Qiuping Qian, Jige Chen, Mingming Qin, Yu Pei, Chunxiu Chen, Dongping Tang, Pooyan Makvandi, Wei Du, Guoqiang Yang, Haiping Fang, Yunlong Zhou
Optimizing the antibacterial effectiveness of copper ions while reducing environmental and cellular toxicity is essential for public health. A copper chelate, named PAI-Cu, is skillfully created using a specially designed carboxyl copolymer (a combination of acrylic and itaconic acids) with copper ions. PAI-Cu demonstrates a broad-spectrum antibacterial capability both in vitro and in vivo , without causing obvious cytotoxic effects. When compared to free copper ions, PAI-Cu displays markedly enhanced antibacterial potency, being about 35 times more effective against Escherichia coli and 16 times more effective against Staphylococcus aureus ...
May 3, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine