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REVIEW
Lee M Jeys, Joachim Thorkildsen, Vineet Kurisunkal, Ajay Puri, Pietro Ruggieri, Matthew T Houdek, Richard A Boyle, Walid Ebeid, Eduardo Botello, Guy V Morris, Minna K Laitinen, Adesegun Abudu, Keisuke Ae, Manish Agarwal, Vivek Ajit Singh, Toru Akiyama, Jose I Albergo, John Alexander, Bugra Alpan, Ahmed Aoude, Apichat Asavamongkolkul, William Aston, Thomas Baad-Hansen, Tessa Balach, Joseph Benevenia, Peter Bergh, Nicholas Bernthal, Odion Binitie, Michele Boffano, Jos Bramer, Harriet Branford White, Bernadette Brennan, Jorge Cabrolier, Jose A Calvo Haro, Domenico A Campanacci, Rodrigo Cardoso, Richard Carey Smith, Nicolas Casales Fresnga, Jose M Casanova, Oscar Ceballos, Chung M Chan, Yang-Guk Chung, Miguel A Clara-Altamirano, Gillian Cribb, Solomon Dadia, Dietmar Dammerer, Marieke de Vaal, Javier Delgado Obando, Shaneel Deo, Claudia Di Bella, Davide M Donati, Makoto Endo, Levent Eralp, Bulent Erol, Scott Evans, Will Eward, Fabrice Fiorenza, Joao Freitas, Philipp T Funovics, Marcos Galli Serra, Michelle Ghert, Kanishka Ghosh, Luis C Gomez Mier, Jesus Gomez Vallejo, Anthony Griffin, Ashish Gulia, Maurice Guzman, Jendrik Hardes, John Healey, Adriana Hernandez, Asle Hesla, Chindanai Hongsaprabhas, Francis Hornicek, Keith Hosking, Shintaro Iwata, Jake Jagiello, Luke Johnson, Andy Johnston, Min Wook Joo, Paul Jutte, Bilal Kapanci, Zeeshan Khan, Hiroshi Kobayashi, Yehuda Kollender, Sebastian Koob, Daniel Kotrych, Louis-Romee Le Nail, Pawel Legosz, Burkhard Lehner, Andreas Leithner, Valerae Lewis, Peng Lin, Francisco Linares, Santiago Lozano Calderon, Ashish Mahendra, Ferdiansyah Mahyudin, Eric Mascard, Jean-Camille Mattei, Louise McCullough, Manuel R Medellin Rincon, Rhidian Morgan-Jones, Diego J Moriel Garcesco, Sophie Mottard, Robert Nakayama, Prashant Narhari, Gary O'Toole, Oliveira Vania, André Olivier, Mohamed Omar, Eduardo Ortiz-Cruz, Harzem Ozger, Korhan Ozkan, Emanuela Palmerini, Panayiotis Papagelopoulos, Michael Parry, Sam Patton, Michael M Petersen, Gerard Powell, Mark Puhaindran, Anand Raja, Raja B Rajasekaran, Lauris Repsa, Mickael Ropars, Andrea Sambri, Thomas Schubert, Ahmad Shehadeh, Geoffrey Siegel, Scott Sommerville, Andre Spiguel, Jonathan Stevenson, Gwen Sys, Thomas Temple, Frank Traub, Hiroyuki Tsuchiya, Juan Valencia, Michel Van de Sande, Gualter Vaz, Roberto Velez Villa, Oleg Vyrva, Hazem Wafa, Wan I Wan Faisham Numan, Edward Wang, David Warnock, Joel Werier, Kwok-Chuen Wong, Yamamoto Norio, Ye Zhaoming, Suraya Zainul Abidin, Tomas Zamora, Juan P Zumarraga, Ghaith Abou-Nouar, Carsten Gebert, R L Randall
Chondrosarcoma is the second most common surgically treated primary bone sarcoma. Despite a large number of scientific papers in the literature, there is still significant controversy about diagnostics, treatment of the primary tumour, subtypes, and complications. Therefore, consensus on its day-to-day treatment decisions is needed. In January 2024, the Birmingham Orthopaedic Oncology Meeting (BOOM) attempted to gain global consensus from 300 delegates from over 50 countries. The meeting focused on these critical areas and aimed to generate consensus statements based on evidence amalgamation and expert opinion from diverse geographical regions...
May 1, 2024: Bone & Joint Journal
#22
JOURNAL ARTICLE
Robin Schaffar, Simone Benhamou, Pierre O Chappuis, Elisabetta Rapiti
PURPOSE: Breast cancer (BC) in women under 45 is rare yet often aggressive. We aim to analyze loco-regional recurrences (LR), distant recurrences (DR), second breast cancers, and mortality in young BC patients. METHODS: We enrolled 776 women with non-metastatic BC ≤45 years diagnosed from 1970 to 2012. Variables included age, family history, tumor stage/grade, and treatment. We used multivariate Cox regression and competing risk models. RESULTS: Among the participants, 37...
