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Parkinson AND Treatment

Elizabeth L Stegemöller, Kasandra Diaz, Judith Craig, David Brown
INTRODUCTION: Group therapeutic singing (GTS) may be an effective treatment for voice and respiratory impairments in persons with Parkinson's disease (PD). However, it remains unknown if GTS can be effectively delivered through telemedicine. METHODS: Participants with PD from rural areas were recruited to complete a prerecorded GTS program, once a week for 8 weeks. Voice and respiratory outcome measures were collected 1 week before and 1 week after intervention...
February 20, 2019: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
Norbert Kovács, Zsuzsanna Aschermann, Annamária Juhász, Márk Harmat, Dávid Pintér, József Janszky
For the treatment of advanced Parkinson's disease the deep brain stimulation (DBS) and the levodopa/carbidopa intestinal gel (LCIG) therapies are available in Hungary. Although they may have similar impact on the health-related quality of life and disabilities associated with the disease, they have different indications, and inclusion- and exclusion criteria. Consequently, the patient population treated with DBS and LCIG may be different. In the present review, the authors try to help the process of selection of the optimal device-aided therapy for the patients with advanced Parkinson's disease...
January 30, 2019: Ideggyógyászati Szemle
Yang Zhang, Junbiao Ying, Jiajun Hong, Fengcheng Li, Tingting Fu, Fengyuan Yang, Guoxun Zheng, Xiaojun Yao, Yan Lou, Yun Qing Qiu, Weiwei Xue, Feng Zhu
Histone deacetylase 6 (HDAC6) plays a key role in a variety of neurological disorders, which makes it attractive drug target for the treatment of Alzheimer's disease, Parkinson disease and memory/learning impairment. The selectivity of HDAC6 inhibitors (sHDAC6Is) are widely considered to be susceptible to their sizes of Cap group and their physicochemical properties of linker or zinc-binding group, which makes the discovery of new sHDAC6Is extremely difficult. With the discovery of the distinct selectivity between Trichostatin A (TSA) enantiomers, the chirality residing in the connective units between TSA's Cap and linker shows a great impact on its selectivity...
February 20, 2019: ACS Chemical Neuroscience
Yuta Manabe, Toshinari Odawara, Osamu Konishi
BACKGROUND: We performed a questionnaire survey of medical doctors engaged in the management of dementia to identify the actual status of treatment for dementia with Lewy bodies (DLB) in Japan. METHODS: Among participating medical doctors, we selected neurologists (Group N) and psychiatrists (Group P) because these physicians are usually involved in the management of DLB patients. The two groups were compared based on their diagnosis and treatment of DLB and in particular, parkinsonism...
February 19, 2019: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Fabrizio Vallelonga, Cristina Di Stefano, Aristide Merola, Alberto Romagnolo, Gabriele Sobrero, Valeria Milazzo, Alessio Burrello, Jacopo Burrello, Maurizio Zibetti, Franco Veglio, Simona Maule
INTRODUCTION: We sought to analyze the blood pressure (BP) circadian rhythm in Parkinson's disease (PD), multiple system atrophy (MSA), and pure autonomic failure (PAF) and to evaluate the effect of vasoactive and dopaminergic medications on BP fluctuations during activities of daily living. METHODS: We analyzed data from patients with PD (n = 72), MSA (n = 18), and PAF (n = 17) evaluated with 24-h ambulatory BP monitoring (ABPM) at our Center between 1996 and 2015...
February 19, 2019: Journal of Neurology
Yan-Hong Meng, Pan-Pan Wang, Ya-Xue Song, Jian-Hua Wang
Recently, several randomized controlled trials on the use of cholinesterase inhibitors or memantine as treatments for cognitive impairment in Parkinson's disease (CIND-PD), Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) were completed. The present study provided a meta-analysis of these studies to evaluate the efficacy of cholinesterase inhibitors and memantine on CIND-PD, PDD and DLB. The Cochrane Library, Pubmed, Embase and Web of Science databases were searched to retrieve eligible studies...
March 2019: Experimental and Therapeutic Medicine
Alexandra M C Fragniere, Simon R W Stott, Shaline V Fazal, Maria Andreasen, Kirsten Scott, Roger A Barker
The aggregation of alpha-synuclein (α-syn) is a pathological feature of a number of neurodegenerative conditions, including Parkinson's disease. Genetic mutations, abnormal protein synthesis, environmental stress, and aging have all been implicated as causative factors in this process. The importance of water in the polymerisation of monomers, however, has largely been overlooked. In the present study, we highlight the role of hyperosmotic stress in inducing human α-syn to aggregate in cells in vitro, through rapid treatment of the cells with three different osmolytes: sugar, salt and alcohol...
