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https://read.qxmd.com/read/30753632/multifocal-necrotizing-leukoencephalopathy-expanding-the-clinicopathologic-spectrum
#1
Sarah Premji, Loveleen Kang, Mumtaz V Rojiani, Jesse Kresak, Amyn M Rojiani
Multifocal necrotizing leukoencephalopathy (MNL) is a rare condition typically described in patients undergoing chemotherapy or with HIV/AIDS. As a pathologic entity, it is characterized by multiple small foci of necrosis typically within white matter of the pons and occasionally in other areas. Herein we describe findings in 6 patients with MNL, 5 diagnosed at postmortem examination and 1 by surgical biopsy. Histopathologic features were characteristic, with generally small foci of necrosis, most frequently within the pontine base, although larger lesions were seen in the frontal white matter and basal ganglia...
February 7, 2019: Journal of Neuropathology and Experimental Neurology
https://read.qxmd.com/read/30741358/treatment-approaches-for-cisplatin-ineligible-patients-with-invasive-bladder-cancer
#2
REVIEW
David J Einstein, Guru Sonpavde
Cisplatin has been established as an important agent in the neoadjuvant setting prior to radical cystectomy (RC) surgery for muscle-invasive urothelial cancer (MIUC) as well as in the unresectable or metastatic urothelial carcinoma (mUC) setting. Unfortunately, many patients in practice are felt to be "cisplatin-ineligible." Thus, it is vital that we develop treatment approaches and novel therapeutics for this population. We evaluate therapeutic alternatives to cisplatin-based treatment. For patients undergoing RC, there is no recommended alternative to neoadjuvant cisplatin-based combination therapy, and upfront RC or clinical trials are preferable...
February 11, 2019: Current Treatment Options in Oncology
https://read.qxmd.com/read/30739837/ten-year-outcomes-of-survival-and-toxicity-for-a-phase-iii-randomised-trial-of-concurrent-chemoradiotherapy-versus-radiotherapy-alone-in-stage-ii-nasopharyngeal-carcinoma
#3
Xiao-Yun Li, Qiu-Yan Chen, Xue-Song Sun, Sai-Lan Liu, Jin-Jie Yan, Shan-Shan Guo, Li-Ting Liu, Hao-Jun Xie, Qing-Nan Tang, Yu-Jing Liang, Yue-Feng Wen, Ling Guo, Hao-Yuan Mo, Ming-Yuan Chen, Ying Sun, Jun Ma, Lin-Quan Tang, Hai-Qiang Mai
PURPOSE: Our previous results showed survival benefits of concurrent chemoradiotherapy (CCRT) in treating stage II nasopharyngeal carcinoma (NPC) compared with radiotherapy (RT) alone. Here, we present the updated 10-year survival results and late toxicity profile to assess the ultimate effectiveness of concurrent chemotherapy. METHODS: Patients with stage II NPC were randomly assigned to RT arm (n = 114) or to CCRT arm (n = 116) with a concurrent weekly cisplatin regimen...
February 7, 2019: European Journal of Cancer
https://read.qxmd.com/read/30739743/increasing-the-dose-intensity-of-chemotherapy-by-more-frequent-administration-or-sequential-scheduling-a-patient-level-meta-analysis-of-37-298-women-with-early-breast-cancer-in-26-randomised-trials
#4
(no author information available yet)
BACKGROUND: Increasing the dose intensity of cytotoxic therapy by shortening the intervals between cycles, or by giving individual drugs sequentially at full dose rather than in lower-dose concurrent treatment schedules, might enhance efficacy. METHODS: To clarify the relative benefits and risks of dose-intense and standard-schedule chemotherapy in early breast cancer, we did an individual patient-level meta-analysis of trials comparing 2-weekly versus standard 3-weekly schedules, and of trials comparing sequential versus concurrent administration of anthracycline and taxane chemotherapy...
