Kyung Hoon Kim, Jongmin Lee, Hee-Je Kim, Seok Lee, Yoo-Jin Kim, Jong Hyuk Lee, Chin Kook Rhee
Background: Bronchiolitis obliterans syndrome (BOS) is a rare, progressive and irreversible airway disease associated with significant mortality after allogeneic hematopoietic stem-cell transplantation (HSCT). In this study, we investigated the therapeutic effect of high-dose budesonide/formoterol (320/9 µg bid) in patients with BOS after HSCT already using low-dose budesonide/formoterol (160/4.5 µg bid). Methods: After a retrospective chart review, patients who were initially treated with budesonide/formoterol 160/4...
August 2020: Journal of Thoracic Disease
Xiao-Wen Chen, De-Hui Chen, Shang-Zhi Wu, Na Xie, Wen-Kuan Liu, Yu-Neng Lin, Ya-Wen Zhang, Qing-Si Zeng
OBJECTIVE: To study the value of anti-neutrophil cytoplasmic antibody (ANCA) in assessing the severity of bronchiolitis obliterans (BO) in children. METHODS: A prospective analysis was performed on 59 children who were diagnosed with BO from June 2009 to October 2014. ELISA was used to measure the concentrations of myeloperoxidase (MPO)-ANCA and proteinase 3 (PR3)-ANCA in serum. According to the results of ELISA, the children were divided into three groups: double-negative ANCA (n=22), single-positive ANCA (n=17), and double-positive ANCA (n=20)...
September 2020: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Takeshi Shiraishi, Haruhisa Yanagida, Yuhki Koga, Shouichi Ohga, Masaki Fujita, Masafumi Hiratsuka, So Miyahara, Ryuichi Waseda, Toshihiko Sato, Akinori Iwasaki
Left-unilateral single-lobe lung transplantation from a living donor was performed in a 4-year-old boy who suffered from severe respiratory failure caused by bronchiolitis obliterans (BO) as a result of graft versus host disease (GVHD) after peripheral blood stem cell transplantation (PBSCT). The patient grew well during his early childhood years, with an excellent lung allograft function. However, severe thoracic scoliosis occurred 7 years after lung transplantation, which ultimately resulted in compression of the lung allograft followed by severe respiratory dysfunction, and the patient became dependent on mechanical ventilation support...
September 15, 2020: General Thoracic and Cardiovascular Surgery
Zhenjie Liu, Aijun Shang, Zexin Chen, Li Yin, Hongjun Qi
Serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) are standard biomarkers of contrast-induced nephropathy (CIN). However, recent studies suggest that serum neutrophil gelatinase-associated lipocalin (sNGAL) and urine neutrophil gelatinase-associated lipocalin (uNGAL) may be better predictors, particularly within 24 hours of contrast medium exposure.We conducted a prospective, observational cohort study of 107 consecutive patients diagnosed with arteriosclerosis obliterans between February 2016 and October 2018...
September 11, 2020: Medicine (Baltimore)
Stacy Chapman, Karen Ballinger, Ming-Ka Chan, Camelia Stefanovici, Katya Rozovsky, April Boyd, Magimairajan I Vanan
Arterial occlusive disease of the limb is very rare in children. Buerger's disease (BD) is a nonatherosclerotic, segmental inflammatory arteritis affecting the small and medium-sized vessels of the extremities. We report BD in a 16-year-old male presenting with arterial insufficiency of left foot and history of smoking cigarettes and cannabis for 2 years. BD was diagnosed based on history of smoking in combination with clinical, laboratory, and radiologic findings. Pediatric hemato-oncologists should consider BD in the differential diagnosis in adolescents who smoke cigarettes and/or cannabis and present with vascular insufficiency of the hands and/or feet...
September 9, 2020: Journal of Pediatric Hematology/oncology
Masayuki Nakamura, Amane Ike, Yuta Kato, Makito Futami, Takashi Kuwano, Makoto Sugihara, Atsushi Iwata, Akira Kawamura, Yasunori Suematsu, Shin-Ichiro Miura
We investigated the lesion characteristics and patient background factors associated with the medium-term incidence of major adverse cardiac events (MACEs) for bare-metal stents (BMS) and 1st-, 2nd- and 3rd-generation drug-eluting stents (DES) using the PCI-Registry (FU-Registry). Between January 2003 and March 2016, 2967 cases/3508 lesions for which percutaneous coronary intervention was performed at Fukuoka University Hospital and related facilities were enrolled. Patients were divided into BMS and 1st-, 2nd- and 3rd-generation drug-eluting stent (DES) groups...
