Peter Boknik, Katharina Drzewiecki, John Eskandar, Ulrich Gergs, Britt Hofmann, Hendrik Treede, Stephanie Grote-Wessels, Larissa Fabritz, Paulus Kirchhof, Lisa Fortmüller, Frank Ulrich Müller, Wilhelm Schmitz, Norbert Zimmermann, Uwe Kirchhefer, Joachim Neumann
Adenosine can be released from the heart and may stimulate four different cardiac adenosine receptors. A receptor subtype that couples to the generation of cyclic adenosine monophosphate (cAMP) is the A2A -adenosine receptor (A2A -AR). To better understand its role in cardiac function, we studied mechanical and electrophysiological effects in transgenic mice that overexpress the human A2A -AR in cardiomyocytes (A2A -TG). We used isolated preparations from the left atrium, the right atrium, isolated perfused hearts with surface electrocardiogram (ECG) recording, and surface body ECG recordings of living mice...
2019: Frontiers in Pharmacology