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Osteosarcoma of lung metastasis

Yilong Dai, Yifu Tang, Xuemei Xu, Zhongwei Luo, Yu Zhang, Zhaohui Li, Zhangyuan Lin, Shushan Zhao, Min Zeng, Buhua Sun, Liang Cheng, Jianxi Zhu, Zeng Xiong, Haitao Long, Yong Zhu, Kun Yu
Osteosarcoma is a malignant primary bone tumor, which often associates with pulmonary metastasis. The radical surgery of osteosarcoma often requires internal orthopedic implants. Therefore, implants with antitumor properties should be developed. Magnesium (Mg) and its alloys possess great potential as orthopedic materials, given their biodegradable properties, superior osteogenesis performance, and antitumor features. However, problems arise with their uncontrolled degradation rates and their unknown antitumor mechanisms...
February 19, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Liang Wang, Yang Liu, Guanzhen Yu
Background: Osteosarcoma (OS) is a rare bone tumor with a high propensity for lung metastasis and poor patient outcomes. It is crucial to identify novel therapeutic strategies and biomarkers. Patients and methods: ARK1C1 staining was detected in OS specimens, and its clinical significance was assessed. A potential AKR1C1 inhibitor, avasimibe, was used to target AKR1C1. Results: High expression of AKR1C1 was observed in OS and was associated with poor outcomes for patients with OS...
2019: OncoTargets and Therapy
Huahui Zhang, Jian-S Mao, Wei-F Hu
BACKGROUND Cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) encodes several tumor suppressor proteins. Aberrant genetic alterations in CDKN2A/B were found in some malignancies, which were believed to be associated with tumor originating and progression. We hypothesized that CDKN2A/B genetic polymorphisms might be associated with the risk of poorer prognosis of osteosarcoma in Chinese populations. MATERIAL AND METHODS We included 184 validated osteosarcoma cases and 185 cancer-free healthy controls in the study...
February 18, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Jisheng Sui, Guoqiang Shao, Lulu Zhang, Pengjun Zhang, Ting Bu, Qingqiang Yao, Liming Wang
Objective: To investigate the value of integrin α v β 3 targeted microPET/CT imaging with 68 Ga-NODAGA-RGD 2 as radiotracer for the detection of osteosarcoma and theranostics of osteosarcoma lung metastasis. Methods: The 68 Ga-NODAGA-RGD 2 and 177 Lu-NODAGA-RGD 2 were prepared via one-step method and their stability and integrin α v β 3 binding specificity were investigated in vitro . Forty-one nude mice were injected with human MG63 osteosarcoma to established the animal model bearing subcutaneous osteosarcoma ( n =21), osteosarcoma in tibia ( n =5), and osteosarcoma pulmonary metastatic ( n =15)...
February 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
Gangyang Wang, Mengxiong Sun, Yafei Jiang, Tao Zhang, Wei Sun, Hongsheng Wang, Fei Yin, Zhuoying Wang, Weilin Sang, Jing Xu, Min Mao, Dongqing Zuo, Zifei Zhou, Chongren Wang, Zeze Fu, Zongyi Wang, Zhenfeng Duan, Yingqi Hua, Zhengdong Cai
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents, with highly aggressive behavior and early systemic metastasis. The survival rates for osteosarcoma remain unchanged over the past two decades. Studies aiming to find new or alternative therapies for patients with refractory osteosarcoma are urgently needed. Anlotinib, a novel multi-targeted tyrosine kinase inhibitor (TKI), has exhibited encouraging clinical activity in NSLCC and soft tissue sarcoma, whereas its effect on osteosarcoma has not been studied...
February 4, 2019: International Journal of Cancer. Journal International du Cancer
Kenta Watanabe, Yoshihiro Yui, Satoru Sasagawa, Kayo Suzuki, Masahiko Kanamori, Taketoshi Yasuda, Tomoatsu Kimura
Lung metastasis markedly reduces the prognosis of osteosarcoma. Moreover, there is no effective treatment for lung metastasis, and a new treatment strategy for the treatment of osteosarcoma lung metastasis is required. Therefore, in this study, we investigated the suppressive effect of the microtubule inhibitor eribulin mesylate (eribulin) on lung metastasis of osteosarcoma. At concentrations >proliferation IC50 , eribulin induced cell cycle arrest and apoptosis in a metastatic osteosarcoma cell line, LM8...
January 4, 2019: Oncotarget
Kai Shi, Sheng-Lin Wang, Bin Shen, Feng-Qiang Yu, Dan-Feng Weng, Jian-Hua Lin
BACKGROUND: Osteosarcoma is a malignant bone tumor with a high potential for lung metastasis, and the prognosis for patients with metastatic disease is very poor. The interaction between fibronectin (FN) and integrin αvβ3 in soft-tissue sarcoma promotes cell migration, invasion, and lung metastasis. This study aimed to investigate the prognostic significance of FN and αvβ3 in osteosarcoma. METHODS: Immunohistochemistry and western blotting were used to detect the expression of FN and αvβ3 in 60 osteosarcoma specimens and in 30 osteochondroma specimens...
