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https://read.qxmd.com/read/30879165/improved-in-vivo-targeting-of-bcl-2-phenotypic-conversion-through-hollow-gold-nanoshell-delivery
#1
Erin Morgan, John T Gamble, Martin C Pearce, Daniel J Elson, Robert L Tanguay, Siva Kumar Kolluri, Norbert O Reich
Although new cancer therapeutics are discovered at a rapid pace, lack of effective means of delivery and cancer chemoresistance thwart many of the promising therapeutics. We demonstrate a method that confronts both of these issues with the light-activated delivery of a Bcl-2 functional converting peptide, NuBCP-9, using hollow gold nanoshells. This approach has shown not only to increase the efficacy of the peptide 30-fold in vitro but also has shown to reduce paclitaxel resistant H460 lung xenograft tumor growth by 56...
March 16, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30879160/importance-of-m-n-6-methyladenosine-m-6-a-rna-modification-in-cancer
#2
REVIEW
Gulten Tuncel, Rasime Kalkan
RNA methylation, which was identified back in 1970s, has gained remarkable interest in recent years as it was shown to be a reversible modification involved in many cellular processes like mRNA and miRNA processing, mRNA localisation, translation suppression, or activation. These, in turn, affect important bioprocesses such as tissue development, sex determination, and DNA damage response. Important group of proteins are responsible for adding, recognizing, and removing the methyl group to and from the RNA molecules, which are referred as writers, readers, and erasers, respectively...
March 16, 2019: Medical Oncology
https://read.qxmd.com/read/30879057/prenatal-smoke-exposure-dna-methylation-and-a-link-between-drd1-and-lung-cancer
#3
Bríd M Ryan, Ana I Robles
No abstract text is available yet for this article.
March 15, 2019: International Journal of Epidemiology
https://read.qxmd.com/read/30879028/championing-a-unified-approach-to-lung-cancer-screening-in-europe
#4
Joel M Sternbach, Kathleen S Berfield, Douglas E Wood
No abstract text is available yet for this article.
March 15, 2019: Interactive Cardiovascular and Thoracic Surgery
https://read.qxmd.com/read/30879017/murrayanine-induces-cell-cycle-arrest-oxidative-stress-and-inhibition-of-phosphorylated-p38-expression-in-a549-lung-adenocarcinoma-cells
#5
Jingbao Zhang, Yanfei Gao, Changbo Ma, Yi Wang
BACKGROUND Murrayanine is a carbazole alkaloid derived from Murraya koenigii, which has been used in traditional Chinese medicine in the treatment of cancer. This study aimed to investigate the effects of murrayanine on human lung adenocarcinoma cells in vitro and to investigate the mechanisms of its action. MATERIAL AND METHODS A549 human lung adenocarcinoma cells and MRC-5 human lung fibroblasts were grown in culture, and an MTT assay determined cell viability. Cells were treated for 24 h with increasing doses of murrayanine (0, 9, 18, and 36 µM)...
March 17, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30878997/role-of-immunocytochemistry-in-the-cytological-diagnosis-of-pulmonary-tumors
#6
REVIEW
Jasna Metovic, Luisella Righi, Luisa Delsedime, Marco Volante, Mauro Papotti
Pulmonary cytology is a challenging diagnostic tool, and it is usually evaluated considering medical history and radiological findings in order to reach an accurate diagnosis. Since the majority of lung cancer patients have an advanced stage at diagnosis, a cytological specimen is frequently the only material available for diagnosis and further prognostic/predictive marker determination. Several types of specimens can be obtained from the respiratory system (including sputum, bronchoalveolar lavage, bronchial brushing, fine needle aspiration, and pleural fluid) with different technical preclinical management protocols and different diagnostic yields...
