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Intestinal and antifungal perforation

R Usha Devi, Anitha Balachandran, C N Kamalarathnam, S Pappathi
BACKGROUND: Mucormycosis of the gastrointestinal tract is a rare fungal infection of neonates. CASE CHARACTERISTICS: 48-hours-old term neonate presented with intestinal obstruction and perforation. No significant risk factors were present. Histopathological examination of the resected gangrenous bowel revealed mucormycosis. Cutaneous involvement due to systemic spread led to dermal necrosis in toes. OUTCOME: Though cutaneous lesions responded promptly to antifungal therapy, gastrointestinal manifestations required multiple antifungal therapy for prolonged period apart from surgical debridement...
May 15, 2018: Indian Pediatrics
Hisato Shima, Shogo Mizoguchi, Yuji Morine, Manabu Tashiro, Kazuyoshi Okada, Jun Minakuchi, Shu Kawashima
Intestinal perforation by a peritoneal catheter is an uncommon, but serious, complication that has a high mortality rate. Intestinal perforation in peritoneal dialysis (PD) patients is difficult to diagnose using symptoms and radiological findings, which may result in a delay in diagnosis. Moreover, intestinal perforation complicated with fungal peritonitis is reportedly a severe condition with a poor prognosis. Herein, we report the case of a 78-year-old man on PD, whose diagnosis of perforative peritonitis was difficult to diagnose preoperatively...
November 2018: CEN Case Reports
Kevin McElvanna, Maurice B Loughrey, Scott Gillespie, Keith R Gardiner
Disseminated aspergillosis is a rare, invasive, opportunistic, fungal infection associated with a high mortality. We report a non-fatal case diagnosed following extensive enterectomy for intestinal infarction in a patient recovering from emergency abdominal colectomy for perforated ulcerative colitis. This resulted in intestinal failure necessitating life-long parenteral nutrition and prolonged antifungal therapy.
April 2016: Frontline Gastroenterology
Masaya Yamoto, Yusuke Nakazawa, Koji Fukumoto, Hiromu Miyake, Hideaki Nakajima, Akinori Sekioka, Akiyoshi Nomura, Kei Ooyama, Yutaka Yamada, Katsushi Nogami, Yuko Van, Chisako Furuta, Reiji Nakano, Yasuhiko Tanaka, Naoto Urushihara
PURPOSE: Surgical intestinal disorders (SID), such as necrotizing enterocolitis (NEC), focal intestinal perforation (FIP), and meconium-related ileus (MRI), are serious morbidities in extremely low birth weight (ELBW, birth weight <1000 g) infants. From 2010, we performed enteral antifungal prophylaxis (EAP) in ELBWI to prevent for SID. The aim of this study was to identify disease-specific risk factors and to evaluate the efficacy of prevention for SID in ELBW infants. METHODS: A retrospective chart review of all consecutive patients between January 2006 and March 2015, which included 323 ELBW infants who were admitted to Shizuoka Children's Hospital, was conducted...
September 2016: Pediatric Surgery International
Xuelian Liao, Haibo Qiu, Ruoyu Li, Fengmei Guo, Wei Liu, Mei Kang, Yan Kang
PURPOSE: To assess the risk factors for invasive Candida infection (ICI) caused by fluconazole-resistant (Flu-R) Candida species in intensive care unit (ICU) patients. MATERIALS AND METHODS: Data from China Survey of Candidiasis study were analyzed. Patients with proven ICI were classified into fluconazole-sensitive (Flu-S) and Flu-R groups. Independent risk factors for Flu-R ICI were identified using a multivariate logistic regression. RESULTS: Forty-one percent of ICI patients were infected with Flu-R Candida...
August 2015: Journal of Critical Care
Guy Saltmarsh, David Plurad, Scott Bricker, Fred Bongard, Angela Neville, Brant Putnam, Dennis Kim
No abstract text is available yet for this article.
November 2014: American Surgeon
Ming Y Lim, Alisa P Alker, Sophia Califano, Dimitri G Trembath, Kevin Alby, Peter H Gilligan, Katarzyna Jamieson, Jonathan S Serody, Thomas C Shea
No abstract text is available yet for this article.
