Virginia Marcia Concato-Lopes, Manoela Daiele Gonçalves-Lens, Fernanda Tomiotto-Pellissier, Mariana Barbosa Detoni, Ellen Mayara Souza Cruz, Bruna Taciane da Silva Bortoleti, Amanda Cristina Machado Carloto, Ana Carolina Jacob Rodrigues, Taylon Felipe Silva, Elaine da Silva Siqueira, Ricardo Luís Nascimento de Matos, Ian Lucas Alves Cardoso, Ivete Conchon-Costa, Danielle Lazarin-Bidóia, Nilton Syogo Arakawa, Robert F H Dekker, Mário Sérgio Mantovani, Wander Rogério Pavanelli
BACKGROUND: Lung cancer, a chronic and heterogeneous disease, is the leading cause of cancer-related death on a global scale. Presently, despite a variety of available treatments, their effectiveness is limited, often resulting in considerable toxicity and adverse effects. Additionally, the development of chemoresistance in cancer cells poses a challenge. Trilobolide-6-O-isobutyrate (TBB), a natural sesquiterpene lactone extracted from Sphagneticola trilobata, has exhibited antitumor effects...
March 13, 2024: Phytomedicine