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https://read.qxmd.com/read/30766809/once-weekly-dulaglutide-therapy-in-type-2-diabetic-subjects-real-world-evidence-from-a-tertiary-care-diabetes-center-in-india
#1
Jasjeet S Wasir, Ambrish Mithal, Paras Agarwal, Apeksha Mittal
Aims: To evaluate the real-world efficacy, durability, and side-effect profile of once weekly GLP1RA: dulaglutide in Indian type 2 diabetes mellitus (T2DM) patients. Materials and Methods: A retrospective observational study. Data for efficacy (HbA1c and weight), adherence/discontinuation and patient reported side-effects, of 117 patients who were prescribed dulaglutide were analyzed. Results: Final analysis was done on complete data of 74 patients (6 months follow-up), this indicated that dulaglutide is effective (mean-reduction at 6 months of: HbA1c; 0...
November 2018: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/30765421/evaluation-of-the-psychiatric-decisions-unit-pdu-effect-on-emergency-department-presentations-and-psychiatric-inpatient-admissions
#2
Samuel P Trethewey, Shantal Deepak, Samuel Saad, Ellen Hughes, George Tadros
BACKGROUND: Busy emergency departments (EDs) are not the optimum environment for assessment of patients in mental health crisis. The Psychiatric Decisions Unit (PDU) was developed by the Birmingham and Solihull Mental Health Foundation Trust as an enhanced assessment service to ensure patients in mental health crisis receive optimal care. AIMS: To evaluate the activities of the PDU and its impact on the frequency of ED presentations and inpatient admissions, and to explore patient satisfaction...
February 14, 2019: Postgraduate Medical Journal
https://read.qxmd.com/read/30761428/mercury-accumulation-speciation-and-temporal-trends-in-atlantic-stingrays-hypanus-sabinus
#3
Brianne K Soulen, Douglas H Adams, Aaron P Roberts
Mercury (Hg) deposited into aquatic sediments can be converted into the more toxic methylmercury (MeHg) by microbial activity. Atlantic stingrays (Hypanus sabinus) are an estuarine and nearshore species found in coastal regions of the western North Atlantic, occurring in multiple habitat types, and feeding mainly on benthic invertebrates. Mercury dynamics and speciation in stingrays have not been well examined. This study quantified total Hg and Hg species (Hg (II) and MeHg) in Atlantic stingrays sampled from Florida's Indian River Lagoon (IRL) from 2012 to 2013...
February 13, 2019: Ecotoxicology
https://read.qxmd.com/read/30755545/comparative-study-of-stabilization-of-humerus-supracondylar-fracture-in-children-by-percutaneous-pinning-from-lateral-side-and-both-sides
#4
M K Roy, M T Alam, M W Rahman, M S Islam, K A Sayeed, M Z Kamal, M K Alamgir, B Nandi, A M Mohiuddin
The aim of this prospective experimental study was to analyze the radiological and clinical results of the supra condylar fracture of Humerus in children and conducted the functional outcome of closed reduction and internal fixation by percutaneous Kirschner-wire from lateral side and crossed technique in the National Institute of Traumatology and Orthopaedic Rehabilitation (NITOR), Sher-E-Bangla Nagor, Dhaka, Bangladesh from July 2011 to June 2013. Patients diagnosed as closed Supracondylar fracture of Humerus in children due to trauma were the study population...
January 2019: Mymensingh Medical Journal: MMJ
https://read.qxmd.com/read/30755449/perspectives-of-healthcare-professionals-in-england-on-falls-interventions-for-people-with-dementia-a-qualitative-interview-study
#5
Clare Burgon, Janet Darby, Kristian Pollock, Veronika van der Wardt, Tamsin Peach, Lyndsay Beck, Pip Logan, Rowan H Harwood
OBJECTIVE: To explore the experiences of healthcare professionals working in falls prevention and memory assessment services in providing assessments and interventions for falls risk reduction in people with dementia. DESIGN: This is a qualitative study using 19 semistructured interviews. Interviews were analysed through thematic analysis. SETTING: Community-based falls and memory assessment services in the East Midlands, UK. PARTICIPANTS: Nurses (n=10), physiotherapists (n=5), occupational therapists (n=3) and a psychiatrist (n=1)...