April 30, 2024: Breast Cancer Research and Treatment
#23
REVIEW
Mazin M Almomani, Faisal F Al-Shaikhly, Rahaf T Oduibat, Abedallah J Al-Adwan, Lina M Al-Tarawneh
Echinococcal cysts (ECs) are a significant public health concern globally, particularly in endemic regions. Among these, primary retroperitoneal echinococcal cysts (PRECs) present unique challenges due to their location and complex presentations. Total cystectomy, involving complete removal of the EC and surrounding tissue, is a surgical option for managing PRECs. However, evidence regarding its efficacy and safety is limited. We conducted a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to evaluate the role of total cystectomy in managing PRECs...
March 2024: Curēus
#24
JOURNAL ARTICLE
Matteo Ghilli, Carlotta Becherini, Icro Meattini, Catia Angiolini, Carmelo Bengala, Aroldo Marconi, Lorenzo Galli, Giovanni Angiolucci, Luigi Coltelli, Simona Borghesi, Luciana Lastrucci, Gianpiero Manca, Simonetta Bianchi, Morena Doria, Donato Casella, Lorenza Marotti, Gianni Amunni, Manuela Roncella
PURPOSE: Data from recently trials have provided practice-changing recommendations in management of the axilla in early breast cancer (eBC). However, further controversies have been raised, resulting in heterogeneous diffusion of these recommendations. Our purpose was to obtain a better homogeneity. MATERIAL AND METHODS: In 2021, the Tuscan Breast Network (TBN) established a consensus with the aim to update recommendations in this area. We performed a literature review on axillary management in eBC patients which led to an expert Delphi consensus aiming to explore the gray areas, build consensus and propose evidence-based suggestions for an appropriate management...
April 29, 2024: La Radiologia Medica
#25
JOURNAL ARTICLE
Jochen Utikal, Pia Nagel, Verena Müller, Jürgen C Becker, Edgar Dippel, Alexander Frisman, Martin Gschnell, Klaus Griewank, Eva Hadaschik, Doris Helbig, Uwe Hillen, Ulrike Leiter, Claudia Pföhler, Lisa Krönig, Mirjana Ziemer, Selma Ugurel
Sebaceous gland carcinomas are rare malignant cutaneous adnexal tumors with sebocytic differentiation. The typical predilection area is the head and neck region, where sebaceous gland carcinomas are the most common malignant adnexal tumors of the skin. According to their localization a distinction is made between periocular and extraocular sebaceous gland carcinomas. Muir-Torre syndrome (MTS) should always be ruled out if it is suspected. In terms of prognosis, sebaceous gland carcinomas are potentially aggressive tumors with a clear tendency to recur and metastasize...
April 28, 2024: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
#26
JOURNAL ARTICLE
Miao Ding, Yu Yang, Ziyang Zhang, Hongxiang Liu, Yingdi Dai, Zixuan Wang, Sijia Ma, Yang Liu, Qi Wang
In this study, one water soluble polysaccharide (IOP1-1) with a weight average molecular weight of 6886 Da was obtained from the black crystal region of Inonotus obliquus by hot water extraction, DEAE-52 cellulose extraction and Sephadex-100 column chromatography purification. Structural analysis indicated that IOP1-1 was a glucan with a main chain composed of α-Glcp-(1 → 4)-α-Glcp-(1 → 4)-β-Glcp-(1 → 4)-β-Glcp-(1 → 4)-α-Glcp-(1 → 6)-β-Glcp-(1 → 4)-α-Glcp-(1 → 3)-β-Glcp-(1→...
April 25, 2024: International Journal of Biological Macromolecules
#27
REVIEW
Scott Boop, Nir Shimony, Frederick Boop
Low-grade gliomas are the most common brain tumor of childhood, and complete resection offers a high likelihood of cure. However, in many instances, tumors may not be surgically accessible without substantial morbidity, particularly in regard to gliomas arising from the optic or hypothalamic regions, as well as the brainstem. When gross total resection is not feasible, alternative treatment strategies must be considered. While conventional chemotherapy and radiation therapy have long been the backbone of adjuvant therapy for low-grade glioma, emerging techniques and technologies are rapidly changing the landscape of care for patients with this disease...
