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QianQian Han, QianQian Liu, Hui Zhang, Meili Lu, Hongxin Wang, Futian Tang, Yingjie Zhang
BACKGROUND Simvastatin, an HMG-CoA reductase inhibitor, has been reported to exert multiple protective effects on the cardiovascular system. However, the molecular mechanism remains to be examined. The present study was designed to study the effects of simvastatin on cardiac hypertrophy in diabetic rats and to explore its potential mechanism. MATERIAL AND METHODS Sprague-Dawley rats were assigned into a control (Con) group, a streptozotocin (STZ) group, and a STZ+simvastatin (STZ+SIM) group. The level of reactive oxygen species (ROS) was measured by using dihydroethidium (DHE) staining...
February 15, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Trevor P Fidler, Alex Marti, Katelyn Gerth, Elizabeth A Middleton, Robert A Campbell, Matthew T Rondina, Andrew S Weyrich, E Dale Abel
Patients with type 1 diabetes mellitus (T1DM) have increased thrombosis and platelet activation. The mechanisms for platelet hyperactivation in diabetes are incompletely understood. T1DM is accompanied by hyperglycemia, dyslipidemia, and increased inflammation, in addition to an altered hormonal milieu. In vitro analysis of platelets revealed that normal glucose reduces platelet activation while hyperglycemic conditions increase platelet activation. We therefore hypothesized that hyperglycemia increases platelet glucose utilization, which increases platelet activation to promote thrombosis...
February 14, 2019: Diabetes
Çiğdem Yücel, Yeşim Altintaş, Zelihagül Değim, Şükran Yılmaz, Taibe Arsoy, Levent Altıntaş, Can Çokçalışkan, Mahmut Sözmen
This study aims to investigate and compare the effects of insulin and embryonic stem-cell (ESC) loaded liposomes (LPs) and nanocochleate formulations and their PEGylated forms on the glucose levels. All formulations were characterized considering particle size, zeta potential, polydispersity index and encapsulation efficiencies. In-vitro insulin that releases from the formulations was determined using Franz-type diffusion cells. A cytotoxicity test revealed that none of the formulations was toxic to cells in any concentrations...
July 1, 2019: Journal of Nanoscience and Nanotechnology
Jong Han Lee, Mithun Kumer Sarker, Hojung Choi, Dongyun Shin, Donghee Kim, Hee-Sook Jun
Diabetic nephropathy (DN) is one of the major long-term complications of diabetes. Lysophosphatidic acid (LPA) signaling has been implicated in renal fibrosis. In our previous study, we found that the LPA receptor 1/3 (LPAR1/3) antagonist, ki16425, protected against DN in diabetic db/db mice. Here, we investigated the effects of a specific pharmacological inhibitor of LPA receptor 1 (LPA1), AM095, on DN in streptozotocin (STZ)-induced diabetic mice to exclude a possible contribution of LPAR3 inhibition. AM095 treatment significantly reduced albuminuria and the albumin to creatinine ratio and significantly decreased the glomerular volume and tuft area in the treated group compared with the STZ-vehicle group...
February 11, 2019: Biochimica et biophysica acta. Molecular basis of disease
M Jahanshahi, M Saeidi, E Nikmahzar, F Babakordi, G Bahlakeh
Age-associated changes in the levels of luteinizing hormone and human chorionic gonadotropin (hCG) are potential risk factors for Alzheimer's disease (AD); hCG concentration is related to the incidence of AD. The highest density of hCG receptors is in zones of the brain that are vulnerable to AD and streptozotocin (STZ) can decrease the density of this receptor. We investigated the effects of different doses of hCG on hCG receptor density in the prefrontal cortex and cerebellum in a rat model of STZ-induced AD...
