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https://read.qxmd.com/read/30760391/neurocognitive-rehabilitation-skills-or-strategies
#1
Gordon Muir Giles
The author describes personal and professional milestones in becoming an occupational therapist and his early experience in the first behavior disorder program for neurologically based aggression in the world. A real clinical example is used to bring these early lessons into vivid focus. New evidence underlines occupational therapists' unique role in skill-habit training in clients with severe neurological impairment. For clients with milder impairments, irrespective of diagnosis, strategy training may maximize community independence and reduce hospital recidivism...
November 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://read.qxmd.com/read/30745366/immune-profiling-and-quantitative-analysis-decipher-the-clinical-role-of-immune-checkpoint-expression-in-the-tumor-immune-microenvironment-of-dlbcl
#2
Ziju Xu-Monette, Min Xiao, Qingyan Au, Raghav Padmanabhan, Bing Xu, Nicholas Hoe, Sandra Rodriguez-Perales, Raul Torres-Ruiz, Ganiraju Manyam, Carlo Visco, Yi Miao, Xiaohong Tan, Hongwei Zhang, Alexandar Tzankov, Jing Wang, Karen Dybkaer, Wayne Tam, Hua You, Govind Bhagat, Eric D Hsi, Maurilio Ponzoni, Andrés J M Ferreri, Michael B Møller, Miguel A Piris, J Han van Krieken, Jane N Winter, Jason R Westin, Lan V Pham, L Jeffrey Medeiros, George Z Rassidakis, Yong Li, Gordon J Freeman, Ken H Young
PD-1/L1 and CTLA-4 blockade immunotherapies have been approved for twelve types of cancer and are being studied in diffuse large B-cell lymphoma (DLBCL), the most common aggressive B-cell lymphoma. However, whether both PD-1 and CTLA-4 checkpoints are active and clinically significant in DLBCL is unknown. Whether PD-1 ligands expressed by tumor cells or by the microenvironment of DLBCL are critical for immune checkpoint is unclear. We performed immunophenotypic profiling for 405 patients with de novo DLBCL using a MultiOmyx immunofluorescence platform and simultaneously quantitated expression/coexpression of 13 immune markers to identify prognostic determinants...
February 11, 2019: Cancer Immunology Research
https://read.qxmd.com/read/30714749/randomized-cost-effectiveness-trial-of-group-interpersonal-psychotherapy-ipt-for-prisoners-with-major-depression
#3
Jennifer E Johnson, Robert L Stout, Ted R Miller, Caron Zlotnick, Louis A Cerbo, Joel T Andrade, Jessica Nargiso, Joseph Bonner, Shannon Wiltsey-Stirman
OBJECTIVE: This study tested the effectiveness and cost-effectiveness of interpersonal psychotherapy (IPT) for major depressive disorder (MDD) among prisoners. It is the first fully powered randomized trial of any treatment (pharmacological or psychosocial) targeting MDD among incarcerated individuals. METHOD: One hundred eighty-one male (n = 117) and female (n = 64) prisoners from prison facilities in 2 states were randomized to group IPT (delivered by master's-level and nonspecialist prison counselors) for MDD plus prison treatment as usual (TAU) or to TAU alone...
February 4, 2019: Journal of Consulting and Clinical Psychology
https://read.qxmd.com/read/30713802/pd-l2-expression-is-correlated-with-the-molecular-and-clinical-features-of-glioma-and-acts-as-an-unfavorable-prognostic-factor
#4
Zhi-Liang Wang, Guan-Zhang Li, Qiang-Wei Wang, Zhao-Shi Bao, Zheng Wang, Chuan-Bao Zhang, Tao Jiang
Background : Gliomas are aggressive tumors with various molecular and clinical characteristics and exhibit strongly resistance to radio-chemotherapy. Programmed cell death 1 ligand 2 (PD-L2) is a cell surface protein, which was reported in many cancers, modulating cancer-associated immune responses, while the role of PD-L2 in gliomas remained unclear. Herein, we aimed to investigate the biological behaviors and clinical prognostic values of PD-L2 in gliomas. Methods : Totally, we enrolled RNA sequencing data of 325 glioma samples from Chinese Glioma Genome Atlas (CGGA) as training cohort and RNA expression data of 1032 samples from The Cancer Genome Atlas (TCGA) dataset as validation cohort in this research...
