Ali Haluk Düzkalir, Yavuz Samanci, Cheng-Chia Lee, Huai-Che Yang, Ajay Niranjan, L Dade Lunsford, Zhishuo Wei, Priyanka N Srinivasan, Samantha Dayawansa, Jason P Sheehan, Samir Patel, David Mathieu, Brad E Zacharia, Brandon Santhumayor, Douglas Kondziolka, Selcuk Peker
OBJECTIVE: Accounting for approximately 15% of primary liver cancers and 3% of gastrointestinal malignancies, cholangiocarcinoma (CCA) poses a serious health concern given its high mortality rate. Managing brain metastases (BMs) from CCA is challenging because of their rarity and poor prognosis, with little guidance on treatment from the literature. In this study, the authors aimed to evaluate the safety and efficacy of stereotactic radiosurgery (SRS) in managing BMs from CCA. METHODS: This multicenter retrospective study included 13 CCA patients with 41 BMs treated with SRS from October 2006 to April 2022 at eight institutions affiliated with the International Radiosurgery Research Foundation...
May 10, 2024: Journal of Neurosurgery