Meilin Zhu, Matthew W Frank, Christopher D Radka, Sarah Jeanfavre, Megan W Tse, Julian Avila Pacheco, Kerry Pierce, Amy Deik, Jiawu Xu, Salina Hussain, Fatima Aysha Hussain, Nondumiso Xulu, Nasreen Khan, Vanessa Pillay, Krista L Dong, Thumbi Ndung'u, Clary B Clish, Charles O Rock, Paul C Blainey, Seth M Bloom, Douglas S Kwon
Bacterial vaginosis (BV), a common syndrome characterized by Lactobacillus -deficient vaginal microbiota, is associated with adverse health outcomes. BV often recurs after standard antibiotic therapy in part because antibiotics promote microbiota dominance by Lactobacillus iners instead of Lactobacillus crispatus , which has more beneficial health associations. Strategies to promote L. crispatus and inhibit L. iners are thus needed. We show that oleic acid (OA) and similar long-chain fatty acids simultaneously inhibit L...
December 30, 2023: bioRxiv