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https://read.qxmd.com/read/30781429/comparison-of-30-day-mace-between-immediate-versus-staged-complete-revascularization-in-acute-myocardial-infarction-with-multivessel-disease-and-the-effect-of-coronary-lesion-complexity
#1
Cem Doğan, Zübeyde Bayram, Murat Çap, Flora Özkalaycı, Tuba Unkun, Emrah Erdoğan, Abdulkadir Uslu, Rezzan Deniz Acar, Busra Guvendi, Özgur Yaşar Akbal, Ali Karagöz, Aykun Hakgor, Ahmet Karaduman, Samet Uysal, Ahmet Aykan, Cihangir Kaymaz, Nihal Özdemir
Background and objective: In patients with acute myocardial infarction and multivessel disease, the timing of intervention to non-culprit lesions is still a matter of debate, especially in patients without shock. This study aimed to compare the effect of multivessel intervention, performed at index percutaneous coronary intervention (PCI) (MVI-I) or index hospitalization (MVI-S), on the 30-day results of acute myocardial infarction (AMI), and to investigate the effect of coronary lesion complexity assessed by the Syntax (Sx) score on the timing of multivessel intervention...
February 15, 2019: Medicina
https://read.qxmd.com/read/30778285/targeting-tnfr2-as-a-novel-therapeutic-strategy-for-alzheimer-s-disease
#2
Natalia Ortí-Casañ, Yingying Wu, Petrus J W Naudé, Peter P De Deyn, Inge S Zuhorn, Ulrich L M Eisel
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Accumulating experimental evidence shows the important linkage between tumor necrosis factor-α (TNF) and AD, but the exact role of TNF in AD is still not completely understood. Although TNF-inhibitors are successfully used for treating several diseases, total inhibition of TNF can cause side effects, particularly in neurological diseases. This is attributed to the opposing roles of the two TNF receptors...
2019: Frontiers in Neuroscience
https://read.qxmd.com/read/30774332/pemetrexed-loaded-nanoparticles-targeted-to-malignant-pleural-mesothelioma-cells-an-in-vitro-study
#3
Emanuela Cova, Laura Pandolfi, Miriam Colombo, Vanessa Frangipane, Simona Inghilleri, Monica Morosini, Simona Mrakic-Sposta, Sarah Moretti, Manuela Monti, Ymera Pignochino, Silvia Benvenuti, Davide Prosperi, Giulia Stella, Patrizia Morbini, Federica Meloni
Purpose: Malignant pleural mesothelioma (MPM) is an aggressive tumor characterized by poor prognosis. Its incidence is steadily increasing due to widespread asbestos exposure. There is still no effective therapy for MPM. Pemetrexed (Pe) is one of the few chemotherapeutic agents approved for advanced-stage disease, although the objective response to the drug is limited. The use of gold nanoparticles (GNPs) as a drug delivery system promises several advantages, including specific targeting of malignant cells, with increased intracellular drug accumulation and reduced systemic toxicity, and, in the case of MPM, direct treatment administration into the pleural space...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30773195/implications-of-declining-donor-offers-with-increased-risk-of-disease-transmission-on-waiting-list-survival-in-lung-transplantation
#4
Morgan L Cox, Michael S Mulvihill, Ashley Y Choi, Muath Bishawi, Asishana A Osho, John C Haney, Mani Daneshmand, Jacob A Klapper, Cameron R Wolfe, Matthew Hartwig
BACKGROUND: Donors with characteristics that may increase the likelihood of disease transmission with transplantation are noted as increased risk via Public Health Service criteria. This study aimed to establish the implications of declining an increased-risk donor (IRD) organ offer in lung transplantation. METHODS: Adult candidates waitlisted for isolated lung transplantation in the United States using the Organ Procurement and Transplantation Network /United Network of Organ Sharing registry from 2007 to 2017 were identified...
March 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/30772849/trial-summary-and-protocol-for-a-phase-ii-randomised-placebo-controlled-double-blinded-trial-of-interleukin-1-blockade-in-acute-severe-colitis-the-iaso-trial
#5
Martin Geoffrey Thomas, Carrie Bayliss, Simon Bond, Francis Dowling, James Galea, Vipul Jairath, Christopher Lamb, Christopher Probert, Elizabeth Timperley-Preece, Alastair Watson, Lynne Whitehead, John G Williams, Miles Parkes, Arthur Kaser, Tim Raine
INTRODUCTION: Acute severe ulcerative colitis (ASUC) is a severe manifestation of ulcerative colitis (UC) that warrants hospitalisation. Despite significant advances in therapeutic options for UC and in the medical management of steroid-refractory ASUC, the initial treatment paradigm has not changed since 1955 and is based on the use of intravenous corticosteroids. This treatment is successful in approximately 50% of patients but failure of this and subsequent medical therapy still occurs, with colectomy rates of up to 40% reported...