April 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Yahuza Siba, Saritha Gorantla, Anand Gupta, Edward Lung, Joan Culpepper-Morgan
Esophageal intramural pseudodiverticulosis (EIPD) is a rare, benign condition of uncertain etiology and pathogenesis, which usually presents with either progressive or intermittent dysphagia. Acute presentation with food impaction, requiring emergency esophago-gastroduodenoscopy (EGD), is rare. We report a case of EIPD presenting as food bolus impaction in an elderly black female. The patient had no previous history of dysphagia or odynophagia. Currently accepted risk factors, such as diabetes mellitus, chronic alcoholism, and reflux esophagitis, were not present in our patient...
May 2015: Gastroenterology Report
Daniel K Benjamin, Mark L Hudak, Shahnaz Duara, David A Randolph, Margarita Bidegain, Gratias T Mundakel, Girija Natarajan, David J Burchfield, Robert D White, Karen E Shattuck, Natalie Neu, Catherine M Bendel, M Roger Kim, Neil N Finer, Dan L Stewart, Antonio C Arrieta, Kelly C Wade, David A Kaufman, Paolo Manzoni, Kristi O Prather, Daniela Testoni, Katherine Y Berezny, P Brian Smith
IMPORTANCE: Invasive candidiasis in premature infants causes death and neurodevelopmental impairment. Fluconazole prophylaxis reduces candidiasis, but its effect on mortality and the safety of fluconazole are unknown. OBJECTIVE: To evaluate the efficacy and safety of fluconazole in preventing death or invasive candidiasis in extremely low-birth-weight infants. DESIGN, SETTING, AND PATIENTS: This study was a randomized, blinded, placebo-controlled trial of fluconazole in premature infants...
May 7, 2014: JAMA: the Journal of the American Medical Association
Frederic Tissot, Frederic Lamoth, Philippe M Hauser, Christina Orasch, Ursula Flückiger, Martin Siegemund, Stefan Zimmerli, Thierry Calandra, Jacques Bille, Philippe Eggimann, Oscar Marchetti
RATIONALE: Life-threatening intraabdominal candidiasis (IAC) occurs in 30 to 40% of high-risk surgical intensive care unit (ICU) patients. Although early IAC diagnosis is crucial, blood cultures are negative, and the role of Candida score/colonization indexes is not established. OBJECTIVES: The aim of this prospective Fungal Infection Network of Switzerland (FUNGINOS) cohort study was to assess accuracy of 1,3-β-d-glucan (BG) antigenemia for diagnosis of IAC. METHODS: Four hundred thirty-four consecutive adults with abdominal surgery or acute pancreatitis and ICU stay 72 hours or longer were screened: 89 (20...
November 1, 2013: American Journal of Respiratory and Critical Care Medicine
Katy Bradford, Jim Meinkoth, Kelci McKeirnen, Brenda Love
Candida peritonitis is reported in people and is associated with significant morbidity and mortality compared with sterile or bacterial peritonitis. Recognized predisposing risk factors include peritoneal dialysis, hollow viscous organ perforation, abdominal surgery, inflamed intestinal mucosa, antimicrobial administration, and immunosuppression. In this report, we describe 5 cases of dogs with peritonitis complicated by Candida spp; 3 dogs with C albicans, one dog with C albicans and C glabrata, and one dog with C glabrata only...
June 2013: Veterinary Clinical Pathology
Nita Radhakrishnan, Satya Prakash Yadav, Jaswinder Oberoi, Rajeev Kulshreshta, Sunita Bhalla, Anupam Sachdeva
Mucormycosis is increasingly emerging as an important cause of invasive fungal infection in immunocompromised patients. Intestinal mucormycosis is extremely rare, difficult to diagnose, and has dismal prognosis. We report two children with acute lymphoblastic leukemia and intestinal mucormycosis. Despite surgery and appropriate antifungal therapy, only one survived. Literature review showed only 10 other childhood cancer cases with intestinal mucormycosis. All had abdominal pain preceding gut perforation. All except one had leukemia and majority were in induction phase of therapy...
April 2013: Pediatric Hematology and Oncology
Camila M P França, Erica G Cavalcante, Aline S M Ribeiro, Guilherme T Oliveira, Nadia Litvinov, Clovis A Silva
INTRODUCTION: Histoplasmosis is an infection caused by dimorphic fungus, Histoplasma capsulatum, and it has not been reported in juvenile systemic lupus erythematosus (JSLE) patients, particularly progressive disseminated histoplasmosis (PDH) subtype. CASE REPORT: We reported herein a 14-year old girl who was diagnosed with JSLE. Six months later, she had abdominal distension and received prednisone, hydroxychloroquine and azathioprine. Computer tomography evidenced hepatosplenomegaly and multiple mesenteric, mediastinal and retroperitoneal enlarged lymph nodes, forming large conglomerates at the mesentery, suggestive of lymphoproliferative disorder...
