Jordan A Hartmann, Marcella R Cardoso, Maria Cecilia Ramiro Talarico, Devin J Kenney, Madison R Leone, Dagny C Reese, Jacquelyn Turcinovic, Aoife K O'Connell, Hans P Gertje, Caitlin Marino, Pedro E Ojeda, Erich V De Paula, Fernanda A Orsi, Licio Augusto Velloso, Thomas R Cafiero, John H Connor, Alexander Ploss, Angelique Hoelzemer, Mary Carrington, Amy K Barczak, Nicholas A Crossland, Florian Douam, Julie Boucau, Wilfredo F Garcia-Beltran
SARS-CoV-2 and other sarbecoviruses continue to threaten humanity, highlighting the need to characterize common mechanisms of viral immune evasion for pandemic preparedness. Cytotoxic lymphocytes are vital for antiviral immunity and express NKG2D, an activating receptor conserved among mammals that recognizes infection-induced stress ligands (e.g., MIC-A/B). We found that SARS-CoV-2 evades NKG2D recognition by surface downregulation of MIC-A/B via shedding, observed in human lung tissue and COVID-19 patient serum...
April 11, 2024: Cell