March 15, 2019: Acta Cytologica
https://read.qxmd.com/read/30878976/effects-of-removing-reimbursement-restrictions-on-targeted-therapy-accessibility-for-non-small-cell-lung-cancer-treatment-in-taiwan-an-interrupted-time-series-study
#7
Jason C Hsu, Chen-Fang Wei, Szu-Chun Yang
INTERVENTIONS: Targeted therapies have been proven to provide clinical benefits to patients with metastatic non-small cell lung cancer (NSCLC). Gefitinib was initially approved and reimbursed as a third-line therapy for patients with advanced NSCLC by the Taiwan National Health Insurance (NHI) in 2004; subsequently it became a second-line therapy (in 2007) and further a first-line therapy (in 2011) for patients with epidermal growth factor receptor mutation-positive advanced NSCLC. Another targeted therapy, erlotinib, was initially approved as a third-line therapy in 2007, and it became a second-line therapy in 2008...
March 15, 2019: BMJ Open
https://read.qxmd.com/read/30878891/design-synthesis-and-dna-interaction-studies-of-furo-imidazo-3-3-3-propellane-derivatives-potential-anticancer-agents
#8
Alaa A Hassan, Ashraf A Aly, Nasr K Mohamed, Kamal M El Shaieb, Maysa M Makhlouf, El-Shimaa M N Abdelhafez, Stefan Bräse, Martin Nieger, Kevin N Dalby, Tamer S Kaoud
A large number of natural products containing the propellane scaffold have been reported to exhibit cytotoxicity against several cancers; however, their mechanism of action is still unknown. Anticancer drugs targeting DNA are mainly composed of small planar molecule/s that can interact with the DNA helix, causing DNA malfunction and cell death. The aim of this study was to design and synthesize propellane derivatives that can act as DNA intercalators and/or groove binders. The unique structure of the propellane derivatives and their ability to display planar ligands with numerous possible geometries, renders them potential starting points to design new drugs targeting DNA in cancer cells...
February 13, 2019: Bioorganic Chemistry
https://read.qxmd.com/read/30878832/recent-advancements-of-4-aminoquinazoline-derivatives-as-kinase-inhibitors-and-their-applications-in-medicinal-chemistry
#9
REVIEW
Debasis Das, Jian Hong
The 4-aminoquinazoline core is an interesting pharmacophore and its applications in medicinal chemistry are wide spread. The core has been used for making many kinase inhibitors in past few years. Many researcher demonstrated 4-aminoquinazoline derivatives as specific kinase inhibitors, including tyrosine kinase and serine/theronine kinases. A number of anticancer drugs with 4-aminoquinazoline core are in the market, e.g. gefitinib, erlotinib, afatinib, lapatinib, decomitinib etc. 4-aminoquinazoline derivatives are applied for target specific treatment of lung, breast, colon, prostate cancers...
March 7, 2019: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/30878799/future-of-cancer-incidence-in-shanghai-china-predicting-the-burden-upon-the-ageing-population
#10
Zhenqiu Liu, Yanfeng Jiang, Qiwen Fang, Huangbo Yuan, Ning Cai, Chen Suo, Weimin Ye, Xingdong Chen, Tiejun Zhang
AIM: The age-specific cancer patterns have changed significantly over the last few decades in urban Shanghai. Predicting the cancer incidence in an ageing population can help to anticipate future resource needs, evaluate primary prevention strategies, and inform further research studies. MATERIALS AND METHODS: Annual cancer cases and population data from 1988 to 2013 were collected from Shanghai Cancer Registry. A Bayesian age-period-cohort model was applied to project the future cancer incidence with demographical changes from 2014 to 2025...
March 14, 2019: Cancer Epidemiology
https://read.qxmd.com/read/30878600/concurrent-driver-gene-mutations-as-negative-predictive-factors-in-epidermal-growth-factor-receptor-positive-non-small-cell-lung-cancer
#11
Minjiang Chen, Yan Xu, Jing Zhao, Wei Zhong, Li Zhang, Yalan Bi, Mengzhao Wang
BACKGROUND: Tyrosine kinase inhibitors (TKIs) are clinically effective in non-small cell lung cancer (NSCLC) patients harbouring epidermal growth factor receptor (EGFR) oncogene mutations. Genetic factors, other than EGFR sensitive mutations, that allow prognosis of TKI treatment remain undefined. METHODS: We retrospectively screened 423 consecutive patients with advanced NSCLC and EGFR 19del or 21L858R mutations. A total of 71 patients whose progression-free survivals (PFS) were shorter than 6 months or longer than 24 months were included and stratified into separate groups...
