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REVIEW
Xia-Hui Huang, Tian-Xiang Chen, Hong-Liang Liu, Ming-Wen Huang
Intraductal papillary neoplasm of the bile duct (IPNB) is a heterogeneous disease similar to intraductal papillary mucinous neoplasm of the pancreas. These lesions have been recognized as one of the three major precancerous lesions in the biliary tract since 2010. In 2018, Japanese and Korean pathologists reached a consensus, classifying IPNBs into type l and type 2 IPNBs. IPNBs are more prevalent in male patients in East Asia and are closely related to diseases such as cholelithiasis and schistosomiasis. From a molecular genetic perspective, IPNBs exhibit early genetic variations, and different molecular pathways may be involved in the tumorigenesis of type 1 and type 2 IPNBs...
May 15, 2024: Current Medical Science
#2
JOURNAL ARTICLE
HeeSoo Kim, Jung Hoon Kim, Jihae An, Jin Sol Choi
PURPOSE: To perform a comparative analysis of surgically resected mucinous cystic neoplasm (MCN) of pancreas and branch-duct type intraductal papillary mucinous neoplasms (BD-IPMN) considering clinico-radiological high-risk predictors for malignant tumors using the current management guidelines. MATERIALS AND METHODS: 224 patients who underwent surgical resection and had histopathologically confirmed MCNs (benign 73; malignant 17) or BD-IPMNs (benign 110; malignant 24) and had pre-operative CT or MRI were retrospectively reviewed...
May 15, 2024: Abdominal Radiology
#3
JOURNAL ARTICLE
Hideyuki Oi, Yuto Hozaka, Toshiaki Akahane, Kosuke Fukuda, Tetsuya Idichi, Kiyonori Tanoue, Yoichi Yamasaki, Yota Kawasaki, Yuko Mataki, Hiroshi Kurahara, Michiyo Higashi, Akihide Tanimoto, Takao Ohtsuka
OBJECTIVE: Krüppel-like transcription factor 4(KLF4) mutations are more frequently observed in low-grade lesions than in high-grade lesions of intraductal papillary mucinous neoplasms (IPMN) of the pancreas. However, the role of KLF4 mutations in IPMNs with concomitant pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study clarified the rate and effect of KLF4 mutations in IPMN with concomitant PDAC. METHODS: DNA was extracted from 65 formalin-fixed and paraffin-embedded samples from 52 patients including 13 IPMN with concomitant PDAC and 39 IPMN alone...
May 15, 2024: Pancreas
#4
JOURNAL ARTICLE
Tokio Wakabayashi, Yukihiro Shirota, Yasuhito Takeda, Yuji Hodo, Yoshimichi Ueda
A 70-year-old man receiving treatment for diabetes mellitus presented with a cystic mass in the border area of the pancreatic body and tail on plain computed tomography (CT) due to impaired glucose intolerance. Contrast-enhanced CT showed a faint hyperattenuated nodular mass extending from the dilated main pancreatic duct (MPD) to the branch duct. Endoscopic retrograde cholangiopancreatography revealed a mildly dilated orifice of the papilla of Vater and MPD stenosis with entire upstream and immediate downstream dilatations...
2024: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
#5
JOURNAL ARTICLE
Ezra Baraban, Elizabeth D Thompson, Andres Matoso, Ralph H Hruban, Pedram Argani
The presence of epithelial cells within lymph node parenchyma is typically indicative of a metastatic malignancy. However, there are rare instances in which non-neoplastic epithelial or epithelioid cells may be found within lymph nodes, either due to aberrant embryologic migration, mechanical displacement, or physiological trafficking. These can potentially lead to serious potential diagnostic pitfalls, as when such situations are encountered by surgical pathologists, there is substantial risk of overdiagnosing these as metastatic malignancy...