2019: Oncoimmunology
https://read.qxmd.com/read/30687982/effects-of-mindfulness-coping-styles-and-resilience-on-job-retention-and-burnout-in-caregivers-supporting-aggressive-adults-with-developmental-disabilities
#5
R E Nevill, S M Havercamp
BACKGROUND: Considering the growing body of studies investigating the effects of mindfulness-based interventions on caregivers supporting people with developmental disabilities, the current study aimed to explore the role that the cognitive processes of mindfulness, coping style and resilience played in predicting caregiver retention and burnout among a sample of direct support professionals working with aggressive adults with developmental disabilities. METHODS: Ninety-seven direct support professionals were surveyed to determine level of mindfulness, coping styles, resilience and burnout and were interviewed 3 months later to determine if they were still working with the aggressive adult...
January 27, 2019: Journal of Intellectual Disability Research: JIDR
https://read.qxmd.com/read/30686140/2d-and-3d-qsar-modelling-molecular-docking-and-in-vitro-evaluation-studies-on-18%C3%AE-glycyrrhetinic-acid-derivatives-against-triple-negative-breast-cancer-cell-line
#6
Aparna Shukla, Rekha Tyagi, Sanjeev Meena, Dipak Datta, Santosh Kumar Srivastava, Feroz Khan
Triple negative breast cancers (TNBC) are one of the most aggressive and complex forms of cancers in women. TNBCs are commonly known for their complex heterogeneity and poor prognosis. The present work aimed to develop a predictive 2D and 3D quantitative structure activity relationship (QSAR) models against metastatic TNBC cell line. The 2D-QSAR was based on multiple linear regression analysis and validated by Leave-One-Out (LOO) and external test set prediction approach. QSAR model presented regression coefficient values for training set (r2 ), LOO based internal regression (q2 ) and external test set regression (pred_r2 ) are 0...
January 28, 2019: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/30675203/diagnosis-of-mesothelioma-with-deep-learning
#7
Xue Hu, Zebo Yu
Malignant mesothelioma (MM) is a rare but aggressive cancer. The definitive diagnosis of MM is critical for effective treatment and has important medicolegal significance. However, the definitive diagnosis of MM is challenging due to its composite epithelial/mesenchymal pattern. The aim of the current study was to develop a deep learning method to automatically diagnose MM. A retrospective analysis of 324 participants with or without MM was performed. Significant features were selected using a genetic algorithm (GA) or a ReliefF algorithm performed in MATLAB software...
February 2019: Oncology Letters
https://read.qxmd.com/read/30672967/does-cyberbullying-occur-simultaneously-with-other-types-of-violence-exposure
#8
Marlene A Vieira, John A Rønning, Jair de J Mari, Isabel A Bordin
OBJECTIVE: Our study aimed to verify whether cyberbullying victimization among adolescents occurs concomitantly with other forms of violence exposure (at home, at school and in the community). METHODS: A collaborative longitudinal study by Norwegian and Brazilian researchers was conducted in Itaboraí, a low-income city in southeast Brazil. At baseline, trained interviewers applied a semi-structured questionnaire to a population-based sample of 669 in-school adolescents (11-15 years old)...
January 17, 2019: Revista Brasileira de Psiquiatria
https://read.qxmd.com/read/30671629/the-role-of-bladder-function-in-the-pathogenesis-and-treatment-of-urinary-tract-infections-in-toilet-trained-children
#9
Armando J Lorenzo, Mandy Rickard, Joana Dos Santos
Urinary tract infections (UTIs) are a common reason for referral to pediatric specialists and the risk profile of these children is influenced by age, sex, and underlying urinary tract abnormalities. UTIs in toilet-trained children represent a different entity than confirmed, febrile UTIs that occur in infants, impacted by suboptimal bladder habits, bladder dysfunction, constipation, or a combination of these factors. A comprehensive literature search was conducted using PubMed and MEDLINE and search terms included recurrent UTI, VUR, bladder and bowel dysfunction (BBD), constipation, lower urinary tract symptoms, and voiding dysfunction...
