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Ana Karolinne da Silva Brito, Geovanni de Morais Lima, Luciana Melo de Farias, Lays Arnaud Rosal Lopes Rodrigues, Vanessa Brito Lira de Carvalho, Cristian Francisco de Carvalho Pereira, Karoline de Macedo Gonçalves Frota, Airton Mendes Conde-Júnior, Ana Mara Oliveira Silva, Márcia Dos Santos Rizzo, Clarisse Maria Barbosa Fonseca, Rayane Carvalho de Moura, Raimunda Cardoso Dos Santos, José Roberto de Souza de Almeida Leite, Marcos Antônio Pereira Dos Santos, Paulo Humberto Moreira Nunes, Daniel Dias Rufino Arcanjo, Maria do Carmo de Carvalho E Martins
This work assessed the effects of a 28-day treatment with lycopene-rich extract (LRE) from red guava fruit ( Psidium guajava L.) on the lipid profile and oxidative stress in an experimental model of dyslipidemia. Male hamsters (116.5 ± 2.16 g) were fed with the AIN 93G diet containing casein (20%), coconut fat (13.5%) and cholesterol (0.1%). The animals were divided into four groups: normolipidemic control (standard feed; NC, n = 7); hypercholesterolemic control (HC, n = 7); LRE 25 mg/kg/day (LRE-25, n = 7) and LRE 50 mg/kg/day (LRE-50, n = 9)...
February 13, 2019: Nutrients
Liang-Chia Chen, Thanh-Hung Nguyen
This paper presents a novel approach to the automated recognition and localization of 3-D objects. The proposed approach uses 3-D object segmentation to segment randomly stacked objects in an unstructured point cloud. Each segmented object is then represented by a regional area-based descriptor, which measures the distribution of surface area in the oriented bounding box (OBB) of the segmented object. By comparing the estimated descriptor with the template descriptors stored in the database, the object can be recognized...
February 13, 2019: Sensors
Erik R Andersson, Rusty D Day, Julie M Loewenstein, Cheryl M Woodley, Tracey B Schock
The field of metabolomics generally lacks standardized methods for the preparation of samples prior to analysis. This is especially true for metabolomics of reef-building corals, where the handful of studies that were published employ a range of sample preparation protocols. The utilization of metabolomics may prove essential in understanding coral biology in the face of increasing environmental threats, and an optimized method for preparing coral samples for metabolomics analysis would aid this cause. The current study evaluates three important steps during sample processing of stony corals: (i) metabolite extraction, (ii) metabolism preservation, and (iii) subsampling...
February 13, 2019: Metabolites
Alice Monzani, Roberta Ricotti, Marina Caputo, Arianna Solito, Francesca Archero, Simonetta Bellone, Flavia Prodam
The incidence of skipping breakfast in pediatric subjects is rising, and a relationship with overweight (OW) and obesity (OB) has been shown. Associations with cardiovascular outcomes and skipping breakfast in adults have been reported. The purpose of this systematic review was to summarize the association of skipping breakfast with body weight and metabolic outcomes in the pediatric population. We searched relevant databases (2008⁻2018) and identified 56 articles, of which 39 were suitable to be included, basing on inclusion criteria (observational; defined breakfast skipping; weight and/or metabolic outcomes)...
February 13, 2019: Nutrients
Mohd Farhan, Arshi Malik, Mohammad Fahad Ullah, Sarah Afaq, Mohd Faisal, Ammad Ahmad Farooqi, Bernhard Biersack, Rainer Schobert, Aamir Ahmad
Garcinol, a dietary factor obtained from Garcinia indica , modulates several key cellular signaling pathways as well as the expression of miRNAs. Acquired resistance to standard therapies, such as erlotinib and cisplatin, is a hallmark of non-small cell lung cancer (NSCLC) cells that often involves miRNA-regulated epithelial-to-mesenchymal transition (EMT). We used A549 cells that were exposed to transforming growth factor beta 1 (TGF-β1), resulting in A549M cells with mesenchymal and drug resistant phenotype, and report that garcinol sensitized resistant cells with mesenchymal phenotype to erlotinib as well as cisplatin with significant decrease in their IC50 values...
February 13, 2019: International Journal of Molecular Sciences
Yaseen M Arabi, Waleed Tamimi, Gwynne Jones, Dunia Jawdat, Hani Tamim, Hasan M Al-Dorzi, Musharaf Sadat, Lara Afesh, Maram Sakhija, Abdulaziz Al-Dawood
OBJECTIVES: The objectives of this study were to evaluate the clinical and nutritional correlates of high free fatty acids (FFAs) level in critically ill patients and the association with outcomes, and to study the effect of short-term caloric restriction (permissive underfeeding) on FFAs level during critical illness. PATIENTS/METHOD: In this pre-planned sub-study of the PermiT (Permissive Underfeeding vs. Target Enteral Feeding in Adult Critically Ill Patients) trial, we included critically ill patients who were expected to stay for ≥14 days in the intensive care unit...
