Bryanna Shao, Mason Killion, Ashton Oliver, Chia Vang, Faben Zeleke, Kit Neikirk, Zer Vue, Edgar Garza-Lopez, Jian-Qiang Shao, Margaret Mungai, Jacob Lam, Qiana Williams, Christopher T Altamura, Aaron Whiteside, Kinuthia Kabugi, Jessica McKenzie, Maria Ezedimma, Han Le, Alice Koh, Estevão Scudese, Larry Vang, Andrea G Marshall, Amber Crabtree, Janelle I Tanghal, Dominique Stephens, Ho-Jin Koh, Brenita C Jenkins, Sandra A Murray, Anthonya T Cooper, Clintoria Williams, Steven M Damo, Melanie R McReynolds, Jennifer A Gaddy, Celestine N Wanjalla, Heather K Beasley, Antentor Hinton
The sorting and assembly machinery (SAM) Complex is responsible for assembling β-barrel proteins in the mitochondrial membrane. Comprising three subunits, Sam35, Sam37, and Sam50, the SAM complex connects the inner and outer mitochondrial membranes by interacting with the mitochondrial contact site and cristae organizing system complex. Sam50, in particular, stabilizes the mitochondrial intermembrane space bridging (MIB) complex, which is crucial for protein transport, respiratory chain complex assembly, and regulation of cristae integrity...
May 21, 2024: Journal of Cellular Physiology