Shohei Nakano, Norihisa Mikami, Mai Miyawaki, Saho Yamasaki, Shoko Miyamoto, Mayu Yamada, Tomoya Temma, Yousuke Nishi, Arata Nagaike, Seijun Sakae, Takuya Furusawa, Ryoji Kawakami, Takumi Tsuji, Takeyuki Kohno, Yuya Yoshida
Combination treatment using fingolimod (FTY720), an immunomodulator, and a pathogenic antigen prevents the progression of glucose-6-phosphate isomerase (GPI)325-339 -induced arthritis. In this study, we focused on myeloid-derived suppressor cells (MDSCs; CD11b+ Gr-1+ cells) and investigated the effects of the combination treatment on these cells. DBA/1J mice with GPI325-339 -induced arthritis were treated using FTY720 and/or GPI325-339 for five days. The expanded CD11b+ Gr-1+ cell population and its inhibitory potential were examined...
August 1, 2022: Biological & Pharmaceutical Bulletin