February 13, 2019: Nutrients
Joshua Y C Yang, Stijn E Verleden, Arya Zarinsefat, Bart M Vanaudenaerde, Robin Vos, Geert M Verleden, Reuben D Sarwal, Tara K Sigdel, Juliane M Liberto, Izabella Damm, Drew Watson, Minnie M Sarwal
Standard methods for detecting chronic lung allograft dysfunction (CLAD) and rejection have poor sensitivity and specificity and have conventionally required bronchoscopies and biopsies. Plasma cell-free DNA (cfDNA) has been shown to be increased in various types of allograft injury in transplant recipients and CXCL10 has been reported to be increased in the lung tissue of patients undergoing CLAD. This study used a novel cfDNA and CXCL10 assay to evaluate the noninvasive assessment of CLAD phenotype and prediction of survival from bronchoalveolar lavage (BAL) fluid...
February 13, 2019: Journal of Clinical Medicine
Dae-Hwan Park, Seung-Taek Oh, Jae-Hyun Lim
Ultraviolet (UV) rays are electromagnetic waves that account for about 5% of solar light, and when overexposed, they pose malevolent effects on human skin and health. However, with recent reports on the beneficial effects of some wavelength bands of UV rays, people's interest in UV information has increased. This has resulted in requiring not just simple information, such as the amount of UV or UV index (UVI), but detailed UV information that directly affects health, such as EUVB (erythemally weighted UVB)...
February 13, 2019: Sensors
Ufuk Tan Timur, Marjolein Caron, Guus van den Akker, Anna van der Windt, Jenny Visser, Lodewijk van Rhijn, Harrie Weinans, Tim Welting, Pieter Emans, Holger Jahr
During standard expansion culture (i.e., plasma osmolarity, 280 mOsm) human articular chondrocytes dedifferentiate, making them inappropriate for autologous chondrocyte implantation to treat cartilage defects. Increasing the osmolarity of culture media to physiological osmolarity levels of cartilage (i.e., 380 mOsm), increases collagen type II ( COL2A1 ) expression of human articular chondrocytes in vitro , but the underlying molecular mechanism is not fully understood. We hypothesized that TGF-β superfamily signaling may drive expression of COL2A1 under physiological osmolarity culture conditions...
February 13, 2019: International Journal of Molecular Sciences
Jennifer Tse, Rashed Ghandour, Nirmish Singla, Yair Lotan
Urothelial carcinoma of the bladder (UCB) and upper tracts (UTUC) is often regarded as one entity and is managed generally with similar principles. While neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) is an established standard of care in UCB, strong evidence for a similar approach is lacking in UTUC. The longest survival is seen in patients with complete response (pT0) on pathological examination of the RC specimen, but impact of delayed RC in nonresponders may be detrimental. The rate of pT0 following NAC in UTUC is considerably lower than that in UCB due to differences in access and instrumentation...
February 13, 2019: International Journal of Molecular Sciences
Manoj K Dhar, Jasmeet Kour, Sanjana Kaul
B chromosomes have been reported in many eukaryotic organisms. These chromosomes occur in addition to the standard complement of a species. Bs do not pair with any of the A chromosomes and they have generally been considered to be non-essential and genetically inert. However, due to tremendous advancements in the technologies, the molecular composition of B chromosomes has been determined. The sequencing data has revealed that B chromosomes have originated from A chromosomes and they are rich in repetitive elements...
February 18, 2019: Genes
Lama Jaffal, Wissam H Joumaa, Alexandre Assi, Charles Helou, Christel Condroyer, Maya El Dor, Georges Cherfan, Christina Zeitz, Isabelle Audo, Kazem Zibara, Said El Shamieh
To identify Bestrophin 1 ( BEST1 ) causative mutations in six Lebanese patients from three families, of whom four had a presumed clinical diagnosis of autosomal recessive bestrophinopathy (ARB) and two showed a phenotype with a single vitelliform lesion, patients were subjected to standard ophthalmic examinations. In addition, BEST1 exons and their flanking regions were amplified and sequenced by Sanger sequencing. Co-segregation and detailed bio-informatic analyses were performed. Clinical examination results were consistent with ARB diagnosis for all index patients showing multifocal vitelliform lesions and a markedly reduced light peak in the electrooculogram, including the two patients with a single vitelliform lesion...