February 11, 2019: BMJ Open
https://read.qxmd.com/read/30745113/ipsilateral-proximal-and-distal-radius-fractures-with-unstable-elbow-joint-which-should-we-address-first
#6
Nur Azuatul Akma Kamaludin, Nur Azree Ferdaus Kamudin, Shalimar Abdullah, Jamari Sapuan
Simultaneous ipsilateral fractures involving radial head and distal end of radius are uncommon. We present our thoughts on which fracture should be addressed first. A 68-year-old lady sustained an ipsilateral fracture of the right radial head and distal end of radius following a fall. Clinically her right elbow was posteriorly dislocated and right wrist was deformed. Plain radiographs showed an intraarticular fracture of the distal end of radius and a comminution radial head fracture with a proximally migrated radius...
December 30, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://read.qxmd.com/read/30744838/reduction-of-falling-number-in-soft-white-spring-wheat-caused-by-an-increased-proportion-of-spherical-b-type-starch-granules
#7
Yijing Shao, Min-Hui Tsai, Yuezhen He, Jianli Chen, Cathy Wilson, Amy Hui-Mei Lin
A low falling number (FN) in wheat indicates high α-amylase activity associated with poor end-use quality. We hypothesize starch - the substrate of α-amylase, can directly influence hot flour pasting properties and its susceptibility to α-amylase, which further affects viscosity. We examined the structural characteristics of starch in three soft white spring wheat cultivars grown in Idaho in 2013 (normal FN year) and 2014 (low FN year with pre-harvest rains). Our data surprisingly show that starch in some low FN wheat was not significantly degraded by α-amylase but had developmental changes with an increased proportion of B-type wheat starch...
June 30, 2019: Food Chemistry
https://read.qxmd.com/read/30741371/eugms-task-and-finish-group-on-fall-risk-increasing-drugs-frids-position-on-knowledge-dissemination-management-and-future-research
#8
L J Seppala, N van der Velde, T Masud, H Blain, M Petrovic, T J van der Cammen, K Szczerbińska, S Hartikainen, R A Kenny, J Ryg, P Eklund, E Topinková, A Mair, L Laflamme, H Thaler, G Bahat, M Gutiérrez-Valencia, M A Caballero-Mora, F Landi, M H Emmelot-Vonk, A Cherubini, J P Baeyens, A Correa-Pérez, A Gudmundsson, A Marengoni, D O'Mahony, N Parekh, F E Pisa, C Rajkumar, M Wehling, G Ziere
Falls are a major public health concern in the older population, and certain medication classes are a significant risk factor for falls. However, knowledge is lacking among both physicians and older people, including caregivers, concerning the role of medication as a risk factor. In the present statement, the European Geriatric Medicine Society (EuGMS) Task and Finish group on fall-risk-increasing drugs (FRIDs), in collaboration with the EuGMS Special Interest group on Pharmacology and the European Union of Medical Specialists (UEMS) Geriatric Medicine Section, outlines its position regarding knowledge dissemination on medication-related falls in older people across Europe...
February 11, 2019: Drugs & Aging
https://read.qxmd.com/read/30741158/a-hospital-based-fall-prevention-program-in-the-community-opportunities-for-frail-older-adults-to-participate-in-ongoing-physical-activity
#9
Laurie Bernick, Anne McKye, Andrea Brown-Strachan, Georgina Corsianos
A hospital-based falls prevention program offered in the community enabled older adults to sustain participation in physical activity beyond completion of the six-week program. The participants sustained gains with the support of an interdisciplinary comprehensive falls risk assessment, individualized goal setting, group exercise and education, home visits by health professionals when needed and partnership with community agencies for follow-up exercises. Participants (n = 162) demonstrated improvement at three months in comparison with their baseline Berg Balance Scale and Falls Efficacy Scale - International confidence scores and a 55% reduction in the average number of falls...
October 2018: Healthcare Quarterly
https://read.qxmd.com/read/30740367/type-iii-monteggia-equivalent-lesion-with-ipsilateral-fracture-lateral-condyle-of-humerus-in-a-four-year-old-child-a-case-report-and-literature-review
#10
Mark Bugeja, Arsen Avakyan, Eliezer Zahra Bianco, Thomas Azzopardi
Introduction: Monteggia fracture-dislocations are uncommon injuries in children, rarely associated with other ipsilateral upper limb injuries. We present a case of type III Monteggia lesion associated with an ipsilateral fracture of the lateral condyle of the humerus in a child. Case Report: A 4-year-old girl presented with a left elbow swelling after falling from a height of 2 meters. X-rays showed a fracture of the proximal ulna with lateral dislocation of the radial head (type III Monteggia) associated with an ipsilateral fracture of the lateral condyle of the humerus...
