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Emiri Miura, Naho Tsuchiya, Yu Igarashi, Ritsuko Arakawa, Etsuhiro Nikkuni, Tokiwa Tamai, Masao Tabata, Shinya Ohkouchi, Toshiya Irokawa, Hiromasa Ogawa, Takako Takai-Igarashi, Yoichi Suzuki, Shinichi Kuriyama, Gen Tamiya, Atsushi Hozawa, Masayuki Yamamoto, Hajime Kurosawa
BACKGROUND: Forced oscillation technique (FOT) is a noninvasive method used to measure respiratory system resistance (Rrs) and reactance (Xrs) during quiet breathing, which has been extensively studied in clinical settings. The distribution of measured FOT values was previously assessed in a community-based cohort study. In this study, we aimed to confirm the distribution of measured FOT values in a different cohort in order to investigate the relationship between these values and patient clinical and biological data...
February 12, 2019: Respiratory Investigation
Ren-Fang Zeng, Jing-Jing Zhou, Sheng-Rui Liu, Zhi-Meng Gan, Jin-Zhi Zhang, Chun-Gen Hu
SQUAMOSA-promoter binding protein (SBP)-box genes encode a family of plant-specific transcription factors that play vital roles in plant growth and development. In this study, 15 SBP-box genes were identified and isolated from Citrus clementina ( CclSBPs ), where 10 of these genes were predicted to be putative targets of Citrus clementina microRNA156 (CclmiR156). The 15 CclSBP genes could be classified into six groups based on phylogenetic analysis, diverse intron⁻exon structure, and motif prediction, similar to the SQUAMOSA promoter binding protein-like (SPL) gene family of Populus trichocarpa and Arabidopsis thaliana ...
February 14, 2019: Biomolecules
Nisha B Patel, Alexandra J Obregón-Tito, Raul Y Tito, Omar Trujillo-Villaroel, Luis Marin-Reyes, Luzmila Troncoso-Corzo, Emilio Guija-Poma, Cecil M Lewis, Paul A Lawson
A novel Gram-stain-positive, non-motile, non-spore-forming coccus-shaped obligately anaerobic bacterium was recovered from a fecal sample obtained from an individual from a traditional community located on the southern coast of Peru. The results of analysis based on 16S rRNA gene sequencing indicated the novel bacterium to be phylogenetically distinct from other genera of members of the Peptoniphilaceae family, sharing a loose affinity with the genera Ezakiella, Finegoldia, Gallicola and Parvimonas. The major cellular fatty acids of the novel isolate were determined to be C16:0, C17:1ω8c, and C18:1ω9c...
February 15, 2019: International Journal of Systematic and Evolutionary Microbiology
Domenico Davolos, Biancamaria Pietrangeli, Anna Maria Persiani, Oriana Maggi
In this study, we propose a new genus, Victoriomyces, with a new species, Victoriomyces antarcticus, isolated from soil samples collected in Victoria Land, Antarctica. To determine its taxonomic status and evolutionary relationships, phylogenetic analysis was performed on DNA sequences from the nuclear 18S rRNA, 28S rRNA and the second largest subunit of RNA polymerase II (RPB2) genes. Victoriomyces antarcticus constitutes one well-supported distinct lineage within the Cephalothecaceae (family incertae sedis in Sordariomycetes), in which the only recognised asexual morphs belong to the genus Phialemonium and to Acremonium thermophilum...
February 15, 2019: International Journal of Systematic and Evolutionary Microbiology
Wan-Gen Liu, Li-Li Han, Rong Xiang
OBJECTIVE: To study the role and mechanism of microRNA 19b (miR-19b) in hypoxia/reoxygenation (H/R)-induced injury by targeting PTEN. METHODS: PC12 and BV2 cells induced by H/R were treated with miR-19b mimics/inhibitors or small interfering PTEN (si-PTEN), respectively. Lactate dehydrogenase (LDH) level, malondialdehyde (MDA), and superoxide dismutase (SOD) content was detected. Besides, cell viability and apoptosis were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Hoechst33342 staining, and flow cytometry, whereas mitochondrial membrane potential (MMP) tested by JC-1 assay, and reactive oxygen species (ROS) evaluated by the dichloro-dihydro-fluorescein diacetate assay...