February 7, 2019: Lancet
https://read.qxmd.com/read/30738780/addition-of-radium-223-to-abiraterone-acetate-and-prednisone-or-prednisolone-in-patients-with-castration-resistant-prostate-cancer-and-bone-metastases-era-223-a-randomised-double-blind-placebo-controlled-phase-3-trial
#5
Matthew Smith, Chris Parker, Fred Saad, Kurt Miller, Bertrand Tombal, Quan Sing Ng, Martin Boegemann, Vsevolod Matveev, Josep Maria Piulats, Luis Eduardo Zucca, Oleg Karyakin, Go Kimura, Nobuaki Matsubara, William Carlos Nahas, Franco Nolè, Eli Rosenbaum, Axel Heidenreich, Yoshiyuki Kakehi, Amily Zhang, Heiko Krissel, Michael Teufel, Junwu Shen, Volker Wagner, Celestia Higano
BACKGROUND: Abiraterone acetate plus prednisone or prednisolone improves progression-free survival and overall survival in patients with metastatic castration-resistant prostate cancer. Radium-223 improves overall survival and delays the onset of symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases. We assessed concurrent treatment with abiraterone acetate plus prednisone or prednisolone and radium-223 in such patients. METHODS: We did a randomised, double-blind, placebo-controlled, phase 3 trial at 165 oncology and urology centres in 19 countries...
February 6, 2019: Lancet Oncology
https://read.qxmd.com/read/30738577/breast-cancer-after-multiple-myeloma-treatment
#6
Ahmet Gulmez
Breast cancer is the most common cancer in women. In addition, it is the second leading cause of death after lung cancer.1 , 2 The prevalence of epidemiological studies in previous studies is 22%-26%. The risk of mortality due to breast cancer is around 18%.3 , 4 Multiple myeloma (MM) is a malignant disease of differentiated plasma cells. It is also the most common hematological neoplasm after lymphoma. Thirty five percent of MM patients are under the age of 65, 28% are between 65 and 74 of age and 37% are over the age of 75...
February 1, 2019: Current Problems in Cancer
https://read.qxmd.com/read/30737068/hypofractionated-radiotherapy-in-oesophageal-cancer-for-patients-unfit-for-systemic-therapy-a-retrospective-single-centre-analysis
#7
C M Jones, K Spencer, C Hitchen, T Pelly, B Wood, P Hatfield, A Crellin, D Sebag-Montefiore, R Goody, T Crosby, G Radhakrishna
AIMS: Chemoradiotherapy (CRT) is established as a superior treatment option to definitive radiotherapy in the non-surgical management of oesophageal cancer. For patients precluded from CRT through choice or comorbidity there is little evidence to guide delivery of single-modality radiotherapy. In this study we outline outcomes for patients unfit for CRT who received a hypofractionated radiotherapy (HRT) regimen. MATERIALS AND METHODS: A retrospective UK single-centre analysis of 61 consecutive patients with lower- or middle-third adenocarcinoma (OAC; 61%) or squamous cell carcinoma of the oesophagus managed using HRT with radical intent between April 2009 and 2014...
February 5, 2019: Clinical Oncology: a Journal of the Royal College of Radiologists
https://read.qxmd.com/read/30736102/exercise-prescription-and-tailored-physical-activity-intervention-in-onco-hematology-inpatients-a-personalised-bedside-approach-to-improve-clinical-best-practice
#8
Federica Duregon, Stefano Gobbo, Valentina Bullo, Enrico Roma, Barbara Vendramin, Manuele Bergamo, Danilo Sales Bocalini, Andrea Di Blasio, Lucia Cugusi, Daniel Neunhaeuserer, Marco Bergamin, Andrea Ermolao
Therapy of hematological malignancies lasts for long periods implicating various complications. The chemotherapy induces fatigue and forces bed rest. These features strongly contribute to a general impairment of the physical efficiency. Oppositely, an increase of physical exercise can prevent or reduce this weakening. Few trials examined the efficacy of an exercise in onco-hematological inpatients, during their hospitalization. Therefore, this study aimed to determine the feasibility of an inter-hospital intervention and the beneficial role of a tailored exercise program in the maintenance of the physical function in onco-hematological inpatients...