September 2018: Journal of Orthopaedic Case Reports
https://read.qxmd.com/read/30739765/stentoplasty-of-calcaneal-fractures-surgical-technique-and-early-outcomes
#11
Giuseppe Toro, Francesco Langella, Michele Gison, Gabriella Toro, Antimo Moretti, Antonio Toro, Giovanni Iolascon
Calcaneus is the most common site of hindfoot fracture, frequently caused by fall from height or high energy trauma. The therapeutic strategy ranged from non-operative to ORIF (Open Reduction Internal Fixation). Indications for percutaneous fixation include soft tissue damage or relative contraindications to open surgery. Minimally invasive percutaneous calcaneoplasty should be an alternative to ORIF aiming to reach a stable reduction, early functional recovery and short hospital stay. The aim of our study was to evaluate the clinical and radiographic outcomes of calcaneus fractures treated with balloon calcaneoplasty (BCP) by using a new generation vertebral augmentation system, VBS™-Vertebral Body Stent-DePuy Synthes...
February 2, 2019: Injury
https://read.qxmd.com/read/30738568/the-increasing-role-of-reverse-total-shoulder-arthroplasty-in-the-treatment-of-proximal-humerus-fractures
#12
Mark T Dillon, Heather A Prentice, William E Burfeind, Priscilla H Chan, Ronald A Navarro
INTRODUCTION: Hemiarthroplasty of the shoulder is a well established treatment for proximal humerus fractures not amenable to open reduction internal fixation. However, orthopedic surgeons have recently increased utilization of reverse total shoulder arthroplasty (RTSA) in the treatment of these injuries. The purpose of this study was to evaluate the use of hemiarthroplasty and RTSA between 2009 and 2016 for the treatment of proximal humerus fractures within a large United States integrated healthcare system...
January 30, 2019: Injury
https://read.qxmd.com/read/30735480/benefits-of-treatment-completion-over-premature-termination-findings-from-the-national-child-traumatic-stress-network
#13
Alan M Steinberg, Christopher M Layne, Ernestine C Briggs, Li-Jung Liang, Melissa J Brymer, Thomas R Belin, John A Fairbank, Robert S Pynoos
OBJECTIVE: To evaluate potential differences in therapeutic outcomes between youths who completed a full course of treatment as planned compared to youths who terminated treatment prematurely. METHOD: Using longitudinal data from the National Child Traumatic Stress Network (NCTSN) Core Data Set, the present study examined demographic characteristics, trauma history, scores on standardized measures, and ratings of functional impairment and behavior problems in a large clinical sample of children and adolescents exposed to trauma who received treatment at NCTSN centers across the United States...
February 8, 2019: Psychiatry
https://read.qxmd.com/read/30732631/disease-characteristics-prognosis-and-miglustat-treatment-effects-on-disease-progression-in-patients-with-niemann-pick-disease-type-c-an-international-multicenter-retrospective-chart-review
#14
Mercedes Pineda, Katarína Juríčková, Parvaneh Karimzadeh, Miriam Kolnikova, Vera Malinova, Jose Luis Insua, Christian Velten, Stefan A Kolb
BACKGROUND: Niemann-Pick disease Type C (NP-C) is a lysosomal lipid storage disorder characterized by progressive neurodegenerative symptomatology. The signs and symptoms of NP-C vary with age at disease onset, and available therapies are directed at alleviating symptoms and stabilizing disease progression. We report the characteristics and factors related to disease progression, and analyze the effect of miglustat treatment on disease progression and patient survival using NP-C disability scales...