February 14, 2019: Journal of Cellular Physiology
T Susanna Meijer, Mark C Burgmans, Marta Fiocco, Lioe-Fee de Geus-Oei, Ellen Kapiteijn, Eleonora M de Leede, Christian H Martini, Rutger W van der Meer, Fred G J Tijl, Alexander L Vahrmeijer
PURPOSE: To investigate the safety and toxicity of percutaneous hepatic perfusion with melphalan (M-PHP) with the Delcath Systems' second-generation (GEN 2) filter and compare the outcomes with historical data from studies using the first-generation filter. MATERIALS AND METHODS: A prospective, single-arm, single-center phase II study was carried out including 35 patients with unresectable, histologically confirmed liver metastases from ocular melanoma between February 2014 and June 2017...
February 14, 2019: Cardiovascular and Interventional Radiology
Ana Claudia R Durante, Danielle V Sobral, Ana Claudia C Miranda, Érika V de Almeida, Leonardo L Fuscaldi, Marycel R F F de Barboza, Luciana Malavolta
Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta , leading to alteration of the integrity of dopaminergic transporters (DATs). In recent years, some radiopharmaceuticals have been used in the clinic to evaluate the integrity of DATs. These include tropane derivatives such as radiolabeled β-CIT and FP-CIT with iodine-123 (123 I), and TRODAT-1 with metastable technetium-99 (99m Tc). Radiolabeling of β-CIT with radioactive iodine is based on electrophilic radioiodination using oxidizing agents, such as Chloramine T or Iodo-Gen® ...
February 5, 2019: Pharmaceuticals
Bailong Tao, Yiman Deng, Liying Song, Wenwen Ma, Ying Qian, Chuanchuan Lin, Zhang Yuan, Lu Lu, Maowen Chen, Xin Yang, Kaiyong Cai
Bacterial infection and surface biointertness are two main causes for titanium (Ti)-based orthopedic implants failure. To improve the antibacterial ability and enhance poor osteogenic property of Ti substrates, in this work, we employed titania nanotubes (TNTs) as Bone Morphogenetic Protein 2 (BMP2) carrier, and a pH-responsive multilayer film composed of alginate dialdehyde-gentamicin (ADA-Gen) and chitosan (Chi) was constructed onto BMP2-loaded TNTs substrates through layer-by-layer (LBL) assembly technique, resulting in TNT-BMP2-LBLg samples...
February 7, 2019: Colloids and Surfaces. B, Biointerfaces
Itaru Dekio, Andrew McDowell, Mitsuo Sakamoto, Shuta Tomida, Moriya Ohkuma
In 2016, division of the genus Propionibacterium into four distinct genera was proposed. As a consequence, the species Propionibacterium acnes was transferred to Cutibacterium gen. nov. as Cutibacterium acnes comb. nov. The three recently proposed subspecies of P. acnes were not, however, accommodated in this proposal. Following a very recent validation of a new combination for C. acnessubsp.defendens and an automatically created C. acnessubsp.acnes, we now propose the new combination, C. acnessubsp. elongatum comb...
