Yichen Yan, Xiaoli Zheng, Gang Liu, Guocheng Shi, Cong Li, Hongtong Chen, Xiaomin He, Kana Lin, Zhaohui Deng, Hao Zhang, Wei-Guang Li, Huiwen Chen, Xiaoping Tong, Zhongqun Zhu
Chronic hypoxia, common in neonates, disrupts gut microbiota balance, which is crucial for brain development. This study utilized cyanotic congenital heart disease (CCHD) patients and a neonatal hypoxic rat model to explore the association. Both hypoxic rats and CCHD infants exhibited brain immaturity, white matter injury (WMI), brain inflammation, and motor/learning deficits. Through 16s rRNA sequencing and metabolomic analysis, a reduction in B. thetaiotaomicron and P. distasonis was identified, leading to cholic acid accumulation...
May 17, 2024: IScience