January 22, 2019: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30670912/biomarker-identification-and-trans-regulatory-network-analyses-in-esophageal-adenocarcinoma-and-barrett-s-esophagus
#10
Jing Lv, Lei Guo, Ji-Han Wang, Yu-Zhu Yan, Jun Zhang, Yang-Yang Wang, Yan Yu, Yun-Fei Huang, He-Ping Zhao
BACKGROUND: Esophageal adenocarcinoma (EAC) is an aggressive disease with high mortality and an overall 5-year survival rate of less than 20%. Barrett's esophagus (BE) is the only known precursor of EAC, and patients with BE have a persistent and excessive risk of EAC over time. Individuals with BE are up to 30-125 times more likely to develop EAC than the general population. Thus, early detection of EAC and BE could significantly improve the 5-year survival rate of EAC. Due to the limitations of endoscopic surveillance and the lack of clinical risk stratification strategies, molecular biomarkers should be considered and thoroughly investigated...
January 14, 2019: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/30669859/aggression-in-acute-inpatient-psychiatric-care-a-survey-of-staff-attitudes
#11
Ifeoma E Ezeobele, Rachel McBride, Allison Engstrom, Scott D Lane
INTRODUCTION: Inpatient aggression poses consistent complications for psychiatric hospitals. It can affect patient and staff safety, morale, and quality of care. Research on staff attitudes toward patient aggression is sparse. PURPOSE: The study explored staff attitudes toward patient aggression by hospital position types and years of experience in a psychiatric hospital. We predicted that staff experiencing patient aggression would be related to working in less trained positions, having less psychiatric work experience, and demonstrating attitudes that were consistent with attributes internal to the patient and not external...
January 22, 2019: Canadian Journal of Nursing Research, Revue Canadienne de Recherche en Sciences Infirmières
https://read.qxmd.com/read/30655356/nucleus-accumbens-drd1-expressing-neurons-control-aggression-self-administration-and-aggression-seeking-in-mice
#12
Sam A Golden, Michelle Jin, Conor Heins, Marco Venniro, Michael Michaelides, Yavin Shaham
We recently developed a mouse model of appetitive operant aggression and reported that adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate male mice and relapse to aggression seeking during abstinence. Here we studied the role of nucleus accumbens (NAc) dopamine D1- and D2-receptor (Drd1 and Drd2) expressing neurons in aggression self-administration and aggression seeking. We trained CD-1 mice to self-administer intruders (9 d, 12 trials/d) and tested them for aggression self-administration and aggression seeking on abstinence day 1...
January 17, 2019: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://read.qxmd.com/read/30646329/risk-factors-associated-with-boys-and-girls-developmental-trajectories-of-physical-aggression-from-early-childhood-through-early-adolescence
#13
Ali Teymoori, Sylvana M Côté, Bobby L Jones, Daniel S Nagin, Michel Boivin, Frank Vitaro, Massimiliano Orri, Richard E Tremblay
Importance: This study used multitrajectory modeling to identify distinct trajectories of physical aggression from ages 1.5 to 13 years for boys and girls. Objectives: To trace the development of boys' and girls' physical aggression problems from infancy to adolescence using mother ratings, teacher ratings, and self-ratings and to identify early family predictors of children on the high physical aggression trajectories. Design, Setting, and Participants: This cohort study used data from the Quebec Longitudinal Study of Child Development (QLSCD), a study of a representative, population-based sample of 2223 infants born in 1997 and 1998 in the Canadian province of Quebec...
December 7, 2018: JAMA network open
https://read.qxmd.com/read/30646102/risk-factors-associated-with-major-cardiovascular-events-1-year-after-acute-myocardial-infarction
#14
Yun Wang, Jing Li, Xin Zheng, Zihan Jiang, Shuang Hu, Rishi K Wadhera, Xueke Bai, Jiapeng Lu, Qianying Wang, Yetong Li, Chaoqun Wu, Chao Xing, Sharon-Lise Normand, Harlan M Krumholz, Lixin Jiang
Importance: Patients who survive acute myocardial infarction (AMI) have a high risk of subsequent major cardiovascular events. Efforts to identify risk factors for recurrence have primarily focused on the period immediately following AMI admission. Objectives: To identify risk factors and develop and evaluate a risk model that predicts 1-year cardiovascular events after AMI. Design, Setting, and Participants: Prospective cohort study. Patients with AMI (n = 4227), aged 18 years or older, discharged alive from 53 acute-care hospitals across China from January 1, 2013, to July 17, 2014...
August 3, 2018: JAMA network open
https://read.qxmd.com/read/30644767/symptom-dimension-response-in-children-and-adolescents-with-obsessive-compulsive-disorder
#15
Joseph F McGuire, Patricia Z Tan, John Piacentini
This report examined the nature of obsessive-compulsive disorder (OCD) symptoms nominated for treatment and investigate improvement in OCD symptom dimensions. Youth with OCD (N = 71) participated in a clinical trial that compared exposure-based cognitive behavior therapy (CBT) to psychoeducation plus relaxation training (PRT). Participants completed a baseline assessment to characterize OCD severity. Next, parents and youth collaboratively developed an OCD symptom treatment hierarchy. Afterward, these symptoms were independently reassessed at each session by youth and parents...