February 14, 2019: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
Marius Mbiantcha, Rauf Khalid, Amadou Dawe, Arif Mehreen, Donatien Albert Atsamo, Gilbert Ateufack, Dar Hamza, William Yousseu Nana, Francis Tatsinkou Desire Bomba, Rehman Ur Naeem, Ahmad Izhar
Painful diabetic neuropathy (PDN) is known to adversely affect psychosocial functioning by enhancing levels of anxiety and depression. This study was designed to verify the antihypernociceptive, anxiolytic, and antidepressant-like effects of Combretin A and Combretin B (two triterpenes cycloartane-type isolated from the leaves of Combretum fragrans) in streptozotocin-induced diabetic neuropathy in mice. PDN was induced in mice by the administration of streptozotocin (STZ, 200 mg/kg, i.p.). The effect of oral administration of Combretin A (25 and 50 mg/kg) and Combretin B (25 and 50 mg/kg) on nociception (mechanical allodynia, thermal hyperalgesia, cold allodynia, and chemical hyperalgesia), anxiety (elevated plus maze, light-dark box test, social interaction), and depressant (open field test, forced swimming test, tail suspension test) was evaluated...
February 13, 2019: Naunyn-Schmiedeberg's Archives of Pharmacology
Osama Y Althunibat, Amir M Al Hroob, Mohammad H Abukhalil, Mousa O Germoush, May Bin-Jumah, Ayman M Mahmoud
AIMS: Hyperglycemia-mediated oxidative damage has been described as a major mechanism leading to pathologic changes associated with diabetic cardiomyopathy (DCM). Fisetin is a bioactive flavonol molecule found in many plants and possesses various biological activities. The present study investigated the protective effect of fisetin on diabetes-induced cardiac injury. METHODS: Diabetes was induced by streptozotocin (STZ) and both diabetic and control rats were treated with 2...
February 8, 2019: Life Sciences
Vladimirs Pilipenko, Karina Narbute, Ines Amara, Angela Trovato, Maria Scuto, Jolanta Pupure, Baiba Jansone, Janis Poikans, Egils Bisenieks, Vija Klusa, Vittorio Calabrese
Neuroinflammation, oxidative stress, decreased glucose/energy metabolism, and disrupted neurotransmission are changes that occur early in sporadic Alzheimer's disease (AD), manifesting as mild cognitive impairment. Recently, the imbalanced function of the gamma-aminobutyric acid (GABA) system was identified as a critical factor in AD progression. Thus, maintaining balance among neurotransmitter systems, particularly the GABA system, can be considered a beneficial strategy to slow AD progression. The present study investigated the effects of the compound gammapyrone, a molecule containing three GABA moieties: "free" moiety attached to the position 4 of the 1,4-dihydropyridine (DHP) ring, and two "crypto" moieties as part of the DHP scaffold...
February 11, 2019: Journal of Neuroscience Research
Yajuan Li, Qingsong Hu, Chunlai Li, Ke Liang, Yu Xiang, Heidi Hsiao, Tina K Nguyen, Peter K Park, Sergey D Egranov, Chandrashekar R Ambati, Nagireddy Putluri, David H Hawke, Leng Han, Mien-Chie Hung, Farhad R Danesh, Liuqing Yang, Chunru Lin
Epithelial-mesenchymal transition (EMT) contributes significantly to interstitial matrix deposition in diabetic kidney disease (DKD). However, detection of EMT in kidney tissue is impracticable, and anti-EMT therapies have long been hindered. We reported that phosphatase and tensin homolog (PTEN) promoted transforming growth factor beta 1 (TGF-β), sonic hedgehog (SHH), connective tissue growth factor (CTGF), interleukin 6 (IL-6), and hyperglycemia-induced EMT when PTEN was modified by a MEX3C-catalyzed K27-linked polyubiquitination at lysine 80 (referred to as PTENK27-polyUb)...
February 11, 2019: Journal of Clinical Investigation
Lubomir T Lubomirov, Hristo Gagov, Mechthild M Schroeter, Rudolf J Wiesner, Andras Franko
Diabetes mellitus (DM) is a metabolic disorder with high prevalence, and a major risk factor for macro- and microvascular abnormalities. This study was undertaken to explore the mechanisms of hypercontractility of murine femoral arteries (FA) obtained from mice with streptozotocin (STZ)-induced diabetes and its relation to the phosphorylation profile of the myosin phosphatase target subunit 1, MYPT1. The immunoreactivity of MYPT1 toward phospho-MYPT1-T696, MYPT1-T853, or MYPT1-S695, used as a read out for MYPT1 phosphorylation, has been studied by Western Blotting...
