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Scheuerman treatment

Nathalie A Reisbig, Erin Pinnell, Logan Scheuerman, Hayam Hussein, Alicia L Bertone
Osteoarthritis (OA) is a progressive disease associated with cartilage injury and its inherently limited repair capability. Synovium-based cellular constructs (sConstructs) are proposed as possible treatments. Equine sConstructs were produced from decellularized synovium-based extracellular matrix scaffolds (sECM) seeded with synovium-derived mesenchymal stem cells (sMSC), and engineered to express green fluorescent protein (GFP), or bone morphogenetic protein-2 (BMP-2). Survival, distribution, and chondrogenic potential of the sConstructs in vitro and in vivo were assessed...
2019: PloS One
Naama Orenstein, Hadassa Goldberg-Stern, Rachel Straussberg, Lily Bazak, Monika Weisz Hubshman, Nesia Kropach, Oded Gilad, Oded Scheuerman, Yahav Dory, Dror Kraus, Shay Tzur, Nurit Magal, Yael Kilim, Vered Shkalim Zemer, Lina Basel-Salmon
BACKGROUND: Early-onset epileptic encephalopathy (EOEE) is a severe convulsive disorder with a poor developmental prognosis. Although it has been associated with mutations in a number of genes, the fact that there is a large proportion of patients who remain undiagnosed suggests that there are many more still-unknown genetic causes of EOEE. Achieving a genetic diagnosis is important for understanding the biological basis of the disease, with its implications for treatment and family planning...
May 2018: European Journal of Paediatric Neurology: EJPN
Nufar Marcus, Keren Smuel, Moran Almog, Dario Prais, Rachel Straussberg, Daniel Landau, Oded Scheuerman
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, potentially life-threatening delayed drug-induced hypersensitivity reaction. The most frequently reported drugs causing DRESS are aromatic antiepileptic agents. Prompt withdrawal of the offending drug and administering systemic corticosteroids is the most widely accepted and used treatment. The treatment of severe DRESS not responsive to systemic corticosteroids is uncertain. OBJECTIVE: The objective of this study was to describe a case series of pediatric patients with DRESS who were treated successfully with intravenous immunoglobulins (IVIGs)...
July 2018: Journal of Allergy and Clinical Immunology in Practice
Mark A Snyder, Alexandra N Sympson, Christina M Scheuerman, Justin L Gregg, Lala R Hussain
BACKGROUND: Aspirin at 325 mg twice daily is now included as a nationally approved venous thromboembolism (VTE) prophylaxis protocol for low-risk total knee arthroplasty (TKA) patients. The purpose of this study is to examine whether there is a difference in deep vein thrombosis (DVT) occurrence after a limited tourniquet TKA using aspirin-based prophylaxis with or without extended use of mechanical compression device (MCD) therapy. METHODS: One hundred limited tourniquet TKA patients, whose DVT risk was managed with aspirin 325 mg twice daily for 3 weeks, were randomized to either using an MCD during hospitalization only or extended use at home up to 6 weeks postoperatively...
May 2017: Journal of Arthroplasty
Liat Ashkenazi-Hoffnung, Anne Ari, Efraim Bilavsky, Oded Scheuerman, Jacob Amir, Dario Prais
AIM: Data on the causative pathogens and optimal empirical therapy of aspiration pneumonia in children are limited. This study sought to describe the bacteriology of aspiration pneumonia in hospitalised children with a high aspiration risk. METHODS: Respiratory tract specimens were prospectively collected using the induced sputum technique from children with a high aspiration risk who were hospitalised for aspiration pneumonia in a tertiary paediatric medical centre from 2009 to 2014...
December 2016: Acta Paediatrica
Oded Scheuerman, Daniel Landau, Michael Schwarz, Vered Hoffer, Nufar Marcus, Liat Ashkenazi Hoffnung, Itzhak Levy
Cervical discitis, though rare, should be included in the differential diagnosis of torticollis, neck pain and neurodevelopmental regression in motor skills in children and infants. Magnetic resonance imaging is the diagnostic method of choice. Treatment should be conservative with antibiotics only. The aim of this study was to describe the 10-year experience of a tertiary pediatric medical center with cervical discitis.
July 2015: Pediatric Infectious Disease Journal
Oded Scheuerman, Iris Grinbaum, Ben Zion Garty
Münchausen syndrome by proxy (also known as factitious disorder by proxy) is a psychiatric disorder which consists of fabricating or inducing illness in a child, usually by his mother. The motivation for the perpetrator's behavior is receivng satisfaction from the investigations and treatments that the child receives and from the medical environment, as part of a unique mental disturbance. External incentives for the behavior (such as economic gain) are absent. During the last few years about 20 cases of Münchausen syndrome by proxy were diagnosed in our ward...
