Duan Liu, Min Wang, Vishakantha Murthy, Dennis M McNamara, Thanh Thanh L Nguyen, Trudy J Philips, Hridyanshu Vyas, Huanyao Gao, Jyotan Sahni, Randall C Starling, Leslie T Cooper, Michelle K Skime, Anthony Batzler, Gregory D Jenkins, Simona Barlera, Silvana Pileggi, Luisa Mestroni, Marco Merlo, Gianfranco Sinagra, Florence Pinet, Jan Krejčí, Anna Chaloupka, Jordan D Miller, Pascal de Groote, Daniel J Tschumperlin, Richard M Weinshilboum, Naveen L Pereira
BACKGROUND: Dilated cardiomyopathy (DCM) is a major cause of heart failure and carries a high mortality rate. Myocardial recovery in DCM-related heart failure patients is highly variable, with some patients having little or no response to standard drug therapy. A genome-wide association study may agnostically identify biomarkers and provide novel insight into the biology of myocardial recovery in DCM. METHODS: A genome-wide association study for change in left ventricular ejection fraction was performed in 686 White subjects with recent-onset DCM who received standard pharmacotherapy...
October 27, 2023: Circulation Research