February 18, 2019: Genes
Zhaowei Deng, Qiang Shen, Zilong Deng, Jisi Cheng
As roll angle measurement is essential for two-dimensional course correction fuze (2-D CCF) technology, a real-time estimation of roll angle of spinning projectile by single-axis magnetometer is studied. Based on the measurement model, a second-order frequency-locked loop (FLL)-assisted third-order phase-locked loop (PLL) is designed to obtain rolling information from magnetic signals, which is less dependent on the amplitude and able to reduce effect from geomagnetic blind area. Method of parameters optimization of tracking loop is discussed in the circumstance of different speed and it is verified by six degrees of freedom (six degrees of freedom (DoF)) trajectory...
February 18, 2019: Sensors
Tommaso Polonelli, Davide Brunelli, Achille Marzocchi, Luca Benini
LoRaWAN is one of the most promising standards for long-range sensing applications. However, the high number of end devices expected in at-scale deployment, combined with the absence of an effective synchronization scheme, challenge the scalability of this standard. In this paper, we present an approach to increase network throughput through a Slotted-ALOHA overlay on LoRaWAN networks. To increase the single channel capacity, we propose to regulate the communication of LoRaWAN networks using a Slotted-ALOHA variant on the top of the Pure-ALOHA approach used by the standard; thus, no modification in pre-existing libraries is necessary...
February 18, 2019: Sensors
Nora Wiium, Reidar Säfvenbom
Engagement in organized sports is associated with developmental factors, such as, healthy growth, cognitive abilities, psychological well-being and lower substance use. Research also suggest that the spontaneous free play that characterises self-organized physical activity (PA) provides young people with opportunities to learn social skills, such as self-regulation and conflict-resolution skills. We assessed associations between participation in the two activity types and several demographics along with developmental factors (e...
February 18, 2019: International Journal of Environmental Research and Public Health
Florian Zikeli, Vittorio Vinciguerra, Alessandro D'Annibale, Donatella Capitani, Manuela Romagnoli, Giuseppe Scarascia Mugnozza
Lignin was isolated from wood wastes comprising Iroko sawdust (IR) and mixed sawdust from Iroko and Norway spruce (IRNS), furnished by a local wood houses producer. The respective acidolysis lignin fractions were structurally characterized using pyrolysis (Py)-GCMS, two-dimensional heteronuclear single quantum correlation nuclear magnetic resonance (2D HSQC NMR), Fourier-transform infrared FTIR and ultraviolet-visible (UV-VIS) spectroscopies, size exclusion chromatography, and standard wet-chemistry methods for Klason lignin and polysaccharides determination...
February 17, 2019: Nanomaterials
Faisal I Shalabi, Javed Mazher, Kaffayatullah Khan, Mohammed Alsuliman, Ibrahim Almustafa, Ward Mahmoud, Naif Alomran
In this study, cement-treated waste sand as a by-product material produced from Al-Ahsa quarries (Saudi Arabia) was experimentally tested and investigated as a base course material for the foundation of structures and roads. The study aimed to use the waste sand as a construction material by improving its strength, bearing capacity, and stiffness. The waste sand was mixed with different percentages of Portland cement content (0, 2, 4, 6, and 8%) at the maximum dry density and optimum water content of the standard Proctor compaction conditions of a non-treated sample...
February 17, 2019: Materials
Gaoyuan Qin, Fengming Tao, Lixia Li
Under fierce market competition and the demand for low-carbon economy, cold chain logistics companies have to pay attention to customer satisfaction and carbon emissions for better development. In order to simultaneously consider cost, customer satisfaction, and carbon emissions in the cold chain logistics path optimization problem, based on the idea of cost⁻benefit, this paper proposes a comprehensive cold chain vehicle routing problem optimization model with the objective function of minimizing the cost of unit satisfied customer...
February 16, 2019: International Journal of Environmental Research and Public Health
María Gallardo, Luis Arias-Darraz, Juan Cárcamo
This experiment was carried out to determine the effect of breed on mRNA and protein expression levels of lipogenic enzymes acetyl-CoA carboxylase α (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase 1 (SCD1) plus sterol regulatory element binding transcription factor 1c (SREBP1c) in the subcutaneous fat (SCF) from the back of the animal, and tail fat (TF) of both Chilota and Suffolk Down lambs grazing Calafatal. Eight Chilota and six Suffolk Down 2-month-old male lambs were allocated to graze a "Calafatal", a typical secondary succession of Chiloé Archipelago, Chile...
February 15, 2019: Animals: An Open Access Journal From MDPI
Harold S Bernhardt
A mixture of sugar diphosphates is produced in reactions between small aldehyde phosphates catalysed by layered double hydroxide (LDH) clays under plausibly prebiotic conditions. A subset of these, pentose diphosphates, constitute the backbone subunits of nucleic acids capable of base pairing, which is not the case for the other products of these LDH-catalysed reactions. Not only that, but to date no other polymer found capable of base pairing-and therefore information transfer-has a backbone for which its monomer subunits have a plausible prebiotic synthesis, including the ribose-5-phosphate backbone subunit of RNA...
February 15, 2019: Life
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