William A Hall, Angela J Mathison, Elias DeVoe, Michael Tschannen, Jaime Wendt-Andrae, Michael Straza, Musaddiq Awan, Lindsay L Puckett, Colleen A F Lawton, Christopher Schultz, Raul Urrutia, Sarah Kerns, Javier F Torres-Roca, X Allen Li, Beth Erickson, Marja T Nevalainen, Michael T Zimmermann, Eric Paulson
PURPOSE: Changes in quantitative magnetic resonance imaging (qMRI) are frequently observed during chemotherapy or radiation therapy (RT). It is hypothesized that qMRI features are reflective of underlying tissue responses. It's unknown what underlying genomic characteristics underly qMRI changes. We hypothesized that qMRI changes may correlate with DNA damage response (DDR) capacity within human tumors. Therefore, we designed the current study to correlate qMRI changes from daily RT treatment with underlying tumor transcriptomic profiles...
May 29, 2024: International Journal of Radiation Oncology, Biology, Physics