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Dirk Lindenblatt, Mareike Horn, Claudia Götz, Karsten Niefind, Ines Neundorf, Markus Pietsch
The ubiquitously expressed Ser/Thr kinase CK2 is a key regulator in a variety of key processes in normal and malignant cells. Due to its distinctive anti-apoptotic and tumor-driving properties, elevated levels of CK2 have frequently been found in tumors of different origin. In recent years, development of CK2 inhibitors has largely been focused on ATP-competitive compounds; however, targeting the CK2α/CK2β interface has emerged as a further concept that might avoid selectivity issues. In order to address the CK2 subunit interaction site, we have synthesized halogenated CK2β-mimicking cyclic peptides modified with the cell-penetrating peptide sC18 to mediate cellular uptake...
February 20, 2019: ChemMedChem
Arash Ghalayani Esfahani, Mehdi Soleimanzade, Chiara Emma Campiglio, Angelica Federici, Lina Altomare, Lorenza Draghi, Aldo R Boccaccini, Luigi De Nardo
One of the main challenges in the design of scaffolds for cortical bone regeneration is mimicking the highly oriented, hierarchical structure of the native tissue in an efficient, simple, and consistent way. As a possible solution to this challenge, positive replica based on electrophoretic deposition (EPD) was here evaluated as a technique to produce organic/inorganic scaffolds with oriented micro-porosities mimicking Haversian canals diameter and spacing. Two different sizes of 45S5 bioactive glass (BG) powders were chosen as inclusions and loaded in a chitosan matrix via EPD on micro-patterned cathodes...
February 20, 2019: Journal of Biomedical Materials Research. Part A
Larisa Lehmer, Sama Kassira Carly, Sebastien de Feraudy
Matrical carcinoma with melanocytic hyperplasia (MCMH), previously referred to as malignant melanocytic matricoma, is a rare variant of the uncommon pilomatrical carcinoma, which occurs most often on the head/neck and upper backs of middle-aged men. Nodular lesions may resemble pigmented basal cell carcinoma or melanoma clinically. We present a case of MCMH in a Hispanic patient with history of melanoma. Histopathologic clues to appropriate diagnosis include basaloid cells, numerous atypical mitoses, matrical differentiation, shadow cells, strong diffuse nuclear and cytoplasmic expression of beta catenin, and interspersed pigmented dendritic melanocytes...
February 20, 2019: Journal of Cutaneous Pathology
Kiduk Han, Tae Yoon Park, Kijung Yong, Hyung Joon Cha
The surface wetting occurring in daily life causes undesired contaminations, which are critical issues in various fields. To solve these problems, the nonwetting property of a superhydrophobic (SH) surface has proven its utility by preventing contaminant infiltration, serious infections, or malfunction. However, applying SH surfaces in the biomedical field has been limited due to the weak durability and toxicity of the related components. To overcome these limitations, we developed a robust and biocompatible SH surface through combinational biomimicking of three natural organisms: lotus leaf, mussel, and sandcastle worm, for the first time...
February 20, 2019: ACS Applied Materials & Interfaces
James A Smith, Elisa Mele, Rowan P Rimington, Andrew J Capel, Mark P Lewis, Vadim V Silberschmidt, Simin Li
Functionally graded materials (FGMs), with varying spatial, chemical and mechanical gradients (continuous or stepwise), have the potential to mimic heterogenous properties found across biological tissues. They can prevent stress concentrations and retain healthy cellular functions. Here, we show for the first time the fabrication of polydimethylsiloxane and poly(ether) ether ketone (PDMS-PEEK) composites. These were successfully manufactured as a bulk material and functionally graded (stepwise) without the use of hazardous solvents or the need of additives...
February 12, 2019: Journal of the Mechanical Behavior of Biomedical Materials
Kie Abe, Yuhei Chiba
We report a case of probable dementia with Lewy bodies (DLB) with several findings indicating autoimmune encephalitis (e.g. anti-thyroid antibodies in serum and oligoclonal band and anti-N-methyl-d-aspartic acid receptor antibodies in cerebrospinal fluid). The symptoms and the findings of ancillary tests such as Iodine-123-metaiodobenzylguanidine myocardial scintigraphy and 99m Technetium-ethyl-cysteinate-dimer single photon emission computed tomography were improved after the pulse and oral steroid treatment...
