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JOURNAL ARTICLE
Ganesh Viswanathan, Vivek Mathew, Mallikarjuna Jeeragi, Belinda George, Ganapathi Bantwal, Vageesh Ayyar, John Michael
Primary hyperparathyroidism (PHPT) is a common endocrine disease with a variable presentation. There is a recent increase in the number of asymptomatic cases due to the use of multichannel automated analyzers.
April 30, 2024: Folia Medica
#2
JOURNAL ARTICLE
I-L Nilsson, D Thorsteinsson, C Nylén, A Koman, Fredrik Granath, R Bränström
BACKGROUND: The extent of parathyroidectomy (PTX) recommendation in patients with lithium-associated hyperparathyroidism (LAH) remains controversial. The primary objectives of this study were to analyze extent of surgery, complications, and long-term outcomes. METHODS: A population-based study, including all primary hyperparathyroidism (PHPT) patients who underwent PTX in Sweden between 2008 and 2017. Data on exhibited lithium prescriptions, morbidity, surgical approach, and outcomes were collected from relevant national registers and the Scandinavian Quality Register of Thyroid, Parathyroid, and Adrenal Surgery...
February 2024: World Journal of Surgery
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JOURNAL ARTICLE
Pilar de Las Mercedes Pereyra, María de Los Ángeles Aciar, María Mercedes Fregenal, Gustavo A Ceballos, Luis A Ramírez Stieben
Primary hyperparathyroidism (PHPT) is characterized by elevated levels of calcium and parathyroid hormone (PTH). However, the interpretation of diagnostic tests, such as serum calcium and PTH levels, is complex in pregnant women. The aim of this report is to present a case of PHTP in a pregnant adolescent, with a special emphasis on an uncommon complication, as well as diagnostic and treatment strategies. A 17-year-old pregnant female presented with hyperemesis gravidarum and neurological symptoms, leading to the diagnosis of cerebral venous thrombosis...
2024: Medicina
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JOURNAL ARTICLE
Areej I Alhazmi, Abdullah Mushra Alghamdi, Fahad S Alghamdi, Maathir N Alhumam, Mujahid Khalid Nasser Alghamdi, Ghayda A Alghamdi, Salman Ahmed S Jathmi
Introduction Anxiety and depression are prevalent psychological issues among hemodialysis patients, adversely affecting their well-being and treatment response. The study aims to identify the relationship between these mental health concerns and hyperparathyroidism in chronic hemodialysis patients from the Al Baha Region, Kingdom of Saudi Arabia. Methods This retrospective study included 143 chronic hemodialysis patients aged 18-85 years. Monthly laboratory records for parathyroid hormone (PTH) levels and the Hospital Anxiety and Depression Scale (HADS) for mental health assessment were utilized...
March 2024: Curēus
#5
Francesco Di Marco, Claudio Cusini, Anna Ferrulli, Giovanni Mauri, Livio Luzi
BACKGROUND: Currently, parathyroidectomy is the standard treatment for Primary Hyperparathyroidism (PHPT). Surgical treatment is often effective, although not free of complications and relapses. Minimally invasive techniques, such as Microwave Ablation (MWA) and Radiofrequency Ablation (RFA), are an alternative to surgery in selected patients. We have, herein, reported on the successful use of RFA in a patient with post-surgical persistent hyperparathyroidism. CASE PRESENTATION: A 54-year-old woman was referred to our Center for mild hypercalcemia with exams revealing Primary Hyperparathyroidism (PHPT)...
April 26, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
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JOURNAL ARTICLE
Emilie Kirstein, Dirk Schaudien, Mathias Wagner, Coline M Diebolt, Alessandro Bozzato, Thomas Tschernig, Colya N Englisch
Transient receptor potential canonical sub-family channel 3 (TRPC3) is considered to play a critical role in calcium homeostasis. However, there are no established findings in this respect with regard to TRPC6. Although the parathyroid gland is a crucial organ in calcium household regulation, little is known about the protein distribution of TRPC channels-especially TRPC3 and TRPC6-in this organ. Our aim was therefore to investigate the protein expression profile of TRPC3 and TRPC6 in healthy and diseased human parathyroid glands...
