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Jak2 Positive And CD Markers

Saeid Shahrabi, Ali Ehsanpour, Somayyeh Heidary, Mohammad Shahjahani, Masumeh Maleki Behzad
Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by the presence of JAK2V617F mutation. Thrombohemorrhagic as well as autoimmune or inflammatory phenomena are common clinical outcomes of these disorders. Recent studies have shown that abnormality in frequency and function of blood cells manifested by an alteration in CD markers' expression patterns play a key role in these complications. So, there may be a relationship between CD markers' expressions and prognosis of JAK2V617F positive MPNs...
July 4, 2018: Oncology Reviews
Graciela Cascio, Noa B Martín-Cófreces, José Miguel Rodríguez-Frade, Pilar López-Cotarelo, Gabriel Criado, José L Pablos, José Luis Rodríguez-Fernández, Francisco Sánchez-Madrid, Mario Mellado
The adaptive immune response requires interaction between T cells and APC to form a specialized structure termed the immune synapse (IS). Although the TCR is essential for IS organization, other factors such as chemokines participate in this process. In this study, we show that the chemokine CXCL12-mediated signaling contributes to correct IS organization and therefore influences T cell activation. CXCR4 downregulation or blockade on T cells caused defective actin polymerization at the contact site with APC, altered microtubule-organizing center polarization and the IS structure, and reduced T cell/APC contact duration...
June 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
Audrey Ferrand, Mauro S Sandrin, Arthur Shulkes, Graham S Baldwin
Precursors of the hormone gastrin, progastrin and glycine-extended gastrin (G-gly), have been detected in colorectal polyps and tumours, and in the blood of patients with colorectal cancer (CRC), while their expression is lower in healthy subjects. The surface glycoproteins CD133 and CD44 have been identified as possible markers for CRC stem cells. Our aims were to investigate whether progastrin and G-gly are expressed by CD133-positive cells in human CRC tissues and in the human CRC cell line DLD-1, and to determine whether this expression is biologically relevant...
March 2009: Biochimica et Biophysica Acta
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