Ying Zhou, Rui Xue, Yifei Li, Wang Ran, Yuping Chen, Zhongyu Luo, Kemeng Zhang, Ruoxia Zhang, Junjun Wang, Mengmeng Fang, Cong Chen, Min Lou
White matter hyperintensity (WMH) represents a critical global medical concern linked to cognitive decline and dementia, yet its underlying mechanisms remain poorly understood. Here, humans are directly demonstrated that high WMH burden correlates with delayed drainage of meningeal lymphatic vessels (mLVs) and glymphatic pathway. Additionally, a longitudinal cohort study reveals that glymphatic dysfunction predicts WMH progression. Next, in a rat model of WMH, the presence of impaired lymphangiogenesis and glymphatic drainage is confirmed, followed by elevated microglial activation and white matter demyelination...
May 5, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)