Shuangqin Yin, Weihong Dai, Tianyin Kuang, Jing Zhou, Li Luo, Shengxiang Ao, Xue Yang, Hongyan Xiao, Lin Qiao, Rixing Wang, Fei Wang, Caihong Yun, Shaowen Cheng, Junyu Zhu, Huaping Liang
Punicalagin (PUN) is a polyphenol derived from the pomegranate peel. It has been reported to have many beneficial effects, including anti-inflammatory, anti-oxidant, and anti-proliferation. However, the role of PUN in macrophage phagocytosis is currently unknown. In this study, we found that pre-treatment with PUN significantly enhanced phagocytosis by macrophages in a time- and dose-dependent manner in vitro. Moreover, KEGG enrichment analysis by RNA-sequencing showed that differentially expressed genes following PUN treatment were significantly enriched in phagocyte-related receptors, such as the C-type lectin receptor signaling pathway...
February 28, 2024: European Journal of Pharmacology