May 9, 2024: American Journal of Surgical Pathology
#6
JOURNAL ARTICLE
Shinnosuke Nakayama, Akihisa Fukuda, Satoru Nishikawa, Ayako Hirata, Mari Teramura, Atsushi Takai, Hiroshi Seno
A 77-year-old woman was referred to our hospital due to left upper abdominal pain, appetite loss and body weight loss for 1 month. Her past medical history was diabetes and intraductal papillary mucinous neoplasms (IPMNs). She had no fever and physical examination revealed mild tenderness in the left upper abdomen. Blood tests showed elevated inflammatory response with normal serum pancreatic enzymes. Contrast-enhanced CT showed marked swelling of the pancreatic tail, increased peripancreatic fatty tissue density, multiple IPMNs and obscuration of the enlarged main pancreatic duct at the tail...
May 6, 2024: Clinical Journal of Gastroenterology
#7
JOURNAL ARTICLE
Tomoki Takata, Akihiro Nakamura, Hiroaki Yasuda, Hayato Miyake, Yoshio Sogame, Yuki Sawai, Michiyo Hayakawa, Kentaro Mochizuki, Ryuta Nakao, Takehiro Ogata, Hisashi Ikoma, Eiichi Konishi, Yoshinori Harada, Eigo Otsuji, Yoshito Itoh, Hideo Tanaka
Protein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine...
April 25, 2024: Acta Histochemica et Cytochemica
#8
JOURNAL ARTICLE
Min Cheol Kim, Jung Hoon Kim, Sun Kyung Jeon, Hyo-Jin Kang
PURPOSE: To investigate the common CT findings of high-grade (HG) PanIN and clinical effects in the remnant pancreas in patients with intraductal papillary mucinous neoplasm (IPMN) of the pancreas. MATERIALS AND METHODS: Two hundred fifty-one patients with surgically confirmed IPMNs (118 malignant [invasive carcinoma/high-grade dysplasia] and 133 benign [low-grade dysplasia]) were retrospectively enrolled. The grade of PanIN (233 absent/low-grade and 18 high-grade) was recorded, and all patients underwent serial CT follow-up before and after surgery...
2024: PloS One
#9
Masashi Kuno, Katsutoshi Murase, Masahiro Fukada, Yuta Sato, Jesse Yu Tajima, Nobuhisa Matsuhashi
INTRODUCTION: Dermadrome is a term coined by combining the words "dermatology" and "syndrome," and it refers to dermatological symptoms that reflect visceral lesions. PRESENTATION OF CASE: Herein, we present the case of an 83-year-old female patient who presented with generalized blistering and erythema during treatment for acute pancreatitis. She was referred to our dermatology department with worsening erythema, although the acute pancreatitis improved. The cause of the erythema was suspected to be drug-induced, infectious, or related to collagen disease; however, the exact cause was unknown...
April 21, 2024: International Journal of Surgery Case Reports
#10
JOURNAL ARTICLE
Alessandro Fogliati, Andrea Zironda, Guido Fiorentini, Stella Adjei, Abdelrahman Amro, Patrick P Starlinger, Travis E Grotz, Susanne G Warner, Rory L Smoot, Cornelius A Thiels, Michael L Kendrick, Sean P Cleary, Mark J Truty
No abstract text is available yet for this article.
April 26, 2024: Annals of Surgical Oncology
#11
JOURNAL ARTICLE
Vanisha Patel, Ahmed Abdelbaki, Nirav C Thosani, Somashekar G Krishna
PURPOSE OF REVIEW: Surgery is a cornerstone in the management of pancreatic cancer and precancerous pancreatic lesions. However, many patients are not suitable candidates for surgery at the time of diagnosis for various reasons. Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) appears to be a promising treatment option for patients who are ineligible for surgery for management of pancreatic adenocarcinoma (PDAC), and pancreatic neuroendocrine tumors (PNETs), and pancreatic cystic lesions (PCLs)...