February 8, 2019: Hematological Oncology
https://read.qxmd.com/read/30733496/prognostic-utility-of-tumor-infiltrating-lymphocytes-in-residual-tumor-after-neoadjuvant-chemotherapy-with-trastuzumab-for-her2-positive-breast-cancer
#9
Sasagu Kurozumi, Kenichi Inoue, Hiroshi Matsumoto, Takaaki Fujii, Jun Horiguchi, Tetsunari Oyama, Masafumi Kurosumi, Ken Shirabe
Predictive utility of tumor-infiltrating lymphocytes (TILs) in HER2-positive breast cancer patients receiving neoadjuvant chemotherapy (NAC) with concurrent trastuzumab remains unclear. We examined TILs grades of pretreatment cancer tissue specimens and residual tumors after NAC with trastuzumab and determined the predictive utility of the TILs grade in pathological complete response (pCR) and the prognostic power of TILs in HER2-positive breast cancer. This cohort study included 128 HER2-positive breast cancer who received NAC with trastuzumab...
February 7, 2019: Scientific Reports
https://read.qxmd.com/read/30732946/optimizing-the-cumulative-cisplatin-dose-during-radiotherapy-in-nasopharyngeal-carcinoma-dose-effect-analysis-for-a-large-cohort
#10
Liang Peng, Cheng Xu, Yu-Pei Chen, Rui Guo, Yan-Ping Mao, Ying Sun, Jun Ma, Ling-Long Tang
OBJECTIVES: Definitive concurrent chemoradiotherapy (CCRT) is the standard treatment for locoregionally advanced nasopharyngeal carcinoma (NPC). The cumulative cisplatin dose (CCD) during radiotherapy is an important prognostic factor; however, the optimal CCD is undetermined. MATERIALS AND METHODS: In this retrospective analysis, patients with locoregionally advanced NPC treated with single-agent cisplatin-based CCRT or RT alone from 2009 through 2015 were identified...
February 2019: Oral Oncology
https://read.qxmd.com/read/30723701/a-multicenter-phase-ii-trial-of-docetaxel-cisplatin-and-cetuximab-tpex-followed-by-cetuximab-and-concurrent-radiotherapy-for-patients-with-local-advanced-squamous-cell-carcinoma-of-the-head-and-neck-cspor-hn01-ecrips-study
#11
Sadamoto Zenda, Yosuke Ota, Naomi Kiyota, Susumu Okano, Masato Fujii, Morimasa Kitamura, Shunji Takahashi, Tsutomu Ueda, Nobuya Monden, Takeharu Yamanaka, Makoto Tahara
Background: Induction chemotherapy (IC) is a treatment option for locally advanced squamous cell carcinoma of the head and neck (LA SCCHN). However, treatment with docetaxel, cisplatin, and 5-FU (TPF) followed by cisplatin and radiotherapy is controversial because of toxicity concerns. The aim of this phase II study was to assess the feasibility of docetaxel, cisplatin, and cetuximab (TPEx) followed by cetuximab and concurrent radiotherapy for LA SCCHN. Patients and Methods: We enrolled patients with histological evidence of squamous cell carcinoma of the oropharynx, hypopharynx, or larynx without distant metastases...
2019: Frontiers in Oncology
https://read.qxmd.com/read/30719317/a-case-of-an-endobronchial-metastasis-from-an-endometrial-carcinoma
#12
Chan-Hee Lee, Hyun Jung Kim, Chi-Heum Cho, IlSeon Hwang
A 73-year-old woman was referred to the pulmonology department for abnormal findings on chest computed tomography. She had undergone a laparoscopic staging operation including a hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvic node and para-aortic node dissection, and concurrent chemo-radiation therapy for endometrial serous carcinoma stage IIIc cancer 15 months earlier. A follow-up chest computed tomography after the chemotherapy showed that the right lower lobe bronchus was obstructed, and it was necessary to differentiate a primary lung malignancy from a metastasis and secretion...