February 14, 2019: International Journal of Systematic and Evolutionary Microbiology
Ralf Rabus, Lars Wöhlbrand, Daniela Thies, Markus Meyer, Barbara Reinhold-Hurek, Peter Kämpfer
Comparative 16S rRNA gene sequence analysis and major physiological differences indicate two distinct sublineages within the genus Azoarcus: the Azoarcus evansii lineage, comprising Azoarcusevansii (type strain KB740T =DSM 6898T =CIP 109473T =NBRC 107771T ), Azoarcusbuckelii (type strain U120T =DSM 14744T =LMG 26916T ), Azoarcusanaerobius (type strain LuFRes1T =DSM 12081T =LMG 30943T ), Azoarcustolulyticus (type strain Tol-4T =ATCC 51758T =CIP 109470T ), Azoarcustoluvorans (type strain Td21T =ATCC 700604T =DSM 15124T ) and Azoarcustoluclasticus (type strain MF63T =ATCC 700605T ), and the Azoarcus indigens lineage, comprising Azoarcusindigens (type strain VB32T =ATCC 51398T =LMG 9092T ), Azoarcus communis (type strain SWub3T =ATCC 51397T =LMG 9095T ) and Azoarcusolearius (type strain DQS-4T =BCRC 80407T =KCTC 23918T =LMG 26893T )...
February 14, 2019: International Journal of Systematic and Evolutionary Microbiology
Wei Sun, Xiaodong Zhang, Hao-Ran Jia, Ya-Xuan Zhu, Yuxin Guo, Ge Gao, Yan-Hong Li, Fu-Gen Wu
Herein, water-dispersible carbon nano-onion clusters (CNOCs) with an average hydrodynamic size of ≈90 nm are prepared by simply sonicating candle soot in a mixture of oxidizing acid. The obtained CNOCs have high photothermal conversion efficiency (57.5%), excellent aqueous dispersibility (stable in water for more than a year without precipitation), and benign biocompatibility. After polyethylenimine (PEI) and poly(ethylene glycol) (PEG) modification, the resultant CNOCs-PEI-PEG have a high photothermal conversion efficiency (56...
February 14, 2019: Small
Sonali Garg, S D Biju
Anurans in Peninsular India exhibit close biogeographical links with Gondwana as well as Laurasia, often explainable by the geological history of the Indian subcontinent; its breakup from Gondwanan landmasses followed by long isolation that resulted in diversification of endemic lineages, and subsequent land connections with Asia that enabled dispersal of widespread groups. Although widely distributed, the frog subfamily Microhylinae mostly comprises of geographically restricted genera found either in Southeast and East Asia or Peninsular India and Sri Lanka...
February 13, 2019: Scientific Reports
Daigo Saito, Yoichi Oikawa, Gen Mizutani, Kazuyuki Inoue, Masako Hatano, Ikuo Inoue, Mitsuhiko Noda, Akira Shimada
This research aimed to examine the relationship between anti-glutamic acid decarboxylase antibody (GADA) titers and clinical parameters at onset and to clarify the association between clinical severity and GADA titers in GADA-positive fulminant type 1 diabetes. This cross-sectional observational study included 20 cases with GADA-positive fulminant type 1 diabetes (4 cases from our hospital and 16 from cases reported in the literature). The association between GADA titers and clinical parameters [age, sex, body weight, body mass index, period from appearance of any prodromal symptoms to diagnosis, period from development of hyperglycemic symptoms to diagnosis, GADA titer, HbA1c level, blood pH and HCO3 - level, serum levels of ketone bodies and pancreatic exocrine enzymes] were analyzed...
February 14, 2019: Endocrine Journal
Gen Nakamura, Muneaki Abe, Hozumi Kumano
Acute compartment syndrome of the forearm secondary to hematoma without direct trauma has been reported rarely. We report a case of acute compartment syndrome of the forearm following a hematoma after playing golf. A 55-year-old man felt pain in his left forearm while playing golf that gradually worsened. He could not continue to play and visited the emergency department of our hospital. The radial side of his left forearm was markedly swollen on presentation, and he suffered severe pain that worsened with ulnar flexion of the wrist; no paralysis or hypesthesia was observed...