July 2012: Acta Reumatológica Portuguesa
Asfandyar Sheikh, Syed Hassan Abbas Naqvi, Syed Hassan Shiraz Naqvi, Kainat Sheikh
Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disorder involving mainly synovial joints. It can progress to a severely debilitating form with pulmonary, renal and cardiovascular involvement. Currently, disease-modifying antirheumatic drugs (DMARDs) remain the gold standard pharmacological therapy for RA (along with nonsteroidal anti-inflammatory drugs and corticosteroids). However, DMARDs are more or less ineffective in the late phase of the disease and adverse effects often limit their use...
September 2012: Medical Hypotheses
Mortada H F El-Shabrawi, Naglaa Mohamed Kamal, Riyadh Jouini, Abdullah Al-Harbi, Kerstin Voigt, Talal Al-Malki
Basidiobolomycosis is an unusual fungal skin infection that rarely involves the gastrointestinal (GI) tract. We report a 10-year-old boy diagnosed as suffering GI basidiobolomycosis after being misdiagnosed first as suffering intestinal malignancy then schistosomiasis. The patient presented with fever, abdominal pain, vomiting, abdominal tenderness and rigidity with marked blood eosinophilia. Abdominal ultrasonographic and computed tomographic scans revealed a large caecal mass. Biopsy of the mass showed transmural granulomatous inflammation interpreted as schistosomal granuloma, ruling out lymphoma...
September 2011: Journal of Medical Microbiology
Demetrios Tzimas, David Wan
No abstract text is available yet for this article.
June 2011: Gastroenterology
Rahul Gupta, Sandesh V Parelkar, Sanjay Oak, Beejal Sanghvi, Advait Prakash
We report a 1.7 kg male infant with a low anorectal malformation treated at an outside facility and referred to us on postoperative day 11. At presentation, his upper abdomen was distended, and he had perianal mucoid discharge. The tongue had a blackish discoloration. An erect abdominal radiograph showed a few fluid-filled bowel loops in the upper abdomen with a gasless lower abdomen and pelvis, suggestive of upper small bowel obstruction. There were no specific radiological features of necrotizing enterocolitis...
April 2011: Journal of Pediatric Surgery
Yu-Hua Deng, Chun-Bao Guo, Ming-Man Zhang, Ying-Cun Li
OBJECTIVE: To summarize experience of pediatric intensive care and explore the incidence of complications, the involved pathogens among liver recipients to determine the effective strategies for preventing complications. METHODS: Between June 2006 and July 2009, 35 children under the age of 14 yr received 35 liver transplantations (LTs) performed at the center. A retrospective review of 22 infants weighing 8.8 kg or less underwent 23 transplants was conducted. Indication for transplantation was biliary atresia...
January 2011: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
B J Holzknecht, J Thorup, M C Arendrup, S E Andersen, M Steensen, P Hesselfeldt, J M Nielsen, J D Knudsen
Although abdominal surgery is an established risk factor for invasive candidiasis, the precise role of antifungal prophylaxis in these patients is not agreed upon. In 2007, fluconazole was added to the prophylactic antibiotic treatment for patients with gastrointestinal tract perforations or reoperation after colorectal surgery in two university hospitals in Copenhagen. Changes in candidaemia rates associated with this intervention were examined and potential interfering factors evaluated. Rates and clinical characteristics of candidaemias and other blood stream infections (BSIs) in abdominal surgery patients were compared before (1 January 2006 to 30 June 2007) and after the intervention (1 January 2008 to 30 June 2009)...
September 2011: Clinical Microbiology and Infection
Antonio Cascio, Marcello Bartolotta, Antonella Venneri, Cinzia Musolino, Chiara Iaria, Demetrio Delfino, Giuseppe Navarra
A case of a 62-year-old man with Candida krusei peritonitis secondary to duodenal perforation due to Candida duodenitis that was successfully treated with a 14-day course of caspofungin is reported. The potential role of Candida infection in the pathogenesis of peptic ulcers and duodenal perforation is considered. If this role is confirmed, antifungal treatment should be included in the therapeutic armamentarium of peptic disease.
January 2011: Mycopathologia
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