Zhigui He, Qiao Chen, Xinmei Duan, Yuan Zhong, Li Zhu, Nianlian Mou, Xu Yang, Yu Cao, Zhiqiang Han, Houhua He, Shuai Wu, Guixue Wang, Xian Qin, Kai Qu, Kun Zhang, Jie Liu, Wei Wu
Atherosclerosis (AS), a pathological cause of cardiovascular disease, results from endothelial injury, local progressive inflammation, and excessive lipid accumulation. AS plaques rich in foam cells are prone to rupture and form thrombus, which can cause life-threatening complications. Therefore, the assessment of atherosclerotic plaque vulnerability and early intervention are crucial in reducing the mortality rates associated with cardiovascular disease. In this work, A fluorescent probe FC-TPA was synthesized, which switches the fluorescence state between protonated and non-protonated, reducing background fluorescence and enhancing signal-to-noise ratio...
May 9, 2024: Acta Biomaterialia