February 19, 2019: Scientific Reports
Luiz Alexandre Viana Magno, Helia Tenza-Ferrer, Mélcar Collodetti, Matheus Felipe Guimarães Aguiar, Ana Paula Carneiro Rodrigues, Rodrigo Souza da Silva, Joice do Prado Silva, Nycolle Ferreira Nicolau, Daniela Valadão Freitas Rosa, Alexander Birbrair, Débora Marques Miranda, Marco Aurélio Romano-Silva
Neuromodulation of deep brain structures (deep brain stimulation - DBS) is the current surgical procedure for treatment of Parkinson's disease. Less studied is the stimulation of cortical motor areas to treat PD symptoms, although also known to alleviate motor disturbances in PD. We were able to show that optogenetic activation of secondary (M2) motor cortex improves motor functions in dopamine-depleted male mice. The stimulated M2 cortex harbors glutamatergic pyramidal neurons that project to subcortical structures, critically involved in motor control, and makes synaptic contacts with dopaminergic neurons...
February 19, 2019: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
M Toledo, C Carnero-Pardo, M Carreno-Martinez, J Escudero-Torrella, C Gaig, G Garcia-Ribas, A Gil-Nagel, F J Grandas, J Kulisevsky, J M Lainez-Andres, J A Pareja, J Porta-Etessam, J J Poza-Aldea, M C Rodriguez-Oroz, J M Serratosa, V Villanueva
«Apuntes en Neurologia» is an initiative in which prominent national and international leaders, with broad academic recognition, came together to synthesise the most outstanding clinical aspects within their area of interest and to discuss the latest developments in a more accessible language. Understanding the factors that affect the onset and progression of any neurological disease through a review is important to be able to develop strategies to reduce the burden of these diseases. Moreover, knowledge of the clinical aspects is essential to solve the problems of daily clinical practice...
November 26, 2018: Revista de Neurologia
Patricia Limousin, Tom Foltynie
The efficacy of deep brain stimulation (DBS) for Parkinson disease (PD) is well established for up to 1 or 2 years, but long-term outcome data are still limited. In this Review, we critically discuss the evidence on the long-term outcomes of DBS and consider the clinical implications. Although many patients are lost to follow-up, the evidence indicates that subthalamic nucleus DBS improves motor function for up to 10 years, although the magnitude of improvement tends to decline over time. Functional scores recorded during on-medication periods worsen more quickly than those recorded in off periods, consistent with the degeneration of non-dopaminergic pathways...
February 18, 2019: Nature Reviews. Neurology
Paula Trujillo, Nelleke C van Wouwe, Ya-Chen Lin, Adam J Stark, Kalen J Petersen, Hakmook Kang, David H Zald, Manus J Donahue, Daniel O Claassen
Parkinson's disease (PD) is characterized by dysfunction in frontal cortical and striatal networks that regulate action control. We investigated the pharmacological effect of dopamine agonist replacement therapy on frontal cortical activity and motor inhibition. Using Arterial Spin Labeling MRI, we examined 26 PD patients in the off- and on-dopamine agonist medication states to assess the effect of dopamine agonists on frontal cortical regional cerebral blood flow. Motor inhibition was measured by the Simon task in both medication states...
January 29, 2019: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Nitya Beriwal, Tashi Namgyal, Pema Sangay, Asmaa Monther Al Quraan
The anti-oxidant effects of melatonin and the immune-pineal axis are well established. However, how they play a role in the pathogenesis of neurodegenerative diseases is not well elucidated. A better understanding of this neuro-immuno-endocrinological link can help in the development of novel therapies with higher efficacy to alleviate symptomatology, slow disease progression and improve the quality of life. Recent studies have shown that the immune-pineal axis acts as an immunological buffer, neurohormonal switch and it also intricately links the pathogenesis of neurodegenerative diseases (like Multiple sclerosis, Alzheimer's disease, Parkinson's disease) and inflammation at a molecular level...
January 2019: Heliyon
Hua Zhao, Jie Jiang
Endoplasmic reticulum stress (ERS) is one of the major defense networks in mammals, but continuous ERS will lead to cell apoptosis, inducing initiation and progression of many human diseases. Biochemical, physiological and pathological stimuli induced ERS may help the cells adapt to and survive stress conditions by activating unfolded protein response (UPR), ER-overload response and sterol modulation cascade reaction. Abundant outcomes of clinical and experimental studies in recent 5 years showed that acupuncture and moxibustion therapies are effective in improving some symptoms of nervous system diseases as stroke, Parkinson's disease, convulsion, cardiovascular diseases, diabetes mellitus, non-alcoholic fatty liver disease, spinal cord injury, muscular injury, etc...
January 25, 2019: Zhen Ci Yan Jiu, Acupuncture Research
Dominique Lesuisse, André Malanda, Jean-François Peyronel, Yannick Evanno, Patrick Lardenois, Danielle De-Peretti, Pierre-Yves Abécassis, Pascal Barnéoud, Pascale Brunel, Marie-Claude Burgevin, Céline Cegarra, Florian Auger, Amélie Dommergue, Corinne Lafon, Luc Even, Joanna Tsi, Thy Phuong Hieu Luc, Antonio Almario, Anne Olivier, Marie-Noëlle Castel, Véronique Taupin, Thomas Rooney, Xavier Vigé
In the course of a programme aimed at identifying Nurr1/NOT agonists for potential treatment of Parkinson's disease, a few hits from high throughput screening were identified and characterized. A combined optimization pointed to a very narrow and stringent structure activity relationship. A comprehensive program of optimization led to a potent and safe candidate drug displaying neuroprotective and anti-inflammatory activity in several in vitro and in vivo models.