April 16, 2024: International Journal of Molecular Sciences
#7
JOURNAL ARTICLE
Ritwik Ghosh, Moisés León-Ruiz, Kunal Bole, Souvik Dubey, Julián Benito-León
BACKGROUND: Hypercalcemia-induced posterior reversible encephalopathy syndrome (PRES) is a rare entity primarily associated with iatrogenic vitamin D/calcium overdose, malignancy, or, infrequently, primary hyperparathyroidism. CASE REPORT: We present a novel case of an adult male from rural India who experienced recurrent acute pancreatitis caused by hypercalcemia with concurrent manifestation of PRES. Diagnostic evaluation revealed markedly elevated serum calcium levels and parathyroid hormone concentrations, consistent with primary hyperparathyroidism...
April 2024: Neurohospitalist
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REVIEW
Dorota Leszczyńska, Alicja Szatko, Julia Latocha, Magdalena Kochman, Maria Duchnowska, Anna Wójcicka, Waldemar Misiorowski, Wojciech Zgliczyníski, Piotr Glinicki
INTRODUCTION: 24-Hydroxylase, encoded by the CYP24A1 gene, is a crucial enzyme involved in the catabolism of vitamin D. Loss-of-function mutations in CYP24A1 result in PTH-independent hypercalcaemia with high levels of 1,25(OH)2 D3 . The variety of clinical manifestations depends on age, and underlying genetic predisposition mutations can lead to fatal infantile hypercalcaemia among neonates, whereas adult symptoms are usually mild. AIM OF THE STUDY: We report a rare case of an adult with primary hyperparathyroidism and loss-of-function mutations in the CYP24A1 gene and a review of similar cases...
2024: Frontiers in Endocrinology
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JOURNAL ARTICLE
Kamal Govind, Imran M Paruk, Ayesha A Motala
BACKGROUND: There has been a notable shift towards the diagnosis of less severe and asymptomatic primary hyperparathyroidism (PHPT) in developed countries. However, there is a paucity of recent data from sub-Saharan Africa (SSA), and also, no reported data from SSA on the utility of intra-operative parathyroid hormone (IO-PTH) monitoring. In an earlier study from Inkosi Albert Luthuli Central Hospital (IALCH), Durban, South Africa (2003-2009), majority of patients (92.9%) had symptomatic disease...
April 25, 2024: BMC Endocrine Disorders
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JOURNAL ARTICLE
Hiroyuki Yamashita, Hisakazu Shindo, Kouichi Yoshimoto, Yusuke Mori, Takashi Fukuda, Seigo Tachibana, Hiroshi Takahashi, Shinya Sato
BACKGROUND: Intraoperative parathyroid hormone (IOPTH) monitoring is a critical surgical adjunct for determining the extent of surgery for primary hyperparathyroidism (PHPT), with reported false-positive and false-negative rates of up to 10%. Surgeons must understand the parathyroid hormone (PTH) dynamics and select the appropriate IOPTH protocol and interpretation criteria for curative surgery. CASE PRESENTATION: We present the case of a 64-year-old woman with a large cystic parathyroid tumor and PHPT who experienced a significant delay in IOPTH decrease but was cured without additional surgery...
April 25, 2024: Surgical Case Reports
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Helena Martínez Sánchez, Francisca Moreno Macián, Sara León Cariñena, Carmen de Mingo Alemany, Lidia Blasco González, Raquel Sánchez Vañó
OBJECTIVES: The most common cause of primary hyperparathyroidism (PPH) in children is a parathyroid adenoma. Among this population, PPH exhibits higher levels of morbidity, severity and target organ involvement compared to adults. When there is suspicion of PPH, cervical ultrasound and 99m Tc-sestamibi SPECT/CT are the imaging test traditionally indicated. Among adults, the use of [18 F]fluorocholine PET/CT has shown a higher sensitivity than ultrasound and [99m Tc]sestamibi SPECT/CT, leading to an expanding adoption in recent years...
