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Platelet mapping

Sukhi Singh, Tor Damén, Mikael Dellborg, Anders Jeppsson, Andreas Nygren
BACKGROUND: New approaches to prevent bleeding complications during cardiac surgery are needed. OBJECTIVE: To investigate if noradrenaline (NA) enhances platelet aggregation in CABG patients. PATIENTS/METHODS: Twenty-four CABG patients were included in a prospective parallel-group randomized study. All patients but one, were treated with acetylsalicylic acid (ASA). In the treatment group (n=12), mean arterial blood pressure (MAP) was maintained at pre-induction levels by NA infusion...
February 14, 2019: Journal of Thrombosis and Haemostasis: JTH
Saad Atiq, James M Mobley, Osman O Atiq, Mohammad O Atiq, Nikhil Meena
Anemia is a frequently encountered problem in the healthcare system. Common causes of anemia include blood loss, followed by impaired red blood cell production and red blood cell destruction. This case demonstrates the need for cognizance of the less frequent causes of anemia. A 27-year-old male with a history of traumatic brain injury and quadriplegia with chronic respiratory failure on home ventilator support presented to the emergency department with dyspnea and no bowel movements for three days. The patient received nutrition via percutaneous endoscopic gastostromy (PEG) tube...
November 26, 2018: Curēus
H D Siti Rahmalia Hairani Damanik, Gamya Tri Utami, Sofiana Nurcahyati, Safri
OBJECTIVE: This study aimed to describe the relationship between the score of sequence organ failure assessment (SOFA) and the length of time of vventilatoruse by patients hospitalized in Intensive Care Unit. METHOD: This research is analytic observational with a cross-sectional design. Data collected include age, sex, diagnosis medic, length of stay in ICU, length of ventilator use and SOFA score. The SOFA components include respiratory, platelet, liver, neurology, cardiovascular, renal and urine output in 24h...
February 1, 2019: Enfermería Clínica
Silvia Sookoian, Carlos J Pirola
BACKGROUND/AIM: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. Characterised by abnormal fat accumulation in the liver, NAFLD presents high degree of comorbidity with disorders of the Metabolic syndrome, including type 2 diabetes, obesity and cardiovascular disease. These comorbidities have strong negative impact on the natural course of NAFLD and vice versa, whereby the presence of NAFLD substantially modifies the course and prognosis of Metabolic syndrome-associated diseases...
February 4, 2019: Alimentary Pharmacology & Therapeutics
Zongyu Zheng, Tianjiao Ma, Xin Lian, Jialin Gao, Weigang Wang, Wenya Weng, Xuemian Lu, Weixia Sun, Yanli Cheng, Yaowen Fu, Madhavi J Rane, Evelyne Gozal, Lu Cai
Hyperglycemia-induced renal fibrosis causes end-stage renal disease. Clopidogrel, a platelet inhibitor, is often administered to decrease cardiovascular events in diabetic patients. We investigated whether clopidogrel can reduce diabetes-induced renal fibrosis in a streptozotocin-induced type 1 diabetes murine model and fibronectin involvement in this protective response. Diabetic and age-matched controls were sacrificed three months after the onset of diabetes, and additional controls and diabetic animals were further treated with clopidogrel or vehicle for three months...
2019: International Journal of Biological Sciences
Katalin Bartus, Emily R Burnside, Jorge Galino, Nicholas D James, David L H Bennett, Elizabeth J Bradbury
We recently discovered a novel role for neuregulin-1 (Nrg1) signaling in mediating spontaneous regenerative processes and functional repair after spinal cord injury (SCI). We revealed that Nrg1 is the molecular signal responsible for spontaneous functional remyelination of dorsal column axons by peripheral nervous system (PNS)-like Schwann cells after SCI. Here, we investigate whether Nrg1/ErbB signaling controls the unusual transformation of centrally derived progenitor cells into these functional myelinating Schwann cells after SCI using a fate-mapping/lineage tracing approach...
January 13, 2019: Glia
Chukwuemeka R Nwokocha, Isheba Warren, Javier Palacios, Mario Simirgiotis, Magdalene Nwokocha, Sharon Harrison, Rory Thompson, Adrian Paredes, Jorge Bórquez, Astrid Lavado, Fredi Cifuentes
Guinep is traditionally used in the management of cardiovascular ailments. This study aims to evaluate its medicinal constituents and effects in the management of myocardial injury in an experimental isoproterenol (ISO) rat model. Sprague-Dawley rats were randomly assigned to four groups: Group 1 was the control group; Group 2 received M. bijugatus extract (100 mg/Kg; MB) for six weeks; Group 3 was given ISO (85 mg/Kg) i.p. twice during a 24-hour period; and Group 4 was given ISO (85 mg/Kg) i.p. and MB extract (100 mg/Kg) for six weeks...