March 14, 2019: EBioMedicine
https://read.qxmd.com/read/30878596/simultaneous-blocking-of-cd47-and-pd-l1-increases-innate-and-adaptive-cancer-immune-responses-and-cytokine-release
#12
Shu Lian, Ruizhi Xie, Yuying Ye, Xiaodong Xie, Shuhui Li, Yusheng Lu, Bifei Li, Yunlong Cheng, Vladimir L Katanaev, Lee Jia
BACKGROUND: Treatment multiple tumors by immune therapy can be achieved by mobilizing both innate and adaptive immunity. The programmed death ligand 1 (PD-L1; or CD274, B7-H1) is a critical "don't find me" signal to the adaptive immune system. Equally CD47 is a critical "don't eat me" signal to the innate immune system and a regulator of the adaptive immune response. METHOD: Both of CD47 and PD-L1 are overexpressed on the surface of cancer cells to enable to escape immune-surveillance...
March 14, 2019: EBioMedicine
https://read.qxmd.com/read/30878484/ventriculostomy-and-endoscopic-biopsy-of-pineal-mass-with-hydrocephalus-and-unexpected-definitive-diagnosis
#13
Antonio José Vargas López, Rafael Luque Barona, José Manuel Galicia Bulnes, Rajab Al Ghanem Al Ghanem, Osamah El Rubaidi Abdullah
A 72-year-old female with no relevant medical history consulted in the emergency room for a two-week history of headache, vomiting and gait disturbance. Head CT scan revealed obstructive hydrocephalus secondary to a pineal mass with compression of the third ventricle. Magnetic Resonance showed another mass located in the right Lushcka foramen. Endoscopic third-ventriculostomy and biopsy of pineal mass were performed. Pathological analysis was consistent with metastasis of carcinoma. Full-body CT scan showed a lung mass related to primary carcinoma...
March 13, 2019: Neurocirugía
https://read.qxmd.com/read/30878308/aspirin-inhibits-hypoxia-mediated-lung-cancer-cell-stemness-and-exosome-function
#14
Jinghua Chen, Ruilian Xu, Junxian Xia, Jiacheng Huang, Binbin Su, Senming Wang
BACKGROUND: Epidemiological studies have illustrated that regular aspirin consumption may decrease the risk of non-small cell lung cancer (NSCLC). The present study aims to investigate the mechanism of aspirin-induced inhibition of NSCLC development during hypoxia. METHODS: A549 cells were pre-treated with the vehicle control or aspirin and then subjected to hypoxic culture. Cell viability was monitored by CCK-8 assay, and flow cytometry was performed to detect cell cycle distributions, apoptosis, and proportion of cancer stem cells (CSCs)...
March 11, 2019: Pathology, Research and Practice
https://read.qxmd.com/read/30878212/corrigendum-to-correlation-of-tumor-spread-through-air-spaces-and-clinicopathological-characteristics-in-surgically-resected-lung-adenocarcinomas-lung-cancer-126-2018-189-193
#15
Szu-Yen Hu, Min-Shu Hsieh, Hsao-Hsun Hsu, Tung-Ming Tsai, Xu-Heng Chiang, Kuan-Chuan Tsou, Hsien-Chi Liao, Mong-Wei Lin, Jin-Shing Chen
No abstract text is available yet for this article.
March 13, 2019: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://read.qxmd.com/read/30878193/synthesis-and-structure-activity-relationships-of-pyrazine-2-carboxamide-derivatives-as-novel-echinoderm-microtubule-associated-protein-like-4-eml4-anaplastic-lymphoma-kinase-alk-inhibitors
#16
Kazuhiko Iikubo, Kazuo Kurosawa, Takahiro Matsuya, Yutaka Kondoh, Akio Kamikawa, Ayako Moritomo, Yoshinori Iwai, Hiroshi Tomiyama, Itsuro Shimada
Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) is a valid therapeutic target for the treatment of EML4-ALK-positive non-small cell lung cancer (NSCLC). We discovered 12c as a novel and potent EML4-ALK inhibitor through structural optimization of 5a. In mice xenografted with 3T3 cells expressing EML4-ALK, oral administration of 12c demonstrated potent antitumor activity. This article describes the synthesis and biological evaluation of pyrazine-2-carboxamide derivatives along with studies of their structure-activity relationship (SAR) using computational modeling...