February 7, 2019: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/30724383/inotropic-and-lusitropic-effects-of-incremental-doses-of-dobutamine-in-dogs-with-right-ventricular-apical-pacing-induced-cardiac-dysfunction
#15
Telma Mary Nakata, Hideki Kaji, Naoya Matsuura, Miki Shimizu, Ryou Tanaka
This study aimed to assess the effects of incremental doses of dobutamine on diastolic function in healthy and rapid ventricular apical pacing (RVAP)-induced cardiac dysfunction anesthetized dogs. Inotropic and lusitropic effects of dobutamine (2, 4, 8, and 12 μg kg-1  min-1 ) were assessed through left ventricle (LV) pressure-volume relation and Doppler echocardiography in six female dogs before and after 8 weeks of RVAP. Peak rate of LV pressure fall (-dP/dtmin ) improved with doses >4 μg kg-1  min-1 in healthy (4,490 ± 970 vs...
February 6, 2019: Journal of Veterinary Pharmacology and Therapeutics
https://read.qxmd.com/read/30722731/-obstructive-sleep-apnea-syndrome
#16
Anne-Christin Stöwhas, Mona Lichtblau, Konrad E Bloch
Obstructive Sleep Apnea Syndrome Abstract. The obstructive sleep apnea syndrome (OSAS) is a disorder of the control of breathing in which repetitive collapse of the upper airway during sleep leads to frequent apneas/hypopneas with cyclic oxygen desaturation and arousals. Sleep is fragmented and unrefreshing. The affected patients suffer from an increased tendency to fall asleep, impaired concentration and a reduced quality of life. The consequences of OSAS also include an increased risk of accidents caused by falling asleep as well as cardiovascular diseases...
January 2019: Praxis
https://read.qxmd.com/read/30721957/perspective-are-we-ready-to-measure-child-nutritional-status-with-lasers
#17
Joel Conkle, Reynaldo Martorell
The continued use of basic, manual anthropometric tools (e.g., boards and tapes) leaves anthropometry susceptible to human error. A potential solution, 3-dimensional (3D) imaging systems for anthropometry, has been around since the 1950s. In the 1980s, 3D imaging technology advanced from photographs to the use of lasers for body digitization; and by the 2000s, the falling price of 3D scanners made commercial application feasible. The garment sector quickly adopted imaging technology for surveys because of the need for numerous measurements and large sample sizes...
January 1, 2019: Advances in Nutrition
https://read.qxmd.com/read/30720884/cholinergic-system-changes-of-falls-and-freezing-of-gait-in-parkinson-disease
#18
Nicolaas I Bohnen, Prabesh Kanel, Zhi Zhou, Robert A Koeppe, Kirk A Frey, William T Dauer, Roger L Albin, Martijn L T M Müller
OBJECTIVE: Postural instability and gait difficulties (PIGD) represent debilitating disturbances in Parkinson's disease (PD). Prior acetylcholinesterase PET imaging studies implicate cholinergic changes as significant contributors to PIGD features. These studies were limited in quantification of striatal cholinergic synapse integrity. Vesicular acetylcholine transporter (VAChT) PET ligands are better suited for evaluation of high binding areas. We examined associations between regional VAChT expression and freezing of gait (FoG) and falls...
February 5, 2019: Annals of Neurology
https://read.qxmd.com/read/30714614/evidence-based-hospital-design-a-literature-review-of-the-recent-publications-about-the-ebd-impact-of-built-environment-on-hospital-occupants-and-organizational-outcomes
#19
A Brambilla, A Rebecchi, S Capolongo
INTRODUCTION: Healthcare facilities are complex infrastructures where different features from technological, social, clinical and architectural field interact. In modern healthcare systems there is a growing attention to the need of quality in terms of process and outcome, while the structural (physical) aspects are not often considered. Since the Nineties the theory of the Evidence Based Design (EBD) states that there is significant relationship between built environment and health related outcome...
March 2019: Annali di Igiene: Medicina Preventiva e di Comunità
https://read.qxmd.com/read/30712518/impact-of-mind-body-interventions-in-older-adults-with-mild-cognitive-impairment-a-systematic-review
#20
Maryam Farhang, Claudia Miranda-Castillo, Miriam Rubio, Guilherme Furtado
ABSTRACTBackground:Mind-body interventions have been associated with a range of positive outcomes in older adults with mild cognitive impairment (MCI). The aim of the present study was to review the impact of different non-pharmacological programs based on mind-body intervention for older adults with MCI. METHODS: A comprehensive search method as required by the Cochrane Collaboration has been performed through the following databases: Google Scholar, Science Direct, PubMed, PsycINFO, MEDLINE, EMBASE, CINHAL, Cochrane, Ebsco...
February 4, 2019: International Psychogeriatrics
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