September 11, 2020: Heart and Vessels
Gabriela Leuschner, Michael Lauseker, Anne-Sophie Howanietz, Katrin Milger, Tobias Veit, Dieter Munker, Christian Schneider, Thomas Weig, Sebastian Michel, Jürgen Barton, Bruno Meiser, Julien Dinkel, Claus Neurohr, Jürgen Behr, Nikolaus Kneidinger
BACKGROUND: Phenotyping chronic lung allograft dysfunction (CLAD) in single lung transplant (SLTX) recipients is challenging. The aim of this study was to assess the diagnostic and prognostic value of longitudinal lung function tests in SLTX recipients with CLAD. METHODS: A total of 295 SLTX recipients were analyzed and stratified according to native lung physiology. In addition to spirometry, measurements of static lung volumes and lung capacities were used to phenotype patients and to assess their prognostic value...
August 26, 2020: Journal of Heart and Lung Transplantation
Ming Dong, Xin Wang, Tong L, Jing Wang, Yunwei Yang, Yi Liu, Yaqing Jing, Honglin Zhao, Jun Chen
Bronchiolitis obliterans (BO), is a chronic rejection phenotype characterized by chronic small airway fibrous obliteration, hinders the patients who suffer from lung transplanting for surviving longer. Cell-based therapies using dendritic cells (DCs) and T regulatory cells (Tregs) have been developed to regulate allograft rejection, and to induce and maintain immune tolerance. In the present study, the effects of mir-27a-3p on regulating DCs as well as resulting effects on BO attenuation have been investigated...
August 2020: Clinical and Translational Medicine
Wenjiao Tang, Ting Yu, Tian Dong, Ting Liu, Jie Ji
Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic cell transplantation (allo-HCT) usually confers poor prognosis and high mortality. Currently, therapeutic options are limited. Here we report an 18-year-old man with acute myeloid leukemia developed BOS after allo-HCT and responded poorly to inhaled corticosteroids and short-acting β-agonist, azithromycin, montelukast, and immunosuppressants. Then he started nintedanib treatment, and the symptoms of nonproductive cough and dyspnea were alleviated gradually...
September 2020: Chest
Ajay Sheshadri
No abstract text is available yet for this article.
September 2020: Chest
Yue Lin, Shichai Hong, WeiGuo Fu, LiXin Wang, Daqiao Guo, Zhenyu Shi, Weifeng Lu, Xiang Hong, Gang Chen, Yulong Huang, Yihui Chen
BACKGROUND: The aim of this study was to evaluate the efficacy and safety of a novel self-expanding nitinol stent (Smartflex stent) in femoropopliteal artery obliterans disease. METHODS: From June 2016 to May 2019, patients with atherosclerotic occlusion disease of the superficial femoral and popliteal arteries using the Smartflex stents were retrospectively analyzed in our institution. Patients were monitored at 1, 3, 6 and 12 months and annually thereafter. The main characteristics of the diseased vessels, perioperative and follow up outcome were evaluated...
September 3, 2020: Annals of Vascular Surgery
Yoshihiro Itabashi, Ranjithkumar Ravichandran, Sandhya Bansal, Ankit Bharat, Ramsey Hachem, Ross Bremner, Michael Smith, T Mohanakumar
BACKGROUND: Chronic lung allograft dysfunction (CLAD), is a major hurdle for long-term lung allograft survival after lung transplant and roughly 50% of lung transplant recipients (LTxRs) develop CLAD within 5 years. The mechanisms of CLAD development remain unknown. Donor-specific immune responses to human leukocyte antigen (HLA) and lung self-antigens (SAgs) are vital to the pathogenesis of CLAD. Reduction in Club cell secretory protein (CCSP) has been reported in bronchoalveolar lavage (BAL) fluid samples from LTxRs with bronchiolitis obliterans syndrome (BOS)...
September 1, 2020: Transplantation
Rakesh Kodati, Anuradha Tadepalli, Chandana Reddy, Rajasekhara Chakravarthi, Girish Kumthekar, Ravindranath Tagore
Organizing pneumonia (OP), previously known as bronchiolitis obliterans OP, is a diffuse parenchymal lung disease affecting the distal bronchioles, alveolar ducts, and alveolar walls. Pulmonary infections, especially bacterial and viral diseases, are known to be associated with the secondary form of OP. OP secondary to fungal infections is less common. Here, we report a case of OP associated with pneumocystis pneumonia (PCP) in a kidney transplant recipient on tacrolimus-based triple immunosuppression. The index case had developed new lung consolidation toward the end of trimethoprim-sulfamethoxazole therapy for PCP...