April 15, 2024: Current Opinion in Gastroenterology
#12
REVIEW
Michael Goggins
Pancreatic surveillance can detect early-stage pancreatic cancer and achieve long-term survival, but currently involves annual endoscopic ultrasound and MRI/MRCP, and is recommended only for individuals who meet familial/genetic risk criteria. To improve upon current approaches to pancreatic cancer early detection and to expand access, more accurate, inexpensive, and safe biomarkers are needed, but finding them has remained elusive. Newer approaches to early detection, such as using gene tests to personalize biomarker interpretation, and the increasing application of artificial intelligence approaches to integrate complex biomarker data, offer promise that clinically useful biomarkers for early pancreatic cancer detection are on the horizon...
April 25, 2024: Familial Cancer
#13
JOURNAL ARTICLE
M Lisa Zhang, Yuko Omori, Seung-Mo Hong, Noboru Ideno, Kenjiro Date, Dario M Rocha Castellanos, Stuti G Shroff, Giuseppe Zamboni, Raul S Gonzalez, Toru Furukawa, Carlos Fernandez-Del Castillo, Mari Mino-Kenudson
AIMS: Small invasive carcinomas arising in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas can present as multiple, small foci. In such cases, there is no clear optimal measurement method for determining the invasive size for tumour staging and prognostication. METHODS: In all, 117 small invasive IPMNs (size of largest invasive component ≤2 cm) from seven institutions (2000-2016) were reviewed, and all individual foci of invasive carcinoma were measured...
April 25, 2024: Histopathology
#14
MULTICENTER STUDY
James Lucocq, Jake Hawkyard, Beate Haugk, Omar Mownah, Krishna Menon, Takaki Furukawa, Yosuke Inoue, Yuki Hirose, Naoki Sasahira, Michael Feretis, Anita Balakrishnan, Carlo Ceresa, Brian Davidson, Rupaly Pande, Bobby Dasari, Lulu Tanno, Dimitrios Karavias, Jack Helliwell, Alistair Young, Quentin Nunes, Tomas Urbonas, Michael Silva, Alex Gordon-Weeks, Jenifer Barrie, Dhanny Gomez, Stijn Van Laarhoven, Francis Robertson, Hossain Nawara, Joseph Doyle, Ricky Bhogal, Ewen Harrison, Marcus Roalso, Debora Ciprani, Somaiah Aroori, Bathiya Ratnayake, Jonathan Koea, Gabriele Capurso, Ruben Bellotti, Stefan Stättner, Tareq Alsaoudi, Neil Bhardwaj, Srujan Rajesh, Fraser Jeffery, Saxon Connor, Andrew Cameron, Nigel Jamieson, Amy Sheen, Anubhav Mittal, Jas Samra, Anthony Gill, Keith Roberts, Kjetil Søreide, Sanjay Pandanaboyana
BACKGROUND: The clinical impact of adjuvant chemotherapy after resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia is unclear. The aim of this study was to identify factors related to receipt of adjuvant chemotherapy and its impact on recurrence and survival. METHODS: This was a multicentre retrospective study of patients undergoing pancreatic resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia between January 2010 and December 2020 at 18 centres...
April 3, 2024: British Journal of Surgery
#15
JOURNAL ARTICLE
Stefano Crippa, Giovanni Marchegiani, Giulio Belfiori, Paola Vittoria Maria Rancoita, Tommaso Pollini, Anna Burelli, Laura Apadula, Maria Giovanna Scarale, Davide Socci, Marco Biancotto, Giuseppe Vanella, Paolo Giorgio Arcidiacono, Gabriele Capurso, Roberto Salvia, Massimo Falconi
OBJECTIVE: Cost-effectiveness of surveillance for branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) is debated. We combined different categories of risks of IPMN progression and of IPMN-unrelated mortality to improve surveillance strategies. DESIGN: Retrospective analysis of 926 presumed BD-IPMNs lacking worrisome features (WFs)/high-risk stigmata (HRS) under surveillance. Charlson Comorbidity Index (CACI) defined the severity of comorbidities. IPMN relevant changes included development of WF/HRS, pancreatectomy or death for IPMN or pancreatic cancer...