January 28, 2019: World Journal of Surgical Oncology
Changkun Huang, Xuan Zhu, Wei Xiong, Xiaokun Zhao, Ran Xu
RATIONALE: Primary osteosarcoma of the kidney is a very rare subtype of renal neoplasms. There are only 27 cases reported in the literature since 1936. In addition, it has a high risk of metastasis and very low survival rate. PATIENT'S CONCERNS: In this report, we present a case of unique large osteosarcoma originated from the left kidney (21 cm × 18 cm × 11 cm) with lung metastasis. A 48-year-old female patient presented with intermittent abdominal distension and gross hematuria...
January 2019: Medicine (Baltimore)
Yi Luo, Anqi Zeng, Aiping Fang, Linjiang Song, Chen Fan, Chenjuan Zeng, Tinghong Ye, Hao Chen, Chongqi Tu, Yongmei Xie
Osteosarcoma is the most common primary malignancy of bone and characterized by an appendicular primary tumor with a high rate of metastasis to the lungs. Unfortunately, there is no effective strategy to treat osteosarcoma in current clinical practice. In this study, the anticancer effects and potential mechanisms of nifuroxazide, an oral nitrofuran antibiotic, on two osteosarcoma cell lines were investigated. The results of the antiproliferative activity in vitro showed that nifuroxazide inhibited cell proliferation of UMR106 and MG63 cells in a dose- and time-dependent manner...
January 25, 2019: Investigational New Drugs
Xue-Feng Tang, Ya Cao, Dong-Bin Peng, Guo-Sheng Zhao, Ying Zeng, Zi-Ran Gao, Yang-Fan Lv, Qiao-Nan Guo
Background: Notch signaling abnormalities are associated with the development of various tumors, including hematopoietic and epithelium-derived tumors. However, the role of Notch signaling in tumors originating from mesenchymal cells is unclear. The effect of Notch3 expression on the prognosis of osteosarcoma and its role and mechanism in osteosarcoma cells have never been reported. Materials and methods: In this study, we performed a clinicopathological analysis of 70 cases of osteosarcoma, with primary focus on survival...
2019: Cancer Management and Research
Matthias J Arlt, Aleksandar Kuzmanov, Jess G Snedeker, Bruno Fuchs, Unai Silvan, Adam A Sabile
BACKGROUND: Fascin-1, a prominent actin-bundling protein, is found to be upregulated in several human carcinomas. While it is accepted that Fascin-1 expression correlates with poor clinical outcome and decreased survival in various carcinomas, its role in sarcoma such as osteosarcoma (OS) remains unknown. In the present study, we evaluated the prognostic value and biological relevance of Fascin-1 in OS. METHODS: The correlation between Fascin-1 expression and the outcome of OS patients was determined by immunohistochemistry analysis of Fascin-1 expression in a tissue microarray of OS tissue specimens collected during primary tumor resection...
January 17, 2019: BMC Cancer
Fan Wu, Xiang Fang, Zhigang Lang, Hongyuan Liu, Yan Xiong, Wenli Zhang, Yi Luo, Chongqi Tu, Hong Duan
Objective: To investigate the procedure and effectiveness of total femoral replacement for treating femur malignant tumor. Methods: The clinical data of 9 patients with femoral malignant tumors who underwent total femoral replacement between July 2013 and March 2017 were retrospectively analyzed. There were 5 males and 4 females, aged 16-75 years with an average of 44.8 years. The disease duration ranged from 2 to 6 months with an average of 3.5 months. There were 5 cases of osteosarcoma (3 cases were staged as Enneking ⅡB, 2 cases were staged as Enneking Ⅲ), 1 case of malignant fibrosarcoma (staged as Enneking ⅡB), 1 case of chondrosarcoma (staged as Enneking ⅠB), 2 cases of femoral muti-metastasis of lung cancer with pathological fracture...
January 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
Francisco Villanueva, Hector Araya, Pedro Briceño, Nelson Varela, Andres Stevenson, Sofia Jerez, Fabian Tempio, Jonas Chnaiderman, Carola Perez, Milena Villarroel, Emma Concha, Farzaneh Khani, Roman Thaler, Flavio Salazar-Onfray, Gary S Stein, Andre J van Wijnen, Mario Galindo
Osteosarcomas are bone tumors that frequently metastasize to the lung. Aberrant expression of the transcription factor, runt-related transcription factor 2 (RUNX2), is a key pathological feature in osteosarcoma and associated with loss of p53 and miR-34 expression. Elevated RUNX2 may transcriptionally activate genes mediating tumor progression and metastasis, including the RUNX2 target gene osteopontin (OPN/SPP1). This gene encodes a secreted matricellular protein produced by osteoblasts to regulate bone matrix remodeling and tissue calcification...