September 2020: Lung India: Official Organ of Indian Chest Society
Yoshiko Watanabe, Tetsuro Miyata, Kunihiro Shigematsu, Kazuo Tanemoto, Yoshikazu Nakaoka, Masayoshi Harigai
BACKGROUND: The epidemiology and clinical features of thromboangiitis obliterans (TAO) in Japan have not been updated extensively.Methods and Results:This retrospective study used the Japanese Ministry of Health, Labour and Welfare (JMHLW) medical support system database and associated health insurance data. The number of medical financial support recipients registered as TAO patients and estimated prevalence of TAO decreased from fiscal year (FY) 2000 (10,089 and 7.95 [95% confidence interval, CI: 7...
September 1, 2020: Circulation Journal: Official Journal of the Japanese Circulation Society
Dzh V Kosaev
OBJECTIVE: To study the immediate results of therapy and indirect revascularization in patients with critical ischemia of the lower limbs. MATERIAL AND METHODS: The results of medication and surgical treatment were analyzed in 210 patients with critical ischemia of the lower limbs. Atherosclerosis obliterans was diagnosed in 142 patients, thromboangiitis obliterans - in 68 patients. Lesion of femoropopliteal segment was observed in 32 (15.2%) cases, popliteal-tibial segment - 68 (32...
2020: Khirurgiia
Nobuyuki Yoshiyasu, Masaaki Sato
Chronic lung allograft dysfunction (CLAD) following lung transplantation limits long-term survival considerably. The main reason for this is a lack of knowledge regarding the pathological condition and the establishment of treatment. The consensus statement from the International Society for Heart and Lung Transplantation on CLAD in 2019 classified CLAD into two main phenotypes: Bronchiolitis obliterans syndrome and restrictive allograft syndrome. Along with this clear classification, further exploration of the mechanisms and the development of appropriate prevention and treatment strategies for each phenotype are desired...
May 29, 2020: World Journal of Transplantation
Xiang Zhang, Xinglan Wang, Huimin Li, Wei Wang, Shunying Zhao
Importance: Nasal nitric oxide (nNO) testing is a method used in the diagnosis of primary ciliary dyskinesia (PCD). It has not been evaluated in Chinese population. Objective: To establish a reference nNO value to assist in the diagnosis of PCD in Chinese children. Methods: nNO values were measured in children with PCD ( n = 36), cystic fibrosis (CF) ( n = 20), asthma ( n = 45), post-infectious bronchiolitis obliterans (BO) ( n = 41) and non-PCD/non-CF bronchiectasis ( n = 32)...
December 2019: Pediatric investigation
Ole Henrik Myrdal, Phoi Phoi Diep, Ellen Ruud, Lorentz Brinch, Richard John Massey, Elisabeth Edvardsen, Johny Kongerud, May B Lund, Liv Ingunn Sikkeland
PURPOSE: Survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at risk for cardiopulmonary adverse events. Data on long-term effects on cardiorespiratory fitness are limited. To address the gap in knowledge, we aimed to determine peak oxygen uptake (V̇O2 peak) and identify associations between cardiorespiratory fitness and clinical characteristics, self-reported physical activity, cardiac, and pulmonary function. METHODS: In a nationwide, single-center cross-sectional study, 90 survivors [aged median (range) 35 (17-54) years, 56% females] were examined, 17 (6-26) years after allo-HSCT...
August 21, 2020: Supportive Care in Cancer
Evangelia Nena, Paschalis Steiropoulos, Athanasios Voulgaris, Marios Froudarakis, Georgia Karpathiou
Bronchiolitis obliterans is a clinical entity which results from a variety of etiologies and has a detrimental impact on patients' quality of life when it remains undiagnosed and untreated. Due to its non-pathognomic clinical symptoms and signs, physicians often proceed to radiological examination, especially with high resolution chest tomography. Histological examination reveals constrictive bronchiolitis, the pathological definition of bronchiolitis obliterans. Due to an almost normal aspect of the lung parenchyma this condition can be missed...
September 2020: Pathology, Research and Practice
C La Fay, E Bosdure, M Baravalle-Einaudi, N Stremler-Le Bel, J-C Dubus, J Mazenq
We report the case of an 18-month-old infant with severe serotype 3 adenovirus pneumonia, exceptionally associated with hemophagocytic syndrome. Treatment included cidofovir and mechanical ventilation for 13 days. The child developed chronic respiratory insufficiency due to bronchiectasis and bronchiolitis obliterans.
August 15, 2020: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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