April 23, 2024: Gut
#16
JOURNAL ARTICLE
Jenny H Chang, Chase Wehrle, Mir Shanaz Hossain, Kimberly Woo, Kathryn Stackhouse, Toms Augustin, Robert Simon, Daniel Joyce, Jason B Fleming, Samer A Naffouje
No abstract text is available yet for this article.
October 17, 2023: Annals of Surgery
#17
Hao Chi, Xiaodong Yan, Wen Tong, Qing Tian
Intraductal papillary mucinous neoplasm of the bile tract is a rare biliary tumor characterized by mucin growth within the bile duct. In the early stages, it often presents without significant obstruction, this often leads to its discovery in the advanced stages. We report a case of a 63-year-old female with an intraductal papillary mucinous neoplasm of the bile duct (IPMN-B). The patient had a history of intrahepatic bile duct stones and biliary ascariasis. She gradually developed symptoms such as jaundice and intermittent fever before admission, and a bile duct biopsy confirmed the diagnosis of IPMN-B...
April 18, 2024: Photodiagnosis and Photodynamic Therapy
#18
JOURNAL ARTICLE
Austin M Eckhoff, Ashley A Fletcher, Matthew S Kelly, Anders Dohlman, Caitlin A McIntyre, Xiling Shen, Matthew K Iyer, Daniel P Nussbaum, Peter J Allen
OBJECTIVE: We sought to comprehensively profile tissue and cyst fluid in patients with benign, precancerous, and cancerous conditions of the pancreas to characterize the intrinsic pancreatic microbiome. SUMMARY BACKGROUND DATA: Small studies in pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) have suggested that intra-pancreatic microbial dysbiosis may drive malignant transformation. METHODS: Pancreatic samples were collected at the time of resection from 109 patients...
April 16, 2024: Annals of Surgery
#19
JOURNAL ARTICLE
Mirko D'Onofrio, Luca Geraci, Riccardo Lombardi De Robertis, Nicolò Cardobi, Alberto Balduzzi, Luisa Tomaiuolo, Eda Bardhi, Niccolò Faccioli, Gregorio Aluffi, Giovanni Marchegiani, Roberto Salvia
BACKGROUND/OBJECTIVES: To analyze the diagnostic performance of three short magnetic resonance imaging (MRI) protocols for the follow-up of pancratic intraductal papillary mucinous neoplasms (IPMN). METHODS: Follow-up MRI examinations of 287 patients with IPMN performed in two centers were retrospectively retrieved. Four MRI protocols were identified as follows: T1-weighted (T1w), T2-weighted (T2w), and MRCP sequences (protocol 1); T1w, T2w, MRCP, and diffusion-weighted (DWI) sequences (protocol 2); T1w, T2w, MRCP, and post-contrast T1w-sequences (protocol 3); and a comprehensive protocol including all previous sequences (protocol 4)...
April 12, 2024: Digestive and Liver Disease
#20
JOURNAL ARTICLE
Sonaz Malekzadeh, Roberto Cannella, Ian Fournier, Philippe Hiroz, Christian Mottet, Christophe Constantin, Lucien Widmer
PURPOSE: To assess the diagnostic value of abbreviated protocol (AP) MRI to detect the degeneration signs in branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) in patients undergoing a routine MRI follow-up. METHODS: This dual-center retrospective study include patients with BD-IPMN diagnosed on initial comprehensive protocol (CP) MRI who underwent routine MRI follow-up. CP included axial and coronal T2-weighted images (T2WI), axial T1-weighted images (T1WI) before and after contrast administration, 3D MR cholangiopancreatography (MRCP) and diffusion-weighted images (DWI)...
April 6, 2024: European Journal of Radiology
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