January 10, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jonathan R Dillman, Suraj D Serai, Andrew T Trout, Ruchi Singh, Jean A Tkach, Amy E Taylor, Burns C Blaxall, Lin Fei, Alexander G Miethke
BACKGROUND: Primary sclerosing cholangitis, autoimmune hepatitis and autoimmune sclerosing cholangitis are forms of chronic, progressive autoimmune liver disease (AILD) that can affect the pediatric population. OBJECTIVE: To determine whether quantitative MRI- and laboratory-based biomarkers are associated with conventional imaging findings of portal hypertension (radiologic portal hypertension) in children and young adults with AILD. MATERIALS AND METHODS: Forty-four patients with AILD enrolled in an institutional registry underwent a research abdominal MRI examination at 1...
January 3, 2019: Pediatric Radiology
Joanna Yilin Huang, Diajeng Ayesha Soeharto, Ivan Damara, Vera Ignjatovic, Matthew D Linden, Paul Monagle
Antiplatelet agents are used for the prevention and treatment of thromboembolic disease in an increasingly complex population of pediatric patients. Despite their importance for clinical outcome, there is no consensus on the most effective monitoring strategies. This review describes the current state of knowledge focusing on antiplatelet therapy monitoring in children. The authors searched five databases (PubMed-NCBI, MEDLINE-OVID, SCOPUS-Elsevier, ScienceDirect, and Cochrane) from January 2000 to October 2017 using keywords selected a priori ...
December 19, 2018: Seminars in Thrombosis and Hemostasis
Kaipu Jin, Heqing Wang, Mengsu Zeng, Shengxiang Rao, Lixia Yan, Yuan Ji, Caixia Fu, Ruofan Sheng
OBJECTIVE: To evaluate the value of MR liver extracellular volume (ECVliver ) in assessment of liver fibrosis with chronic hepatitis B (CHB), and to compare its performance with two-dimensional (2D) shear-wave elastography (SWE). MATERIALS AND METHODS: A total of 68 CHB patients who were histologically diagnosed as fibrosis stages F0 to F4 were retrospectively analyzed. All patients underwent gadopentetate dimeglumine-enhanced T1-mapping and 2D SWE. ECVliver and liver stiffness were measured and compared between fibrosis subgroups; their correlations with histologic findings were evaluated using Spearman correlation test and multiple regression analysis...
December 7, 2018: Abdominal Radiology
José Juan-Colás, Ian S Hitchcock, Mark Coles, Steven Johnson, Thomas F Krauss
Cell communication is primarily regulated by secreted proteins, whose inhomogeneous secretion often indicates physiological disorder. Parallel monitoring of innate protein-secretion kinetics from individual cells is thus crucial to unravel systemic malfunctions. Here, we report a label-free, high-throughput method for parallel, in vitro, and real-time analysis of specific single-cell signaling using hyperspectral photonic crystal resonant technology. Heterogeneity in physiological thrombopoietin expression from individual HepG2 liver cells in response to platelet desialylation was quantified demonstrating how mapping real-time protein secretion can provide a simple, yet powerful approach for studying complex physiological systems regulating protein production at single-cell resolution...
December 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
Lindsay S Hall, Charlotte S Lennon, Andrew M Hall, Stanislaw J Urbaniak, Mark A Vickers, Robert N Barker
Platelet destruction in immune thrombocytopenia is caused by autoreactive antibody and T cell responses, most commonly directed against platelet glycoprotein IIb/IIIa. Loss of self-tolerance in the disease is also associated with deficient activity of regulatory T cells. Having previously mapped seven major epitopes on platelet glycoprotein IIIa that are recognised by helper T cells from patients with immune thrombocytopenia, the aim was to test whether peptide therapy with any of these sequences, alone or in combination, could inhibit responses to the antigen in humanized mice expressing HLA-DR15...
December 4, 2018: Haematologica
Khairul Syahputra, Per W Kania, Azmi Al-Jubury, Rzgar M Jafaar, Ron P Dirks, Kurt Buchmann
The parasite Ichthyophthirius multifiliis infecting skin, fins and gills of a wide range of freshwater fish species, including rainbow trout, is known to induce a protective immune response in the host. Although a number of studies have reported activation of several immune genes in infected fish host, the immune response picture is still considered incomplete. In order to address this issue, a comparative transcriptomic analysis was performed on infected versus uninfected rainbow trout gills and it showed that a total of 3352 (7...
December 1, 2018: Fish & Shellfish Immunology
Fernando M Berganza, Cesar Gonzalez de Alba, Alexander C Egbe, Sergio Bartakian, John Brownlee
RationaleAspirin resistance has been reported in up to 80% of children with cardiovascular defects undergoing surgery. Because of a patient who had embolic stroke while on therapeutic aspirin dose but in whom aspirin resistance was present on his thromboelastography platelet mapping, we chose to obtain thromboelastography platelet mapping on cardiac patients on aspirin to assess their risk. OBJECTIVES: This study evaluates aspirin resistance noted in these patients and their characteristics.Methods and resultsThis is a retrospective study of 25 patients taking aspirin for a month at therapeutic dose...