March 7, 2019: Bioorganic & Medicinal Chemistry
https://read.qxmd.com/read/30878179/oncogenic-role-of-arsenic-exposure-in-lung-cancer-a-forgotten-risk-factor
#17
REVIEW
Cristian Soza-Ried, Eva Bustamante, Christian Caglevic, Christian Rolfo, Rafael Sirera, Hugo Marsiglia
Several drinkable water sources worldwide have been highly contaminated with arsenic, which means that an estimated 160 million people have been exposed to this chemical agent. If we analyse exposure by region, we will find a high correlation between arsenic contamination and the incidence of lung cancer (among other malignancies). In order to determine what the risks of these exposures are, we need to understand how this chemical is processed in our body and how it is linked to cancer. In this article we reviewed how biotransformation of ingested arsenic may lead to cancer by modulating the activation of several essential signalling pathways such as EGFR, PI3K/AKT, RTK/Ras/PI3K, JNK/STAT3 and Nrf2-KEAP1; by producing epigenetics modifications and by disrupting normal expression of miRNAs...
January 25, 2019: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/30878128/alk-rearrangements-biology-detection-and-opportunities-of-therapy-in-non-small-cell-lung-cancer
#18
REVIEW
Gina Rosas, Rossana Ruiz, Jhajaira M Araujo, Joseph A Pinto, Luis Mas
The ALK receptor tyrosine kinase (ALK) gene encodes a transmembrane protein rearranged in 2-7% of non-small cell lung cancer (NSCLC) cases. This gene has become the second most studied therapeutic target after EGFR due to the implied therapeutic opportunities. While the diagnostic of ALK rearrangements is well established, small molecules targeting ALK are in constant evolution because tumor cells eventually will develop mechanisms of resistance. In this review we describe the biology of the ALK gene, alterations, epidemiology, diagnostic tests as well as strategies of treatment...
April 2019: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/30878126/liquid-biopsy-beyond-of-cancer-circulating-pulmonary-cells-as-biomarkers-of-copd-aggressivity
#19
REVIEW
Pedro J Romero-Palacios, Bernardino Alcázar-Navarrete, Juan J Díaz Mochón, Diego de Miguel-Pérez, Javier L López Hidalgo, María Del Carmen Garrido-Navas, Florencio Quero Valenzuela, José Antonio Lorente, María José Serrano
BACKGROUND: Pulmonary parenchymal destruction is consequence of Chronic Obstructive Pulmonary Disease (COPD), which results in degradation of the extracellular matrix and the appearance of peripheral pulmonary cells. The aim of this study is to demonstrate the feasibility of the detection and isolation of Circulating Pulmonary Cells (CPCs) in peripheral blood of patients with COPD. METHODS: 17 COPD patients were enrolled in this prospective study to isolate CPCs...
April 2019: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/30877512/role-of-phospholipase-d-in-migration-and-invasion-induced-by-linoleic-acid-in-breast-cancer-cells
#20
Ricardo Diaz-Aragon, Javier Ramirez-Ricardo, Pedro Cortes-Reynosa, Arturo Simoni-Nieves, Luis-Enrique Gomez-Quiroz, Eduardo Perez Salazar
Linoleic acid (LA) is an essential and omega-6 polyunsaturated fatty acid that mediates a variety of biological processes, including migration and invasion in breast cancer cells. Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Increases of expression and activity of PLD are reported in several human cancers, including gastric, colorectal, renal, stomach, lung and breast. In this article, we demonstrate that LA induces an increase of PLD activity in MDA-MB-231 breast cancer cells...
March 15, 2019: Molecular and Cellular Biochemistry
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