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Igor P Dolbnya, Kawal J S Sawhney, Stewart M Scott, Andy J Dent, Giannantonio Cibin, Geoff M Preece, Ulrik K Pedersen, Jon Kelly, Paul Murray
Systematic studies of the performance of a water-cooled X-ray monochromator, designed and built for the B16 Test beamline at the Diamond Light Source, UK, are presented. A technical description of the monochromator is given and the results of commissioning measurements are discussed. Overall, the monochromator satisfies the original specifications well and meets all the major requirements of the versatile beamline. Following its successful implementation on B16, the basic monochromator design has been reproduced and adapted on other Diamond Light Source beamlines, including B18 and B21...
January 1, 2019: Journal of Synchrotron Radiation
Mohammed Naghizadeh, Frederik T Larsen, Eva Wattrang, Liselotte R Norup, Tina S Dalgaard
Phagocytic activity of leukocytes in whole blood was assessed as a potential immune competence trait in chickens. A flow cytometry based whole blood phagocytosis (WBP) assay was set up and evaluated using blood from chickens homozygous for four different MHC haplotypes, B12, B15, B19 and B21. Fluorescent latex beads and two serotypes of fluorescently labelled heat-killed bacteria (Salmonella Infantis and Salmonella. Typhimurium) were evaluated as phagocytic targets. In addition, the opsonophagocytic potential (OPp) of individual sera from the birds was included in a phagocytosis assay using the HD11 chicken macrophage cell line...
January 2019: Veterinary Immunology and Immunopathology
Ying-Qiang Song, Xin Zhao, Hui-Yue Su, Bo Li, Yue-Ming Hu, Xue-Sen Cui
Rapid acquisition of the spatial distribution of soil nutrients holds great implications for farmland soil productivity safety, food security and agricultural management. To this end, we collected 1297 soil samples and measured the content of soil total nitrogen (TN), soil available phosphorus (AP) and soil available potassium (AK) in Zengcheng, north of the Pearl River Delta, China. Hyperspectral remote sensing images (115 bands) of the Chinese Environmental 1A satellite were used as auxiliary variables and dimensionality reduction was performed using Pearson correlation analysis and principal component analysis...
September 13, 2018: Sensors
Simon J Cassidy, Fabio Orlandi, Pascal Manuel, Joke Hadermann, Alex Scrimshire, Paul A Bingham, Simon J Clarke
Sr2 Fe3 Se2 O3 is a localized-moment iron oxide selenide in which two unusual coordinations for Fe2+ ions form two sublattices in a 2:1 ratio. In the paramagnetic region at room temperature, the compound adopts the crystal structure first reported for Sr2 Co3 S2 O3 , crystallizing in space group Pbam with a = 7.8121 Å, b = 10.2375 Å, c = 3.9939 Å, and Z = 2. The sublattice occupied by two-thirds of the iron ions (Fe2 site) is formed by a network of distorted mer-[FeSe3 O3 ] octahedra linked via shared Se2 edges and O vertices forming layers, which connect to other layers by shared Se vertices...
August 20, 2018: Inorganic Chemistry
Hui Liu, Qiang Chen, Hai-Ru Li, Xiao-Yun Zhao, Xin-Xin Tian, Yue-Wen Mu, Hai-Gang Lu, Si-Dian Li
Shortly after the discovery of all-boron fullerenes D2d B40-/0 (borospherenes), the first axially chiral borospherenes C3/C2 B39- were characterized in experiments in 2015. Based on extensive global minimum searches and first-principles theory calculations, we present herein two new axially chiral members to the borospherene family: the aromatic cage-like C2 B34(1) and C2 B35+(2). Both B34(1) and B35+(2) feature one B21 boron triple chain on the waist and two equivalent heptagons and hexagons on the cage surface, with the latter being obtained by the addition of B+ into the former at the tetracoordinate defect site...
June 6, 2018: Physical Chemistry Chemical Physics: PCCP
Vishwa Mohini Khare, Vishesh Kumar Saxena, Alka Tomar, Karam Pal Singh, Kunwar Bahadur Singh, Amit Kumar Tiwari
We investigated the impact of haplotype of major histocompatibility complex (MHC)-B on the outcome of infection of Synthetic Dam Line (SDL) broiler strain with Rous Sarcoma Virus (RSV). Genomic analysis of MHC-B haplotypes, revealed a total of 12 known standard haplotypes that constituted to twenty-five different genotypes and one new haplotype of 217 bp size, designated BX . The inoculation of RSV-A in SDL chicks resulted in the development of tumors of progressive or regressive phenotypes with varying tumor profile index (TPI)...
June 1, 2018: Frontiers in Bioscience (Elite Edition)
Lei Chen, Michaela Fakiola, Karen Staines, Colin Butter, Jim Kaufman
γδ T cells recognize a wide variety of ligands in mammals, among them members of the butyrophilin (BTN) family. Nothing is known about γδ T cell ligands in chickens, despite there being many such cells in blood and lymphoid tissues, as well as in mucosal surfaces. The major histocompatibility complex (MHC) of chickens was discovered because of polymorphic BG genes, part of the BTN family. All but two BG genes are located in the BG region, oriented head-to-tail so that unequal crossing-over has led to copy number variation (CNV) as well as hybrid (chimeric) genes, making it difficult to identify true alleles...
