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JOURNAL ARTICLE
Giuseppe Giuliani, Francesco Guerra, Francesco Matarazzo, Lorenzo De Franco, Michele Di Marino, Andrea Coratti
BACKGROUND: Central pancreatectomy (CP) is a parenchymal-sparing technique indicated for the resection of selected lesions of the neck or proximal body of the pancreas.1,2 The risk of postoperative complications is theoretically doubled because the surgeon has to manage two cut surfaces of the pancreas. The video shows a fully robotic CP to treat a 62-year-old male patient with a mixed-type intraductal papillary mucinous neoplasm (IPMN) of the pancreatic neck, using ultrasound (US) and Wirsung endoscopic evaluation to guide the pancreatic resection and ensure optimal resection margins...
March 31, 2024: Annals of Surgical Oncology
#22
JOURNAL ARTICLE
Antonio Agostini, Geny Piro, Frediano Inzani, Giuseppe Quero, Annachiara Esposito, Alessia Caggiano, Lorenzo Priori, Alberto Larghi, Sergio Alfieri, Raffaella Casolino, Giulia Scaglione, Vincenzo Tondolo, Giovanni Cammarota, Gianluca Ianiro, Vincenzo Corbo, Andrew V Biankin, Giampaolo Tortora, Carmine Carbone
The existing Intraductal Papillary Mucinous Neoplasm (IPMN) risk stratification relies on clinical and histological factors, resulting in inaccuracies and leading to suboptimal treatment. This is due to the lack of appropriate molecular markers that can guide patients toward the best therapeutic options. Here, we assess and confirm subtype-specific markers for IPMN across two independent cohorts of patients using two Spatial Transcriptomics (ST) technologies. Specifically, we identify HOXB3 and ZNF117 as markers for Low-Grade Dysplasia, SPDEF and gastric neck cell markers in borderline cases, and NKX6-2 and gastric isthmus cell markers in High-Grade-Dysplasia Gastric IPMN, highlighting the role of TNFα and MYC activation in IPMN progression and the role of NKX6-2 in the specific Gastric IPMN progression...
March 29, 2024: Nature Communications
#23
JOURNAL ARTICLE
Pingping Yan, Yu Dong, Fenfen Zhang, Tiantian Zhen, Jiangtao Liang, Huijuan Shi, Anjia Han
AIMS: To clarify claudin18.2 expression and its clinicopathological features in various cancers, especially in lung adenocarcinoma. METHODS: Immunohistochemistry staining and fluorescence in situ hybridisation (FISH) were performed to detect claudin18.2 expression and CLDN18 gene rearrangement in adenocarcinoma from different organs. RESULTS: The results showed that claudin18.2 expression was found in 68% (27 of 40) of lung mucinous adenocarcinoma, 52% (16 of 31) of cholangiocarcinoma, 2% (10 of 423) of colorectal adenocarcinoma tissue microarray, 27% (6 of 22) of colorectal mucinous adenocarcinoma and 30% (3 of 10) of cervical adenocarcinoma, but not in all 39 cases of invasive breast adenocarcinoma by immunohistochemistry staining...
March 28, 2024: Journal of Clinical Pathology
#24
REVIEW
Shreyas Krishna, Ahmed Abdelbaki, Phil A Hart, Jorge D Machicado
Pancreatic cancer is on track to become the second leading cause of cancer-related deaths by 2030, yet there is a lack of accurate diagnostic tests for early detection. Intraductal papillary mucinous neoplasms (IPMNs) are precursors to pancreatic cancer and are increasingly being detected. Despite the development and refinement of multiple guidelines, diagnosing high-grade dysplasia or cancer in IPMNs using clinical, radiologic, endosonographic, and cyst fluid features still falls short in terms of accuracy, leading to both under- and overtreatment...