2019: SAGE Open Medical Case Reports
https://read.qxmd.com/read/30719172/the-survival-benefit-of-intensified-full-dose-xelox-chemotherapy-concomitant-to-radiotherapy-and-then-resting-period-consolidation-chemotherapy-in-locally-advanced-rectal-cancer
#13
Rong Zheng, ShiFeng Lian, XiaoXue Huang, GuoXian Guan, XiaoBo Li, Pan Chi, BenHua Xu
Purpose: To evaluate the effect of an intensified capecitabine and oxaliplatin (XELOX) chemoradiation treatment followed by one cycle of consolidation chemotherapy before surgery in locally advanced rectal cancer (LARC). Methods and Materials: Patients with histologically confirmed, newly diagnosed, locally advanced rectal adenocarcinoma (cT3-T4 and/or cN+) were enrolled. All patients received 3-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) with a dose 50.4Gy in 25 fraction, with two cycles of concurrent XELOX chemotherapy...
2019: Journal of Cancer
https://read.qxmd.com/read/30719140/adjuvant-radiochemotherapy-versus-chemotherapy-alone-for-gastric-cancer-implications-for-target-definition
#14
REVIEW
Jing Xu, Jonathan Zhu, Qichun Wei
The INT0116 trial was a milestone study and laid the foundation for the adjuvant radiotherapy (RT) associated to concurrent chemotherapy (CT) for the treatment of gastric cancer (GC) after gastrectomy. However, it is still controversial whether adding RT to CT could further benefit D2-dissected GC patients. The ARTIST trial indicated that the addition of RT to CT did not have a positive impact on disease-free survival (DFS). Nevertheless, in a subgroup of 396 patients with positive pathological lymph nodes, combined treatment with RT was superior to CT alone...
2019: Journal of Cancer
https://read.qxmd.com/read/30718446/-paraneoplastic-cerebellar-degeneration-with-lambert-eaton-myasthenic-syndrome-a-report-of-an-effectively-treated-case-and-systematic-review-of-japanese-cases
#15
Hiroko Kitanosono, Masakatsu Motomura, Hiroki Tomita, Hiroshi Iwanaga, Naoki Iwanaga, Takashi Irioka, Hirokazu Shiraishi, Akira Tsujino
A 63-year-old female who developed dizziness, diplopia and subsequent gait disturbance from September X-1 year was analyzed. The first neurological findings in May X year revealed cerebellar ataxia, weakness in the proximal limbs, decreased tendon reflexes, and autonomic symptoms (ADL:mRS 3). Furthermore, an incremental phenomenon was observed in the repetitive nerve stimulation test, and she was diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) based on the serum P/Q-type calcium channel (VGCC) antibody positivity...
February 2019: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/30712019/magnetic-resonance-imaging-after-external-beam-radiotherapy-and-concurrent-chemotherapy-for-locally-advanced-cervical-cancer-helps-to-identify-patients-at-risk-of-recurrence
#16
Martina Aida Angeles, Pauline Baissas, Eric Leblanc, Amélie Lusque, Gwénaël Ferron, Anne Ducassou, Carlos Martínez-Gómez, Denis Querleu, Alejandra Martinez
OBJECTIVE: Tumor volume and regression after external beam radiotherapy have been shown to be accurate parameters to assess treatment response via magnetic resonance imaging (MRI). The aim of the study was to evaluate the prognostic value of tumor size reduction rate after external beam radiotherapy and chemotherapy prior to brachytherapy. METHODS: Patients with locally advanced cervical cancer treated at two French comprehensive cancer centers between 1998 and 2010 were included...
