Matthew M Behymer, Huaping Mo, Naoaki Fujii, Vallabh Suresh, Adriano Chan, Jangweon Lee, Anjali K Nath, Kusumika Saha, Sari B Mahon, Matthew Brenner, Calum A MacRae, Randall Peterson, Gerry R Boss, Gregory T Knipp, Vincent Jo Davisson
The development of rapidly acting cyanide countermeasures using intramuscular injection (IM) represents an unmet medical need to mitigate toxicant exposures in mass casualty settings. Previous work established that cisplatin and other platinum(II) or platinum(IV)-based agents effectively mitigate cyanide toxicity in zebrafish. Cyanide's in vivo reaction with platinum-containing materials was proposed to reduce the risk of acute toxicities. However, cyanide antidote activity depended on a formulation of platinum-chloride salts with dimethyl sulfoxide (DMSO) followed by dilution in phosphate-buffered saline (PBS)...
October 6, 2022: Chemical Research in Toxicology