Read by QxMD icon Read

regional adjuvant

Sam Donche, Jeroen Verhoeven, Benedicte Descamps, Julie Bolcaen, Karel Deblaere, Tom Boterberg, Caroline Van den Broecke, Christian Vanhove, Ingeborg Goethals
Glioblastoma is the most aggressive and malignant primary brain tumor in adults. Despite the current state-of-the-art treatment, which consists of maximal surgical resection followed by radiation therapy, concomitant, and adjuvant chemotherapy, progression remains rapid due to aggressive tumor characteristics. Several new therapeutic targets have been investigated using chemotherapeutics and targeted molecular drugs, however, the intrinsic resistance to induced cell death of brain cells impede the effectiveness of systemic therapies...
2019: Frontiers in Medicine
Joseph Zenga, Evan Graboyes, Tyler Janz, Virgina Drake, Eleni Rettig, Shaun Desai, Christopher Nickel, Sepehr Shabani, Tapan Padhya, Mario Scarpinato, Michael Stadler, Becky Massey, Bruce Campbell, Monica Shukla, Musaddiq Awan, Christopher J Schultz, Stuart Wong, Ryan S Jackson, Patrick Pipkorn
OBJECTIVES: To determine the oncologic outcomes of patients undergoing salvage surgery for recurrent oral cavity squamous cell carcinoma (OCSCC) and oropharyngeal squamous cell carcinoma (OPSCC) after initial treatment with surgery and adjuvant therapy. STUDY DESIGN: Retrospective case series with chart review. SETTING: Five academic tertiary care centers. SUBJECTS AND METHODS: Patients included those with OCSCC and OPSCC who were initially treated with surgery and adjuvant therapy between 2000 and 2015 and underwent salvage surgery for local and/or regional recurrence...
February 12, 2019: Otolaryngology—Head and Neck Surgery
Patrick Bach, Georg Weil, Enrico Pompili, Sabine Hoffmann, Derik Hermann, Sabine Vollstädt-Klein, Karl Mann, Ursula Perez-Ramirez, David Moratal, Santiago Canals, Serdar M Dursun, Andrew J Greenshaw, Peter Kirsch, Falk Kiefer, Wolfgang H Sommer
During the first weeks of abstinence, alcohol craving in patients may increase or "incubate." We hypothesize that Naltrexone (NTX) blocks this incubation effect. Here, we compared NTX effects on neural alcohol cue reactivity (CR) over the first weeks of abstinence and on long-term clinical outcomes to standard treatment. Male alcohol-dependent patients (n = 55) and healthy controls (n = 35) were enrolled. Participants underwent baseline psychometric testing and functional magnetic resonance imaging (fMRI) assessment of mesolimbic alcohol CR...
February 12, 2019: Addiction Biology
Beverly Tambe, Clara V Wang, Erik Noren, M Philip Duldulao, Afsaneh Barzi, Sang W Lee
For stage II/III rectal cancer patients, comprehensive multidisciplinary care (MDC) affects outcomes. Randomized trials have shown the effectiveness of adjuvant and neoadjuvant therapy in treatment of these patients. However, the effectiveness of collaboration within MDC is undetermined. It is possible that regional variation in survival outcomes may be tied to treatment facility. We retrospectively reviewed a prospectively collected database of patients with stage II/III rectal cancer who received MDC at any location and underwent oncologic colorectal resection at a tertiary care center (TCC) between 2005 and 2011...
October 1, 2018: American Surgeon
Mohamed M Abdelfatah, Eric M Gochanour
A 53-year-old male was diagnosed with invasive adenocarcinoma of the pre-pyloric region. Imaging studies ruled out metastatic disease. The patient underwent neo-adjuvant chemotherapy followed by a partial gastrectomy. CT scan at 18 months' post-resection demonstrated right upper quadrant lesions suspicious for metastatic disease. EUS exam shows two round hypoechoic lesions. Fine needle aspiration with suction was performed with on-site cytology confirming malignant cells in the masses. Five gold fiducial markers were placed...