February 1, 2019: International Journal of Gynecological Cancer
https://read.qxmd.com/read/30707665/adjuvant-hysterectomy-in-patients-with-residual-disease-after-radiation-for-locally-advanced-cervical-cancer-a-prospective-longitudinal-study
#17
Shahana Pervin, Farzana Islam Ruma, Khadija Rahman, Jannatul Ferdous, Rifat Ara, Mollah Mohamed Abu Syed, Annekathryn Goodman
PURPOSE: The aim of the study was to evaluate the efficacy of hysterectomy in the control of pelvic disease in patients with post-irradiated residual cervical cancer. PATIENTS AND METHODS: Forty patients were treated at either National Institute of Cancer Research and Hospital (NICRH) or Delta Cancer Hospital in Dhaka, Bangladesh, with International Federation of Gynecology and Obstetrics stage IIB to IIIB disease with residual disease after the following: either concurrent chemoradiation with or without brachytherapy, induction chemotherapy and external-beam radiotherapy (EBRT) with or without brachytherapy, or only EBRT...
January 2019: Journal of Global Oncology
https://read.qxmd.com/read/30706012/a-comparison-of-grade-4-lymphopenia-with-proton-versus-photon-radiation-therapy-for-esophageal-cancer
#18
David M Routman, Aurelie Garant, Scott C Lester, Courtney N Day, William S Harmsen, Cristobal T Sanheuza, Harry H Yoon, Michelle A Neben-Wittich, James A Martenson, Michael G Haddock, Christopher L Hallemeier, Kenneth W Merrell
Purpose: Grade 4 lymphopenia (G4L) during radiation therapy (RT) is associated with higher rates of distant metastasis and decreased overall survival in a number of malignancies, including esophageal cancer (EC). Through a reduction in integral radiation dose, proton RT (PRT) may reduce G4L relative to photon RT (XRT). The purpose of this study was to compare G4L in patients with EC undergoing PRT versus XRT. Methods and materials: Patients receiving curative-intent RT and concurrent chemotherapy for EC were identified...
January 2019: Advances in Radiation Oncology
https://read.qxmd.com/read/30703348/ct-guided-percutaneous-cryoablation-combined-with-systemic-chemotherapy-for-liver-metastases-from-esophageal-carcinoma-initial-experience
#19
Yan Wang, Wei-Hao Zhang, Xu Chang, Fei Cao, Hai-Peng Yu, Wen-Ge Xing, Xue-Ling Yang, Zhi Guo
OBJECTIVE: To explore the feasibility, safety and effectiveness of percutaneous cryoablation combined with systemic chemotherapy in the treatment of liver metastases from esophageal carcinoma (ECLM). MATERIALS AND METHODS: We retrospectively collected data of 16 patients who received CT-guided percutaneous cryoablation concurrent systemic chemotherapy for liver metastases after primary esophageal carcinoma resection. Functional Assessment of Cancer Therapy-General (FACT-G) was used for the assessment of quality of life (QOL), and overall survival (OS), progression-free survival (PFS) and complications were also evaluated...
January 28, 2019: Cryobiology
https://read.qxmd.com/read/30703105/current-management-of-cervical-cancer-in-poland-analysis-of-the-questionnaire-trial-for-the-years-2002-2014-in-relation-to-asco-2016-recommendations
#20
Tomasz Basta, Paweł Knapp, Paweł Blecharz, Lubomir Bodnar, Iwona Gawron, Dorota Babczyk, Magdalena Piróg, Tomasz Kluz, Anna Markowska, Anna Horbaczewska, Robert Jach
OBJECTIVES: To assess the survival of patients with cervical cancer (CC). Since the recommendations concerning cervical cancer management adopted by Polish medical societies do not differ significantly from the ESGO or non-European guidelines, and the fact that evaluation of the system for CC treatment in Poland, as well as the mortality rate of Polish women with CC, which is 70% higher than the average for European Union (EU) countries, justifies the hypothesis that treatment of CC in Poland deviates from the Polish and international recommendations...
2019: PloS One
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