February 2019: Physiological Reports
Qi Wu, Haojie Liu, Ming Zhou
BACKGROUND Diabetic retinopathy (DR) is a macrovascular complication that occurs in diabetic patients. Conventional treatments for the management of DR have many limitations. Thus, the present investigation evaluated the protective effect of fangchinoline against diabetic retinopathy (DR). MATERIAL AND METHODS DR was induced by streptozotocin (STZ; 60 mg/kg; i.p.) and rats were treated with fangchinoline 1, 3, and 10 mg/kg for 16 weeks. DR was confirmed by determining the concentration of advanced glycation end-products (AGEs) and morphology of retinal tissues...
February 11, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Aina He, Wenqian Fang, Kun Zhao, Yajun Wang, Jie Li, Chongzhe Yang, Feriel Benadjaoud, Guo-Ping Shi
Mast cells (MCs) have been implicated in the pathogenesis of cardiometabolic diseases by releasing pro-inflammatory mediators. Patients and animals with diabetic cardiomyopathy (DCM) also show inflammatory cell accumulation in the heart. Here, we detected MCs in mouse heart after streptozotocin (STZ)-induced DCM. DCM production caused significant systole and diastole interventricular septum and left ventricular (LV) posterior wall thinning, and systolic LV internal dilation in wild-type (WT) mice. DCM production also led to significant reductions of fractional shortening percentage, heart rate, body weight, heart weight, and significant increases of kidney, pancreas, and lung weight to body weight ratios, and blood hemoglobin HbA1c and glucose levels in WT mice...
January 19, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
Yanfu Han, Tianjun Sun, Yanqing Han, Lingling Lin, Chang Liu, Jing Liu, Guangzhi Yan, Ran Tao
OBJECTIVE: Difficulty in wound healing is one common complication of diabetes mellitus. The study explored whether the therapeutic effect of human umbilical cord mesenchymal stem cells (hUCMSCs) on diabetic ulcer wound was enhanced by the activation of the Wnt signaling pathway. METHODS: Rat diabetic model was established by intraperitoneal injection of Streptozotocin (STZ). hUCMSCs were purified and seeded on the collagen-chitosan laser drilling acellular dermal matrix (CCLDADM) scaffold, which was subsequently implanted into the cutaneous wound of normal and diabetic rats, followed by daily injection of Wnt signaling pathway agonist (Wnt3a) or antagonist (sFRP3) at the edge of the scaffold...
February 8, 2019: European Journal of Medical Research
Kentaro Higashi, Asami Mori, Kenji Sakamoto, Kunio Ishii, Tsutomu Nakahara
We examined the effect of probucol, an antihyperlipidemic drug with potent antioxidant properties, on cataract formation in streptozotocin (STZ)-induced hyperglycemic rats that were given 5% D-glucose as drinking water. Probucol treatment was initiated immediately after the induction of hyperglycemia was confirmed. Using full horizontal-plane lens images captured with an original digital camera system, the opacity of central region of lens was assessed by measuring the opaque area in the region. Central opacities were detected after 3 weeks of hyperglycemia, and progressed in a time-dependent manner...
February 5, 2019: Pharmacology
Camille Gaube Guex, Fernanda Ziegler Reginato, Patrícia Romualdo de Jesus, Juliana Calil Brondani, Gilberti Helena Hübscher Lopes, Liliane de Freitas Bauermann
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia, insulin resistance, and dyslipidemia. It has broad occurrence worldwide, affecting millions of people, and can cause serious complications. The olive (Olea europaea L.) has important pharmacological functions, including anti-inflammatory, antioxidant, and hypoglycemic activities. Olive leaves are used in traditional medicine for diabetes and hypertension. AIM OF THE STUDY: To evaluate the effect of the ethanolic extract of olive leaves (EEOL) on the metabolism of rats with diabetes induced by a high-fat diet and low dose of streptozotocin (STZ)...
