Martin Kello, Michal Goga, Klaudia Kotorova, Dominika Sebova, Richard Frenak, Ludmila Tkacikova, Jan Mojzis
Lichen metabolites represent a wide range of substances with a variety of biological effects. The present study was designed to analyze the potential antiproliferative, antimicrobial and antioxidative effects of several extracts from lichens ( Pseudevernia furfuracea , Lobaria pulmonaria , Cetraria islandica , Evernia prunastri , Stereocaulon tomentosum , Xanthoria elegans and Umbilicaria hirsuta ) and their secondary metabolites (atranorin, physodic acid, evernic acid and gyrophoric acid). The crude extract, as well as the isolated metabolites, showed potent antiproliferative, cytotoxic activity on a broad range of cancer cell lines in 2D (monolayer) and 3D (spheroid) models...
January 30, 2023: Plants (Basel, Switzerland)