February 15, 2019: BMJ Open
https://read.qxmd.com/read/30772094/the-ccr6-ccl20-axis-in-humoral-immunity-and-t-b-cell-immunobiology
#6
REVIEW
Adrian Y S Lee, Heinrich Körner
Traditionally, chemokine immunobiology has focused on chemotaxis and the positioning of cells at sites of inflammation and within lymphoid organs. More recently, however, regulation of intricate immune responses has emerged as a function attributed to chemokines and their receptors. One such pair, CCR6 and its chemokine ligand CCL20, has been receiving interest for its potential role in the coordination and regulation of humoral immune responses and in particular, memory responses, at the cellular level. B cells up-regulate CCR6 after activation in secondary lymphoid organs; however, its function is still unclear...
February 8, 2019: Immunobiology
https://read.qxmd.com/read/30771959/a-rhodamine-deoxylactam-based-fluorescent-probe-for-fast-and-selective-detection-of-nitric-oxide-in-living-cells
#7
Wen-Li Jiang, Yongfei Li, Hong-Wen Liu, Dong-Ye Zhou, Juan Ou-Yang, Lanhua Yi, Chun-Yan Li
Nitric oxide (NO) plays vital roles in many physiological process and is closely related to many diseases. So far, a number of fluorescent probes have been constructed for the detection of NO successfully. However, the probes still suffer from long-time reaction and limited selectivity. Herein, a fluorescent probe named dRB-OPD is synthesized and used to recognize NO. The probe contains a deoxy-rhodamine B as fluorophore and o-phenylenediamino as reaction site. dRB-OPD shows fast response to NO within 40 s with 170-fold fluorescence enhancement...
May 15, 2019: Talanta
https://read.qxmd.com/read/30767846/group-a-streptococcus-mediated-host-cell-signaling
#8
Vijay Pancholi
In the past decade, the field of the cellular microbiology of group A Streptococcus ( S. pyogenes ) infection has made tremendous advances and touched upon several important aspects of pathogenesis, including receptor biology, invasive and evasive phenomena, inflammasome activation, strain-specific autophagic bacterial killing, and virulence factor-mediated programmed cell death. The noteworthy aspect of S. pyogenes -mediated cell signaling is the recognition of the role of M protein in a variety of signaling events, starting with the targeting of specific receptors on the cell surface and on through the induction and evasion of NETosis, inflammasome, and autophagy/xenophagy to pyroptosis and apoptosis...
January 2019: Microbiology Spectrum
https://read.qxmd.com/read/30767415/critical-review-of-the-management-of-primary-central-nervous-nongerminomatous-germ-cell-tumors
#9
REVIEW
Mohammad H Abu Arja, Eric Bouffet, Jonathan L Finlay, Mohamed S AbdelBaki
Multimodal strategies have significantly improved the outcomes for patients with central nervous system nongerminomatous germ cell tumors. Two large cooperative group studies have recently reported much improved outcomes compared with historical series. However, a substantial proportion of patients still attain inadequate responses to initial chemotherapy prior to irradiation, with adverse impact upon survival; optimal induction chemotherapy regimens and radiotherapy strategies are as yet unidentified. Outcomes for patients with relapsed disease remain poor...
February 15, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30767088/estimating-utilities-disutilities-for-high-risk-metastatic-hormone-sensitive-prostate-cancer-mhspc-and-treatment-related-adverse-events
#10
F Hall, H M de Freitas, C Kerr, T Ito, B Nafees, A J Lloyd, J Penton, M Hadi, S Lanar, T P Pham
PURPOSE: To capture UK societal health utility values for high-risk metastatic hormone-sensitive prostate cancer (mHSPC) and the disutility associated with treatment-related adverse events (AEs) to inform future cost-utility analyses. METHODS: A literature review, and patient and clinical expert interviews informed the development of health states characterising mHSPC symptoms and the impact of treatment-related AEs on health-related quality of life (HRQL). Three base health states were developed describing a typical patient with high-risk mHSPC: receiving androgen deprivation therapy (ADT) [Base State 1]; receiving docetaxel plus ADT [Base State 2]; completed docetaxel and still receiving ADT whose disease has not yet progressed [Base State 3]...