March 2019: Journal of Hand Surgery Asian-Pacific Volume
Eric Gorscak, Patrick M O'Connor
The African terrestrial fossil record has been limited in its contribution to our understanding of both regional and global Cretaceous paleobiogeography, an interval of significant geologic and macroevolutionary change. A common component in Cretaceous African faunas, titanosaurian sauropods diversified into one of the most specious groups of dinosaurs worldwide. Here we describe the new titanosaurian Mnyamawamtuka moyowamkia gen. et sp. nov. from the Mtuka Member of the Galula Formation in southwest Tanzania...
2019: PloS One
Sven Le Moine Bauer, Andreas Gilje Sjøberg, Stéphane L'Haridon, Runar Stokke, Irene Roalkvam, Ida Helene Steen, Håkon Dahle
A bacterial strain, designated BAR1T , was isolated from a microbial mat growing on the surface of a barite chimney at the Loki's Castle Vent Field, at a depth of 2216 m. Cells of strain BAR1T were rod-shaped, Gram-reaction-negative and grew on marine broth 2216 at 10-37 °C (optimum 27-35 °C), pH 5.5-8.0 (optimum pH 6.5-7.5) and 0.5-5.0 % NaCl (optimum 2 %). The DNA G+C content was 57.38 mol%. The membrane-associated major ubiquinone was Q-10, the fatty acid profile was dominated by C18 : 1ω7c (91 %), and the polar lipids detected were phosphatidylcholine, phosphatidylglycerol, phosphatidylethanolamine, one unidentified aminolipid, one unidentified lipid and one unidentified phospholipid...
February 13, 2019: International Journal of Systematic and Evolutionary Microbiology
Teng-Fei Lou, Gen Wen, Chun-Yang Wang, Yi-Min Chai, Pei Han, Xiao-Fan Yin
BACKGROUND: We described the use of the technique of L-shaped corticotomy with bone flap sliding to treat chronic osteomyelitis of the tibia in eight patients and presented the preliminary results. METHODS: L-shaped corticotomy with bone flap sliding was performed in eight patients between 2007 and 2014. All patients had chronic tibial osteomyelitis involving the anterior tibial cortex with intact and healthy posterior cortex. The size of bone defects following sequestrectomy and radical debridement was 8...
February 12, 2019: Journal of Orthopaedic Surgery and Research
Jiří Vávra, Ivan Fiala, Pavla Krylová, Adam Petrusek, Miroslav Hyliš
Microsporidia are among the most common microparasites of cladocerans and have potentially significant impact on host populations. However, many of these pathogens are known only from molecular-based studies. We provide ultrastructural data supported by molecular phylogeny for a common microsporidium infecting the Daphnia longispina complex, important planktonic filter-feeders in reservoirs and ponds in the temperate Holarctic region. This parasite, previously characterized only by molecular means, infects adipose cells around the Daphnia midgut and eventually fills the centre of the host body with ovoid-shaped spores...
February 9, 2019: Journal of Invertebrate Pathology
Daniel Castillo, Juan Manuel Galvez, Luis J Herrera, Fernando Rojas, Olga Valenzuela, Octavio Caba, Jose Prados, Ignacio Rojas
In more recent years, a significant increase in the number of available biological experiments has taken place due to the widespread use of massive sequencing data. Furthermore, the continuous developments in the machine learning and in the high performance computing areas, are allowing a faster and more efficient analysis and processing of this type of data. However, biological information about a certain disease is normally widespread due to the use of different sequencing technologies and different manufacturers, in different experiments along the years around the world...
2019: PloS One
Corey Frazer, Aaron D Hernday, Richard J Bennett
Candida albicans is an opportunistic human fungal pathogen that is able to cause both mucosal and systemic infections. It is also a frequent human commensal, where it is typically found inhabiting multiple niches including the gastrointestinal tract. One of the most remarkable features of C. albicans biology is its ability to undergo heritable and reversible switching between different phenotypic states, a phenomenon known as phenotypic switching. This is best exemplified by the white-opaque switch, in which cells undergo epigenetic transitions between two alternative cellular states...
February 12, 2019: Current Protocols in Microbiology
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