonore Bovy, Martin Möbius, Martin Dresler, Guillén Fernández, Alan Sanfey, Eni Becker, Indira Tendolkar
High frequency repetitive Transcranial Magnetic Stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) has been shown to reduce depressive symptoms and improve cognitive biases such as attentional bias. One promising technique that may complement rTMS treatment is attentional bias modification (ABM) training, given the similarity in modulating attentional bias and affecting neuronal activity. We tested whether the combination of rTMS treatment and ABM training in a single session would attenuate maladaptive attentional processing and improve mood in participants with subclinical depressive symptoms...
February 4, 2019: Scientific Reports
Erin Hoare, Felice Jacka, Michael Berk
PURPOSE OF REVIEW: Mood disorders are highly prevalent and represent a leading cause of global disability. Urbanization holds great public health implications spanning various environmental, lifestyle behavioural, economic and social domains. Underlying risk factors for mood disorders are heterogeneous but the psychiatric literature has extended beyond individual-level risk, to account for population-level environment and social-related precursors to mental ill health. This review summarizes recent studies published since 2017 examining the impact of urbanization and associated environmental, social and lifestyle risks for mood disorders, specifically depression...
January 22, 2019: Current Opinion in Psychiatry
Rick Wassing, Jeroen S Benjamins, Lucia M Talamini, Frans Schalkwijk, Eus J W Van Someren
Study Objectives: Mechanisms underlying the distress of hyperarousal in people with insomnia remain enigmatic. We investigated whether insomnia impedes the overnight adaptation to emotional distress. Methods: We induced the distressful self-conscious emotion of shame four times across three consecutive days by exposing 64 participants to their often embarrassingly out-of-tune singing, recorded earlier during a Karaoke session. Perceived physical, emotional, and social distress was assessed with the Experiential Shame Scale...
December 26, 2018: Sleep
Wei Guo, Rodrigo Machado-Vieira, Sanjay Mathew, James W Murrough, Dennis S Charney, Matthew Gruenbaum, Maria A Oquendo, Bashkim Kadriu, Nirmala Akula, Ioline Henter, Peixiong Yuan, Kathleen Merikangas, Wayne Drevets, Maura Furey, J John Mann, Francis J McMahon, Carlos A Zarate, Yin Yao Shugart
Growing evidence suggests that the glutamatergic modulator ketamine has rapid antidepressant effects in treatment-resistant depressed subjects. The anticholinergic agent scopolamine has also shown promise as a rapid-acting antidepressant. This study applied genome-wide markers to investigate the role of genetic variants in predicting acute antidepressant response to both agents. The ketamine-treated sample included 157 unrelated European subjects with major depressive disorder (MDD) or bipolar disorder (BD)...
December 14, 2018: Translational Psychiatry
Micaela Mitolo, Caterina Tonon, Chiara La Morgia, Claudia Testa, Valerio Carelli, Raffaele Lodi
BACKGROUND: Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer's disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusions have been drawn about its specific therapeutic effect. SUMMARY: The aim of this review is to provide a critical evaluation of available evidence in this field, highlighting the specific characteristics of effective bright light treatment...
2018: Dementia and Geriatric Cognitive Disorders
Pierre Alexis Geoffroy, El Mountacer Billah El Abbassi, Julia Maruani, Bruno Etain, Michel Lejoyeux, Ali Amad, Philippe Courtet, Caroline Dubertret, Philip Gorwood, Guillaume Vaiva, Frank Bellivier, Sylvie Chevret
Objective: This study protocol aims to determine, using a rigorous approach in patients with bipolar disorder (BD) and non-seasonal major depressive episode (MDE), the characteristics of bright light therapy (BLT) administration (duration, escalation, morning and mid-day exposures) depending on the tolerance (hypomanic symptoms). Methods: Patients with BD I or II and treated by a mood stabilizer are eligible. After 1 week of placebo, patients are randomized between either morning or mid-day exposure for 10 weeks of active BLT with glasses using a dose escalation at 7...
November 26, 2018: Psychiatry Investigation
Klaus Martiny, Carlo Volf, Signe Dunker Svendsen, Mette Kragh, Helle Østergaard Madsen, Ida Hageman
Circadian and seasonal rhythm disturbances are prominent in patients with psychiatric disorders. Properly timed and dosed light of specific spectral composition stabilises mood and sleep through serotonergic mechanisms and through input to the master circadian clock in the hypothalamus. Correctly administered, light can be used as an effective treatment for seasonal and non-seasonal depression and for stabilising the sleep-wake cycle. Blocking blue light in the evening may provide a non-pharmacological anti-manic tool...
