Magen E Francis, Ethan B Jansen, Anthony Yourkowski, Alaa Selim, Cynthia L Swan, Brian K MacPhee, Brittany Thivierge, Rachelle Buchanan, Kerry J Lavender, Joseph Darbellay, Matthew B Rogers, Jocelyne Lew, Volker Gerdts, Darryl Falzarano, Danuta M Skowronski, Calvin Sjaarda, Alyson A Kelvin
SARS-CoV-2 variants and seasonal coronaviruses continue to cause disease and coronaviruses in the animal reservoir pose a constant spillover threat. Importantly, understanding of how previous infection may influence future exposures, especially in the context of seasonal coronaviruses and SARS-CoV-2 variants, is still limited. Here we adopted a step-wise experimental approach to examine the primary immune response and subsequent immune recall toward antigenically distinct coronaviruses using male Syrian hamsters...
September 26, 2023: Nature Communications