2018: Frontiers in Immunology
Jinming Li, Yuan Yang, Yuankai Zhu, Liqiang Zhou, Yunfeng Han, Tao Yin, Zhaoting Cheng, Guopeng Zhang, Yanxia Shen, Jing Chen
BACKGROUND: Major depressive disorder (MDD) is a common mental disorder worldwide, but now there is a lack of clinically effective assessment and management of MDD. In this study, we used technetium-99 m ethylcysteinate dimer ([99m Tc]ECD) SPECT/CT to characterize the regional cerebral blood flow (rCBF) status of MDD patients, and to explore an objective image assessment model of MDD which is non- or minimally-invasive, convenient and accurate in a clinical setting. METHODS: The severity of MDD was assessed by three trained psychiatrists, based on scores obtained from HAMD and HAMA...
March 21, 2018: BMC Psychiatry
Zheng Li, Mengyang Luo, Bin Cai, Lichuan Wu, Mengtian Huang, Haroon-Ur-Rashid, Jun Jiang, Lisheng Wang
Using matrine (1) as the lead compound, a series of new 14-(N-substituted-2-pyrrolemethylene) matrine and 14-(N-substituted-indolemethylene) matrine derivatives was designed and synthesized for their potential application as anticancer agents. The structure of these compounds was characterized by 1 H NMR, 13 C NMR and ESI-MS spectral analyses. The target compounds were evaluated for their in vitro cytotoxicity against three human cancer cell lines (SMMC-7721, A549 and CNE2). The results revealed that compound A6 and B21 displayed the most significant anticancer activity against three cancer cell lines with IC50 values in range of 3...
February 15, 2018: Bioorganic & Medicinal Chemistry Letters
Yan Feng, Anthony Mannion, Carolyn M Madden, Alton G Swennes, Catherine Townes, Charles Byrd, Robert P Marini, James G Fox
Background: Many Escherichia coli strains are considered to be a component of the normal flora found in the human and animal intestinal tracts. While most E. coli strains are commensal, some strains encode virulence factors that enable the bacteria to cause intestinal and extra-intestinal clinically-relevant infections. Colibactin, encoded by a genomic island ( pks island), and cytotoxic necrotizing factor (CNF), encoded by the cnf gene, are genotoxic and can modulate cellular differentiation, apoptosis and proliferation...
2017: Gut Pathogens
I Yu Razumova, A A Godzenko, I A Guseva, O K Vorob'eva
AIM: to evaluate the diagnostic and prognostic significance of HLA class 1 histocompatibility antigens in the development of anterior uveitis. MATERIAL AND METHODS: A total of 137 patients with anterior uveitis followed up at the Research Institute of Eye Diseases in 2009-2016 were tested for HLA antigens (A and B loci). The average patient's age was 29±12.4 years. All patients underwent a thorough medical interview with clinical and laboratory assessment. In case of suspected association with systemic disease, the patients were referred for consultation at the V...
2017: Vestnik Oftalmologii
S H Andersen, L Vervelde, K Sutton, L R Norup, E Wattrang, H R Juul-Madsen, T S Dalgaard
The aim of this study was to optimise and evaluate an intracellular cytokine staining (ICS) assay for assessment of T cell IFN-γ responses in chickens vaccinated against Newcastle disease (ND). We aimed to validate currently available antibodies to chicken IFN-γ using transfected CHO cells. Moreover, this ICS assay was evaluated for use to detect mitogen and antigen induced IFN-γ production in chicken peripheral blood leucocytes. Chickens from an inbred white leghorn line containing two MHC haplotypes, B19 and B21, were divided into three experimental groups; one group was kept as naive controls, one group was vaccinated intramuscularly twice with a commercial inactivated ND virus (NDV) vaccine, and the last group was vaccinated orally twice with a commercial live attenuated NDV vaccine...
December 2017: Veterinary Immunology and Immunopathology
Michael B Townsend, Nadia F Gallardo-Romero, Ekaterine Khmaladze, Neil M Vora, Giorgi Maghlakelidze, Marika Geleishvili, Darin S Carroll, Ginny L Emerson, Mary G Reynolds, P S Satheshkumar
Serologic cross-reactivity, a hallmark of orthopoxvirus (OPXV) infection, makes species-specific diagnosis of infection difficult. In this study, we used a variola virus proteome microarray to characterize and differentiate antibody responses to nonvaccinia OPXV infections from smallpox vaccination. The profile of 2 case patients infected with newly discovered OPXV, Akhmeta virus, exhibited antibody responses of greater intensity and broader recognition of viral proteins and includes the B21/22 family glycoproteins not encoded by vaccinia virus strains used as vaccines...