February 14, 2019: Quality of Life Research
https://read.qxmd.com/read/30766726/modulating-crispr-gene-drive-activity-through-nucleocytoplasmic-localization-of-cas9-in-s-cerevisiae
#11
Megan E Goeckel, Erianna M Basgall, Isabel C Lewis, Samantha C Goetting, Yao Yan, Megan Halloran, Gregory C Finnigan
Background: The bacterial CRISPR/Cas genome editing system has provided a major breakthrough in molecular biology. One use of this technology is within a nuclease-based gene drive. This type of system can install a genetic element within a population at unnatural rates. Combatting of vector-borne diseases carried by metazoans could benefit from a delivery system that bypasses traditional Mendelian laws of segregation. Recently, laboratory studies in fungi, insects, and even mice, have demonstrated successful propagation of CRISPR gene drives and the potential utility of this type of mechanism...
2019: Fungal Biology and Biotechnology
https://read.qxmd.com/read/30762921/parotidectomy-in-patients-with-head-and-neck-cutaneous-melanoma-with-cervical-lymph-node-involvement
#12
Danique M S Berger, Martinus M van Veen, Max F Madu, Alexander C J van Akkooi, Wouter V Vogel, Alfons J M Balm, Willem M C Klop
BACKGROUND: Parotidectomy in melanoma of the coronal scalp and face with clinically involved cervical lymph node metastasis is based on predicted cervical lymphatic drainage described by O'Brien. METHODS: In total, 40 parotidectomies with en bloc therapeutic neck dissection were retrospectively analyzed. RESULTS: Lymphatic spread of melanoma to the parotid lymph nodes was observed in 10 of 40 specimens (25%). Eight of the 10 parotid-positive patients developed a recurrence vs 17 of the 30 parotid-negative patients (P = 0...
February 14, 2019: Head & Neck
https://read.qxmd.com/read/30762427/rna-and-dna-integrity-remain-stable-in-frozen-tissue-after-long-term-storage-at-cryogenic-temperatures-a-report-from-the-ontario-tumour-bank
#13
Rachel Kelly, Monique Albert, Manon de Ladurantaye, Melissa Moore, Olusola Dokun, John M S Bartlett
BACKGROUND: It is widely assumed that the integrity of tissue specimens remains stable indefinitely if preserved at cryogenic temperatures. With biobanking reaching a level of maturity where samples are increasingly stored for 10 years and beyond, this assumption of prolonged stability should be tested. Data from such an assessment are critical to verify if samples stored for extended durations remain "fit for purpose" or if there is need to reconsider the utility of samples stored beyond a certain timeframe...
February 14, 2019: Biopreservation and Biobanking
https://read.qxmd.com/read/30761170/nbs-encoding-genes-in-brassica-napus-evolved-rapidly-after-allopolyploidization-and-co-localize-with-known-disease-resistance-loci
#14
Ying Fu, Yaofeng Zhang, Annaliese S Mason, Baogang Lin, Dongqing Zhang, Huasheng Yu, Donghui Fu
Genes containing nucleotide-binding sites (NBS) play an important role in pathogen resistance in plants. However, the evolutionary fate of NBS-encoding genes after formation of allotetraploid Brassica napus (An An Cn Cn , 2n = 38) is still unknown. We performed a genome-wide comparison of putatively functional NBS-encoding genes in B. napus and its progenitor species Brassica rapa (Ar Ar , 2n = 20) and Brassica oleracea (Co Co , 2n = 18), identifying 464, 202, and 146 putatively functional NBS-encoding genes respectively, with genes unevenly distributed in several clusters...
2019: Frontiers in Plant Science
https://read.qxmd.com/read/30759006/improving-detection-of-early-chronic-obstructive-pulmonary-disease
#15
Wassim W Labaki, MeiLan K Han
Despite being a major cause of morbidity and mortality, chronic obstructive pulmonary disease (COPD) is frequently undiagnosed. Yet the burden of disease among the undiagnosed is significant, as these individuals experience symptoms, exacerbations, and excess mortality compared to those without COPD. The U.S. Preventive Services Task Force recommends against routine screening of asymptomatic individuals with spirometry. Hence, case-finding approaches are needed. A recently developed instrument, the five-item COPD Assessment in Primary Care to Identify Undiagnosed Respiratory Disease and Exacerbation Risk questionnaire plus peak expiratory flow, demonstrates good sensitivity and specificity for distinguishing cases from control subjects and is being studied prospectively in primary care settings to determine its impact on patient outcomes...
December 2018: Annals of the American Thoracic Society
https://read.qxmd.com/read/30753581/the-risk-of-birth-defects-is-not-associated-with-semen-parameters-or-mode-of-conception-in-offspring-of-men-visiting-a-reproductive-health-clinic
#16
Alexander W Pastuszak, Amin S Herati, Michael L Eisenberg, Cenk Cengiz, Peter H Langlois, Taylor P Kohn, Dolores J Lamb, Larry I Lipshultz
STUDY QUESTION: What is the relationship between semen parameters and birth defect (BD) rates in offspring of men evaluated for infertility? SUMMARY ANSWER: Among men undergoing infertility evaluation, there is no significant relationship between semen parameters and defect rates in live or still births, even when considering mode of conception. WHAT IS KNOWN ALREADY: Approximately 15% of couples have fertility difficulties, with up to a 50% male factor contribution...