February 16, 2019: Journal of Neuroimmunology
Anna Bastet, Delyan Zafirov, Nathalie Giovinazzo, Anouchka Guyon-Debast, Fabien Nogué, Christophe Robaglia, Jean-Luc Gallois
In many crop species, natural variation in eIF4E proteins confers resistance to potyviruses. Gene editing offers new opportunities to transfer genetic resistance to crops that seem to lack natural eIF4E alleles. However, because eIF4E are physiologically important proteins, any introduced modification for virus resistance must not bring adverse phenotype effects. In this study, we assessed the role of amino-acid substitutions encoded by a Pisum sativum eIF4E virus-resistance allele (W69L, T80D S81D, S84A, G114R and N176K) by introducing them independently into the Arabidopsis thaliana eIF4E1 gene, a susceptibility factor to the Clover yellow vein virus (ClYVV)...
February 19, 2019: Plant Biotechnology Journal
Alexandria Mullins, Nicholas Pinkin, Joshua Hardin, Marcey L Waters
The methylation states of Lys and Arg represent a particularly challenging set of targets to distinguish selectively in water using synthetic receptors. To date, Kme3 is the only post translational modification (PTM) of the eight possible methylation states of Lys and Arg that can be recognized selectively. Here we report the first synthetic receptor capable of selectively recognizing Rme2a. This was achieved using a biased DCC library to generate a receptor mimicking the 5-sided box-like shape of Rme2 reader proteins, a feature that has been hypothesized to impart selectivity...
February 19, 2019: Angewandte Chemie
Sofiane Tariket, Hind Hamzeh-Cognasse, Charles-Antoine Arthaud, Sandrine Laradi, Thomas Bourlet, Philippe Berthelot, Olivier Garraud, Fabrice Cognasse
BACKGROUND: Acute lung injury (ALI) is a severe complication of transfusion. In a previous study, we saw that inhibition of the CD40/CD40L complex allowed restoration of ALI lesions in an experimental mouse model. OBJECTIVES: This study focused on pancreas-associated injury development during experimental ALI pathogenesis and its limitation through CD40/CD40L complex inhibition. MATERIALS AND METHODS: An ALI mouse model was established through intraperitoneal lipopolysaccharide and intravenous anti-major histocompatibility complex class I monoclonal antibody injection...
February 19, 2019: Transfusion
Chikako Takeuchi-Baba, Shoichi Ito, Rie Kinjo, Hitomi Miyagi, Hiroyasu Yasuda, Kenichi Ogasawara, Hitoshi Ohto
BACKGROUND: Weak D-type RBCs have fewer D epitopes, but it remains unclear whether individuals with certain types of weak D produce alloanti-D directed at D epitopes absent from the RBCs, and whether it is an alloantibody or an autoantibody. We report the first case of a patient with a weak D Type 15 who produced autoantibodies mimicking alloanti-D. CASE REPORT: A 52-year-old Japanese male with weak D developed anti-D 3 months after transfusion of D-negative and -positive RBCs, and the antibody persisted for 24 months with a consistently negative direct antiglobulin test...
February 19, 2019: Transfusion
Yan Chen, Qiankun Li, Zhijun Tan, Cuiping Zhang, Xiaobing Fu
Sweat gland regeneration is important for patients with an extensive deep burn injury. In previous study, we reported that bone marrow-mesenchymal stem cells (BM-MSCs) could differentiate into sweat gland-like cells (SGLCs), but the underlying molecular mechanism remains unclear. Recently, microRNAs (miRNAs or miRs) are reported to manipulate many biological processes. However, whether the process of MSCs differentiation into sweat gland cells (SGCs) is regulated by miRNAs has not been reported. In this study, BM-MSCs were induced into SGLCs by co-culturing with SGCs...
February 19, 2019: Journal of Molecular Histology
Itsuro Kazama, Toshiyuki Nakajima
We report a case of right bundle branch block, in which the patient's symptoms and the electrocardiogram findings mimicked those of acute coronary syndrome. In this case report, we stress the significance of apparent ST segment elevation in right bundle branch block. The differential diagnosis is important because right bundle branch block is often complicated with acute coronary syndrome. In addition, right bundle branch block with an ST segment elevation in the specific leads can be a predictor of sudden cardiac death...
2019: SAGE Open Medical Case Reports
Manjula Talluri, Srinivasa Reddy Yathapu, Dinesh Kumar Bharatraj
CONTEXT: The importance of phytochemicals/natural products as potential therapeutic agents in the present context is gaining a lot of importance. India with a rich heritage of such preparations needs evaluation as potent drugs. Explant culture system is a method, which is sensitive, reliable, reproducible and is capable of mimicking the in situ conditions maintaining the tissue in sufficiently high level of integration. AIM: The current study aimed to test the antioxidant activity of test compounds, namely, traditional aqueous (4212) and aqueous-methanolic (4308) extracts of Rasna panchaka using liver explant cultures...
