Claire Ducos, Naïla Aba, Filippo Rosselli, Brice Fresneau, Baraah Al Ahmad Nachar, Monia Zidane, Florent de Vathaire, Simone Benhamou, Nadia Haddy
Second malignant neoplasm (SMN) is one of the most severe long-term risks for childhood cancer survivors (CCS), significantly impacting long-term patient survival. While radiotherapy and chemotherapy are known risk factors, the observed inter-individual variability suggests a genetic component contributing to the risk of SMN. This article aims to conduct a systematic review of genetic factors implicated in the SMN risk among CCS. Searches were performed in PubMed, Scopus, and Web of Sciences. Eighteen studies were included (eleven candidate gene studies, three genome-wide association studies, and four whole exome/genome sequencing studies)...
May 27, 2024: Cancer Epidemiology, Biomarkers & Prevention