March 21, 2024: Cancers
#25
JOURNAL ARTICLE
Hiromitsu Nakahashi, Tatsuya Oda, Osamu Shimomura, Yoshimasa Akashi, Kazuhiro Takahashi, Yoshihiro Miyazaki, Tomoaki Furuta, Yukihito Kuroda, Pakavarin Louphrasitthiphol, Bryan J Mathis, Hiroaki Tateno
Aberrant glycosylation in tumor cells is a hallmark during carcinogenesis. KRAS gene mutations are the most well-known oncogenic abnormalities but their association with glycan alterations in pancreatic ductal adenocarcinoma (PDAC) is largely unknown. We employed patient-derived 3D organoids to culture pure live PDAC cells, excluding contamination by fibroblasts and immune cells, to gasp the comprehensive cancer cell surface glycan expression profile using lectin microarray and transcriptomic analyses. Surgical specimens from 24 PDAC patients were digested and embedded into a 3D culture system...
2024: Journal of Oncology
#26
JOURNAL ARTICLE
James Lucocq, James Halle-Smith, Beate Haugk, Nejo Joseph, Jake Hawkyard, Jonathan Lye, Daniel Parkinson, Steve White, Omar Mownah, Yoh Zen, Krishna Menon, Takaki Furukawa, Yosuke Inoue, Yuki Hirose, Naoki Sasahira, Anubhav Mittal, Jas Samra, Amy Sheen, Michael Feretis, Anita Balakrishnan, Carlo Ceresa, Brian Davidson, Rupaly Pande, Bobby V M Dasari, Lulu Tanno, Dimitrios Karavias, Jack Helliwell, Alistair Young, Kate Marks, Quentin Nunes, Tomas Urbonas, Michael Silva, Alex Gordon-Weeks, Jenifer Barrie, Dhanny Gomez, Stijn van Laarhoven, Hossam Nawara, Joseph Doyle, Ricky Bhogal, Ewen Harrison, Marcus Roalso, Debora Ciprani, Somaiah Aroori, Bathiya Ratnayake, Jonathan Koea, Gabriele Capurso, Ruben Bellotti, Stefan Stättner, Tareq Alsaoudi, Neil Bhardwaj, Srujan Rajesh, Fraser Jeffery, Saxon Connor, Andrew Cameron, Nigel Jamieson, Kjetil Soreide, Anthony J Gill, Keith Roberts, Sanjay Pandanaboyana
OBJECTIVE: The aim of the present study was to compare long-term post-resection oncological outcomes between A-IPMN and PDAC. SUMMARY BACKGROUND DATA: Knowledge of long term oncological outcomes (e.g recurrence and survival data) comparing between adenocarcinoma arising from intraductal papillary mucinous neoplasms (A-IPMN) and pancreatic ductal adenocarcinoma (PDAC) is scarce. METHODS: Patients undergoing pancreatic resection (2010-2020) for A-IPMN were identified retrospectively from 18 academic pancreatic centres and compared with PDAC patients from the same time-period...
March 22, 2024: Annals of Surgery
#27
JOURNAL ARTICLE
Hiroki Oyama, Tsuyoshi Hamada, Yousuke Nakai, Mariko Tanaka, Kaoru Takagi, Rintaro Fukuda, Ryunosuke Hakuta, Kazunaga Ishigaki, Sachiko Kanai, Yoshikuni Kawaguchi, Kohei Kurihara, Hiroto Nishio, Kensaku Noguchi, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, Yukari Suzuki, Shinya Takaoka, Shuichi Tange, Naminatsu Takahara, Kiyoshi Hasegawa, Tetsuo Ushiku, Mitsuhiro Fujishiro
OBJECTIVE: To examine whether long-term surveillance of intraductal papillary mucinous neoplasms (IPMNs) leads to early diagnosis and better clinical outcomes of pancreatic ductal adenocarcinomas (PDACs) developing concomitantly with IPMNs. SUMMARY BACKGROUND DATA: Long-term image-based surveillance is recommended for patients with low-risk IPMNs. However, it is unknown whether the surveillance can improve surgical and survival outcomes of patients with concomitant PDACs...