April 26, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
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REVIEW
Alexander S Chiu, Markayle Schears, Mary Hitchcock, Rebecca Sippel, Amy Kind
BACKGROUND: Primary hyperparathyroidism is underdiagnosed and surgical treatment is underutilized and inequitably distributed. We present a review of the current literature on disparities in the treatment of hyperparathyroidism, with a focus on gaps in knowledge and paths forward. METHODS: We searched PubMed and Scopus for abstracts related to disparities in hyperparathyroidism. RESULTS: 16 articles (of 1541) met inclusion criteria. The most commonly examined disparity was race...
April 16, 2024: American Journal of Surgery
#13
JOURNAL ARTICLE
Mickael Barbosa, Yannic Pannatier-Schuetz, Anna Chiara Nascimbeni, Daniela Gallo Castro, Nicolas Owlya, Aude Ambresin
No abstract text is available yet for this article.
April 2024: Klinische Monatsblätter Für Augenheilkunde
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JOURNAL ARTICLE
Pieter Evenepoel, Hanne Skou Jørgensen
PURPOSE OF REVIEW: Defining the optimal parathyroid hormone (PTH) target in chronic kidney disease (CKD) is challenging, especially for bone outcomes, due to the substantial variability in the skeleton's response to PTH. Although PTH hyporesponsiveness is as integral a component of CKD-mineral bone disorder as elevated PTH levels, clinical awareness of this condition is limited. In this review, we will discuss factors and mechanisms contributing to PTH hyporesponsiveness in CKD. This knowledge may provide clues towards a personalized approach to treating secondary hyperparathyroidism in CKD...
April 24, 2024: Current Opinion in Nephrology and Hypertension
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Yen Zhir Tay, Narendran Balasubbiah, Raflis Ruzairee Awang, Benedict Dharmaraj Retna Pandian, Narasimman Sathiamurthy
Primary hyperparathyroidism (PHPT) usually presents with symptoms of hypercalcemia which is due to excessive secretion of parathyroid hormone (PTH). Surgical removal of the secreting tumor either adenoma or hyperplasia remains the mainstay of treatment. Around 2% to 25% of the lesions are located in the mediastinum. We reviewed our institution's surgical treatment and approach to mediastinal parathyroid adenoma (MPA). We retrospectively reviewed the demography, comorbidities, clinical presentation, surgical approach, and outcome for patients in our institution who underwent surgery for MPA from September 2019 until August 2023...
March 2024: Curēus
#16
Fabio Vescini, Giorgio Borretta, Iacopo Chiodini, Marco Boniardi, Marina Carotti, Elena Castellano, Cristiana Cipriani, Cristina Eller-Vainicher, Sandro Giannini, Maurizio Iacobone, Antonio Stefano Salcuni, Federica Saponaro, Stefano Spiezia, Annibale Versari, Guido Zavatta, Zuzana Mitrova, Rosella Saulle, Simona Vecchi, Debora Antonini, Michele Basile, Alexia Giovanazzi, Agostino Paoletta, Enrico Papini, Agnese Persichetti, Irene Samperi, Alessandro Scoppola, Roberto Novizio, Pietro Giorgio Calò, Filomena Cetani, Luisella Cianferotti, Sabrina Corbetta, Maria Luisa De Rimini, Alberto Falchetti, Giovanni Iannetti, Stefano Laureti, Celestino Pio Lombardi, Bruno Madeo, Claudio Marcocci, Sandro Mazzaferro, Vittorio Miele, Salvatore Minisola, Andrea Palermo, Jessica Pepe, Alfredo Scillitani, Laura Tonzar, Franco Grimaldi, Renato Cozzi, Roberto Attanasio
AIM: This guideline (GL) is aimed at providing a clinical practice reference for the management of sporadic primary hyperparathyroidism (PHPT) in adults. PHPT management in pregnancy was not considered. METHODS: This GL has been developed following the methods described in the Manual of the Italian National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinology (AME) and Società Italiana dell'Osteoporosi, del Metabolismo Minerale e delle Malattie dello Scheletro (SIOMMMS) identified potentially relevant outcomes, which were then rated for their impact on therapeutic choices...