February 7, 2019: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
Suhail Al-Salam, Manjusha Sudhadevi, Aktham Awwad, Mohamed Al Bashir
BACKGROUND: Breast carcinoma is the commonest cancer among UAE population and the most common cancer among females. Examination of the 5' promoter regions of trefoil factor 3 (TFF3) gene has identified putative estrogen and progesterone receptor-DNA binding domains as direct response elements to estrogen and progesterone that are linked to breast functions or steroid regulation. The study was designed to determine the role of TFF3 in breast cancer chemoresistance with the aim of establishing TFF3 expression as a biomarker for drug resistance...
February 11, 2019: BMC Cancer
Luke Stroman, Rajesh Nair, Beth Russell, Nabiah Malik, Arjun Desai, Ashish Chandra, Ramesh Thurairaja, Prokar Dasgupta, Muhammad Shamim Khan, Sachin Malde
OBJECTIVES: To determine if the presence of non-urothelial variant histology (NUVH) is associated with a poorer prognosis following radical cystectomy compared to pure urothelial carcinoma. PATIENTS AND METHODS: A prospectively maintained database of all patients undergoing radical cystectomy (RC) at a high-volume regional tertiary bladder cancer service between January 2010 and January 2017 was retrospectively analysed looking for patients displaying NUVH. Multivariate Cox proportional hazards regression analysis was used to determine disease recurrence, overall and bladder cancer specific survival as well as lymph node positivity...
February 11, 2019: BJU International
Hua Ma, Minwen Xu, Yuanyuan Song, Ting Zhang, Hanqiu Yin, Songlou Yin
BACKGROUND AND AIM: Interferon-γ (IFN-γ) is a versatile cytokine which broadly involves in the inflammatory diseases, mediating both immune activation and tolerance. Here, we aimed to investigate the role of IFN-γ in the initiation of adjuvant-induced arthritis (AIA). METHODS AND RESULTS: In an AIA mice model, increasing IFN-γ mRNA was observed at day 3 and peaked on day 7. At day 3, the majority of IFN-γ-producing cells were located around vessels observed by immunofluorescent staining...
February 9, 2019: Scandinavian Journal of Immunology
L Hingsammer, T Seier, J Ikenberg, P Schumann, D Zweifel, M Rücker, M Bredell, M Lanzer
This study was performed to report the outcomes of patients with oral squamous cell carcinoma (OSCC) of the tongue over a 10-year period with the aim of testing the hypothesis that the lymph node ratio (LNR) has a significant influence on loco-regional recurrence. The charts of 227 patients with OSCC of the mobile tongue treated at the University Hospital of Zurich from 2003 to 2012 were screened. Following the application of the exclusion criteria (prior chemotherapy, radiotherapy, or surgery, perioperative death, N3 disease, unresectable disease, synchronous second primary, no signed informed consent, and follow-up <3years), prospective data were collected and a retrospective analysis performed for 88 of these patients who were treated with selective neck dissection...
February 6, 2019: International Journal of Oral and Maxillofacial Surgery
Gennadiy A Katsevman, Ryan C Turner, Ogaga Urhie, Joseph L Voelker, Sanjay Bhatia
OBJECTIVEIt is commonly reported that achieving gross-total resection of contrast-enhancing areas in patients with glioblastoma (GBM) improves overall survival. Efforts to achieve an improved resection have included the use of both imaging and pharmacological adjuvants. The authors sought to investigate the role of sodium fluorescein in improving the rates of gross-total resection of GBM and to assess whether patients undergoing resection with fluorescein have improved survival compared to patients undergoing resection without fluorescein...