March 20, 2024: Annals of Surgery
#28
REVIEW
Paul M Schroder, Ben E Biesterveld, David P Al-Adra
End-stage kidney disease patients who are referred for transplant undergo an extensive evaluation process to ensure their health prior to transplant due in part to the shortage of available organs. Although management and surveillance guidelines exist for malignancies identified in the transplant and waitlist populations, less is written about the management of premalignant lesions in this population. This review covers the less common premalignant lesions (intraductal papillary mucinous neoplasm, gastrointestinal stromal tumor, thymoma, and pancreatic neuroendocrine tumor) that can be found in the transplant candidate population...
March 14, 2024: Seminars in Nephrology
#29
JOURNAL ARTICLE
Sayada Zartasha Kazmi, Hye-Sol Jung, Youngmin Han, Won-Gun Yun, Young Jae Cho, Mirang Lee, Wooil Kwon, Carlos Fernandez-Del Castillo, Marco Del Chiaro, Giovanni Marchegiani, Brian K P Goh, Susumu Hijioka, Shounak Majumder, Yousuke Nakai, Aesun Shin, Jin-Young Jang
BACKGROUND: The management of branch-duct type intraductal papillary mucinous neoplasms (BD-IPMN) varies in existing guidelines. This study investigated the optimal surveillance protocol and safe discontinuation of surveillance considering natural history in non-resected IPMN, by systematically reviewing the published literature. METHODS: This review was guided by PRISMA. Research questions were framed in PICO format "CQ1-1: Is size criteria helpful to determine surveillance period? CQ1-2: How often should surveillance be carried out? CQ1-3: When should surveillance be discontinued? CQ1-4: Is nomogram predicting malignancy useful during surveillance?"...
February 28, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
#30
JOURNAL ARTICLE
Thomas Enzler, Jiaqi Shi, Jake McGue, Brian D Griffith, Lei Sun, Vaibhav Sahai, Hari Nathan, Timothy L Frankel
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of 12.5%. PDAC predominantly arises from non-cystic pancreatic intraepithelial neoplasia (PanIN) and cystic intraductal papillary mucinous neoplasm (IPMN). We used multiplex immunofluorescence and computational imaging technology to characterize, map, and compare the immune microenvironments (IMEs) of PDAC and its precursor lesions. We demonstrate that the IME of IPMN was abundantly infiltrated with CD8+ T cells and PD-L1-positive antigen-presenting cells (APCs), whereas the IME of PanIN contained fewer CD8+ T cells and fewer PD-L1-positive APCs but elevated numbers of immunosuppressive regulatory T cells (Tregs)...
March 3, 2024: International Journal of Molecular Sciences
#31
JOURNAL ARTICLE
Hyo Suk Kim, Young Hoon Choi, Jae Sin Lee, Ik Hyun Jo, Sung Woo Ko, Kyu Hyun Paik, Hyun Ho Choi, Han Hee Lee, Yeon Soo Lim, Chang Nyol Paik, In Seok Lee, Jae Hyuck Chang
BACKGROUND: Little is known about the characteristics of early pancreatic cancer. We aimed to identify the characteristics, clues for early detection, and prognostic factors for early pancreatic cancer by analyzing a large number of patients with stage 1 pancreatic cancer. METHODS: A clinical data warehouse that includes databases of all the medical records of eight academic institutions was used to select and analyze patients with pancreatic cancer that had been diagnosed from January 2010 to May 2023...
February 26, 2024: Cancers
#32
REVIEW
Nicolò Brandi, Matteo Renzulli
The increased detection of pancreatic cysts in recent years has triggered extensive diagnostic investigations to clarify their potential risk of malignancy, resulting in a large number of patients undergoing numerous imaging follow-up studies for many years. Therefore, there is a growing need for optimization of the current surveillance protocol to reduce both healthcare costs and waiting lists, while still maintaining appropriate sensibility and specificity. Imaging is an essential tool for evaluating patients with intraductal papillary mucinous neoplasms (IPMNs) since it can assess several predictors for malignancy and thus guide further management recommendations...