December 23, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
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JOURNAL ARTICLE
Donal Fitzpatrick, Eamon Laird, Mary Ward, Leane Hoey, Catherine F Hughes, J J Strain, Conal Cunningham, Martin Healy, Anne M Molloy, Helene McNulty, Rosaleen Lannon, Kevin McCarroll
INTRODUCTION: Secondary hyperparathyroidism (SHPT) has adverse implications for bone health but is relatively understudied. In this study we examine the prevalence and determinants of SHPT and describe the relationship of SHPT with bone turnover markers and bone mineral density (BMD) in older Irish adults. METHOD: Eligible participants (n = 4139) were identified from the Trinity-Ulster-Department of Agriculture (TUDA) study, a cohort of Irish adults aged ≥60 years...
April 18, 2024: Bone
#18
JOURNAL ARTICLE
Meric Coskun, Afruz Babayeva, Tugba Barlas, Mehmet Muhittin Yalcin, Mujde Akturk, Fusun Toruner, Mehmet Ayhan Karakoc, Tarkan Karakan, Mehmet Cindoruk, İlhan Yetkin, Alev Altinova
Parathyroid hormone (PTH) interacts with components of the gut microbiota to exert its bone-regulating effects. This study aimed to investigate the gut microbial composition in patients with primary hyperparathyroidism (PHPT). Nine patients with PHPT and nine age-sex and body mass index-matched healthy controls were included. Gut microbial composition was assessed using 16S rRNA gene amplicon sequencing in both groups at baseline and one month after parathyroidectomy in the PHPT group. Data were imported into QIIME-2 and both QIIME-2 and R packages were used for microbiome analysis...
April 19, 2024: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
#19
JOURNAL ARTICLE
Haleh Chehrehgosha, Hossein Chegini, Iraj Heydari, Hojat Ebrahiminik, Rambod Salouti, Jafar Golzarian
PURPOSE: To present the effectiveness and safety of radiofrequency ablation (RFA) in parathyroid adenoma (PTA). MATERIALS AND METHODS: In this retrospective study, 60 patients with a single PTA were evaluated for changes in biochemical and ultrasonographic features up to 6 months after RFA of the lesion. Adenomas were ablated with an alternative technique so called "Nik jet dissection" which incorporates full hydrodissection and polar artery coagulation. Complications as well as the variations in biochemical data and nodule volumes were analyzed between baseline measurements and at each follow-up interval data (first day, 1, 3, and 6 months after ablation) were analyzed...
April 19, 2024: Cardiovascular and Interventional Radiology
#20
Kimitaka Shibue, Nozomi Kubo, Hiromi Oda, Etsuko Tanabe, Tsutomu Okada, Cheng-Long Huang, Toshihiro Higuchi, Akihiro Hamasaki, Nobuya Inagaki
In the realm of obstetric care, discerning the subtle signs of primary hyperparathyroidism (PHPT) amidst common pregnancy symptoms remains a formidable challenge. Our exploration into a case of gestational hypercalcemia peels back the layers of this complexity, revealing the clinical conundrum posed by overlapping gastrointestinal manifestations. The journey from diagnosis through surgical intervention to the resolution of symptoms underscores the importance of vigilance for PHPT in pregnant patients. This case further prompts consideration of gamma-aminobutyric acid (GABA) as a potential piece in the puzzle of persistent symptoms post-calcium normalization, inviting a broader dialogue on the intricacies of parathyroid pathology in pregnancy...
March 2024: Curēus
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