February 8, 2019: Journal of Neurosurgery
N Latchana, L Davis, N G Coburn, A Mahar, Y Liu, A Hammad, D Kagedan, M Elmi, M Siddiqui, C C Earle, J Hallet
Background: Pancreatic cancer surgery is increasingly regionalized in high-volume centres. Provision of adjuvant chemotherapy in the same institution can place a burden on patients, whereas receiving adjuvant chemotherapy at a different institution closer to home may create disparities in care. This study compared long-term outcomes of patients with pancreatic adenocarcinoma receiving adjuvant chemotherapy at the institution where they had undergone surgery with outcomes for those receiving chemotherapy at a different institution...
February 2019: BJS open
Maria Eriksson, Jenna Kahari, Amanda Vestman, Mattias Hallmans, Mikael Johansson, A Tommy Bergenheim, Maria Sandström
BACKGROUND: Glioblastoma (GBM) is an aggressive brain tumor with a short overall survival (OS) in general. The treatment of GBM has evolved over the last decades and is today multimodal including surgical resection followed by radiochemotherapy and adjuvant chemotherapy for patients in good performance status. The aim of this study was to evaluate the development of treatment and the outcome for GBM patients at a single regional center. PATIENTS AND METHODS: Survival was studied for 571 patients in our region diagnosed with GBM between 1995 and 2015...
February 7, 2019: Acta Oncologica
Konstantinos Samartzis, Nikolaos Thomakos, Michael Liontos, Dimitra Kollia, Anastasios Malakasis, Dimitrios Haidopoulos, Aristotelis Bamias, Alexandros Rodolakis, Dimitrios Loutradis
Ovarian cancer is a leading cause of cancer-related death in women and often is diagnosed at an advanced stage with diffuse peritoneal carcinomatosis. Since it is mainly confined to the peritoneal cavity, even after recurrence, it is an ideal target for loco-regional therapy. The standard therapeutic strategy of advanced ovarian cancer is cytoreductive surgery followed by systemic chemotherapy. Intraperitoneal chemotherapy used as adjuvant therapy has shown a survival benefit in ovarian cancer. Hyperthermic intraperitoneal chemotherapy (HIPEC) has several advantages over simple intraperitoneal chemotherapy...
December 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Dongyun Zhang, Sarah S R Kim, Daniel F Kelly, Sylvia L Asa, Masoud Movassaghi, Sergey Mareninov, William H Yong, Timothy F Cloughesy, Fausto J Rodriguez, Paul McKeever, Jiang Qian, Jian Yi Li, Qinwen Mao, Kathy L Newell, Richard M Green, Cynthia T Welsh, Zhenggang Xiong, Anthony P Heaney
Context: Neurocytoma (NC) is a rare low grade tumor of the central nervous systems with a 10-year survival of 90% and local control rate of 74%. However 25% of NCs are atypical with an elevated Ki-67 labeling index >2%, and exhibit a more aggressive course with high propensity for local recurrence and/or craniospinal dissemination. Although no standard treatment regimen exists for these atypical cases, adjuvant stereotactic or conventional radiotherapy and/or chemotherapy are typically offered but yield inconsistent results...
February 5, 2019: Journal of Clinical Endocrinology and Metabolism
Qi Yu, Ya-Lian Chen, Shui-Hong Zhou, Zhe Chen, Yang-Yang Bao, Han-Jin Yang, Hong-Tian Yao, Ling-Xiang Ruan
BACKGROUND: Collision carcinoma is rare in clinical practice, especially in the head and neck region. In this paper, we report a case of squamous cell carcinoma (SCC) and neuroendocrine carcinoma (NEC) colliding in the larynx and review 12 cases of collision carcinoma in the head and neck to further understand collision carcinoma, including its definition, diagnosis, and treatment. CASE SUMMARY: A 61-year-old man presented with a 1-year history of hoarseness. Contrast-enhanced magnetic resonance imaging of the larynx revealed that the right vocal cord had a nodule-like thickening with obvious enhancement...