January 2019: Cardiology in the Young
Shuang Zhou, Vicky A Appleman, Christopher M Rose, Hyun Jung Jun, Juechen Yang, Yue Zhou, Roderick T Bronson, Steve P Gygi, Al Charest
Activation of the platelet-derived growth factor receptors (PDGFRs) gives rise to some of the most important signaling pathways that regulate mammalian cellular growth, survival, proliferation, and differentiation and their misregulation is common in a variety of diseases. Herein, we present a comprehensive and detailed map of PDGFR signaling pathways assembled from literature and integrate this map in a bioinformatics protocol designed to extract meaningful information from large-scale quantitative proteomics mass spectrometry data...
June 2018: Life science alliance
Katharina Seif, Lejla Alidzanovic, Barbara Tischler, Nahla Ibrahim, Branislav Zagrapan, Sabine Rauscher, Manuel Salzmann, Lena Hell, Lisa-Marie Mauracher, Ulrich Budde, Johannes A Schmid, Bernd Jilma, Ingrid Pabinger, Alice Assinger, Patrick Starlinger, Christine Brostjan
Thrombospondin-1 (TSP-1) is primarily expressed by platelets and endothelial cells (ECs) and rapidly released upon their activation. It functions in haemostasis as a bridging molecule in platelet aggregation, by promoting platelet adhesion to collagen and by protecting von Willebrand factor strings from degradation. In blood of patients undergoing surgery and in co-cultures of neutrophils with platelets or ECs, we observed proteolysis of the 185 kDa full-length TSP-1 to a 160-kDa isoform. We hypothesized that TSP-1 processing may alter its haemostatic properties...
November 12, 2018: Thrombosis and Haemostasis
Stefan Skalsky, John Molloy, Mira Naftaly, Toby Sainsbury, Keith R Paton
Few-layer graphene (FLG) platelets exfoliated directly from graphite are finding a wide range of potential applications, including composites and printed electronics. However, characterisation of the FLG material following incorporation into polymers, including the quality of the dispersion, remains a challenge. Here, we present the use of terahertz time-domain spectroscopy as a potential solution to this challenge which could form the basis of a rapid characterisation tool. The THz refractive index was found to be highly sensitive to the loading of FLG, opening the route to mapping local FLG concentration within a polymer composite sample...
January 11, 2019: Nanotechnology
Sonia Salha, Sebastian Gehmert, Vanessa Brébant, Alexandra Anker, Markus Loibl, Lukas Prantl, Sanga Gehmert
INTRODUCTION: Mesenchymal stem cells (MSCs) have been described in breast cancer models to migrate towards carcinoma and integrate into tumor associated stroma supporting tumor growth, increasing their metastatic potency and contributing to tumor-angiogenesis. Platelet-derived growth factor (PDGF) isoforms (AA, BB, CC) stimulate growth, survival and motility of MSCs and certain other cell types. Noteworthy, breast carcinomas are known to express PDGF. We aim to further shed light on i) the relevance of the different PDGF isoforms on adipose tissue derived stem cells (ASCs) migration and ii) the underlying pathway dependent on PDGF stimulation...
October 19, 2018: Clinical Hemorheology and Microcirculation
John S Kim, Jon Kaufman, Sonali S Patel, Marilyn Manco-Johnson, Jorge Di Paola, Eduardo M da Cruz
BACKGROUND: Ketorolac is used for pediatric analgesia after surgery despite its known platelet inhibition via the arachidonic acid (AA) pathway. The degree of platelet inhibitory effect after cardiac surgery is not well characterized. Thromboelastography with platelet mapping (TEG-PM) is emerging as a frequently used test to evaluate platelet inhibition via the AA pathway. METHODS: Post hoc analysis of a data set collected in a prospective observational cohort study evaluating platelet inhibition in children after congenital heart surgery with cardiopulmonary bypass (CPB)...
November 2018: World Journal for Pediatric & Congenital Heart Surgery
Ruixia Song, Chenming Dong, Cuiting Wang, Hong Zhang, Zhaohui Yang
OBJECTIVE: To systematical evaluate the effect of Xuebijing injection in the treatment of multiple organ dysfunction syndrome (MODS). METHODS: With the keywords including Xuebijing, multiple organ dysfunction syndrome, multiple organ dysfunction and multiple organ failure, PubMed, the Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), VIP and Wanfang Data from the database start until March 4th, 2018 were searched for relevant randomized controlled trials (RCTs) related to Xuebijing injection combined conventional treatment versus conventional treatment alone for MODS...
September 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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