January 13, 2019: Journal of Cellular Physiology
Adesina O Adewale, Ladeji A Mofoluwake, Opaleye T Olamide, Salami A Yussuf
Metastatic tumours of the oral cavity are not common. The most common site for bone metastases in the head and neck region is the mandible. Metastatic lesion of the mandible most commonly originate from the lungs in men and breast in women, and these lesions (or tumours) usually are carcinomas rather than sarcomas. We report two cases of metastatic lesions in the mandible: (1) A 19year old male with right mandibular swelling and a nodular swelling in the distal two-third of the right tibia. Radiograghs revealed sclerotic lesion with a sunburst appearance in both the jaw and tibia...
September 2018: Ghana Medical Journal
Wei Li, Shiquan Zhang
PURPOSE: To investigate the survival of patients with primary osteosarcoma and lung metastases. METHODS: Clinical data of 128 patients with primary osteosarcoma and lung metastases who were admitted to Shenzhen Second People's Hospital from January 2013 to January 2015, were enrolled and retrospectively analyzed. Follow-up lasted for 3 years and after follow-up, patients were divided into survival group (n=54) and death group (n=74) according to their survival status...
September 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Jing-Jing Yu, Wen-Sen Pi, Yuan Cao, Ai-Fen Peng, Zhi-Yuan Cao, Jia-Ming Liu, Shan-Hu Huang, Zhi-Li Liu, Wei Zhang
Purpose: Accumulating studies showed that the expression of microRNAs (miRNAs) was dysregulated in osteosarcoma (OS). In this study, we sought to investigate the effect of let-7a on OS progression and its potential molecular mechanism. Patients and methods: Quantitative real-time PCR (qRT-PCR) was performed to evaluate the expression level of let-7a and Aurora-B (AURKB) in OS tissues and cells. The OS cells were treated with let-7a mimic, let7a inhibitor, negative mimic and Lv-AURKB combined with let-7a...
2018: Cancer Management and Research
M A Clara-Altamirano, D Y García-Ortega, A Maciel-Miranda, H Martínez-Said, J L Martínez-Tlahuel, C H S Caro-Sánchez, G C García-Ruíz, M Cuellar-Hubbe
Dedifferentiated parosteal osteosarcoma is a variant in which a high grade osteosarcoma coexists with a parosteal osteosarcoma. We report the case of a 20-year-old female patient who presented with six months of evolution of pain and functional limitation of the right forearm, with no apparent cause; radiographs were performed, observing a tumoral lesion in the diaphysis of the right ulna. Physical examination showed pain upon palpation in the diaphysis of the ulna and limitation of prone-supination. Axial computed tomography of the thorax revealed metastatic disease in the upper lobe of the left lung...
May 2018: Acta Ortopédica Mexicana
Steven Georges, Lidia Rodriguez Calleja, Camille Jacques, Melanie Lavaud, Brice Moukengue, Fernando Lecanda, Thibaut Quillard, Marta Tellez Gabriel, Pierre-François Cartron, Marc Baud'huin, François Lamoureux, Dominique Heymann, Benjamin Ory
The metastatic dissemination is a complex multistep process by which tumor cells from a primary site enter into the systemic circulation to finally spread at distant sites. Even if this mechanism is rare at the tumor level, it remains the major cause of Osteosarcoma-patients' relapse and mortality. MicroRNAs (miRNAs) have recently been described as novel epigenetics' genes' expression regulators actively implicated in cancer progression and dissemination. The understanding of their implication in the metastatic spreading could help clinicians to improve the outcome of osteosarcoma...
November 6, 2018: Oncotarget
Ming-Wei Chen, Xue-Jian Wu
Osteosarcoma is a highly malignant bone tumor. However, due to the high complexity of the occurrence and metastasis of osteosarcoma, the exact mechanism promoting its development and progression remains to be elucidated. This study highlights the causal link between solute carrier family 25 member 22 (SLC25A22) and the development, progression, and metastasis of osteosarcoma. SLC25A22 is upregulated in human osteosarcoma and predicts a poor prognosis. The upregulation of SLC25A22 in osteosarcoma tissues was significantly associated with cell proliferation, invasion, and metastasis...
January 1, 2018: Technology in Cancer Research & Treatment
Wei Yang, Zhiming Shan, Xinfang Zhou, Liangqun Peng, Chongyang Zhi, Junhui Chai, Hongxing Liu, Junmei Yang, Zhandong Zhang
OBJECTIVE: Osteosarcoma is the most common primary malignant skeleton tumor that derives from mesenchymal cells. Emerging evidences have identified the vital role of long non-coding RNAs (lncRNAs) in the development of osteosarcoma. In this study, we aimed to investigate the role of lncRNA gastric carcinoma highly expressed transcript 1 (GHET1) in osteosarcoma progression. METHODS: The expression levels of relevant genes in clinical samples and cell lines were determined by quantitative real-time PCR...
November 8, 2018: Cancer Biomarkers: Section A of Disease Markers
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