February 23, 2024: Cancers
#33
Vincent Quoc-Huy Trinh, Katherine E Ankenbauer, Jiayue Liu, Maelle Batardiere, H Carlo Maurer, Celina Copeland, Jahg Wong, Olivia Ben-Levy, Sabrina M Torbit, Brenda Jarvis, Frank Revetta, Sergey Ivanov, Nidhi Jyotsana, Yuki Makino, Amanda M Ruelas, Anna L Means, Anirban Maitra, Marcus C B Tan, Kathleen E DelGiorno
OBJECTIVE: Intraductal Papillary Mucinous Neoplasms (IPMNs) are cystic lesions and bona fide precursors for pancreatic ductal adenocarcinoma (PDAC). Recently, we showed that acinar to ductal metaplasia, an injury repair program, is characterized by a transcriptomic program similar to gastric spasmolytic polypeptide expressing metaplasia (SPEM), suggesting common mechanisms of reprogramming between the stomach and pancreas. The aims of this study were to assay IPMN for pyloric markers and to identify molecular drivers of this program...
February 28, 2024: bioRxiv
#34
JOURNAL ARTICLE
Timothy Chao, Zi-Xuan Wang, Wilbur B Bowne, Clifford J Yudkoff, Ava Torjani, Vishal Swaminathan, Taylor R Kavanagh, Austin Roadarmel, Cyrus J Sholevar, Shawnna Cannaday, Geoffrey Krampitz, Tingting Zhan, Eliyahu Gorgov, Avinoam Nevler, Harish Lavu, Charles J Yeo, Stephen C Peiper, Wei Jiang
CONTEXT.—: Mutant KRAS is the main oncogenic driver in pancreatic ductal adenocarcinomas (PDACs). However, the clinical and phenotypic implications of harboring different mutant KRAS alleles remain poorly understood. OBJECTIVE.—: To characterize the potential morphologic and clinical outcome differences in PDACs harboring distinct mutant KRAS alleles. DESIGN.—: Cohort 1 consisted of 127 primary conventional PDACs with no neoadjuvant therapy, excluding colloid/mucinous, adenosquamous, undifferentiated, and intraductal papillary mucinous neoplasm-associated carcinomas, for which an in-house 42-gene mutational panel had been performed...
March 8, 2024: Archives of Pathology & Laboratory Medicine
#35
JOURNAL ARTICLE
Marco Lanzillotta, Lino Iago Belli, Giulio Belfiori, Diego Palumbo, Marco Schiavo-Lena, Gabriele Capurso, Paolo Giorgio Arcidiacono, Lorenzo Dagna, Massimo Falconi, Stefano Crippa, Emanuel Della-Torre
BACKGROUND: Autoimmune Pancreatitis (AIP) is a rare chronic inflammatory disease affecting the pancreas. Chronic pancreatic inflammation represents a risk factor for pre-neoplastic conditions such as Intraductal Papillary Mucinous Neoplasia (IPMN). Due to the rarity of AIP, the incidence, and clinical features of IPMN occurring in AIP patients remains unknown. AIMS: In the present study we aimed to explore the relationship between AIP and IPMN and to characterize the clinical features and outcomes of IPMN occurring in the context of AIP...
March 1, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
#36
JOURNAL ARTICLE
Marie-Madlen Pust, Darío Missael Rocha Castellanos, Kara Rzasa, Andrea Dame, Gleb Pishchany, Charnwit Assawasirisin, Andrew Liss, Carlos Fernandez-Del Castillo, Ramnik J Xavier
OBJECTIVE: This study aims to validate the existence of a microbiome within intraductal papillary mucinous neoplasm (IPMN) that can be differentiated from the taxonomically diverse DNA background of next-generation sequencing procedures. DESIGN: We generated 16S rRNA amplicon sequencing data to analyse 338 cyst fluid samples from 190 patients and 19 negative controls, the latter collected directly from sterile syringes in the operating room. A subset of samples (n=20) and blanks (n=5) were spiked with known concentrations of bacterial cells alien to the human microbiome to infer absolute abundances of microbial traces...