April 27, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#28
RANDOMIZED CONTROLLED TRIAL
A A Belkin, V A Belkin, I E Vasilchenko, E A Pinchuk
OBJECTIVE: Evaluation of the effect of pharmacological modulation of the rehabilitation process with the drug mexidol as an adjuvant component of the rehabilitation treatment of cognitive-emotional disorders in patients who have suffered acute cerebral insufficiency (ACI) due to acute cerebrovascular accident or traumatic brain injury. MATERIAL AND METHODS: The study was conducted as a randomized interventional prospective study and consisted of 5 visits. Patients were divided into 2 groups: main ( n =30, standard therapy + Mexidol IV 500 mg per day for 10 days, followed by Mexidol FORTE 250 orally, 1 tablet 3 times a day for 8 weeks) and control ( n =30, standard therapy for 66 days)...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#29
MULTICENTER STUDY
A B Danilov, F I Devlikamova, O V Kurushina, Yu V Karakulova, D Yu Butko, A A Smirnova
OBJECTIVE: Evaluation of the effect of Neuromidine on the dynamics of pain syndrome in the treatment of patients with discogenic lumbosacral radiculopathy. MATERIAL AND METHODS: Patients with a confirmed diagnosis of discogenic lumbosacral radiculopathy no more than one year old and moderate intensity of pain syndrome on a visual analog scale were included in the main group (OH, n =62, age - 53.1±15.6 yrs) and the comparison group (HS, n =40, age - 53.7±12...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#30
REVIEW
Angelo Michele Inchingolo, Gianna Dipalma, Alessio Danilo Inchingolo, Irene Palumbo, Mariafrancesca Guglielmo, Roberta Morolla, Antonio Mancini, Francesco Inchingolo
The goal of this review is to shed light on the management of orofacial discomfort after a cancer diagnosis in the head and neck region. A search was conducted on PubMed, Scopus, and Web of Science to identify studies on postoperative pain control in oral cancer. The review included open-access research, investigations into pain management, randomized clinical trials, retrospective studies, case-control studies, prospective studies, English-written studies, and full-text publications. Exclusion criteria included animal studies; in vitro studies; off-topic studies; reviews, case reports, letters, or comments; and non-English language...
April 22, 2024: Pharmaceuticals
#31
JOURNAL ARTICLE
Lucian Dragoș Bratu, Michael Schenker, Puiu Olivian Stovicek, Ramona Adriana Schenker, Alina Maria Mehedințeanu, Tradian Ciprian Berisha, Andreas Donoiu, Stelian Ștefăniță Mogoantă
Background and Objective : In the therapeutic strategy of rectal cancer, radiotherapy has consolidated its important position and frequent use in current practice due to its indications as neoadjuvant, adjuvant, definitive, or palliative treatment. In recent years, total neoadjuvant therapy (TNT) has been established as the preferred regimen compared to concurrent neoadjuvant chemoradiotherapy (CRT). In relation to better outcomes, the percentage of patients who achieved pathological complete response (pCR) after neoadjuvant treatment is higher in the case of TNT...
April 19, 2024: Medicina
#32
REVIEW
David K Lerner, James N Palmer
Olfactory neuroblastoma (ONB) is an uncommon neuroendocrine malignancy arising from the olfactory neuroepithelium. ONB frequently presents with nonspecific sinonasal complaints, including nasal obstruction and epistaxis, and diagnosis can be obtained through a combination of physical examination, nasal endoscopy, and computed tomography and magnetic resonance imaging. Endoscopic resection with negative margins, with or without craniotomy, as necessary, is the standard of care for definitive treatment of ONB...
April 16, 2024: Journal of Personalized Medicine
#33
Tareq Muhammad, Ahmad Alkheder, Abdaljawad Mazloum, Adeeb Almooay, Laura Naziha, Mostafa Shaheen
INTRODUCTION: Castleman Disease (CD) is a rare benign disorder characterized by abnormal lymphoid tissue growth. It can be classified as unicentric CD (UCD) affecting a single lymph node region or multicentric CD (MCD) involving multiple regions. While UCD typically occurs in the mediastinum, MCD is associated with inflammatory symptoms and abnormal lab findings. We present a case of a young Syrian male with pelvic UCD, exhibiting unusual symptoms. Surgical excision led to complete recovery...
April 24, 2024: International Journal of Surgery Case Reports
#34
Abdulrahman F Alesawi, Osamah H Abualross, Norah F Alesawi, Ramy S Samargandi
An osteoblastoma is a benign bone tumor characterized by osteoblast proliferation that is more commonly diagnosed in young men during adolescence and youth. The condition mainly occurs in the posterior regions of the spine and sacrum, but in rare cases, the patella as well. We present a case of patellar osteoblastoma successfully managed through intralesional curettage and grafting, highlighting the need for comprehensive imaging and pathological studies to ensure an accurate diagnosis. A 26-year-old male with a history of knee plica excision presented with persistent knee pain over 1 year...