January 26, 2019: World Journal of Clinical Cases
Rohan Fuladi, Rajnish Nagarkar, Sirshendu Roy
BACKGROUND Anaplastic thyroid carcinoma (ATC) is an uncommon and aggressive form of human cancer. Despite advancement in multimodal therapy for patients with ATC, the prognosis remains poor. Most patients presenting with ATC have metastasis to the lungs and regional lymph nodes. Gastrointestinal tract metastasis is a rare entity observed among patients with ATC. We report a case of ATC with gastrointestinal metastasis. CASE REPORT A 72-year-old euthyroid female with hypertension presented to the clinic with swelling of the neck and breathlessness...
February 1, 2019: American Journal of Case Reports
Peng Liu, Zheng Lou, Zubing Mei, Xianhua Gao, Liqiang Hao, Lianjie Liu, Haifeng Gong, Ronggui Meng, Enda Yu, Hantao Wang, Hao Wang, Wei Zhang
OBJECTIVE: To investigate the surgical efficacy and prognostic factors of T3NxM0 middle-low rectal cancer without neoadjuvant therapy. METHODS: Clinical data of patients with middle-low rectal cancer undergoing TME surgery with T3NxM0 confirmed by postoperative pathology at Colorectal Surgery Department of Changhai Hospital from January 2008 to December 2010 were analyzed retrospectively. INCLUSION CRITERIA: (1)no preoperative neoadjuvant chemoradiotherapy (nCRT); (2) complete preoperative evaluation, including medical history, preoperative colonoscopy or digital examination, blood tumor marker examination, and imaging examination; (3) distance between tumor lower margin and anal verge was ≤ 10 cm; (4) negative circumferential resection margin (CRM-)...
January 25, 2019: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Dauren Adilbay, Fariza Khozhamkul, Samal Toiynbekova, Daniar Ahmetov
INTRODUCTION: Dermatofibrosarcoma protuberans (DFSP) is a cutaneous malignancy that arises from the dermis and invades deeper tissue. The cellular origin of DFSP is not clear. Evidence supports the cellular origin being fibroblastic, histiocytic, or neuroectodermal. PRESENTATION OF CASE: A 38 years old, women presented with slow-growing large right parotid mass. A total parotidectomy performed with auriculectomy and reconstruction using ALT flap. Diagnosis confirmed by pathology and immunohistochemistry...
January 22, 2019: International Journal of Surgery Case Reports
Anna Olsson-Brown, Pavlos Piskilidis, Julie O'Hagan, Nicky Thorp, Peter Robson, Helen Innes, Helen Wong, Silvia Cicconi, Richard Jackson, Tamara Kiernan, Christopher Holcombe, Susan O'Reilly, Carlo Palmieri
PURPOSE: The 21-gene recurrence score (Oncotype DX) (RS) informs systemic therapy decision making in ER-positive HER2-negative early breast cancer (BC). To date no study has described the more nuanced discussions that take place regarding systemic therapy or the impact of the RS on concordance in such decision making. Here we utilized a novel decision making tool to assess the impact of the RS on decision making as well as concordance of treatment recommendations. PATIENTS AND METHODS: The clinicopathological information (CPI) of 50 BCs without and with the RS were presented to a panel of breast oncologists in a simulated MDT...
January 18, 2019: Breast: Official Journal of the European Society of Mastology
Di Wei, Guojun Wu, Yu Zheng, Fubao Chen, Jingyi Lu, Yangmin Wang, Dalin He, He Wang, Zhiping Wang, Peng Chen, Yujie Wang, Zhiyong Wang, Yongli Ye, Zheng Zhu, Jianlin Yuan
Recent studies have confirmed the efficacy of sorafenib for patients with advanced renal cell carcinoma; however, its efficacy and safety as an adjuvant therapy in patients with non-metastatic and loco-regional renal cell carcinoma after surgery remains controversial. Thus, the aim of the present retrospective study was to evaluate the efficacy of adjuvant sorafenib therapy in such patients from 8 centers in northwestern China that were treated from August 2009 to December 2016.After surgery, the patients (n = 48) received oral sorafenib for 3 months...
February 2019: Medicine (Baltimore)
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"