March 1, 2024: Gut
#37
JOURNAL ARTICLE
William E Allen, Joshua D Greendyk, H Richard Alexander, Toni Beninato, Mariam F Eskander, Miral S Grandhi, Haejin In, Timothy J Kennedy, Russell C Langan, Jason C Maggi, Dirk F Moore, Henry A Pitt, Subhajoyti De, Syed F Haider, Brett L Ecker
BACKGROUND: Racial and ethnic disparities have been observed in the multidisciplinary management of pancreatic ductal adenocarcinoma. Intraductal papillary mucinous neoplasm is the most common identifiable precursor to pancreatic ductal adenocarcinoma, where early surgical intervention before the development of an invasive intraductal papillary mucinous neoplasm improves survival. The association of race/ethnicity with the risk of identifying invasive intraductal papillary mucinous neoplasms during resection has not been previously defined...
February 28, 2024: Surgery
#38
JOURNAL ARTICLE
Kenji Takahashi, Tatsutoshi Inuzuka, Yuta Shimizu, Kazuki Sawamoto, Kenzui Taniue, Yusuke Ono, Fumi Asai, Kazuya Koyama, Hiroki Sato, Hidemasa Kawabata, Hidetaka Iwamoto, Keisuke Yamakita, Yohei Kitano, Takashi Teramoto, Mikihiro Fujiya, Satoshi Fujii, Yusuke Mizukami, Toshikatsu Okumura
OBJECTIVES: The role of long noncoding RNAs (lncRNAs) in pancreatic ductal adenocarcinoma (PDAC) remain unclear. Extracellular vesicle (EV)-encapsulated RNAs could be effective targets for liquid biopsy. We aimed to identify previously unknown EV-encapsulated lncRNAs in PDAC and establish highly accurate methods for isolating EVs. MATERIALS AND METHODS: Extracellular vesicles were isolated using existing and newly developed methods, namely, PEViA-UC and PEViA-IP, from serum samples of 20 patients with PDAC, 22 patients with intraductal papillary mucinous neoplasms, and 21 healthy individuals...
February 26, 2024: Pancreas
#39
JOURNAL ARTICLE
Koji Tezuka, Mitsunori Yamakawa, Ryoko Murakami, Ichiro Hirai, Ryo Toya, Akihiko Suzuki, Hiroshi Kawamura, Yuki Miyano, Hidenori Sato, Fuyuhiko Motoi
OBJECTIVES: Intraductal papillary mucinous neoplasm (IPMN) in individuals with at least one first-degree relative with IPMN is defined as familial IPMN. However, few studies have reported on familial IPMN, its clinical characteristics, or the associated genetic factors. MATERIALS AND METHODS: We report the case of a 58-year-old woman with multifocal IPMN and a mural nodule in the pancreatic body. The patient underwent a distal pancreatectomy and developed pancreatic head cancer 1 year and 6 months postoperatively...
February 26, 2024: Pancreas
#40
JOURNAL ARTICLE
Jiandong Yu, Zhu Lin, Zhiping Chen, Guolin Li, Yunle Wan
Minimally invasive pancreatic resections are gaining popularity despite being technically demanding. However, in contrast to laparoscopic pancreatoduodenectomy (LPD), laparoscopic duodenum-preserving pancreatic head resection (LDPPHR) has not yet obtained wide acceptance. This could be attributed to the technical challenges involved in preserving the blood supply of the duodenum and bile duct. This study describes and demonstrates all the steps of LDPPHR. A 48-year-old woman was diagnosed with a 3.0 cm x 2...
February 9, 2024: Journal of Visualized Experiments: JoVE
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