November 2018: Indian Journal of Pharmacology
Matthias Imboden, Etienne de Coulon, Alexandre Poulin, Christian Dellenbach, Samuel Rosset, Herbert Shea, Stephan Rohr
Systematic investigations of the effects of mechano-electric coupling (MEC) on cellular cardiac electrophysiology lack experimental systems suitable to subject tissues to in-vivo like strain patterns while simultaneously reporting changes in electrical activation. Here, we describe a self-contained motor-less device (mechano-active multielectrode-array, MaMEA) that permits the assessment of impulse conduction along bioengineered strands of cardiac tissue in response to dynamic strain cycles. The device is based on polydimethylsiloxane (PDMS) cell culture substrates patterned with dielectric actuators (DEAs) and compliant gold ion-implanted extracellular electrodes...
February 19, 2019: Nature Communications
Merab Kiladze, G Mikeladze, M Mizandar, O Kepuladze, Ts Gatenadze
Problem of retained foreign bodies is still actual challenge at surgical practice at the present time. Retained surgical sponges (cotton or gauze pads), which can be mistakenly left behind during different surgical operations, represent a difficult diagnostic problem despite of using modern technologic procedures, such as US, CT, MRI and etc. These foreign materials may cause serious complications and may lead even to mortality. Here, we describe a case of textiloma in which the patient presented with abdominal discomfort, pain and fever after 28 years of partial gastrectomy operation...
February 18, 2019: Annali Italiani di Chirurgia
Lizzy de Groene, Anne P De Jaegere, Olivier J Nijland, Anton H van Kaam
OBJECTIVE: The Neo-Tee Infant T-piece resuscitator is a disposable T-piece resuscitator. The aim of this bench study was to assess the accuracy of the Neo-Tee using a measurement set-up and settings mimicking clinical practice. STUDY DESIGN: Nine Neo-Tee devices were tested using a face mask interface and a manikin. Pressures were set using the built-in manometer and simultaneously measured at the interface. Peak inspiratory pressure (PIP) and positive end-expiratory pressure (PEEP) were studied under static conditions and positive pressure ventilation (PPV), using a wide range of clinically relevant flows and pressures...
February 19, 2019: Archives of Disease in Childhood. Fetal and Neonatal Edition
Thuy-Truc Ta, Hasan Onur Dikmen, Simone Schilling, Bruno Chausse, Andrea Lewen, Jan-Oliver Hollnagel, Oliver Kann
Type II IFN (IFN-γ) is a proinflammatory T lymphocyte cytokine that serves in priming of microglia-resident CNS macrophages-during the complex microglial activation process under pathological conditions. Priming generally permits an exaggerated microglial response to a secondary inflammatory stimulus. The impact of primed microglia on physiological neuronal function in intact cortical tissue (in situ) is widely unknown, however. We explored the effects of chronic IFN-γ exposure on microglia in hippocampal slice cultures, i...
February 19, 2019: Proceedings of the National Academy of Sciences of the United States of America
Hideharu Hagiya
No abstract text is available yet for this article.
February 18, 2019: BMJ Case Reports
Espen Skjong, Tor Arne Johansen, Marta Molinas
It can be challenging to design and implement Model Predictive Control (MPC) schemes in systems with fast dynamics. As MPCs often introduce high computational loads, it can be hard to assure real-time properties required by the dynamic system. An understanding of the system's behavior, to exploit system properties that can benefit real-time implementation is imperative. Moreover, MPC implementations on embedded local devices rarely allows flexibility to changes in model and control philosophy, due to increased complexity and computational loads...
February 12, 2019: ISA Transactions
Lingshuang Sheng, Wei Zhang, Jia Gu, Kefeng Shen, Hui Luo, Yang Yang
BACKGROUND: Haemophagocytic lymphohistiocytosis is a life-threatening disease resulting from primary or secondary hyper-inflammatory disorders. The typical symptoms include persistent fever, splenomegaly, cytopenia and significant elevation of serum ferritin. CASE PRESENTATION: We report a 30-year-old Chinese female patient who was diagnosed with chronic active Epstein-Barr virus infection more than 9 months prior and has since been presenting with cutaneous lymphoproliferative disorders mimicking hydroa vacciniforme and subsequent haemophagocytic lymphohistiocytosis...
February 19, 2019: BMC Medical Genetics
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