Bang-Ning Lee, Robert Dantzer, Keith E Langley, Gary J Bennett, Patrick M Dougherty, Adrian J Dunn, Christina A Meyers, Andrew H Miller, Richard Payne, James M Reuben, Xin Shelley Wang, Charles S Cleeland
While many of the multiple symptoms that cancer patients have are due to the disease, it is increasingly recognized that pain, fatigue, sleep disturbance, cognitive dysfunction and affective symptoms are treatment related, and may lead to treatment delays or premature treatment termination. This symptom burden, a subjective counterpart of tumor burden, causes significant distress. Progress in understanding the mechanisms that underlie these symptoms may lead to new therapies for symptom control. Recently, some of these symptoms have been related to the actions of certain cytokines that produce a constellation of symptoms and behavioral signs when given exogenously to both humans and animals...
2004: Neuroimmunomodulation