September 3, 2018: Ugeskrift for Laeger
Simone de Jong, Mateus Jose Abdalla Diniz, Andiara Saloma, Ary Gadelha, Marcos L Santoro, Vanessa K Ota, Cristiano Noto, Charles Curtis, Stephen J Newhouse, Hamel Patel, Lynsey S Hall, Paul F O Reilly, Sintia I Belangero, Rodrigo A Bressan, Gerome Breen
Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree ( n  ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations...
2018: Communications Biology
Rébecca Robillard, Joanne S Carpenter, Naomi L Rogers, Sarah Fares, Ashlee B Grierson, Daniel F Hermens, Sharon L Naismith, Sharon J Mullin, Kristy-Lee Feilds, Nick Glozier, Elizabeth M Scott, Ian B Hickie
Abnormalities in circadian rhythms have been reported in people with mood disorders, but these abnormalities are marked by considerable inter-individual variability. This study aimed to identify pathophysiological subgroups on the basis of circadian markers and evaluate how these subgroups relate to psychiatric profiles. Thirty-five young adults (18-31 years old) receiving clinical care for unipolar depressive disorders and 15 healthy controls took part to this study. The Hamilton Rating Scale for Depression and the Young Mania rating scale were used to evaluate the severity of mood symptoms in participants with depressive disorders...
October 9, 2018: Translational Psychiatry
Beatrix Feigl, Govinda Ojha, Leanne Hides, Andrew J Zele
Background: Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGCs) signal non-imaging forming effects of environmental light for circadian phoentrainment, the pupil light reflex, and mood regulation. In seasonal affective disorder, ipRGC dysfunction is thought to cause abberant transmission of the external illumination for photoentrainment. It is not known if patients with non-seasonal depression have abnormal melanospin mediated signaling and/or irregular environmental light exposure...
2018: Frontiers in Neurology
S K Tahajjul Taufique, Abhilash Prabhat, Vinod Kumar
Artificial light at night induces circadian disruptions and causes cognitive impairment and mood disorders; yet very little is known about the neural and molecular correlates of these effects in diurnal animals. We manipulated the night environment and examined cellular and molecular changes in hippocampus, the brain region involved in cognition and mood, of Indian house crows (Corvus splendens) exposed to 12 hr light (150 lux): 12 hr darkness (0 lux). Diurnal corvids are an ideal model species with cognitive abilities at par with mammals...
September 15, 2018: European Journal of Neuroscience
Giulia Menculini, Norma Verdolini, Andrea Murru, Isabella Pacchiarotti, Umberto Volpe, Antonella Cervino, Luca Steardo, Patrizia Moretti, Eduard Vieta, Alfonso Tortorella
BACKGROUND: The present systematic review was aimed at critically summarizing the evidence about interventions focused on circadian rhythms and mood symptoms in seasonal affective disorder (SAD). METHODS: A systematic search of the electronic databases PUBMED, PsycINFO and Web of Science was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Original papers reporting data about the effects of treatments on both mood and circadian rhythms disturbances in SAD patients were considered for inclusion...
December 1, 2018: Journal of Affective Disorders
Yam Nath Paudel, Mohd Farooq Shaikh, Sadia Shah, Yatinesh Kumari, Iekhsan Othman
Epilepsy is a devastating condition affecting around 70 million people worldwide. Moreover, the quality of life of people with epilepsy (PWE) is worsened by a series of comorbidities. The neurobehavioral comorbidities discussed herein share a reciprocal and complex relationship with epilepsy, which ultimately complicates the treatment process in PWE. Understanding the mechanistic pathway by which these comorbidities are associated with epilepsy might be instrumental in developing therapeutic interventions. Inflammatory cytokine signaling in the brain regulates important brain functions including neurotransmitter metabolism, neuroendocrine function, synaptic plasticity, dopaminergic transmission, the kynurenine pathway, and affects neurogenesis as well as the neural circuitry of moods...
October 15, 2018: European Journal of Pharmacology
Ancy Joseph, Tran Thi Thu Thuy, Le Tat Thanh, Masayoshi Okada
We screened a library of botanical compounds purified from plants of Vietnam for modulators of the activity of a two-pore domain K+ channel, TREK-1, and we identified a hydroxycoumarin-related compound, ostruthin, as an activator of this channel. Ostruthin increased whole-cell TREK-1 channel currents in 293T cells at a low concentration (EC50 = 5.3 μM), and also activity of the TREK-2 channel (EC50 = 3.7 mM). In contrast, ostruthin inhibited other K+ channels, e.g. human ether-à-go-go-related gene (HERG1), inward-rectifier (Kir2...
2018: PloS One
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