January 15, 2019: Journal of Clinical Child and Adolescent Psychology
https://read.qxmd.com/read/30643514/the-role-of-vascular-echography-in-the-management-of-complications-associated-with-central-venous-access-for-hemodialysis-in-cancer-patients-two-case-reports-and-literature-review
#16
Fernanda Costa Sampaio Silva
Central venous catheter implantation for hemodialysis is commonly performed in large centers and its complications are sometimes associated with insufficient training of those who perform it, but may also be related to the patient's clinical condition. The present study reports two cases of complications related to use of a short-stay catheter for hemodialysis. In the first case, the cannula was inadvertently inserted into the left subclavian artery, causing arterial thrombosis, which was conservatively managed and good collateral perfusion was documented with vascular echography...
July 2018: Jornal Vascular Brasileiro
https://read.qxmd.com/read/30633062/impact-of-behavior-management-training-on-nurses-confidence-in-managing-patient-aggression
#17
Margarita de la Fuente, Ashley Schoenfisch, Barbara Wadsworth, Joyce Foresman-Capuzzi
OBJECTIVE: The aim of this study was to evaluate the impact of behavior management training on nurses' confidence in managing aggressive patients. BACKGROUND: Nurses are at a high risk of experiencing violence directed toward them by patients. METHODS: This quality improvement project used a pre-and-post study design. A survey was administered within 1 month before behavior management training and 1 month after training, capturing participants' demographic and work characteristics, as well as their experiences with patient/visitor-perpetrated violence...
January 9, 2019: Journal of Nursing Administration
https://read.qxmd.com/read/30627904/post-weaning-social-isolation-disturbs-gene-expression-in-rat-brain-structures
#18
E A Zubkov, Ya A Zorkina, E V Orshanskaya, N N Khlebnikova, N A Krupina, V P Chekhonin
Post-weaning social isolation of male Wistar rats for 10 weeks led to an increase of their aggressiveness, sensorimotor reactivity, and cognitive deficiency, manifesting in training disorders evaluated by the acoustic startle response (amplitude of the response decreasing). Expression of gene encoding serine protease prolyl endopeptidase (EC 3.4.21.26) in the frontal cortex was higher than in control rats kept in groups, while the level of mRNA of the gene encoding dipeptidyl peptidase IV (EC 3.4.14.5) did not differ from the control in any of the brain structures...
January 9, 2019: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/30621665/cultural-awareness-workshops-limitations-and-practical-consequences
#19
Stephane M Shepherd
Cultural awareness training for health professionals is now commonplace across a variety of sectors. Its popularity has spawned several alternatives (i.e., cultural competence, cultural safety, cultural humility, cultural intelligence) and overlapping derivatives (diversity training, anti-racism training, micro-aggression training). The ever-increasing reach of cultural awareness initiatives in health settings has generally been well intentioned - to improve cross-cultural clinical encounters and patient outcomes with the broader expectation of reducing health disparities...
January 8, 2019: BMC Medical Education
https://read.qxmd.com/read/30616263/efsumb-position-paper-recommendations-for-gastrointestinal-ultrasound-gius-in-acute-appendicitis-and-diverticulitis
#20
Klaus Dirks, Emma Calabrese, Christoph F Dietrich, Odd Helge Gilja, Trygve Hausken, Antony Higginson, Alois Hollerweger, Giovanni Maconi, Christian Maaser, Dieter Nuernberg, Kim Nylund, Nadia Pallotta, Tomas Ripolles, Laura Romanini, Adrian Saftoiu, Carla Serra, Matthias Wüstner, Ioan Sporea
An interdisciplinary task force of European experts summarizes the value of gastrointestinal ultrasound (GIUS) in the management of acute appendicitis and diverticulitis. Based on an extensive literature review, clinical recommendations for these highly common diseases in visceral medicine are presented.In patients with acute appendicitis, preoperative sonography has been established as a routine procedure in most European countries for medical and legal reasons. Routine sonography in these patients may reduce the rate of unnecessary surgery by half...
January 7, 2019: Ultraschall in der Medizin
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