February 12, 2019: Human Reproduction
https://read.qxmd.com/read/30748099/targeting-pi3k%C3%AE-function-for-amelioration-of-murine-chronic-graft-versus-host-disease
#17
Katelyn Paz, Ryan Flynn, Jing Du, Stacey Tannheimer, Amy J Johnson, Shuai Dong, Anne-Katrien Stark, Klaus Okkenhaug, Angela Panoskaltsis-Mortari, Peter T Sage, Arlene H Sharpe, Leo Luznik, Jerome Ritz, Robert J Soiffer, Corey S Cutler, John Koreth, Joseph H Antin, David B Miklos, Kelli P MacDonald, Geoffrey R Hill, Ivan Maillard, Jonathan S Serody, William J Murphy, David H Munn, Colby Feser, Michael Zaiken, Bart Vanhaesebroeck, Laurence A Turka, John C Byrd, Bruce R Blazar
Chronic graft-versus-host disease is a leading cause of morbidity and mortality following allotransplant. Activated donor effector T-cells can differentiate into pathogenic T helper (Th)-17 cells and germinal center -promoting Tfollicular helper cells, resulting in cGVHD. Phosphoinositide-3-kinase-δ, a lipid kinase, is critical for activated T-cell survival, proliferation, differentiation, and metabolism. We demonstrate PI3Kδ activity in donor T-cells that become Tfhs is required for cGVHD in a non-sclerodermatous multi-organ system disease model that includes bronchiolitis obliterans, dependent upon GC B-cells, Tfhs, and counterbalanced by Tfollicular regulatory cells, each requiring PI3Kδ signaling for function and survival...
February 12, 2019: American Journal of Transplantation
https://read.qxmd.com/read/30747148/evaluating-human-rabies-control-in-asia-using-one-health-principles-to-assess-control-programmes-for-rabies
#18
S Ghai, T Hemachudha
Rabies is a global issue, and kills tens of thousands of people every year, despite being a preventable disease. The goal of the World Health Organization (WHO) and the World Organisation for Animal Health (OIE) to eliminate dog-mediated rabies by 2030 requires serious collaborative efforts across Ministries and countries. This cross-sector cooperation includes, but is not limited to, physicians, veterinarians, local authorities, local communities and the media; in other words, a 'One Health' approach. Countries where human rabies has been successfully eliminated still require constant vigilance, in terms of regulations on companion animal ownership and vaccination, the movement of animals from countries where the disease still exists, and the continued raising of public awareness...
August 2018: Revue Scientifique et Technique
https://read.qxmd.com/read/30747125/proof-of-concept-of-mass-dog-vaccination-for-thecontrol-and-elimination-of-canine-rabies
#19
S Cleaveland, S M Thumbi, M Sambo, A Lugelo, K Lushasi, K Hampson, F Lankester
For more than 100 years, canine rabies vaccination has been available as a tool for rabies control and elimination. However, domestic dogs still remain a major reservoir for rabies, and although canine rabies has been eliminated through mass dog vaccination in some parts of the world, the disease continues to kill tens of thousands of people every year in Africa and Asia. This review focuses on the situation on those two continents, presenting evidence to show that canine rabies elimination is both epidemiologically and operationally feasible, and could be achieved across a wide range of settings in Africa and Asia...
August 2018: Revue Scientifique et Technique
https://read.qxmd.com/read/30744297/-rush-poppers-use-and-risks-of-human-papillomavirus-infection-among-men-who-have-sex-with-men-in-urumqi-mediation-effect-through-high-risk-sexual-behaviors
#20
X Q Tuo, H Wang, Mahan Yeledan, Z L Zhang, Z Gong, T Tian, Z Chen, Hailili Gulisiya, J H Dai
Objective: To study the prevalence of rush poppers use among men who have sex with men (MSM) in Urumqi and to analyze the mediating effect of high-risk sexual behavior between the use of rush poppers and human papillomavirus (HPV) infection. Methods: From January to June 2018, 651 MSM were recruited through network and publicity. Data was collected by using online questionnaire and anal swab were collected from them for HPV genotyping. According to Baron and Kenny ' s criterion, multivariate logistic regression models was used to analyze the mediation effect of high-risks sexual behaviors (multiple sexual partners, anal intercourse condom use) between rush poppers use and HPV infection...
February 6, 2019: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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