July 2024: Radiology Case Reports
#35
Mykhaylo Usyk, Richard B Hayes, Rob Knight, Antonio Gonzalez, Huilin Li, Iman Osman, Jeffrey S Weber, Jiyoung Ahn
UNLABELLED: The gut microbiome (GMB) has been associated with outcomes of immune checkpoint blockade therapy in melanoma, but there is limited consensus on the specific taxa involved, particularly across different geographic regions. We analyzed pre-treatment stool samples from 674 melanoma patients participating in a phase-III trial of adjuvant nivolumab plus ipilimumab versus nivolumab, across three continents and five regions. Longitudinal analysis revealed that GMB was largely unchanged following treatment, offering promise for lasting GMB-based interventions...
April 20, 2024: bioRxiv
#36
Shunsuke Furukawa, Masatsugu Hiraki, Takeshi Oda, Yukihiko Takahashi, Ryuichiro Samejima
Although rarely used in laparoscopic surgery, computed tomography (CT)-guided marking is useful for targeting small lesions. The present study describes the performance of laparoscopic resection with preoperative CT-guided marking for lateral lymph node recurrence of rectal cancer. A 48-year-old man underwent laparoscopic low anterior resection with D3 lymph node dissection for rectal cancer (postoperative diagnosis, stage IIIb). Postoperative adjuvant chemotherapy was then administered. Solitary lymph node recurrence was observed in the left lateral region after 6 months...
June 2024: Oncology Letters
#37
JOURNAL ARTICLE
Yanchao Zhang, Tom S Bailey, Philip Hittmeyer, Ludwig J Dubois, Jan Theys, Philippe Lambin
BACKGROUND: Clostridium spp. has demonstrated therapeutic potential in cancer treatment through intravenous or intratumoral administration. This approach has expanded to include non-pathogenic clostridia for the treatment of various diseases, underscoring the innovative concept of oral-spore vaccination using clostridia. Recent advancements in the field of synthetic biology have significantly enhanced the development of Clostridium-based bio-therapeutics. These advancements are particularly notable in the areas of efficient protein overexpression and secretion, which are crucial for the feasibility of oral vaccination strategies...
April 24, 2024: Microbial Cell Factories
#38
JOURNAL ARTICLE
Fatima Aidil-Carvalho, Ana Caulino-Rocha, Joaquim Alexandre Ribeiro, Diana Cunha-Reis
Novelty influences hippocampal-dependent memory through metaplasticity. Mismatch novelty detection activates the human hippocampal CA1 area and enhances rat hippocampal-dependent learning and exploration. Remarkably, mismatch novelty training (NT) also enhances rodent hippocampal synaptic plasticity while inhibition of VIP interneurons promotes rodent exploration. Since VIP, acting on VPAC1 receptors (Rs), restrains hippocampal LTP and depotentiation by modulating disinhibition, we now investigated the impact of NT on VPAC1 modulation of hippocampal synaptic plasticity in male Wistar rats...
April 2024: Journal of Neuroscience Research
#39
JOURNAL ARTICLE
El Omri Malika, Marwa Ben Njima, Bellakhdher Mouna, Nfikha Zeineb, Kemani Wassim, Sriha Badreddine, Abdelkefi Mohamed
Background: Chondrosarcomas are slow-growing malignant tumors that originate in cartilaginous structures. They typically manifest in the head and neck region, with a preference for the maxillofacial skeleton, particularly the mandible and maxilla. However, chondrosarcoma of the sinonasal tract is exceptionally rare, and only few cases have been reported. Case Presentation: This report details the case of a 43-year-old woman who incidentally discovered chondrosarcoma in the maxillary and ethmoid sinuses with nasal extension...
April 24, 2024: Ear, Nose, & Throat Journal
#40
JOURNAL ARTICLE
Vansh Priya, Rafat Shamim, Brijesh Singh, Shipra Singh, Prateek S Bais, Ganpat Prasad
INTRODUCTION: Abdominal wall blocks, in conjunction with multimodal analgesia, have demonstrated efficacy in providing post-operative analgesia, reducing opioid requirements in patients undergoing inguinal hernia repair. The inguinal region is primarily innervated by the ilioinguinal nerve (IIN) and iliohypogastric nerve (IIH). Posterior transverse abdominis plane block (pTAP) and fascia transversalis plane block (TFP) have been observed to reliably block IIN and IIH. We hypothesized that posterior TAP block (pTAP) owing to its potential paravertebral spread will provide better post-operative analgesia than TFP block in patients undergoing unilateral open inguinal hernia repair...
2024: Saudi Journal of Anaesthesia
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