December 19, 2017: Journal of Infectious Diseases
A P da Silva, R Hauck, H Zhou, R A Gallardo
Genetic resistance or susceptibility to infectious diseases has been largely associated with the avian major histocompatibility complex (MHC) genes. Our goal was to determine resistance and susceptibility of MHC B haplotype in congenic and inbred chicken lines in order to establish a resistant-susceptible model. Eight congenic lines (253/B18, 254/B15, 330/B21, 312/B24, 331/B2, 335/B19, 336/B21, and 342/BO), two inbred lines (003/B17 and 077/B19), and three commercial lines (white leghorn, brown layers, and broilers) were used in two experiments...
September 2017: Avian Diseases
Hai-Ru Li, Hui Liu, Xin-Xin Tian, Wen-Yan Zan, Yue-Wen Mu, Hai-Gang Lu, Jun Li, Yue-Kui Wang, Si-Dian Li
Inspired by the recent discovery of the metal-centered tubular molecular rotor Cs B2 -Ta@B18 - with the record coordination number of CN = 20 and based on extensive first-principles theory calculations, we present herein the possibility of the largest tubular molecular rotors Cs B3 -Ta@B18 (1) and C3v B4 -Ta@B18 + (2) and smallest axially chiral endohedral metalloborospherenes D2 Ta@B22 - (3 and 3'), unveiling a tubular-to-cage-like structural transition in metal-centered boron clusters at Ta@B22 - via effective spherical coordination interactions...
October 11, 2017: Physical Chemistry Chemical Physics: PCCP
Saltuk M Eyrilmez, Eduard Bernhardt, Juan Z Dávalos, Martin Lepšík, Pavel Hobza, Khaleel I Assaf, Werner M Nau, Josef Holub, Josep M Oliva-Enrich, Jindřich Fanfrlík, Drahomír Hnyk
The weakly coordinating binary macropolyhedral anion closo,closo-[B21 H18 ]- (B21; D3h symmetry) has been synthesized using a simplified strategy compared to that in the literature. While gas-phase complexes of B21 with β- and γ-cyclodextrin (CD) were detected using ESI FT-ICR spectrometric measurements, α-CD did not bind to the B21 guest. This spectroscopic evidence has been interpreted using quantum-chemical computations, showing that β- and γ-CD are able to interact with B21 due to their larger cavities, in contrast to the smaller α-CD...
May 17, 2017: Physical Chemistry Chemical Physics: PCCP
Bin Jiang, Praveen Kumar, Jacek Kłos, Millard H Alexander, Bill Poirier, Hua Guo
The low-energy wing of the C∼B21←X∼1 A1 absorption spectra for SO2 in the ultraviolet region is computed for the 32S,33 S,34 S and 36 S isotopes, using the recently developed ab initio potential energy surfaces (PESs) of the two electronic states and the corresponding transition dipole surface. The state-resolved absorption spectra from various ro-vibrational states of SO2 (X∼1 A1 ) are computed. When contributions of these excited ro-vibrational states are included, the thermally averaged spectra are broadened but maintain their key characters...
April 21, 2017: Journal of Chemical Physics
Yue Shi, Minjia Zhu, Yu Chang, Huanyu Qiao, Yongmin Liu
BACKGROUND: This study is to investigate the influence of hemodynamics on Stanford type-A aortic dissection with different tear size and location, to provide some support for the relationships between the risks (rupture, reverse tearing and further tearing) and tear size and location for clinical treatment. METHODS: Four numerical models of Stanford type-A aortic dissection were established, with different size and location of the tears. The ratio of the area between the entry and re-entry tears(RA) is various within the model; while, the size and the location of the re-entry in the distal descending aorta are fixed...
December 28, 2016: Biomedical Engineering Online
Yu Zhou, Qingchang Meng, Yanping Chen, Jirong Wu, Zhuanfang Hao, Zhenhua Wang, Degui Zhang, Mingshun Li, Hongjun Yong, Shihuang Zhang, Xinhai Li, Jianfeng Weng
To analyze the variation in rice black-streaked dwarf virus (RBSDV) in an area with high incidence of maize rough dwarf disease (MRDD), the RBSDV S1 segment in a collection of 100 maize isolates (sample population A100) from Jining, Shandong Province, was sequenced. An additional 21 maize and rice isolates (subpopulation B21) that were sampled from nine other geographic locations in China in 2012 and 2013 were used as a control. A total of 914 nucleotide mutations, including 239 singleton variable and 675 parsimony-informative sites were detected among the segment 1 (S1) sequences from A100...
December 2016: Archives of Virology
Amy C Murillo, Mark A Chappell, Jeb P Owen, Bradley A Mullens
The northern fowl mite, Ornithonyssus sylviarum, is the most damaging ectoparasite on egg-laying hens in the United States. One potential strategy for management is breeding for mite resistance. Genes of white leghorn chickens linked to the major histocompatibility complex (MHC) were previously identified as conferring more (B21 haplotype) or less (B15 haplotype) mite resistance. However, immune responses can be energetically costly to the host and affect the economic damage incurred from mite infestations...
November 1, 2016: Poultry Science
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