November 2013: Harefuah
Oded Scheuerman, Vered Hoffer, Avner Herman Cohen, Cristina Woellner, Bodo Grimbacher, Ben-Zion Garty
BACKGROUND AND PURPOSE: Autosomal dominant hyper-IgE syndrome (AD-HIES) is a rare primary immunodeficiency disorder . It has been recognized as a multisystem disorder and is characterized by both immunologic and non-immunologic manifestations. Possible bone involvement in autosomal dominant HIES include fractures, scoliosis, cystic bone changes, and osteopenia. We sought to evaluate the changes in bone density in adolescents and young adults with AD-HIES, mostly with proven STAT3 mutation, followed in our institute...
July 2013: Journal of Clinical Immunology
Havatzelet Yarden-Bilavsky, Eyal Raveh, Gilat Livni, Oded Scheuerman, Jacob Amir, Efraim Bilavsky
BACKGROUND: Anaerobic bacteria are uncommon etiologic agents of acute mastoiditis in children. However, recent studies suggest an increase in the incidence of Fusobacterium necrophorum mastoid infections in the last two decades. METHODS: A surveillance study performed over 3.5 years in a tertiary pediatric medical center identified 7 children with acute F. necrophorum mastoiditis. Clinical, laboratory, and treatment data were collected by file review. RESULTS: Five of the 7 children presented in the last year of the study...
January 2013: International Journal of Pediatric Otorhinolaryngology
Avichai Weissbach, Irit Tirosh, Oded Scheuerman, Vered Hoffer, Ben Zion Garty
OBJECTIVES: To report on severe acid-base disturbance in a child with symptomatic epilepsy treated with sulthiame. RESULTS: A 9.5-year-old boy with chronic generalized tonic-clonic seizures was treated with carbamazepine and valproic acid. Because of poor seizure control, sulthiame was added to the treatment. Two months later, he presented at the emergency department with severe weakness, headache, dizziness, dyspnea, anorexia, and confusional state. Arterial blood gas analysis showed mixed respiratory alkalosis with high anion gap metabolic acidosis...
October 2010: Pediatric Emergency Care
V Hoffer, O Scheuerman, N Marcus, Y Levy, N Segal, I Lagovsky, Y Monselise, B Z Garty
Little is known about the courses, causes, and clinical features of anaphylaxis in children outside the USA and Europe. Our objective was to evaluate the events of anaphylaxis in children admitted to the Schneider Children's Medical Center of Israel, a major tertiary facility, over a 12-year period. Ninety-two children with anaphylaxis (50 boys, 42 girls) aged 14 days to 18 yr (mean, 7.4 yr) were hospitalized during the study period. The event occurred at home in 52 children (56%), in a medical institution in 24 (26%), outdoors in 13 (15%), at school in 2 (2%), and in an unspecified location in 1 (1%)...
March 2011: Pediatric Allergy and Immunology
Oded Scheuerman, Joseph Meyerovitch, Nufar Marcus, Vered Hoffer, Erez Batt, Ben-Zion Garty
BACKGROUND: The seasonality of asthma morbidity is well recognized. A peak in asthma exacerbations in September has been noted for years at our center. OBJECTIVE: To examine the hypothesis that the increment in asthma exacerbations in September is influenced by the beginning of the kindergarten and school year. METHODS: The monthly admission rate for asthma in patients of different ages was retrospectively evaluated in seven hospitals from various areas in Israel from January 2003 to December 2005...
September 2009: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Vered Shkalim, Jacob Amir, Liora Kornreich, Oded Scheuerman, Rachel Straussberg
Acute cerebellitis is a rare inflammatory syndrome, often characterized by cerebellar dysfunction of rapid onset. We describe two children, a girl aged 5 years and a boy aged 11 years, with acute cerebellitis. Both manifested tonsillar herniation and hydrocephalus. The cause was Mycoplasma pneumoniae infection in the first patient, and unknown in the second. The girl was treated conservatively with steroids and diuretics, as well as vibramycin, and the boy required insertion of a ventriculostomy. Both presented a good prognosis and full recovery...