January 30, 2019: Bioorganic & Medicinal Chemistry Letters
Waseem A Abboud, Sahar Nadel, Sharon Hassin-Baer, Abigail Arad, Alex Dobriyan, Ran Yahalom
BACKGROUND: Drooling is the unintentional loss of saliva from the mouth, usually caused by poor coordination of the swallowing mechanism. It is commonly seen in patients with chronic neurologic disorders, such as Parkinson's disease, amyotrophic lateral sclerosis (ALS), cerebral palsy, and stroke, as well as in patients with cognitive impairment and dementia. OBJECTIVES: To evaluate the efficacy and safety of ultrasound-guided botulinum toxin injections into the parotid and submandibular salivary glands for the treatment of drooling...
February 2019: Israel Medical Association Journal: IMAJ
Roberta A Domenici, Ana Carolina P Campos, Soraya T Maciel, Miriã B Berzuino, Marina S Hernandes, Erich T Fonoff, Rosana L Pagano
Parkinson's disease (PD) is a neurodegenerative disorder that causes progressive dysfunction of dopaminergic and non-dopaminergic neurons, generating motor and nonmotor signs and symptoms. Pain is reported as the most bothersome nonmotor symptom in PD; however, pain remains overlooked and poorly understood. In this study, we evaluated the nociceptive behavior and the descending analgesia circuitry in a rat model of PD. Three independent experiments were performed to investigate: i) thermal nociceptive behavior; ii) mechanical nociceptive behavior and dopaminergic repositioning; and iii) modulation of the pain control circuitry...
February 14, 2019: Experimental Neurology
Karthik Sreenivasan, Virendra Mishra, Christopher Bird, Xiaowei Zhuang, Zhengshi Yang, Dietmar Cordes, Ryan R Walsh
INTRODUCTION: The aim of the study was to identify abnormalities of whole-brain network functional organization and their relation to clinical measures in a well-characterized, multi-site cohort of very early-stage, drug-naïve Parkinson's Disease (PD) patients. METHODS: Functional-MRI data for 16 healthy controls and 20 very early-stage, drug-naïve patients with PD were obtained from the Parkinson's Progression Markers Initiative database after controlling for strict inclusion/exclusion imaging criteria...
February 7, 2019: Parkinsonism & related Disorders
Kirsten Haas, Stephanie Stangl, Frank Steigerwald, Cordula Matthies, Doreen Gruber, Andrea A Kühn, Joachim K Krauss, Friederike Sixel-Döring, Kajetan von Eckardstein, Günther Deuschl, Joseph Classen, Dirk Winkler, Jürgen Voges, Imke Galazky, Wolfgang Oertel, Andres O Ceballos-Baumann, Max Lange, Alireza Gharabaghi, Daniel T Weiss, Jens Volkmann, Peter U Heuschmann
INTRODUCTION: Deep Brain Stimulation (DBS) is a complex, invasive and cost-intensive therapy that requires a high level of expertise. To date, data on quality of DBS in clinical routine in the German health care system are lacking. METHODS: The development of evidence-based QIs for DBS in PD patients was performed following a standardized process by a multidisciplinary board between 2014 and 2016. The process was initiated by the German Parkinson Society and followed international recommendations for developing QIs including: a systematic literature search; an appraisal of the published evidence; a consensus-based selection of the QI set; and a pilot study to assess the feasibility in implementing the QIs in clinical routine...
February 5, 2019: Parkinsonism & related Disorders
Mariana Oliveira Mendes, Alexandra Isabel Rosa, Andreia Neves Carvalho, Maria João Nunes, Pedro Dionísio, Elsa Rodrigues, Daniela Costa, Sara Duarte-Silva, Patrícia Maciel, Cecília Maria Pereira Rodrigues, Maria João Gama, Margarida Castro-Caldas
Parkinson's disease (PD) is a progressive neurological disorder, mainly characterized by the progressive loss of dopaminergic neurons in the Substantia nigra pars compacta (SNpc) and by the presence of intracellular inclusions, known as Lewy bodies. Despite SNpc being considered the primary affected region in PD, the neuropathological features are confined solely to the nigro-striatal axis. With disease progression other brain regions are also affected, namely the cerebral cortex, although the spreading of the neurologic damage to this region is still not completely unraveled...
February 13, 2019: Molecular and Cellular Neurosciences
Aleksandar Videnovic, Lambros Messinis
No abstract text is available yet for this article.
February 15, 2019: Neurology
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