February 2, 2019: Journal of Ethnopharmacology
Jamal Khalilpour, Shiva Roshan-Milani, Farzaneh Hosseini Gharalari, Amin Abdollahzade Fard
INTRODUCTION: It is hypothesized that increased macrophage migration inhibitory factor (MIF) expression may contribute to diabetic nephropathy (DN) pathogenesis. The aim of the present study was to investigate the renal effects of MIF inhibition in a diabetic experimental model. METHODS: Eighteen male Wistar rats (230 ± 20 g) were divided into three groups: 1) control, 2) diabetic (STZ, 50 mg/kg, dissolved in saline, ip), 3) diabetic + MIF antagonist (p425, 1 mg/kg per day, ip, on the 21th day, for 21 consecutive days)...
January 24, 2019: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Jose Eduardo Hernandez-Reyes, Ana Belen Salinas-Abarca, Guadalupe C Vidal-Cantu, Guadalupe Raya-Tafolla, David Elias-Viñas, Vinicio Granados-Soto, Rodolfo Delgado-Lezama
Diabetic neuropathy is an incapacitating complication in diabetic patients. The cellular and molecular mechanisms involved in this pathology are poorly understood. Previous studies have suggested that the loss of spinal GABAergic inhibition participate in painful diabetic neuropathy. However, the role of extrasynaptic α5 subunit-containing GABAA (α5GABAA) receptors in this process is not known. The purpose of this study was to investigate the role of α5GABAA receptors in diabetes-induced tactile allodynia, loss of rate dependent depression (RDD) of the Hoffmann reflex (HR) and modulation of primary afferent excitability...
January 31, 2019: Pain
Xufeng Yang, Dawei Lian, Pinglong Fan, Yifei Xu, Jing Wang, Fangjun Chen, Huanling Lai, Weiwen Jiang, Linjie Zhang, Ping Huang, Hongying Cao
BACKGROUND: This study aimed to elucidate the effects and mechanisms of Radix Linderae (RL) extracts on a mouse model of diabetic bladder dysfunction (DBD), especially on later decompensated phase. METHODS: Male C57BL/6J mice were intraperitoneally injected with streptozotocin (STZ) after 4 weeks of high-fat diet (HFD) feeding. DBD mouse models (later decompensated phase) were developed by 12-weeks persistent hyperglycemia and then treated with RL extracts for 4 weeks...
February 4, 2019: BMC Complementary and Alternative Medicine
Adrián Macho-González, Alba Garcimartín, María Elvira López-Oliva, Baltasar Ruiz-Roso, Isabel Martín de la Torre, Sara Bastida, Juana Benedí, Francisco José Sánchez-Muniz
Carob fruit extract (CFE) has shown remarkable in vitro antioxidant properties and reduces postprandial hyperglycemia and hyperlipidemia in healthy animals. Development of functional meat products that contain bioactive components are presented as a great nutritional strategy. Until now, the effect of the consumption of restructured meat enriched with CFE in a murine model of diabetes has not been investigated. The objective of this study was to evaluate the effect on glycemia, lipemia, lipoprotein profile, Ldlr , arylesterase (AE), and very low-density lipoproteins (VLDL) and liver oxidation in streptozotocin-nicotinamide (STZ-NAD) growing Wistar diabetic rats fed restructured meat in the frame of a high cholesterol/high saturated-fat diet...
February 3, 2019: Nutrients
Jun-Bo Wang, Xin-Ran Liu, Si-Qi Liu, Rui-Xue Mao, Chao Hou, Na Zhu, Rui Liu, Hui-Juan Ma, Yong Li
The study was aimed to determine whether treatment with oat oligopeptides (OOPs) could modulate hyperglycemia related to type 2 diabetes mellitus (T2DM) in Sprague⁻Dawley (SD) rats. Diabetic SD rats modeling by a joint effect of high-calorie diet for 45 days and twice intraperitoneal injection of 30 mg/kg streptozotocin at one-week interval were observed with or without OOPs administration (0.25, 0.50, 1.00, and 2.00 g/kg Body Weight) for 12 weeks. Fasting blood glucose (FBG), oral glucose test tolerance (OGTT), serum insulin, level of antioxidant, and hepatic enzymes were measured...
February 3, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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