September 2009: Pediatric Neurology
Ritu Lal, Juthamas Sukbuntherng, Ezra H L Tai, Shubhra Upadhyay, Fenmei Yao, Mark S Warren, Wendy Luo, Lin Bu, Son Nguyen, Jeanelle Zamora, Ge Peng, Tracy Dias, Ying Bao, Maria Ludwikow, Thu Phan, Randall A Scheuerman, Hui Yan, Mark Gao, Quincey Q Wu, Thamil Annamalai, Stephen P Raillard, Kerry Koller, Mark A Gallop, Kenneth C Cundy
Baclofen is a racemic GABA(B) receptor agonist that has a number of significant pharmacokinetic limitations, including a narrow window of absorption in the upper small intestine and rapid clearance from the blood. Arbaclofen placarbil is a novel transported prodrug of the pharmacologically active R-isomer of baclofen designed to be absorbed throughout the intestine by both passive and active mechanisms via the monocarboxylate type 1 transporter. Arbaclofen placarbil is rapidly converted to R-baclofen in human and animal tissues in vitro...
September 2009: Journal of Pharmacology and Experimental Therapeutics
Gal Dubnov-Raz, Oded Scheuerman, Gabriel Chodick, Yaron Finkelstein, Zmira Samra, Ben-Zion Garty
OBJECTIVE: Kingella kingae, a Gram-negative coccobacillus, is being increasingly recognized as an invasive pathogen in children, causing mainly bacteremia and arthritis; however, there have been only a few studies on K kingae infections to date, mostly small-scale series. The aim of this study was to report our experience with invasive K kingae infections in children who were hospitalized at a major tertiary medical center in Israel. METHODS: The medical charts of 62 children with proven invasive K kingae infections were reviewed: 42 with positive blood culture results and 20 with positive synovial fluid culture results...
December 2008: Pediatrics
Marek Fatyga, Piotr Majcher, Andrzej Skwarcz
Background. Since 1920 there had been many attempts to explain the etiopatogenesis of Scheuerman disease. There were many definitions of clinical and radiological symptoms related to the failure of the corpus vertebrae. Up to days radiological methods (CT, MRI) gave opportunity for the more precise evaluation of the corpus vertebrae and the other structures in the spine, which is very helpful to choose the righ treatment.<br /> Material and methods. Clinical and radiological documentations in over 600 patients with the corpus vertebrae diseases with different localizations and clinical symptoms were studied...
October 30, 2002: Ortopedia, Traumatologia, Rehabilitacja
Jorge E Lopera, Blain Arthurs, Christian Scheuerman, Charles Sandoz, Scott Petersosn, Wildriodo Castaneda-Zuniga
We describe our clinical experience in 4 patients with portal hypertension who presented with bleeding mesenteric varices originating from the superior mesenteric vein with retrograde filling of collaterals draining into the inferior vena cava. The clinical presentation, imaging findings, and potential therapeutic management are discussed.
March 2008: Cardiovascular and Interventional Radiology
Efraim Bilavsky, Oded Scheuerman, Nofar Marcus, Vered Hoffer, Ben Zion Garty
Facial paralysis may occur as a complication of central nervous system leukemias in children, but it is rarely a presenting symptom. This report describes an 8-month-old child who presented with peripheral facial palsy, failure to thrive, anemia, and otitis media. Antibiotic and steroid treatment led to an improvement in the clinical condition, but not the paralysis. At readmission 3 weeks later, physical examination revealed bluish, firm, palpable masses on the scalp and facial areas, and laboratory and imaging studies confirmed the diagnosis of acute myeloid leukemia...
June 2006: Pediatric Neurology
Oded Scheuerman, Elchanan Bruckheimer, Nufar Marcus, Vered Hoffer, Ben-Zion Garty
Advances in interventional cardiology have enabled the treatment of severe congenital heart defects without the need for surgery. The percutaneous closure of atrial septal defects and, more recently, ventricular septal defects is considered a safe procedure with fewer complications and less morbidity compared with surgery. We report on a 2-year-old child who developed endocarditis after ventricular septal defect closure with an Amplatzer device. The patient recovered after intravenous antibiotics and anticoagulation...
June 2006: Pediatrics
Stephen D Yanofsky, Emily S Shen, Frank Holden, Erik Whitehorn, Barbara Aguilar, Emily Tate, Christopher P Holmes, Randall Scheuerman, Derek MacLean, May M Wu, Donald E Frail, Francisco J López, Richard Winneker, Brian J Arey, Ronald W Barrett
The pituitary glycoprotein hormones, luteinizing hormone and follicle-stimulating hormone (FSH), act through their cognate receptors to initiate a series of coordinated physiological events that results in germ cell maturation. Given the importance of FSH in regulating folliculogenesis and fertility, the development of FSH mimetics has been sought to treat infertility. Currently, purified and recombinant human FSH are the only FSH receptor (FSH-R) agonists available for infertility treatment. By screening unbiased combinatorial chemistry libraries, using a cAMP-responsive luciferase reporter assay, we discovered thiazolidinone agonists (EC50's = 20 microm) of the human FSH-R...
May 12, 2006: Journal of Biological Chemistry
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