Jakob Hibberd, Justin Leontini, Thomas Scott, J Jane Pillow, Martijn Miedema, Peter C Rimensberger, David Gerald Tingay
High-frequency oscillatory ventilation (HFOV) is an established mode of respiratory support in the neonatal intensive care unit. Large clinical trial data is based on first intention use in preterm infants with acute respiratory distress syndrome. Clinical practice has evolved from this narrow population. HFOV is most often reserved for term and preterm infants with severe, and often complex, respiratory failure not responding to conventional modalities of respiratory support. Thus, optimal, and safe, application of HFOV requires the clinician to adapt mean airway pressure, frequency, inspiratory:expiratory ratio and tidal volume to individual patient needs based on pathophysiology, lung volume state and infant size...
September 19, 2023: Archives of Disease in Childhood. Fetal and Neonatal Edition